Mediterranean diet and cardiovascular health: Teachings of the PREDIMED Study

Advances in Nutrition

Volumn 5, Issue 3, 2014, Pages 330S-336S

  Ros, Emilio ^a,b   Martínez González, Miguel A ^b,c   Estruch, Ramon ^a,b   Salas Salvadó, Jordi ^b,d   Fitó, Montserrat ^b,e   Martínez, José A ^b,c   Corella, Dolores ^b,f  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

^d HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

^e HOSPITAL DEL MAR   (Spain)

^f UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; OLIVE OIL; VEGETABLE OIL;

AGED; BLOOD; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; FEMALE; HUMAN; LOW FAT DIET; MALE; MEDITERRANEAN DIET; META ANALYSIS (TOPIC); METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; NUT; NUTRIGENOMICS; OBSERVATIONAL STUDY; PRIMARY PREVENTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DIET, FAT-RESTRICTED; DIET, MEDITERRANEAN; FEMALE; HUMANS; MALE; META-ANALYSIS AS TOPIC; METABOLIC SYNDROME X; MIDDLE AGED; NUTRIGENOMICS; NUTS; OBSERVATIONAL STUDY AS TOPIC; PLANT OILS; PRIMARY PREVENTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84906324467     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.113.005389     Document Type: Article

References (47)

1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, et al. Heart disease and stroke statistics-2013 update: A report from the American Heart Association. Circulation. 2013;127:e6-245.
2. Mozaffarian D, Appel LJ, Van Horn L. Components of a cardioprotective diet: New insights. Circulation. 2011;123:2870-91.
3. Hu FB. Dietary pattern analysis: A new direction in nutritional epidemiology. Curr Opin Lipidol. 2002;13:3-9.
4. Appel LJ. Dietary patterns and longevity: Expanding the blue zones. Circulation. 2008;118:214-5.
5. Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D. Mediterranean diet pyramid: A cultural model for healthy eating. Am J Clin Nutr. 1995;61(Suppl. 6):1402S-6S.
6. Mente A, de Koning L, Shannon HS, Anand SS. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med. 2009;169:659-69.
7. Kastorini CM, Milionis HJ, Esposito K, Giugliano D, Goudevenos JA, Panagiotakos DB. The effect of Mediterranean diet on metabolic syndrome and its components: A meta-analysis of 50 studies and 534, 906 individuals. J Am Coll Cardiol. 2011;57:1299-313.
8. Sofi F, Abbate R, Gensini GF, Casini A. Accruing evidence on benefits of adherence to the Mediterranean diet on health: An updated systematic review and meta-analysis. Am J Clin Nutr. 2010;92:1189-96.
9. Dilis V, Katsoulis M, Lagiou P, Trichopoulos D, Naska A, Trichopoulou A. Mediterranean diet and CHD: The Greek European Prospective Investigation into Cancer and Nutrition cohort. Br J Nutr. 2012;108:699-709.
10. Tognon G, Nilsson LM, Lissner L, Johansson I, Hallmans G, Lindahl B, Winkvist A. The Mediterranean diet score and mortality are inversely associated in adults living in the Subartic region. J Nutr. 2012;142:1547-53.
11. Gardener H, Wright CB, Gu Y, Boden-Albala B, Elkind MS, Sacco RL, Scarmeas N. Mediterranean diet and risk of ischemic stroke, myocardial infarction, and vascular death: The Northern Manhattan Study. Am J Clin Nutr. 2011;94:1458-64.
12. Misirli G, Benetou V, Lagiou P, Bamia C, Trichopoulos D, Trichopoulou A. Relation of the traditional Mediterranean diet to cerebrovascular disease in a Mediterranean population. Am J Epidemiol. 2012;176:1185-92.
13. Hoevenaar-Blom MP, Nooyens ACJ, Kromhout D, Spijkerman AM, Beulens JW, van der Schouw YT, Bueno-de-Mesquita B, Verschuren WM. Mediterranean style diet and 12-year incidence of cardiovascular diseases: The EPIC-NL cohort study. PLoS One. 2012;7:e45458.
14. Menotti A, Alberti-Fidanza A, Fidanza F. The association of the Mediterranean Adequacy Index with fatal coronary events in an Italian middleaged male population followed for 40 years. Nutr Metab Cardiovasc Dis. 2012;22:369-75.
15. Tognon G, Lissner L, Sæbye D, Walker KZ, Heitmann BL. The Mediterranean diet in relation to mortality and CVD: A Danish cohort study. Br J Nutr. 2014;111:151-9.
16. Mitrou PN, Kipnis V, Thiébaut AC, Flood A, Mouw T, Hollenbeck AR, Leitzmann MF, Schatzkin A. Mediterranean dietary pattern and prediction of all-cause mortality in a US population: Results from the NIHAARP Diet and Health Study. Arch Intern Med. 2007;167:2461-8.
17. Martinez-Gonzalez MA, Bes-Rastrollo M. Dietary patterns, Mediterranean diet, and cardiovascular disease. Curr Opin Lipidol. 2014;25:20-6.
18. de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: Final report of the Lyon Diet Heart Study. Circulation. 1999;99:779-85.
19. PREDIMED. Prevención con dieta Mediterránea. Available from: http: //www.predimed.es. Accessed 2013 Oct 20.
20. Schröder H, Fitó M, Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Lamuela-Raventós R, Ros E, Salaverría I, Fiol M, et al. A short screener is valid for assessing Mediterranean Diet adherence among older Spanish men and women. J Nutr. 2011;141:1140-5.
21. Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368:1279-90.
22. Ruiz-Canela M, Estruch R, Corella D, Salas-Salvadó J, Martinez-Gonzalez MA. Mediterranean diet inversely associated with peripheral artery disease: The PREDIMED randomized trial. JAMA. 2014;311:415-7.
23. Salas-Salvadó J, Martinez-González MA, Bulló M, Ros E. The role of diet in the prevention of type 2 diabetes. Nutr Metab Cardiovasc Dis. 2011;21:B32-48.
24. Després JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, Rodés-Cabau J, Bertrand OF, Poirier P. Abdominal obesity and the metabolic syndrome: Contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol. 2008;28:1039-49.
25. Salas-Salvadó J, Bulló M, Babio N, Martínez-González Má, Ibarrola-Jurado N, Basora J, Estruch R, Covas MI, Corella D, Arós F, et al. Reduction in the incidence of type 2 diabetes with the Mediterranean diet: Results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care. 2011;34:14-9.
26. Salas-Salvadó J, Bulló M, Estruch R, Ros E, Covas MI, Ibarrola-Jurado N, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, et al. Prevention of diabetes with Mediterranean diets: A subgroup analysis of a randomized trial. Ann Intern Med. 2014;160:1-10.
27. Salas-Salvadó J, Fernández-Ballart J, Ros E, Martínez-González MA, Fitó M, Estruch R, Corella D, Fiol M, Gómez-Gracia E, Arós F, et al.; PREDIMED Study Investigators. Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: Oneyear results of the PREDIMED randomized trial. Arch Intern Med. 2008;168:2449-58.
28. Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Ruiz-Gutiérrez V, Covas MI, Fiol M, Gómez-Gracia E, López-Sabater MC, Vinyoles E, et al. Effects of a Mediterranean-style diet on cardiovascular risk factors. Ann Intern Med. 2006;145:1-11.
29. Damasceno NR, Sala-Vila A, Cofán M, Pérez-Heras AM, Fitó M, Ruiz-Gutiérrez V, Martínez-González MA, Corella D, Arós F, Estruch R, et al. Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipoprotein subfractions to a less atherogenic pattern in subjects at high cardiovascular risk. Atherosclerosis. 2013;230:347-53.
30. Toledo E, Hu FB, Estruch R, Buil-Cosiales P, Corella D, Salas-Salvadó J, Covas MI, Arós F, Gómez-Gracia E, Fiol M, et al. Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: Results from a randomized controlled trial. BMC Med. 2013;11:207.
31. Fitó M, Guxens M, Corella D, Sáez G, Estruch R, de la Torre R, Francés F, Cabezas C, López-Sabater MC, Marrugat J, et al. Effect of a traditional Mediterranean diet on lipoprotein oxidation: A randomized controlled trial. Arch Intern Med. 2007;167:1195-203.
32. Mena MP, Sacanella E, Vazquez-Agell M, Morales M, Fitó M, Escoda R, Serrano-Martínez M, Serra M, Salas-Salvadó J, Benages N, et al. Inhibition of circulating immune cell activation: A molecular antiinflammatory effect of the Mediterranean diet. Am J Clin Nutr. 2009;89:248-56.
33. Murie-Fernández M, Irimia P, Toledo E, Martínez-Vila E, Buil-Cosiales P, Serrano-Martínez M, Ruiz-Gutiérrez V, Ros E, Estruch R, Martínez-González MA. Carotid intima-media thickness changes with Mediterranean diet: A randomizedtrial (PREDIMED-Navarra). Atherosclerosis. 2011;219:158-62.
34. Sala-Vila A, Romero-Mamani ES, Gilabert R, Núñez I, de la Torre R, Corella D, Ruiz-Gutiérrez V, López-Sabater MC, Pintó X, Rekondo J, et al. Changes in ultrasound-assessed carotid intima-media thickness and plaque with a Mediterranean diet. A sub-study of the PREDIMED trial. Arterioscler Thromb Vasc Biol. 2014;34:439-45.
35. Konstantinidou V, Covas MI, Muñoz-Aguayo D, Khymenets O, de la Torre R, Sáez G, Tormos Mdel C, Toledo E, Marti A, Ruiz-Gutiérrez V, et al. In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: A randomized controlled trial. FASEB J. 2010;24:2546-57.
36. Llorente-Cortés V, Estruch R, Mena MP, Ros E, Martínez-González MA, Fitó M, Lamuela-Raventós RM, Badimon L. Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk. Atherosclerosis. 2010;208:442-50.
37. Castañer O, Corella D, Covas MI, Sorlí JV, Subirana I, Flores-Mateo G, Nonell L, Bulló M, de la Torre R, Portolés O, et al. In vivo transcriptomic profile after a Mediterranean diet in high-cardiovascular risk patients: A randomized controlled trial. Am J Clin Nutr. 2013;98:845-53.
38. Ordovas JM, Corella D. Nutritional genomics. Annu Rev Genomics Hum Genet. 2004;5:71-118.
39. Corella D, Ordovas JM. Single nucleotide polymorphisms that influence lipid metabolism: Interaction with dietary factors. Annu Rev Nutr. 2005;25:341-90.
40. Corella D, González JI, Bulló M, Carrasco P, Portolés O, Díez-Espino J, Covas MI, Ruíz-Gutiérrez V, Gómez-Gracia E, Arós F, et al. Polymorphisms cyclooxygenase-2-765G>C and interleukin-6-174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts. J Nutr. 2009;139:128-34.
41. Corella D, Ordovas JM. Nutrigenomics in cardiovascular medicine. Circ Cardiovasc Genet. 2009;2:637-51.
42. Corella D, Peloso G, Arnett DK, Demissie S, Cupples LA, Tucker K, Lai CQ, Parnell LD, Coltell O, Lee YC, et al. APOA2, dietary fat, and body mass index: Replication of a gene-diet interaction in 3 independent populations. Arch Intern Med. 2009;169:1897-906.
43. Corella D, Tai ES, Sorlí JV, Chew SK, Coltell O, Sotos-Prieto M, García-Rios A, Estruch R, Ordovas JM. Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: Replication of agene-saturated fat interaction. Int J Obes (Lond). 2011;35:666-75.
44. Corella D, Carrasco P, Fitó M, Martínez-González MA, Salas-Salvadó J, Arós F, Lapetra J, Guillen M, Ortega-Azorin C, Warnberg J, et al. Geneenvironment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population. J Lipid Res. 2010;51:2798-807.
45. Corella D, Ortega-Azorín C, Sorlí JV, Covas MI, Carrasco P, Salas-Salvadó J, Martínez-González Má, Arós F, Lapetra J, Serra-Majem L, et al. Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: New effects on alcohol consumption. PLoS ONE. 2012;7:e52344.
46. Ortega-Azorín C, Sorlí JV, Asensio EM, Coltell O, Martínez-González MA, Salas-Salvadó J, Covas MI, Arós F, Lapetra J, Serra-Majem L, et al. Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Cardiovasc Diabetol. 2012;11:137.
47. Corella D, Carrasco P, Sorlí JV, Estruch R, Rico-Sanz J, Martínez-González MA, Salas-Salvadó J, Covas MI, Coltell O, Arós F, et al. Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: A randomized controlled trial in a high-cardiovascular-risk population. Diabetes Care. 2013;36:3803-11.