Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: Synthesis, structure-activity relationships, and X-ray crystallographic studies

Journal of Medicinal Chemistry

Volumn 51, Issue 12, 2008, Pages 3540-3554

  Wen, Xiaoan ^a   Sun, Hongbin ^a   Liu, Jun ^a   Cheng, Keguang ^a   Zhang, Pu ^a   Zhang, Liying ^a   Hao, Jia ^a   Zhang, Luyong ^a   Ni, Peizhou ^a   Zographos, Spyros E ^b   Leonidas, Demettes D ^b   Alexacou, Kyra Melinda ^b   Gimisis, Thanasis ^c   Hayes, Joseph M ^b   Oikonomakos, Nikos G ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b INSTITUTE OF BIOLOGY   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

11 DEOXYGLYCYRRHETINIC ACID; 23 HYDROXYBETULINIC ACID; 3 EPIURSOLIC ACID; ADENOSINE PHOSPHATE; AGLYCONE; ASIATIC ACID; BETULIC ACID; BETULIN; COROSOLIC ACID; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE B; GLYCYRRHETINIC ACID; MASLINIC ACID; OLEANOLIC ACID; OLEANONIC ACID; TRITERPENE DERIVATIVE; URSOLIC ACID; URSONIC ACID;

ANIMAL TISSUE; ARTICLE; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; NONHUMAN; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY;

ADENOSINE MONOPHOSPHATE; ALLOSTERIC SITE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLYCOGEN PHOSPHORYLASE; HYPOGLYCEMIC AGENTS; KINETICS; MODELS, MOLECULAR; MUSCLES; OLEANOLIC ACID; PROTEIN BINDING; PROTEIN CONFORMATION; RABBITS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 45749110639     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8000949     Document Type: Article

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