Maslinic acid, a natural inhibitor of glycogen phosphorylase, reduces cerebral ischemic injury in hyperglycemic rats by GLT-1 up-regulation

Journal of Neuroscience Research

Volumn 89, Issue 11, 2011, Pages 1829-1839

  Guan, Teng ^a   Qian, Yisong ^a   Tang, Xuzhen ^a   Huang, Menghao ^a   Huang, Longfei ^a   Li, Yunman ^a   Sun, Hongbin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

GLT 1; Hyperglycemia; Maslinic acid; Neuroprotection; Stroke

Indexed keywords

DIHYDROKAINIC ACID; ENZYME INHIBITOR; GLUTAMIC ACID; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MASLINIC ACID; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD GLUCOSE; BRAIN; BRAIN ISCHEMIA; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; EXCITATORY AMINO ACID TRANSPORTER 2; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; HYPERGLYCEMIA; LIVER; MALE; NEUROGLIA; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN; TRITERPENES; UP-REGULATION;

EID: 80052641113     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22671     Document Type: Article

References (31)

1. Chen JC, Hsu-Chou H, Lu JL, Chiang YC, Huang HM, Wang HL, Wu T, Liao JJ, Yeh TS. 2005. Down-regulation of the glial glutamate transporter GLT-1 in rat hippocampus and striatum and its modulation by a group III metabotropic glutamate receptor antagonist following transient global forebrain ischemia. Neuropharmacology 49: 703-714.
2. Chu K, Lee ST, Sinn DI, Ko SY, Kim EH, Kim JM, Kim SJ, Park DK, Jung KH, Song EC, Lee SK, Kim M, Roh JK. 2007. Pharmacological induction of ischemic tolerance by glutamate transporter-1 (EAAT2) upregulation. Stroke 38: 177-182.
3. Dallas M, Boycott HE, Atkinson L, Miller A, Boyle JP, Pearson HA, Peers C. 2007. Hypoxia suppresses glutamate transport in astrocytes. J Neurosci 27: 3946-3955.
4. Danbolt NC. 2001. Glutamate uptake. Prog Neurobiol 65: 1-105.
5. Duckworth EA, Butler TL, De Mesquita D, Collier SN, Collier L, Pennypacker KR. 2005. Temporary focal ischemia in the mouse: technical aspects and patterns of Fluoro-Jade evident neurodegeneration. Brain Res 1042: 29-36.
6. Guan T, Qian Y-S, Huang M-H, Huang L-F, Tang X-Z, Li Y-M, Sun H-B. 2010. Neuroprotection of maslinic acid, a novel glycogen phosphorylase inhibitor, in type 2 diabetic rats. CJNM 8: 293-297.
7. Hayden MS, Ghosh S. 2004. Signaling to NF-kappaB. Genes Dev 18: 2195-2224.
8. Henke BR, Sparks SM. 2006. Glycogen phosphorylase inhibitors. Mini Rev Med Chem 6: 845-857.
9. Kagansky N, Levy S, Knobler H. 2001. The role of hyperglycemia in acute stroke. Arch Neurol 58: 1209-1212.
10. Krishnamurthy RG, Senut MC, Zemke D, Min J, Frenkel MB, Greenberg EJ, Yu SW, Ahn N, Goudreau J, Kassab M, Panickar KS, Majid A. 2009. Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia. J Neurosci Res 87: 2541-2550.
11. Liu F, Schafer DP, McCullough LD. 2009. TTC, fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion. J Neurosci Methods 179: 1-8.
12. Liu J, Sun H, Duan W, Mu D, Zhang L. 2007. Maslinic acid reduces blood glucose in KK-Ay mice. Biol Pharm Bull 30: 2075-2078.
13. Longa EZ, Weinstein PR, Carlson S, Cummins R. 1989. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91.
14. Mitani A, Tanaka K. 2003. Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1. J Neurosci 23: 7176-7182.
15. Mori T, Tateishi N, Kagamiishi Y, Shimoda T, Satoh S, Ono S, Katsube N, Asano T. 2004. Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-2506. Neurochem Int 45: 381-387.
16. Muranyi M, Ding C, He Q, Lin Y, Li PA. 2006. Streptozotocin-induced diabetes causes astrocyte death after ischemia and reperfusion injury. Diabetes 55: 349-355.
17. Nichols TC. 2004. NF-kappaB and reperfusion injury. Drug News Perspect 17: 99-104.
18. Ouyang YB, Voloboueva LA, Xu LJ, Giffard RG. 2007. Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia. J Neurosci 27: 4253-4260.
19. Paolino AS, Garner KM. 2005. Effects of hyperglycemia on neurologic outcome in stroke patients. J Neurosci Nurs 37: 130-135.
20. Pignataro G, Simon RP, Xiong ZG. 2007. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain 130: 151-158.
21. Qian Y, Guan T, Tang X, Huang L, Huang M, Li Y, Sun H, Yu R, Zhang F. 2011. Astrocytic glutamate transporter-dependent neuroprotection against glutamate toxicity: an in vitro study of maslinic acid. Eur J Pharmacol 651: 59-65.
22. Rao VL, Dogan A, Todd KG, Bowen KK, Kim BT, Rothstein JD, Dempsey RJ. 2001. Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain. J Neurosci 21: 1876-1883.
23. 2-induced injury in vitro. Pharm Biol 49: 78-85.
24. Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF. 1996. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16: 675-686.
25. Shen H, Chen GJ, Harvey BK, Bickford PC, Wang Y. 2005. Inosine reduces ischemic brain injury in rats. Stroke 36: 654-659.
26. Simard JM, Yurovsky V, Tsymbalyuk N, Melnichenko L, Ivanova S, Gerzanich V. 2009. Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke. Stroke 40: 604-609.
27. Sitcheran R, Gupta P, Fisher PB, Baldwin AS. 2005. Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression. EMBO J 24: 510-520.
28. Tang X-Z, Guan T, Qian Y-S, Li Y-M, Sun H-B, Huang J-H, Zhang Y. 2008. Effects of maslinic acid as a novel glycogen phosphorylase inhibitor on blood glucose and hepatic glycogen in mice. CJNM 6: 53-56.
29. Wen X, Zhang P, Liu J, Zhang L, Wu X, Ni P, Sun H. 2006. Pentacyclic triterpenes. Part 2: synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors. Bioorg Med Chem Lett 16: 722-726.
30. Wen X, Sun H, Liu J, Cheng K, Zhang P, Zhang L, Hao J, Ni P, Zographos SE, Leonidas DD, Alexacou KM, Gimisis T, Hayes JM, Oikonomakos NG. 2008. Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. J Med Chem 51: 3540-3554.
31. Yang Y, Shuaib A, Li Q. 1998. Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method. J Neurosci Methods 84: 9-16.