Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity

Endocrinology

Volumn 152, Issue 7, 2011, Pages 2655-2664

  Krawczewski Carhuatanta, Kimberly A ^a   Demuro, Giovanna ^a   Tschöp, Matthias H ^a   Pfluger, Paul T ^a   Benoit, Stephen C ^a   Obici, Silvana ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; TRANSCRIPTION FACTOR FOSB;

ANOREXIA; ARTICLE; BODY WEIGHT; CALORIC RESTRICTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; EXERCISE; FOOD INTAKE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; IMMUNOREACTIVITY; LEAN BODY WEIGHT; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; WEIGHT REDUCTION;

ADIPOSITY; ANIMALS; APPETITE REGULATION; CALORIC RESTRICTION; DIETARY FATS; ENERGY METABOLISM; GENES, REPORTER; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; NEURONS; OBESITY; PROTO-ONCOGENE PROTEINS C-FOS; RANDOM ALLOCATION; RECEPTORS, LEPTIN; VENTROMEDIAL HYPOTHALAMIC NUCLEUS; WEIGHT LOSS;

EID: 79959444288     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1340     Document Type: Article

References (29)

1. Sullivan PW, Morrato EH, Ghushchyan V, Wyatt HR, Hill JO 2005 Obesity, inactivity, and the prevalence of diabetes and diabetesrelated cardiovascular comorbidities in the US, 2000-2002. Diabetes Care 28:1599-1603
2. Hayes C, Kriska A 2008 Role of physical activity in diabetes management and prevention. J Am Diet Assoc 108:S19-S23 (Pubitemid 351389295)
3. Warburton DER, Nicol CW, Bredin SSD 2006 Health benefits of physical activity: the evidence. Can Med Assoc J 174:801-809
4. Fogelholm M 2010 Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review. Obes Rev 11:202-221
5. Hopkins M, King NA, Blundell JE 2010 Acute and long-term effects of exercise on appetite control: is there any benefit for weight control? Curr Opin Clin Nutr Metab Care 13:635-640
6. Melzer K, Kayser B, Saris WH, Pichard C 2005 Effects of physical activity on food intake. Clin Nutr 24:885-895 (Pubitemid 41782444)
7. Church TS, Martin CK, Thompson AM, Earnest CP, Mikus CR, Blair SN 2009 Changes in weight, waist circumference and compensatory responses with different doses of exercise among sedentary, overweight postmenopausal women. PLoS ONE 4:e4515
8. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671 (Pubitemid 30205071)
9. Finlayson G, Caudwell P, Gibbons C, Hopkins M, King N, Blundell J 20 September 2010 Low fat loss response after medium-term supervised exercise in obese is associated with exercise-induced increase in food reward. J Obes 10.1155/2011/615624
10. Martins C, Kulseng B, King NA, Holst JJ, Blundell JE 2010 The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat. J Clin Endocrinol Metab 95:1609-1616
11. Mayer J, Marshall NB, Vitale JJ, Christensen JH, Mashayekhi MB, Stare FJ 1954 Exercise, food intake and body weight in normal rats and genetically obese adult mice. Am J Physiol 177:544-548
12. Patterson CM, Levin BE 2008 Role of exercise in the central regulation of energy homeostasis and in the prevention of obesity. Neuroendocrinology 87:65-70 (Pubitemid 351301278)
13. Patterson CM, Bouret SG, Dunn-Meynell AA, Levin BE 2009 Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling. Am J Physiol Regul Integr Comp Physiol 296:R537-R548
14. Shapiro A, Matheny M, Zhang Y, Tümer N, Cheng KY, Rogrigues E, Zolotukhin S, Scarpace PJ 2008 Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats. Diabetes 57:614-622
15. Chee MJ, Myers Jr MG, Price CJ, Colmers WF 2010 Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus. J Neurosci 30:3380-3390
16. Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH 2008 Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci USA 105:9793-9798 (Pubitemid 352031379)
17. Paxinos G, Franklin KBJ. 2001 The mouse brain in stereotaxic coordinates. San Diego, CA: Academic Press
18. Flak JN, Ostrander MM, Tasker JG, Herman JP 2009 Chronic stress-induced neurotransmitter plasticity in the PVN. J Comp Neurol 517:156-165
19. Werme M, Messer C, Olson L, Gilden L, Thorén P, Nestler EJ, Brené S 2002 ΔFosB regulates wheel running. J Neurosci 22:8133-8138
20. Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua Jr S, Elmquist JK, Lowell BB 2006 Leptin directly activates SF1 neurons in theVMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49: 191-203 (Pubitemid 43089637)
21. Lowell BB, Spiegelman BM 2000 Towards a molecular understanding of adaptive thermogenesis. Nature 404:652-660 (Pubitemid 30205070)
22. Miller NE, Bailey CJ, Stevenson JA 1950 Decreased "hunger" but increased food intake resulting from hypothalamic lesions. Science 112:256-259
23. Minokoshi Y, Haque MS, Shimazu T 1999 Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes 48:287-291 (Pubitemid 29061100)
24. Irani BG, Le Foll C, Dunn-Meynell AA, Levin BE 2009 Ventromedial nucleus neurons are less sensitive to leptin excitation in rats bres to develop diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 296:R521-R527
25. Choi YH, Li C, Hartzell DL, Little DE, Della-Ferra MA, Baile CA 2008 ICV leptin effects on spontaneous physical activity and feeding behavior in rats. Behav Brain Res 188:100-108
26. Morton GJ, Kaiyala KJ, Fisher JD, Ogimoto K, Schwartz MW, Wisse BE 2011 Identificantion of a physiological role for leptin in the regulation of ambulatory activity and wheel running in mice. Am J Physiol Endocrinol Metab 300:E392-E401
27. Chen J, Kelz MB, Hope BT, Nakabeppu Y, Nestler EJ 1997 Chronic Fos-related antigens: stable variants of ΔFosB induced in brain by chronic treatments. J Neurosci 17:4933-4941 (Pubitemid 27263807)
28. Figlewicz DP, Benoit SC 2009 Insulin, leptin, and food reward: update 2008. Am J Physiol Regul Integr Comp Physiol 296:R9-R19
29. Davis JF, Choi DL, Schurdak JD, Fitzgerald MF, Clegg DJ, Lipton JW, Figlewicz DP, Benoit SC 2011 Leptin regulates energy balance and motivation through action at distinct neural circuits. Biol Psychiatry 69:668-674