Neuroprotective and anti-ageing role of leptin

Journal of Molecular Endocrinology

Volumn 49, Issue 3, 2012, Pages

  Folch, Jaume ^b   Pedrós, Ignacio ^b   Patraca, Iván ^b   Sureda, Francesc ^b   Junyent, Félix ^a,b   Beas Zarate, Carlos ^c   Verdaguer, Ester ^a   Pallás, Mercé ^a   Auladell, Carme ^a   Camins, Antoni ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^c UNIVERSITY OF GUADALAJARA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3BETA; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; STAT3 PROTEIN;

AGING; ALZHEIMER DISEASE; AMNESIA; ANTICONVULSANT ACTIVITY; ANTIOXIDANT ACTIVITY; BODY WEIGHT; BRAIN ISCHEMIA; CELL SURVIVAL; COGNITION; ENERGY; EPILEPSY; HUMAN; HYPOTHALAMUS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

AGING; ANIMALS; COGNITION; HUMANS; HYPOTHALAMUS; LEPTIN; MODELS, BIOLOGICAL; RECEPTORS, LEPTIN;

EID: 84867906012     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-12-0151     Document Type: Review

References (56)

1. Arab L, Sadeghi R, Walker DG, Lue LF & Sabbagh MN 2011 Consequences of aberrant insulin regulation in the brain: can treating diabetes be effective for Alzheimer's disease. Current Neuropharmacology 9 693-705. (doi:10.2174/157015911798376334)
2. Avraham Y, Davidi N, Porat M, Chernoguz D, Magen I, Vorobeiv L, Berry EM& Leker RR 2010 Leptin reduces infarct size in association with enhanced expression of CB2, TRPV1, SIRT-1 and leptin receptor. Current Neurovascular Research 7 136-143. (doi:10.2174/ 156720210791184943)
3. Aziz NA, Pijl H, Frölich M, Roelfsema F & Roos RA 2011 Leptin, adiponectin, and resistin secretion and diurnal rhythmicity are unaltered in Parkinson's disease. Movement Disorders 26 760-761. (doi:10.1002/mds.23463)
4. Bonda DJ, Lee HG, Camins A, Pallas M, Casadesus G, Smith MA & Zhu X 2011 The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurology 10 275-279. (doi:10.1016/S1474-4422(11)70013-8)
5. Bjørbaek C & Kahn BB 2004 Leptin signaling in the central nervous system and the periphery. Recent Progress in Hormone Research 59 305-331. (doi:10.1210/rp.59.1.305)
6. Camins A, Sureda FX, Junyent F, Verdaguer E, Folch J, Pelegri C, Vilaplana J, Beas-Zarate C & Pallas M 2010 Sirtuin activators: designing molecules to extend life span. Biochimica et Biophysica Acta 1799 740-749. (doi:10.1016/j.bbagrm.2010.06.005)
7. Carro EM 2009 Therapeutic approaches of leptin in Alzheimer's disease. Recent Patents on CNS Drug Discovery 4 200-208. (doi:10. 2174/157488909789104848)
8. Coccurello R, Brina D, Caprioli A, Conti R, Ghirardi O, Schepis F & Moles A 2009 30 Days of continuous olanzapine infusion determines energy imbalance, glucose intolerance, insulin resistance, and dyslipidemia in mice. Journal of Clinical Psychopharmacology 29 576-583. (doi:10.1097/JCP.0b013e3181bfe13e)
9. Dicou E, Attoub S & Gressens P 2001 Neuroprotective effects of leptin in vivo and in vitro. Neuroreport 12 3947-3951. (doi:10.1097/ 00001756-200112210-00019)
10. Doruk H, Naharci MI, Bozoglu E, Isik AT & Kilic S 2010 The relationship between body mass index and incidental mild cognitive impairment, Alzheimer's disease and vascular dementia in elderly. Journal of Nutrition, Health & Aging 14 834-838. (doi:10.1007/s12603-010-0113-y)
11. Elias CF, Kelly JF, Lee CE, Ahima RS, Drucker DJ, Saper CB & Elmquist JK 2000 Chemical characterization of leptin-activated neurons in the rat brain. Journal of Comparative Neurology 423 261-281. (doi:10.1002/1096-9861(20000724)423:2!261::AIDCNE6O3.0. CO;2-6)
12. Elmquist JK, Bjørbæk C, Ahima RS, Flier JS & Saper CB 1998 Distributions of leptin receptor mRNA isoforms in the rat brain. Journal of Comparative Neurology 395 535-547. (doi:10.1002/ (SICI)1096-9861(19980615)395:4!535::AID-CNE9O3.0.CO;2-2)
13. Erbayat-Altay E, Yamada KA, Wong M & Thio LL 2008 Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice. Neuroscience Letters 433 82-86. (doi:10.1016/j.neulet. 2007.12.051)
14. Fernandez AM & Torres-Alemán I 2012 The many faces of insulin-like peptide signalling in the brain. Nature Reviews. Neuroscience 13 225-239. (doi:10.1038/nrn3209)
15. Fiszer U, Michałowska M, Baranowska B, Woliń ska-Witort E, Jeske W, Jethon M, Piaścik-Gromada M & Marcinowska-Suchowierska E 2010 Leptin and ghrelin concentrations and weight loss in Parkinson's disease. Acta Neurologica Scandinavica 121 230-236. (doi:10.1111/ j.1600-0404.2009.01185.x)
16. Greco SJ, Sarkar S, Johnston JM, Zhu X, Su B, Casadesus G, Ashford JW, Smith MA & Tezapsidis N 2008 Leptin reduces Alzheimer's diseaserelated tau phosphorylation in neuronal cells. Biochemical and Biophysical Research Communications 376 536-541. (doi:10.1016/ j.bbrc.2008.09.026)
17. Greco SJ, Sarkar S, Johnston JM & Tezapsidis N 2009a Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. Biochemical and Biophysical Research Communications 380 98-104. (doi:10.1016/j.bbrc.2009.01.041)
18. Greco SJ, Sarkar S, Casadesus G, Zhu X, Smith MA, Ashford JW, Johnston JM & Tezapsidis N 2009b Leptin inhibits glycogen synthase kinase-3b to prevent tau phosphorylation in neuronal cells. Neuroscience Letters 455 191-194. (doi:10.1016/ j.neulet.2009.03.066)
19. Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N & Casadesus G 2010 Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease 19 1155-1167.
20. Greco SJ, Hamzelou A, Johnston JM, Smith MA, Ashford JW & Tezapsidis N 2011 Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and b-amyloid in neurons. Biochemical and Biophysical Research Communications 414 170-174. (doi:10.1016/j.bbrc.2011.09.050)
21. Guo Z, Jiang H, Xu X, Duan W & Mattson MP 2008 Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. Journal of Biological Chemistry 283 1754-1763. (doi:10.1074/jbc.M703753200)
22. Harvey J 2007 Leptin regulation of neuronal excitability and cognitive function. Current Opinion in Pharmacology 7 643-647. (doi:10.1016/ j.coph.2007.10.006)
23. Harvey J, Solovyova N & Irving A 2006 Leptin and its role in hippocampal synaptic plasticity. Progress in Lipid Research 45 369-378. (doi:10.1016/j.plipres.2006.03.001)
24. He Y, Kastin AJ, Hsuchou H & Pan W 2009 The Cdk5/p35 kinases modulate leptin-induced STAT3 signaling. Journal of Molecular Neuroscience 39 49-58. (doi:10.1007/s12031-008-9174-3)
25. Ho PW, Liu HF, Ho JW, Zhang WY, Chu AC, Kwok KH, Ge X, Chan KH, Ramsden DB & Ho SL 2010 Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPPC toxicity in neuronal cells. Neurotoxicity Research 17 332-343. (doi:10.1007/ s12640-009-9109-y)
26. Hubschle T, Thom E, Watson A, Roth J, Klaus S & Meyerhof W 2001 Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. Journal of Neuroscience 21 2413-2424.
27. Li J, Deng J, Sheng W & Zuo Z 2012 Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice. Pharmacology, Biochemistry, and Behavior 101 564-574. (doi:10.1016/ j.pbb.2012.03.002)
28. Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, Roubenoff R, Auerbach S, DeCarli C, Wolf PA et al. 2009 Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. Journal of the American Medical Association 302 2565-2572. (doi:10.1001/jama.2009.1836)
29. Lorefält B, Toss G & Granérus AK 2009 Weight loss, body fat mass, and leptin in Parkinson's disease. Movement Disorders 24 885-890. (doi:10.1002/mds.22466)
30. Lu J, Park CS, Lee SK, Shin DW & Kang JH 2006 Leptin inhibits 1-methyl-4-phenylpyridinium-induced cell death in SH-SY5Y cells. Neuroscience Letters 407 240-243. (doi:10.1016/j.neulet.2006.08.053)
31. Marwarha G, Dasari B, Prabhakara JP, Schommer J & Ghribi O 2010 b-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway. Journal of Neurochemistry 115 373-384. (doi:10.1111/j.1471-4159.2010.06929.x)
32. Marwarha G, Dasari B & Ghribi O 2012 Endoplasmic reticulum stressinduced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. Cellular Signalling 24 484-492. (doi:10.1016/ j.cellsig.2011.09.029)
33. Morley JE & Banks WA 2010 Lipids and cognition. Journal of Alzheimer's Disease 20 737-747.
34. Moult PR & Harvey J 2008 Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity. Cell Adhesion & Migration 2 269-275. (doi:10.4161/cam.2.4.6354)
35. Moult PR, Cross A, Santos SD, Carvalho AL, Lindsay Y, Connolly CN, Irving AJ, Leslie NR & Harvey J 2010 Leptin regulates AMPA receptor trafficking via PTEN inhibition. Journal of Neuroscience 30 4088-4101.
36. Moult PR & Harvey J 2011 NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity. Neuropharmacology 61 924-936. (doi:10.1016/j.neuropharm.2011. 06.021)
37. Novakova L, Haluzik M, Jech R, Urgosik D, Ruzicka F & Ruzicka E 2011 Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation. Neuroendocrinology Letters 32 437-441.
38. O'Malley D, MacDonald N, Mizielinska S, Connolly CN, Irving AJ & Harvey J 2007 Leptin promotes rapid dynamic changes in hippocampal dendritic morphology. Molecular and Cellular Neurosciences 35 559-572. (doi:10.1016/j.mcn.2007. 05.001)
39. Oomura Y, Hori N, Shiraishi T, Fukunaga K, Takeda H, Tsuji M, Matsumiya T, Ishibashi M, Aou S, Li XL et al. 2006 Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides 27 2738-2749. (doi:10.1016/j.peptides. 2006.07.001)
40. Otvos L Jr, Terrasi M, Cascio S, Cassone M, Abbadessa G, De Pascali F, Scolaro L, Knappe D, Stawikowski M, Cudic P et al. 2008 Development of a pharmacologically improved peptide agonist of the leptin receptor. Biochimica et Biophysica Acta 1783 1745-1754. (doi:10.1016/j.bbamcr.2008.05.007)
41. Otvos L Jr, Shao WH, Vanniasinghe AS, Amon MA, Holub MC, Kovalszky I, Wade JD, Doll M, Cohen PL, Manolios N et al. 2011 Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides 32 1567-1574. (doi:10.1016/j.peptides.2011.06.015)
42. Oury F & Karsenty G 2011 Towards a serotonin-dependent leptin roadmap in the brain. Trends in Endocrinology and Metabolism 22 382-387. (doi:10.1016/j.tem.2011.04.006)
43. Plum L, Schubert M & Brüning JC 2005 The role of insulin receptor signaling in the brain. Trends in Endocrinology and Metabolism 16 59-65. (doi:10.1016/j.tem.2005.01.008)
44. Rosas-Vargas H, Marti{dotless}́nez-Ezquerro JD & Bienvenu T 2011 Brainderived neurotrophic factor, food intake regulation, and obesity. Archives of Medical Research 42 482-494. (doi:10.1016/j.arcmed.2011. 09.005)
45. Salminen A, Kaarniranta K, Haapasalo A, Soininen H & Hiltunen M 2011 AMP-activated protein kinase: a potential player in Alzheimer's disease. Journal of Neurochemistry 118 460-474. (doi:10.1111/ j.1471-4159.2011.07331.x)
46. Sadagurski M, Norquay L, Farhang J, D'Aquino K, Copps K & White MF 2010 Human IL6 enhances leptin action in mice. Diabetologia 53 525-535. (doi:10.1007/s00125-009-1580-8)
47. Scott MM, Lachey JL, Sternson SM, Lee CE, Elias CF, Friedman JM & Elmquist JK 2009 Leptin targets in the mouse brain. Journal of Comparative Neurology 514 518-532. (doi:10.1002/cne.22025)
48. Shanley LJ, O'Malley D, Irving AJ, Ashford ML & Harvey J 2002 Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. Journal of Physiology 545 933-944. (doi:10.1113/jphysiol.2002.029488)
49. Signore AP, Zhang F, Weng Z, Gao Y & Chen J 2008 Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials. Journal of Neurochemistry 106 1977-1990. (doi:10.1111/ j.1471-4159.2008.05457.x)
50. Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ et al. 2009 Leptin: a novel therapeutic strategy for Alzheimer's disease. Journal of Alzheimer's Disease 16 731-740.
51. Thio LL, Erbayat-Altay E, Rensing N & Yamada KA 2006 Leptin contributes to slower weight gain in juvenile rodents on a ketogenic diet. Pediatric Research 60 413-417. (doi:10.1203/01.pdr. 0000238244.54610.27)
52. Valerio A, Dossena M, Bertolotti P, Boroni F, Sarnico I, Faraco G, Chiarugi A, Frontini A, Giordano A, Liou HC et al. 2009 Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-kB/c-Rel-dependent transcription. Stroke 40 610-617. (doi:10.1161/STROKEAHA. 108.528588)
53. Walker CD, Long H, Williams S & Richard D 2007 Long-lasting effects of elevated neonatal leptin on rat hippocampal function, synaptic proteins and NMDA receptor subunits. Journal of Neuroscience Research 85 816-828. (doi:10.1002/jnr.21173)
54. Weng Z, Signore AP, Gao Y, Wang S, Zhang F, Hastings T, Yin XM & Chen J 2007 Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen activated protein kinase signaling. Journal of Biological Chemistry 282 34479-34491. (doi:10.1074/jbc.M705426200)
55. Xu L, Rensing N, Yang XF, Zhang HX, Thio LL, Rothman SM, Weisenfeld AE, Wong M & Yamada KA 2008 Leptin inhibits 4-aminopyridine-and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. Journal of Clinical Investigation 118 272-280. (doi:10.1172/JCI33009)
56. Zhang F & Chen J 2008 Leptin protects hippocampal CA1 neurons against ischemic injury. Journal of Neurochemistry 107 578-587. (doi:10.1111/j.1471-4159.2008.05645.x)