FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 1, 2010, Pages 199-203

  Schildknecht, Anita ^a,b   Brauer, Sabine ^c   Brenner, Corinne ^a   Lahl, Katharina ^d   Schild, Hansjörg ^c   Sparwasser, Tim ^d,e   Probst, Hans Christian ^c,f   Van Broek, Maries Den ^a,f  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Cd8+ T cells; DC; Tolerance; Treg

Indexed keywords

ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL ISOLATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; EX VIVO STUDY; IMMUNOLOGICAL TOLERANCE; LYMPH NODE; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STEADY STATE; UPREGULATION;

ANIMALS; ANTIGENS, CD; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FORKHEAD TRANSCRIPTION FACTORS; IMMUNE TOLERANCE; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; T-LYMPHOCYTES, REGULATORY;

MUS;

EID: 76249119192     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910620107     Document Type: Article

References (39)

1. Bouneaud C, Kourilsky P, Bousso P (2000) Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13:829-840.
2. Hawiger D, et al. (2001) Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 194:769-779.
3. Probst HC, Lagnel J, Kollias G, van den Broek M (2003) Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity 18: 713-720.
4. Probst HC, McCoy K, Okazaki T, Honjo T, van den Broek M (2005) Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4. Nat Immunol 6:280-286.
5. Sakaguchi S (2005) Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6:345-352.
6. Sakaguchi S (2004) Naturally arising CD4+ regulatory T cells for immunologic selftolerance and negative control of immune responses. Annu Rev Immunol 22:531-562.
7. Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057-1061.
8. Fontenot JD, et al. (2005) Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22:329-341.
9. Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4:330-336.
10. Khattri R, Cox T, Yasayko SA, Ramsdell F (2003) An essential role for Scurfin in CD4+ CD25+ T regulatory cells. Nat Immunol 4:337-342.
11. Cederbom L, Hall H, Ivars F (2000) CD4+CD25+ regulatory T cells down-regulate costimulatory molecules on antigen-presenting cells. Eur J Immunol 30:1538-1543.
12. Kim JM, Rasmussen JP, Rudensky AY (2007) Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8:191-197.
13. Lahl K, et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfylike disease. J Exp Med 204:57-63.
14. Brunkow ME, et al. (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27:68-73.
15. Godfrey VL, Wilkinson JE, Rinchik EM, Russell LB (1991) Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education. Proc Natl Acad Sci USA 88:5528-5532.
16. Bennett CL, et al. (2001) The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 27:20-21.
17. Wildin RS, et al. (2001) X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent ofmouse scurfy. Nat Genet 27:18-20.
18. Heit A, et al. (2008) Circumvention of regulatory CD4(+) T cell activity during crosspriming strongly enhances T cell-mediated immunity. Eur J Immunol 38:1585-1597.
19. Zelinskyy G, Dietze K, Sparwasser T, Dittmer U (2009) Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus. PLoS Pathog 5:e1000406.
20. Misra N, Bayry J, Lacroix-Desmazes S, Kazatchkine MD, Kaveri SV (2004) Cutting edge: Human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells. J Immunol 172:4676-4680.
21. Rubtsov YP, et al. (2008) Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28:546-558.
22. Wing K, et al. (2008) CTLA-4 control over Foxp3+ regulatory T cell function. Science 322:271-275.
23. Read S, et al. (2006) Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol 177:4376-4383.
24. Takahashi T, et al. (2000) Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 192:303-310.
25. Friedline RH, et al. (2009) CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 206:421-434.
26. Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133:775-787.
27. Mahnke K, et al. (2007) Induction of immunosuppressive functions of dendritic cells in vivo by CD4+CD25+ regulatory T cells: Role of B7-H3 expression and antigen presentation. Eur J Immunol 37:2117-2126.
28. Veldhoen M, Moncrieffe H, Hocking RJ, Atkins CJ, Stockinger B (2006) Modulation of dendritic cell function by naive and regulatory CD4+ T cells. J Immunol 176:6202-6210.
29. Houot R, Perrot I, Garcia E, Durand I, Lebecque S (2006) Human CD4+CD25 high regulatory T cells modulate myeloid but not plasmacytoid dendritic cells activation. J Immunol 176:5293-5298.
30. Terme M, et al. (2008) Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol 180:4679-4686.
31. Liu K, et al. (2009) In vivo analysis of dendritic cell development and homeostasis. Science 324:392-397.
32. Li MO, Flavell RA (2008) TGF-beta: A master of all T cell trades. Cell 134:392-404.
33. Green EA, Gorelik L, McGregor CM, Tran EH, Flavell RA (2003) CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci USA 100:10878-10883.
34. Fahlén L, et al. (2005) T cells that cannot respond to TGF-beta escape control by CD4(+) CD25(+) regulatory T cells. J Exp Med 201:737-746.
35. Chen ML, et al. (2005) Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci USA 102:419-424.
36. Travis MA, et al. (2007) Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature 449:361-365.
37. Tang Q, et al. (2004) Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur J Immunol 34:2996-3005.
38. Battegay M, et al. (1991) Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J Virol Methods 33:191-198.
39. Altman JD, et al. (1996) Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94-96.