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Volumn 19, Issue 8, 2014, Pages 11538-11559

Maslinic acid, a natural phytoalexin-type triterpene from olives - A promising nutraceutical?

Author keywords

Antidiabetic; Antioxidant; Antitumor; Biological effects; Maslinic acid; Nutraceutical; Pentacyclic triterpene; Phytoalexin; Phytochemical

Indexed keywords

BIOLOGICAL PRODUCT; MASLINIC ACID; PLANT MEDICINAL PRODUCT; TRITERPENE;

EID: 84906672891     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules190811538     Document Type: Review
Times cited : (117)

References (94)
  • 3
    • 70349495174 scopus 로고
    • Crataegolsäure, ein neues triterpenoid aus Crataegus oxyacantha. Ein beitrag zur konstitution der α-amyrine
    • Tschesche, R.; Fugmann, R. Crataegolsäure, ein neues triterpenoid aus Crataegus oxyacantha. Ein beitrag zur konstitution der α-amyrine. Chem. Ber. 1951, 84, 810-826.
    • (1951) Chem. Ber. , vol.84 , pp. 810-826
    • Tschesche, R.1    Fugmann, R.2
  • 4
    • 84906696641 scopus 로고
    • Über triterpenoide, III. Mitteil.: Zur kenntnis der crataegol säure
    • Tschesche, R.; Heesch, A.; Fugmann, R. Über triterpenoide, III. Mitteil.: Zur kenntnis der crataegol säure. Chem. Ber. 1953, 86, 626-629.
    • (1953) Chem. Ber. , vol.86 , pp. 626-629
    • Tschesche, R.1    Heesch, A.2    Fugmann, R.3
  • 7
    • 0343179100 scopus 로고
    • Minor components of olive oils. I. Triterpenoid acids in an acetone-extracted orujo oil
    • Vioque, A.; Morris, L. Minor components of olive oils. I. Triterpenoid acids in an acetone-extracted orujo oil. J. Am. Oil Chem. Soc. 1961, 38, 458-488.
    • (1961) J. Am. Oil Chem. Soc. , vol.38 , pp. 458-488
    • Vioque, A.1    Morris, L.2
  • 8
    • 0028026210 scopus 로고
    • Pentacyclic triterpene acids in olives
    • Bianchi, G.; Pozzi, N.; Vlahov, G. Pentacyclic triterpene acids in olives. Phytochemistry 1994, 37, 205-207.
    • (1994) Phytochemistry , vol.37 , pp. 205-207
    • Bianchi, G.1    Pozzi, N.2    Vlahov, G.3
  • 9
    • 0742307297 scopus 로고    scopus 로고
    • On the origins of triterpenoid skeletal diversity
    • Xu, R.; Fazio, G.C.; Matsuda, S.P.T. On the origins of triterpenoid skeletal diversity. Phytochemistry 2004, 65, 261-291.
    • (2004) Phytochemistry , vol.65 , pp. 261-291
    • Xu, R.1    Fazio, G.C.2    Matsuda, S.P.T.3
  • 10
    • 84981750732 scopus 로고
    • Zur Kenntnis der crataegol säure und über zwei neue triterpencarbonsäuren aus Crataegus oxyacantha L
    • Tschesche, R.; Poppel, G.; Über Triterpene, V. Zur Kenntnis der crataegol säure und über zwei neue triterpencarbonsäuren aus Crataegus oxyacantha L. Chem. Ber. 1959, 92, 320-328.
    • (1959) Chem. Ber. , vol.92 , pp. 320-328
    • Tschesche, R.1    Poppel, G.2    Über Triterpene, V.3
  • 11
    • 33947619581 scopus 로고    scopus 로고
    • Formation of triterpenoids throughout Olea europaea fruit ontogeny
    • Stiti, N.; Triki, S.; Hartmann, M.A. Formation of triterpenoids throughout Olea europaea fruit ontogeny. Lipids 2007, 42, 55-67.
    • (2007) Lipids , vol.42 , pp. 55-67
    • Stiti, N.1    Triki, S.2    Hartmann, M.A.3
  • 12
    • 0007223166 scopus 로고    scopus 로고
    • Effect of olive surface waxes on oviposition by Bactrocera oleae (Diptera: Tephritidae)
    • Kombargi, W.S.; Michelakis, S.E.; Petrakis, C.A. Effect of olive surface waxes on oviposition by Bactrocera oleae (Diptera: Tephritidae). J. Econ. Entomol. 1998, 91, 993-998.
    • (1998) J. Econ. Entomol. , vol.91 , pp. 993-998
    • Kombargi, W.S.1    Michelakis, S.E.2    Petrakis, C.A.3
  • 13
    • 15244361589 scopus 로고    scopus 로고
    • Insecticidal and antifeedant effects of Junellia aspera (Verbenaceae) triterpenes and derivatives on Sitophilus oryzae (Coleoptera: Curculionidae)
    • Pungitore, C.R.; García, M.; Gianello, J.C.; Sosa, M.E.; Tonn, C.E. Insecticidal and antifeedant effects of Junellia aspera (Verbenaceae) triterpenes and derivatives on Sitophilus oryzae (Coleoptera: Curculionidae). J. Stored Prod. Res. 2005, 41, 433-443.
    • (2005) J. Stored Prod. Res. , vol.41 , pp. 433-443
    • Pungitore, C.R.1    García, M.2    Gianello, J.C.3    Sosa, M.E.4    Tonn, C.E.5
  • 14
    • 74049163819 scopus 로고    scopus 로고
    • Determination of triterpenoid acids in leaves of Eriobotrya japonica collected at in different seasons
    • Lu, H.; Xi, C.; Chen, J.; Li, W. Determination of triterpenoid acids in leaves of Eriobotrya japonica collected at in different seasons. Zhongguo Zhong Yao Za Zhi 2009, 34, 2353-2355.
    • (2009) Zhongguo Zhong Yao za Zhi , vol.34 , pp. 2353-2355
    • Lu, H.1    Xi, C.2    Chen, J.3    Li, W.4
  • 17
    • 0029839826 scopus 로고    scopus 로고
    • Anti-HIV triterpene acids from Geum japonicum
    • Xu, H.X.; Zeng, F.Q.; Wan, M.; Sim, K.Y. Anti-HIV triterpene acids from Geum japonicum. J. Nat. Prod. 1996, 59, 643-645.
    • (1996) J. Nat. Prod. , vol.59 , pp. 643-645
    • Xu, H.X.1    Zeng, F.Q.2    Wan, M.3    Sim, K.Y.4
  • 18
    • 37049093895 scopus 로고
    • Tannins of rosaceous medicinal plants. Part 2. Gemins A, B, and C, new dimeric ellagitannins from Geum japonicum
    • Yoshida, T.; Okuda, T.; Memon, M.U.; Shingu, T. Tannins of rosaceous medicinal plants. Part 2. Gemins A, B, and C, new dimeric ellagitannins from Geum japonicum. J. Chem. Soc. Perkin Trans. 1985, 1, 315-321.
    • (1985) J. Chem. Soc. Perkin Trans. , vol.1 , pp. 315-321
    • Yoshida, T.1    Okuda, T.2    Memon, M.U.3    Shingu, T.4
  • 19
    • 0026286139 scopus 로고
    • Studies on the chemical constituents from roots of Agastache rugosa
    • Zou, Z.M.; Cong, P.Z. Studies on the chemical constituents from roots of Agastache rugosa. Yao Xue Xue Bao 1991, 26, 906-910.
    • (1991) Yao Xue Xue Bao , vol.26 , pp. 906-910
    • Zou, Z.M.1    Cong, P.Z.2
  • 20
    • 0037238614 scopus 로고    scopus 로고
    • Antifungal activity of the essential oil of Agastache rugosa Kuntze and its synergism with ketoconazole
    • Shin, S.; Kang, C.A. Antifungal activity of the essential oil of Agastache rugosa Kuntze and its synergism with ketoconazole. Lett. Appl. Microbiol. 2003, 36, 111-115.
    • (2003) Lett. Appl. Microbiol. , vol.36 , pp. 111-115
    • Shin, S.1    Kang, C.A.2
  • 22
    • 78751497839 scopus 로고    scopus 로고
    • Anti angiogenic potential of three triterpenic acids in human liver cancer cells
    • Lin, C.C.; Huang, C.Y.; Mong, M.C.; Chan, C.Y.; Yin, M.C. Anti angiogenic potential of three triterpenic acids in human liver cancer cells. J. Agric. Food Chem. 2011, 59, 755-762.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 755-762
    • Lin, C.C.1    Huang, C.Y.2    Mong, M.C.3    Chan, C.Y.4    Yin, M.C.5
  • 23
    • 84864687685 scopus 로고    scopus 로고
    • Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice
    • Yin, M.C.; Lin, M.C.; Mong, M.C.; Lin, C.Y. Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice. J. Agric. Food Chem. 2012, 60, 7697-7701.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 7697-7701
    • Yin, M.C.1    Lin, M.C.2    Mong, M.C.3    Lin, C.Y.4
  • 24
    • 77649188786 scopus 로고    scopus 로고
    • Nutritional evaluation and bioactive microconstituents (phytosterols, tocopherols, polyphenols, triterpenic acids) in cooked dry legumes usually consumed in the Mediterranean countries
    • Kalogeropoulos, N; Chiou, A.; Ioannou, M.; Karathanos, V.T.; Hassapidou, M.; Andrikopoulos, N.K. Nutritional evaluation and bioactive microconstituents (phytosterols, tocopherols, polyphenols, triterpenic acids) in cooked dry legumes usually consumed in the Mediterranean countries. Food Chem. 2010, 121, 682-690.
    • (2010) Food Chem. , vol.121 , pp. 682-690
    • Kalogeropoulos, N.1    Chiou, A.2    Ioannou, M.3    Karathanos, V.T.4    Hassapidou, M.5    Andrikopoulos, N.K.6
  • 25
    • 79953903917 scopus 로고    scopus 로고
    • Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits
    • Li, G.L.; You, J.M.; Song, C.H.; Xia, L.; Zheng, J.; Suo, Y.R. Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits. J. Agric. Food Chem. 2011, 59, 2972-2979.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 2972-2979
    • Li, G.L.1    You, J.M.2    Song, C.H.3    Xia, L.4    Zheng, J.5    Suo, Y.R.6
  • 27
    • 53049095071 scopus 로고    scopus 로고
    • Anti-proliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells
    • Juan, M.E.; Planas, J.M.; Ruiz-Gutiérrez, V.; Daniel, H.; Wenzel, U. Anti-proliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells. Br. J. Nutr. 2008, 100, 36-43.
    • (2008) Br. J. Nutr. , vol.100 , pp. 36-43
    • Juan, M.E.1    Planas, J.M.2    Ruiz-Gutiérrez, V.3    Daniel, H.4    Wenzel, U.5
  • 28
    • 33751275468 scopus 로고    scopus 로고
    • (2α,3β)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea Europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells
    • Reyes, F.J.; Centelles, J.J.; Lupiáñez, J.A.; Cascante, M. (2α,3β)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. FEBS Lett. 2006, 580, 6302-6310.
    • (2006) FEBS Lett. , vol.580 , pp. 6302-6310
    • Reyes, F.J.1    Centelles, J.J.2    Lupiáñez, J.A.3    Cascante, M.4
  • 29
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner, M.O. The biochemistry of apoptosis. Nature 2000, 407, 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 30
  • 31
    • 56349099145 scopus 로고    scopus 로고
    • Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway
    • Reyes-Zurita, F.J.; Rufino-Palomares, E.E.; Lupiáñez, J.A.; Cascante, M. Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway. Cancer Lett. 2009, 273, 44-54.
    • (2009) Cancer Lett. , vol.273 , pp. 44-54
    • Reyes-Zurita, F.J.1    Rufino-Palomares, E.E.2    Lupiáñez, J.A.3    Cascante, M.4
  • 32
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li, P.; Nijhawan, D.; Budihardjo, I.; Srinivasula, S.M.; Ahmad, M.; Alnemri, E.S.; Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997, 91, 479-489.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 35
    • 0141953270 scopus 로고    scopus 로고
    • A JNK-dependent pathway is required for TNFα-induced apoptosis
    • Deng, Y.; Ren, X.; Yang, L.; Lin, Y.; Wu, X. A JNK-dependent pathway is required for TNFα-induced apoptosis. Cell 2003, 115, 61-70.
    • (2003) Cell , vol.115 , pp. 61-70
    • Deng, Y.1    Ren, X.2    Yang, L.3    Lin, Y.4    Wu, X.5
  • 36
    • 10944247878 scopus 로고    scopus 로고
    • Neutralization of Smac/diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition
    • Wilkinson, J.C.; Wilkinson, A.S.; Scott, F.L.; Csomos, R.A.; Salvesen, G.S.; Duckett, C.S. Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J. Biol. Chem. 2004, 279, 51082-51090.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51082-51090
    • Wilkinson, J.C.1    Wilkinson, A.S.2    Scott, F.L.3    Csomos, R.A.4    Salvesen, G.S.5    Duckett, C.S.6
  • 38
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau, O.; Tschopp, J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003, 114, 181-190.
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 39
    • 84877757564 scopus 로고    scopus 로고
    • Molecular basis of NF-κB signaling
    • Napetschnig, J.; Wu, H. Molecular basis of NF-κB signaling. Annu. Rev. Biophys. 2013, 42, 443-468.
    • (2013) Annu. Rev. Biophys. , vol.42 , pp. 443-468
    • Napetschnig, J.1    Wu, H.2
  • 40
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • Karin M. Nuclear factor-κB in cancer development and progression. Nature 2006, 441, 431-436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 42
    • 79959495308 scopus 로고    scopus 로고
    • Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway
    • 13
    • Li, C.; Yang, Z.; Zhai, C.; Qiu, W.; Li, D.; Yi, Z.; Wang, L.; Tang, J.; Qian, M.; Luo, J.; et al. Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway. Mol. Cancer 2010, 73:1-73:13.
    • (2010) Mol. Cancer , vol.73 , pp. 1-73
    • Li, C.1    Yang, Z.2    Zhai, C.3    Qiu, W.4    Li, D.5    Yi, Z.6    Wang, L.7    Tang, J.8    Qian, M.9    Luo, J.10
  • 43
    • 78651478136 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of maslinic acid: Suppression of COX-2 expression and inhibition of NF-κB and AP-1 activation in Raji cells
    • Hsum, Y.W.; Yew, W.T.; Hong, P.L.; Soo, K.K.; Hoon, L.S.; Chieng, Y.C.; Mooi, L.Y. Cancer chemopreventive activity of maslinic acid: Suppression of COX-2 expression and inhibition of NF-κB and AP-1 activation in Raji cells. Planta Med. 2011, 77, 152-157.
    • (2011) Planta Med. , vol.77 , pp. 152-157
    • Hsum, Y.W.1    Yew, W.T.2    Hong, P.L.3    Soo, K.K.4    Hoon, L.S.5    Chieng, Y.C.6    Mooi, L.Y.7
  • 44
    • 0346368096 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 in human neoplasia: Rationale and promise
    • Dannenberg, A.J.; Subbaramaiah, K. Targeting cyclooxygenase-2 in human neoplasia: Rationale and promise. Cancer Cell 2003, 4, 431-436.
    • (2003) Cancer Cell , vol.4 , pp. 431-436
    • Dannenberg, A.J.1    Subbaramaiah, K.2
  • 46
    • 79954621583 scopus 로고    scopus 로고
    • Maslinic acid induces apoptosis in salivary gland adenoid cystic carcinoma cells by Ca -evoked p38 signaling pathway
    • Wu, D.M.; Zhao, D.; Li, D.Z.; Xu, D.Y.; Chu, W.F.; Wang, X.F. Maslinic acid induces apoptosis in salivary gland adenoid cystic carcinoma cells by Ca -evoked p38 signaling pathway. Naunyn Schmiedebergs Arch. Pharmacol. 2011, 383, 321-330.
    • (2011) Naunyn Schmiedebergs Arch. Pharmacol. , vol.383 , pp. 321-330
    • Wu, D.M.1    Zhao, D.2    Li, D.Z.3    Xu, D.Y.4    Chu, W.F.5    Wang, X.F.6
  • 47
    • 84905171879 scopus 로고    scopus 로고
    • Maslinic acid induced apoptosis in bladder cancer cells through activating p38 MAPK signaling pathway
    • Zhang, S.; Ding, D.; Zhang, X.; Shan, L.; Liu, Z. Maslinic acid induced apoptosis in bladder cancer cells through activating p38 MAPK signaling pathway. Mol. Cell Biochem. 2014, 392, 281-287.
    • (2014) Mol. Cell Biochem. , vol.392 , pp. 281-287
    • Zhang, S.1    Ding, D.2    Zhang, X.3    Shan, L.4    Liu, Z.5
  • 49
    • 34250659001 scopus 로고    scopus 로고
    • Triterpenoids isolated from apple peels have potent anti-proliferative activity and may be partially responsible for apple's anticancer activity
    • He, X.; Liu, R.H. Triterpenoids isolated from apple peels have potent anti-proliferative activity and may be partially responsible for apple's anticancer activity. J. Agric. Food Chem. 2007, 55, 4366-4370.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 4366-4370
    • He, X.1    Liu, R.H.2
  • 51
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in tumorigenesis
    • Rankin, E.B.; Giaccia, A.J. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ. 2008, 15, 678-685.
    • (2008) Cell Death Differ. , vol.15 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 52
    • 77956301181 scopus 로고    scopus 로고
    • Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
    • Bourboulia, D.; Stetler-Stevenson, W.G. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. Semin. Cancer Biol. 2010, 20, 161-168.
    • (2010) Semin. Cancer Biol. , vol.20 , pp. 161-168
    • Bourboulia, D.1    Stetler-Stevenson, W.G.2
  • 53
    • 74949099621 scopus 로고    scopus 로고
    • Urokinase plasminogen activator system as a potential target for cancer therapy
    • Mekkawy, A.H.; Morris, D.L.; Pourgholami, M.H. Urokinase plasminogen activator system as a potential target for cancer therapy. Future Oncol. 2009, 5, 1487-1499.
    • (2009) Future Oncol. , vol.5 , pp. 1487-1499
    • Mekkawy, A.H.1    Morris, D.L.2    Pourgholami, M.H.3
  • 54
    • 84873045777 scopus 로고    scopus 로고
    • Maslinic acid inhibits the metastatic capacity of DU145 human prostate cancer cells: Possible mediation via hypoxia-inducible factor-1α signalling
    • Park, S.Y.; Nho, C.W.; Kwon, D.Y.; Kang, Y.H.; Lee, K.W.; Park, J.H. Maslinic acid inhibits the metastatic capacity of DU145 human prostate cancer cells: Possible mediation via hypoxia-inducible factor-1α signalling. Br. J. Nutr. 2013, 109, 210-222.
    • (2013) Br. J. Nutr. , vol.109 , pp. 210-222
    • Park, S.Y.1    Nho, C.W.2    Kwon, D.Y.3    Kang, Y.H.4    Lee, K.W.5    Park, J.H.6
  • 57
    • 25844437477 scopus 로고    scopus 로고
    • Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases
    • Wen, X.; Sun, H.; Liu, J.; Wu, G.; Zhang, L.; Wu, X.; Ni, P. Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. Bioorg. Med. Chem. Lett. 2005, 15, 4944-4948.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4944-4948
    • Wen, X.1    Sun, H.2    Liu, J.3    Wu, G.4    Zhang, L.5    Wu, X.6    Ni, P.7
  • 58
    • 45749110639 scopus 로고    scopus 로고
    • Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: Synthesis, structure-activity relationships, and X-ray crystallographic studies
    • Wen, X.; Sun, H.; Liu, J.; Cheng, K.; Zhang, P.; Zhang, L.; Hao, J.; Zhang, L.; Ni, P.; Zographos, S.E.; et al. Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: Synthesis, structure-activity relationships, and X-ray crystallographic studies. J. Med. Chem. 2008, 51, 3540-3554.
    • (2008) J. Med. Chem. , vol.51 , pp. 3540-3554
    • Wen, X.1    Sun, H.2    Liu, J.3    Cheng, K.4    Zhang, P.5    Zhang, L.6    Hao, J.7    Zhang, L.8    Ni, P.9    Zographos, S.E.10
  • 60
    • 84896737538 scopus 로고    scopus 로고
    • Effects of Syzygium aromaticum-derived triterpenes on postprandial blood glucose in streptozotocin-induced diabetic rats following carbohydrate challenge
    • Khathi, A.; Serumula, M.R.; Myburg, R.B.; van Heerden, F.R.; Musabayane, C.T. Effects of Syzygium aromaticum-derived triterpenes on postprandial blood glucose in streptozotocin-induced diabetic rats following carbohydrate challenge. PLoS One 2013, 8, e81632.
    • (2013) PLoS One , vol.8
    • Khathi, A.1    Serumula, M.R.2    Myburg, R.B.3    Van Heerden, F.R.4    Musabayane, C.T.5
  • 61
    • 80052641113 scopus 로고    scopus 로고
    • Maslinic acid, a natural inhibitor of glycogen phosphorylase, reduces cerebral ischemic injury in hyperglycemic rats by GLT-1 up-regulation
    • Guan, T.; Qian, Y.; Tang, X.; Huang, M.; Huang, L.; Li, Y.; Sun, H. Maslinic acid, a natural inhibitor of glycogen phosphorylase, reduces cerebral ischemic injury in hyperglycemic rats by GLT-1 up-regulation. J. Neurosci. Res. 2011, 89, 1829-1839.
    • (2011) J. Neurosci. Res. , vol.89 , pp. 1829-1839
    • Guan, T.1    Qian, Y.2    Tang, X.3    Huang, M.4    Huang, L.5    Li, Y.6    Sun, H.7
  • 62
    • 84901378828 scopus 로고    scopus 로고
    • Maslinic acid modulates glycogen metabolism by enhancing the insulin signaling pathway and inhibiting glycogen phosphorylase
    • Liu, J.; Wang, X.; Chen, Y.P.; Mao, L.F.; Shang, J.; Sun, H.B.; Zhang, L.Y. Maslinic acid modulates glycogen metabolism by enhancing the insulin signaling pathway and inhibiting glycogen phosphorylase. Chin. J. Nat. Med. 2014, 12, 259-265.
    • (2014) Chin. J. Nat. Med. , vol.12 , pp. 259-265
    • Liu, J.1    Wang, X.2    Chen, Y.P.3    Mao, L.F.4    Shang, J.5    Sun, H.B.6    Zhang, L.Y.7
  • 63
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel, A.R.; Kahn, C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414, 799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 65
    • 33750933460 scopus 로고    scopus 로고
    • Constituents of the flowers of Punica granatum
    • Wang, R.; Wang, W.; Wang, L.; Liu, R.; Ding, Y.; Du, L. Constituents of the flowers of Punica granatum. Fitoterapia 2006, 77, 534-537.
    • (2006) Fitoterapia , vol.77 , pp. 534-537
    • Wang, R.1    Wang, W.2    Wang, L.3    Liu, R.4    Ding, Y.5    Du, L.6
  • 66
    • 77956339963 scopus 로고    scopus 로고
    • Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids
    • Allouche, Y.; Beltrán, G.; Gaforio, J.J.; Uceda, M.; Mesa, M.D. Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids. Food Chem. Toxicol. 2010, 48, 2885-2890.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 2885-2890
    • Allouche, Y.1    Beltrán, G.2    Gaforio, J.J.3    Uceda, M.4    Mesa, M.D.5
  • 67
    • 34047260054 scopus 로고    scopus 로고
    • Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells
    • Márquez-Martín, A.; de la Puerta, R.; Fernández- Arche, A.; Ruiz-Gutiérrez, V.; Yaqoob P. Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells. Cytokine 2006, 36, 211-217.
    • (2006) Cytokine , vol.36 , pp. 211-217
    • Márquez-Martín, A.1    De La Puerta, R.2    Fernández-Arche, A.3    Ruiz-Gutiérrez, V.4    Yaqoob, P.5
  • 68
    • 81255158024 scopus 로고    scopus 로고
    • Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B
    • Huang, L.; Guan, T.; Qian, Y.; Huang, M.; Tang, X.; Li, Y.; Sun, H. Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B. Eur. J. Pharmacol. 2011, 672, 169-174.
    • (2011) Eur. J. Pharmacol. , vol.672 , pp. 169-174
    • Huang, L.1    Guan, T.2    Qian, Y.3    Huang, M.4    Tang, X.5    Li, Y.6    Sun, H.7
  • 69
    • 33645760731 scopus 로고    scopus 로고
    • Triterpenic compounds from "orujo" olive oil elicit vasorelaxation in aorta from spontaneously hypertensive rats
    • Rodríguez-Rodríguez, R.; Perona, J.S.; Herrera, M.D.; Ruiz-Gutiérrez, V. Triterpenic compounds from "orujo" olive oil elicit vasorelaxation in aorta from spontaneously hypertensive rats. J. Agric. Food Chem. 2006, 54, 2096-2102.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 2096-2102
    • Rodríguez-Rodríguez, R.1    Perona, J.S.2    Herrera, M.D.3    Ruiz-Gutiérrez, V.4
  • 70
    • 36849022040 scopus 로고    scopus 로고
    • Effects of oleanolic acid and maslinic acid on hyperlipidemia
    • Liu, J.; Sun, H.; Wang, X.; Mu, D.; Liao, H.; Zhang, L. Effects of oleanolic acid and maslinic acid on hyperlipidemia. Drug Dev. Res. 2007, 68, 261-266.
    • (2007) Drug Dev. Res. , vol.68 , pp. 261-266
    • Liu, J.1    Sun, H.2    Wang, X.3    Mu, D.4    Liao, H.5    Zhang, L.6
  • 72
  • 74
    • 80054743156 scopus 로고    scopus 로고
    • Maslinic acid, a natural triterpenoid compound from Olea europaea, protects cortical neurons against oxygen-glucose deprivation-induced injury
    • Qian, Y.; Guan, T.; Tang, X.; Huang, L.; Huang, M.; Li, Y.; Sun, H. Maslinic acid, a natural triterpenoid compound from Olea europaea, protects cortical neurons against oxygen-glucose deprivation-induced injury. Eur. J. Pharmacol. 2011, 670, 148-153.
    • (2011) Eur. J. Pharmacol. , vol.670 , pp. 148-153
    • Qian, Y.1    Guan, T.2    Tang, X.3    Huang, L.4    Huang, M.5    Li, Y.6    Sun, H.7
  • 75
    • 0036513249 scopus 로고    scopus 로고
    • Does nitric oxide modulate mitochondrial energy generation and apoptosis?
    • Moncada, S.; Erusalimsky, J.D. Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat. Rev. Mol. Cell Biol. 2002, 3, 214-220.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 214-220
    • Moncada, S.1    Erusalimsky, J.D.2
  • 77
    • 77955570062 scopus 로고    scopus 로고
    • Glutamate receptors, neurotoxicity and neurodegeneration
    • Lau, A.; Tymianski, M. Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch. 2010, 460, 525-542.
    • (2010) Pflugers Arch. , vol.460 , pp. 525-542
    • Lau, A.1    Tymianski, M.2
  • 78
    • 1242317710 scopus 로고    scopus 로고
    • The glutamate/neutral amino acid transporter family SLC1: Molecular, physiological and pharmacological aspects
    • Kanai, Y.; Hediger, M.A. The glutamate/neutral amino acid transporter family SLC1: Molecular, physiological and pharmacological aspects. Pflügers Archiv 2004, 447, 469-479.
    • (2004) Pflügers Archiv , vol.447 , pp. 469-479
    • Kanai, Y.1    Hediger, M.A.2
  • 79
    • 78650679778 scopus 로고    scopus 로고
    • Astrocytic glutamate transporter-dependent neuroprotection against glutamate toxicity: An in vitro study of maslinic acid
    • Qian, Y.; Guan, T.; Tang, X.; Huang, L.; Huang, M.; Li, Y.; Sun, H.; Yu, R.; Zhang, F. Astrocytic glutamate transporter-dependent neuroprotection against glutamate toxicity: An in vitro study of maslinic acid. Eur. J. Pharmacol. 2011, 651, 59-65.
    • (2011) Eur. J. Pharmacol. , vol.651 , pp. 59-65
    • Qian, Y.1    Guan, T.2    Tang, X.3    Huang, L.4    Huang, M.5    Li, Y.6    Sun, H.7    Yu, R.8    Zhang, F.9
  • 80
    • 0034881256 scopus 로고    scopus 로고
    • The role of hyperglycemia in acute stroke
    • Kagansky, N.; Levy, S.; Knobler, H. The role of hyperglycemia in acute stroke. Arch. Neurol. 2001, 58, 1209-1212.
    • (2001) Arch. Neurol. , vol.58 , pp. 1209-1212
    • Kagansky, N.1    Levy, S.2    Knobler, H.3
  • 84
    • 84906705666 scopus 로고    scopus 로고
    • Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages
    • 10
    • Moneriz, C.; Marín-García, P.; García-Granados, A.; Bautista, J.M.; Diez, A.; Puyet, A. Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages. Malar. J. 2011, 82:1-82:10.
    • (2011) Malar. J. , vol.82 , pp. 1-82
    • Moneriz, C.1    Marín-García, P.2    García-Granados, A.3    Bautista, J.M.4    Diez, A.5    Puyet, A.6
  • 85
    • 79955044711 scopus 로고    scopus 로고
    • Parasitostatic effect of maslinic acid. II. Survival increase and immune protection in lethal Plasmodium yoelii-infected mice
    • 9
    • Moneriz, C.; Marín-García, P.; Bautista, J.M.; Diez, A.; Puyet, A. Parasitostatic effect of maslinic acid. II. Survival increase and immune protection in lethal Plasmodium yoelii-infected mice. Malar. J. 2011, 103:1-103:9.
    • (2011) Malar. J. , vol.103 , pp. 1-103
    • Moneriz, C.1    Marín-García, P.2    Bautista, J.M.3    Diez, A.4    Puyet, A.5
  • 86
    • 79961029208 scopus 로고    scopus 로고
    • Multi-targeted activity of maslinic acid as an antimalarial natural compound
    • Moneriz, C.; Mestres, J.; Bautista, J.M.; Diez, A.; Puyet, A. Multi-targeted activity of maslinic acid as an antimalarial natural compound. FEBS J. 2011, 278, 2951-2961.
    • (2011) FEBS J. , vol.278 , pp. 2951-2961
    • Moneriz, C.1    Mestres, J.2    Bautista, J.M.3    Diez, A.4    Puyet, A.5
  • 87
    • 33750193823 scopus 로고    scopus 로고
    • Maslinic acid as a feed additive to stimulate growth and hepatic protein-turnover rates in rainbow trout (Onchorhynchus mykiss)
    • Fernández-Navarro, M.; Peragón, J.; Esteban, F.J.; de la Higuera, M.; Lupiáñez, J.A. Maslinic acid as a feed additive to stimulate growth and hepatic protein-turnover rates in rainbow trout (Onchorhynchus mykiss). Comp. Biochem. Physiol. C 2006, 144, 130-140.
    • (2006) Comp. Biochem. Physiol. C , vol.144 , pp. 130-140
    • Fernández-Navarro, M.1    Peragón, J.2    Esteban, F.J.3    De La Higuera, M.4    Lupiáñez, J.A.5
  • 88
    • 37349117431 scopus 로고    scopus 로고
    • Maslinic acid added to the diet increases growth and protein-turnover rates in the white muscle of rainbow trout (Oncorhynchus mykiss)
    • Fernández-Navarro, M.; Peragón, J.; Amores, V.; de la Higuera, M.; Lupiáñez, J.A. Maslinic acid added to the diet increases growth and protein-turnover rates in the white muscle of rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. C 2008, 147, 158-167.
    • (2008) Comp. Biochem. Physiol. C , vol.147 , pp. 158-167
    • Fernández-Navarro, M.1    Peragón, J.2    Amores, V.3    De La Higuera, M.4    Lupiáñez, J.A.5
  • 89
    • 79960805558 scopus 로고    scopus 로고
    • Proteomics in the liver of gilthead sea bream (Sparus aurata) to elucidate the cellular response induced by the intake of maslinic acid
    • Rufino-Palomares, E.; Reyes-Zurita, F.J.; Fuentes-Almagro, C.A.; de la Higuera, M.; Lupiáñez, J.A.; Peragón, J. Proteomics in the liver of gilthead sea bream (Sparus aurata) to elucidate the cellular response induced by the intake of maslinic acid. Proteomics 2011, 11, 3312-3325.
    • (2011) Proteomics , vol.11 , pp. 3312-3325
    • Rufino-Palomares, E.1    Reyes-Zurita, F.J.2    Fuentes-Almagro, C.A.3    De La Higuera, M.4    Lupiáñez, J.A.5    Peragón, J.6
  • 90
    • 37849009343 scopus 로고    scopus 로고
    • Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa
    • Sultana, N.; Lee, N.H. Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa. Phytother Res. 2007, 21, 1171-1176.
    • (2007) Phytother Res. , vol.21 , pp. 1171-1176
    • Sultana, N.1    Lee, N.H.2
  • 91
    • 36549027860 scopus 로고    scopus 로고
    • Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum
    • Ullah, F.; Hussain, H.; Hussain, J.; Bukhari, I.A.; Khan, M.T.; Choudhary, M.I.; Gilani, A.H.; Ahmad, V.U. Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum. Phytother Res. 2007, 21, 1076-1081.
    • (2007) Phytother Res. , vol.21 , pp. 1076-1081
    • Ullah, F.1    Hussain, H.2    Hussain, J.3    Bukhari, I.A.4    Khan, M.T.5    Choudhary, M.I.6    Gilani, A.H.7    Ahmad, V.U.8
  • 92
    • 79951821134 scopus 로고    scopus 로고
    • Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways
    • Li, C.; Yang, Z.; Li, Z.; Ma, Y.; Zhang, L.; Zheng, C.; Qiu W.; Wu, X.; Wang, X.; Li, H.; et al. Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways. J. Bone Miner. Res. 2011, 26, 644-656.
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 644-656
    • Li, C.1    Yang, Z.2    Li, Z.3    Ma, Y.4    Zhang, L.5    Zheng, C.6    Qiu, W.7    Wu, X.8    Wang, X.9    Li, H.10
  • 93
    • 84876929842 scopus 로고    scopus 로고
    • Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea
    • Nieto, F.R.; Cobos, E.J.; Entrena, J.M.; Parra, A.; García- Granados, A.; Baeyens, J.M. Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. J. Nat. Prod. 2013, 76, 737-740.
    • (2013) J. Nat. Prod. , vol.76 , pp. 737-740
    • Nieto, F.R.1    Cobos, E.J.2    Entrena, J.M.3    Parra, A.4    García-Granados, A.5    Baeyens, J.M.6


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