Effects of diet-induced obesity and voluntary exercise in a tauopathy mouse model: Implications of persistent hyperleptinemia and enhanced astrocytic leptin receptor expression

Neurobiology of Disease

Volumn 71, Issue , 2014, Pages 180-192

  Koga, Shunsuke ^b   Kojima, Ayako ^a   Ishikawa, Chieko ^a   Kuwabara, Satoshi ^b   Arai, Kimihito ^a,b   Yoshiyama, Yasumasa ^a,b  

^a SAKURA NATIONAL HOSPITAL   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Astrocyte; Leptin; Neuroinflammation; Obesity; Tau

Indexed keywords

INTERLEUKIN 1BETA; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR A; LEPTIN RECEPTOR B; MESSENGER RNA; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MAPT PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BODY WEIGHT; BRAIN NERVE CELL; CALORIC INTAKE; CELL ACTIVATION; CONTROLLED STUDY; DISEASE ASSOCIATION; EXERCISE; FEMALE; FOOD INTAKE; GENE EXPRESSION; GLIA CELL; HIPPOCAMPUS; HYPERLEPTINEMIA; INFLAMMATION; INSULIN RESISTANCE; MACROGLIA; MOUSE; MOUSE MODEL; NEUROPATHOLOGY; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; TAUOPATHY; WILD TYPE; ADVERSE EFFECTS; AGE; ANIMAL; BRAIN CORTEX; CELL CULTURE; CYTOLOGY; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; HUMAN; HYPERLACTATEMIA; KINESIOTHERAPY; LIPID DIET; METABOLISM; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PROCEDURES; TAUOPATHIES; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; ASTROCYTES; BODY WEIGHT; CELLS, CULTURED; CEREBRAL CORTEX; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXERCISE THERAPY; HUMANS; HYPERLACTATEMIA; LEPTIN; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; OBESITY; PHOSPHORYLATION; RECEPTORS, LEPTIN; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TAU PROTEINS; TAUOPATHIES;

EID: 84906777660     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.08.015     Document Type: Article

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