Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids

Food and Chemical Toxicology

Volumn 48, Issue 10, 2010, Pages 2885-2890

  Allouche, Yosra ^a,b   Beltrán, Gabriel ^a   Gaforio, José Juan ^b   Uceda, Marino ^a   Mesa, María D ^c  

^a IFAPA CENTRO EL TORUÑO   (Spain)

^b UNIVERSITY OF JAÉN   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

Antioxidants; Cardioprotective activity; LDL oxidation; Thrombin generation; Triterpenic acids; Triterpenic diols

Indexed keywords

ALPHA TOCOPHEROL; COPPER; ERYTHRODIOL; LOW DENSITY LIPOPROTEIN; MASLINIC ACID; OLEANOLIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UVAOL;

ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROGENESIS; CHELATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; HEART PROTECTION; HUMAN; HUMAN CELL; LIPID OXIDATION; THROMBOSIS;

ANTIOXIDANTS; ATHEROSCLEROSIS; CARDIOTONIC AGENTS; CHELATING AGENTS; CHOLESTEROL, LDL; COPPER; FREE RADICAL SCAVENGERS; HUMANS; INDICATORS AND REAGENTS; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; THIOBARBITURIC ACID REACTIVE SUBSTANCES; THROMBIN; TRITERPENES;

EID: 77956339963     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.07.022     Document Type: Article

References (26)

1. Abe I. Enzymatic synthesis of cyclic triterpenes. Nat. Prod. Rep. 2007, 24:1311-1331.
2. Andrikopoulos N.K., Kaliora A.C., Assimopoulou A.N., Papageorgiou V.P. Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation. J. Med. Food 2002, 5:1-7.
3. Badimón L., Vilahur G., Padró T. Lipoproteínas, plaquetas y aterotrombosis. Rev. Esp. Cardiol. 2009, 62:1161-1178.
4. Belinky P.A., Aviram M., Mahmood S., Vaya J. Structural aspects of the inhibitory effect of glabridin on LDL oxidation. Free Radic. Biol. Med. 1998, 24:1419-1429.
5. Chung B.H., Wilkinson T., Geer J.C., Segrest J.P. Preparative and quantitative isolation of plasma lipoprotein: rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor. J. Lipid Res. 1981, 21:284-291.
6. Duke, J., 1998. Dr. Duke's Phytochemical and Ethnobotanical Databases. (10/03/1998). http://www.ars-grin.gov/duke/plants.html.
7. Ferdowsian H.R., Barnard N.D. Effects of plant-based diets on plasma lipids. Am. J. Cardiol. 2009, 104:947-956.
8. Gotfredsen, E., 2010. Liber Herbarum II: the incomplete reference-guide to Herbal medicine. (19/07/2010). http://www.liberherbarum.com/.
9. Laguerre M., Lecomte J., Villeneuve P. Evaluation of the ability of antioxidants to counteract lipid oxidation: existing methods, new trends and challenges. Prog. Lipid Res. 2007, 46:244-282.
10. Lin Y., Vermeer M.A., Trautwein E.A. Triterpenic acids present in hawthorn lower plasma cholesterol by inhibiting intestinal ACAT activity in Hamsters. eCAM 2009, 10.1093/ecam/nep007.
11. Lusis A.J. Atherosclerosis. Nature 2000, 407:233-241.
12. Matasuura E., Hughes G.R., Khamshta M.A. Oxidation of LDL and its clinical implication. Autoimmun. Rev. 2008, 7:558-566.
13. Márquez-Martín A., De la Puerta R., Fernández-Arche A., Ruiz-Gutíerrez V. Suppressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macropahages. Free Radic. Res. 2006, 40:295-302.
14. Márquez-Martín A., De la Puerta R., Fernández-Arche A., Ruiz-Gutíerrez V., Yaqoob P. Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells. Cytokine 2007, 36:211-217.
15. Mesa M.D., Buckley R., Minihane A.M., Yaqoob P. Effects of oil rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoprotein. Atherosclerosis 2004, 175:333-345.
16. Mesa M.D., Silván J.M., Olza J., Gil A., Del Castillo M.D. Antioxidant properties of soy protein-fuctooligosaccharide glycation systems and its hydrolyzates. Food Res. Int. 2008, 41:606-615.
17. Montilla M.P., Agil A., Navarro M.C., Jiménez M.I., García-Granados A., Parra A., Cabo M.M. Antioxidant activity of maslinic acid, a triterpene derivative obtained from Olea europaea. Planta Med. 2003, 69:472-474.
18. Perona J.S., Arcemis C., Ruiz-Gutíerrez V., Catalá A. Effect of dietary high-oleic-acid oils that are rich in antioxidants on microsomal lipid peroxidation in rats. J. Agric. Food Chem. 2005, 53:730-735.
19. Pinchuk I., Lichtenberg D. The mechanism of action of antioxidants against lipoprotein peroxidation, evaluation based on kinetic experiments. Prog. Lipid Res. 2002, 41:279-314.
20. Prior R.L., Hoang H., Gu L., Wu X., Bacchiocca M., Howard L., Hampsch-Woodill M., Huang D., Ou B., Jacob R. Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples. J. Agric. Food Chem. 2003, 51:3273-3279.
21. Rahman A., Shahabuddin S.M.H., Parish J.H. Complexes involving quercetin, DNA, and Cu (II). Carcinogenesis 1990, 11:2001-2003.
22. Rodríguez-Rodríguez R., Perona J.S., Herrera M.D., Ruiz-Gutiérrez R. Triterpenic compounds from 'orujo' olive oil elicit vasorelaxation in aorta from spontaneously hypertensive rats. J. Agric. Food Chem. 2006, 54:2096-2102.
23. Setzer W.C., Setzer M.C. Plant-derived triterpenoids as potential antineoplastic agents. Min. Rev. Med. Chem. 2003, 3:540-556.
24. Somova L.O., Nadar A., Ramnanan P., Shode F.O. Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. Phytomedicine 2003, 10:115-121.
25. Somova L.I., Shode F.O., Ramnanan P., Nadar A. Antihypertensive, antiatherosclerotic and antioxidante activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. J. Ethnopharmacol. 2003, 84:299-305.
26. Wang R., Wang W., Wang L., Liu R., Yi D., Du L. Constituents of the flowers of Punica granatum. Fitoterapia 2006, 77:534-537.