메뉴 건너뛰기




Volumn 5, Issue 3, 2014, Pages 197-202

Neuroinflammation and Alzheimer's disease: Lessons learned from 5-lipoxygenase

Author keywords

5 lipoxygenase; Alzheimer's disease; Inflammation

Indexed keywords

AMYLOID BETA PROTEIN; ARACHIDONATE 5 LIPOXYGENASE; CYTOKINE;

EID: 84906270444     PISSN: 20813856     EISSN: 20816936     Source Type: Journal    
DOI: 10.2478/s13380-014-0225-7     Document Type: Article
Times cited : (14)

References (49)
  • 1
    • 35548940796 scopus 로고    scopus 로고
    • 10, 2, available at
    • Alzheimer's Association, Alzheimer's disease facts and figures, 2014, 10, 2, available at http://www.alz.org/downloads/Facts-Figures-2014.pdf
    • (2014) Alzheimer's Disease Facts and Figures
  • 2
  • 3
    • 79952563494 scopus 로고    scopus 로고
    • Low-n oligomers as therapeutic targets of Alzheimer's disease
    • Ono K., Yamada M., Low-n oligomers as therapeutic targets of Alzheimer's disease, J. Neurochem., 2011, 117, 19-28
    • (2011) J. Neurochem. , vol.117 , pp. 19-28
    • Ono, K.1    Yamada, M.2
  • 5
    • 4043167747 scopus 로고    scopus 로고
    • Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • DOI 10.1016/j.neuron.2004.07.003, PII S0896627304004246
    • Oddo S., Billings L., Kesslak J.P., Cribbs D.H., LaFerla F.M. Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome, Neuron, 2004, 43, 321-332 (Pubitemid 39061125)
    • (2004) Neuron , vol.43 , Issue.3 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    LaFerla, F.M.5
  • 6
    • 33144487701 scopus 로고    scopus 로고
    • Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer's disease. A link between Aβ and tau pathology
    • Oddo S., Caccamo A., Tran L., Lambert M.P., Glabe C.G., Klein W.L., et al., Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer's disease. A link between Aβ and tau pathology, J. Biol. Chem., 2006, 281, 1599-1604
    • (2006) J. Biol. Chem. , vol.281 , pp. 1599-1604
    • Oddo, S.1    Caccamo, A.2    Tran, L.3    Lambert, M.P.4    Glabe, C.G.5    Klein, W.L.6
  • 7
    • 84872472280 scopus 로고    scopus 로고
    • Potential immunotargets for Alzheimer's disease treatment strategies
    • Rao K.S., Britton G.B., Fernandez P.L., Potential immunotargets for Alzheimer's disease treatment strategies, J. Alzheimers Dis., 2010, 33, 297-312
    • (2010) J. Alzheimers Dis. , vol.33 , pp. 297-312
    • Rao, K.S.1    Britton, G.B.2    Fernandez, P.L.3
  • 8
    • 0030757323 scopus 로고    scopus 로고
    • Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms
    • DOI 10.1007/s004010050664
    • Sheng J.G., Mrak R.E., Grifin W.S., Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms, Acta Neuropathol., 1997, 94, 1-5 (Pubitemid 27289095)
    • (1997) Acta Neuropathologica , vol.94 , Issue.1 , pp. 1-5
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.T.3
  • 9
    • 0030778215 scopus 로고    scopus 로고
    • + astrocytes with neurofibrillary tangle stages
    • Sheng J.G., Mrak R.E., Grifin W.S., Glial-neuronal interactions in Alzheimer's disease: progressive association of IL-1α+ microglia and S100β+ astrocytes with neurofibrillary tangle stages, J. Neuropathol. Exp. Neurol., 1997, 56, 285-290 (Pubitemid 27461169)
    • (1997) Journal of Neuropathology and Experimental Neurology , vol.56 , Issue.3 , pp. 285-290
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.T.3
  • 10
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman S.E., Allison E.K., El Khoury J., Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice, J. Neurosci., 2008, 28, 8354-8360
    • (2008) J. Neurosci. , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 11
    • 79960880118 scopus 로고    scopus 로고
    • Assessing the contribution of inflammation in models of Alzheimer's disease
    • Johnston H., Boutin H., Allan S.M., Assessing the contribution of inflammation in models of Alzheimer's disease, Biochem. Soc. Trans., 2011, 39, 886-890
    • (2011) Biochem. Soc. Trans. , vol.39 , pp. 886-890
    • Johnston, H.1    Boutin, H.2    Allan, S.M.3
  • 12
    • 2542431100 scopus 로고    scopus 로고
    • The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
    • DOI 10.1016/j.neurobiolaging.2003.12.026, PII S0197458004001046
    • D'Andrea M.R., Cole G.M., Ard M.D., The microglial phagocytic role with specific plaque types in the Alzheimer's disease brain, Neurobiol. Aging, 2004, 25, 675-683 (Pubitemid 38686491)
    • (2004) Neurobiology of Aging , vol.25 , Issue.5 , pp. 675-683
    • D'Andrea, M.R.1    Cole, G.M.2    Ard, M.D.3
  • 13
    • 0036615884 scopus 로고    scopus 로고
    • Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a β-sheet breaker peptide
    • Permanne B., Adessi C., Saborio G.P., Fraga S., Frossard M.J., Van Dorpe J., et al., Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a β-sheet breaker peptide, FASEB J., 2002, 16, 860-862
    • (2002) FASEB J. , vol.16 , pp. 860-862
    • Permanne, B.1    Adessi, C.2    Saborio, G.P.3    Fraga, S.4    Frossard, M.J.5    Van Dorpe, J.6
  • 14
    • 84876006819 scopus 로고    scopus 로고
    • Functional impairment of microglia coincides with betaamyloid deposition in mice with Alzheimer-like pathology
    • Krabbe G., Halle A., Matyash V., Rinnenthal J.L., Eom G.D., Bernhardt U., et al., Functional impairment of microglia coincides with betaamyloid deposition in mice with Alzheimer-like pathology, PLoS One, 2013, 8, e60921
    • (2013) PLoS One , vol.8
    • Krabbe, G.1    Halle, A.2    Matyash, V.3    Rinnenthal, J.L.4    Eom, G.D.5    Bernhardt, U.6
  • 15
  • 17
    • 0034685692 scopus 로고    scopus 로고
    • Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer's disease
    • DOI 10.1016/S0304-3940(00)01037-5, PII S0304394000010375
    • Shefield L.G., Marquis J.G., Berman N.E., Regional distribution of cortical microglial parallels that of neurofibrillary tangles in Alzheimer's disease, Neurosci. Lett., 2000, 285, 165-168 (Pubitemid 30252054)
    • (2000) Neuroscience Letters , vol.285 , Issue.3 , pp. 165-168
    • Sheffield, L.G.1    Marquis, J.G.2    Berman, N.E.J.3
  • 18
    • 84875640007 scopus 로고    scopus 로고
    • Neuroinflammation an neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease
    • Wright A.L., Zinn R., Hohensinn B., Konen L.M., Beynon S.B., Tan R.P., et al., Neuroinflammation an neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease, PloS One, 2013, 8, e59586
    • (2013) PloS One , vol.8
    • Wright, A.L.1    Zinn, R.2    Hohensinn, B.3    Konen, L.M.4    Beynon, S.B.5    Tan, R.P.6
  • 19
    • 0034523456 scopus 로고    scopus 로고
    • Costimulatory effects of interferon-γ and interleukin-1β or tumor necrosis factor α on the synthesis of Aβ1-40 and Aβ1-42 by human astrocytes
    • DOI 10.1006/nbdi.2000.0321
    • Blasko I., Veerhuis R., Stampfer-Kountchev M., Saurwein-Teissl M., Eikelenboom P., Grubeck-Loebenstein B., Costimulatory efects of interferon-γ and interleukin-1β or tumor necrosis factor α on the synthesis of Aβ1-40 and Aβ1-42 by human astrocytes, Neurobiol. Dis., 2000, 7, 682-689 (Pubitemid 32044292)
    • (2000) Neurobiology of Disease , vol.7 , Issue.6 , pp. 682-689
    • Blasko, I.1    Veerhuis, R.2    Stampfer-Kountchev, M.3    Saurwein-Teissl, M.4    Eikelenboom, P.5    Grubeck-Loebenstein, B.6
  • 20
    • 79959444286 scopus 로고    scopus 로고
    • Glucocorticoids facilitate astrocytic amyloid-β peptide deposition by increased expression of APP and BACE1 and decreasing the expression of amyloid-β-degrading proteases
    • Wang Y., Li M., Tang J., Song M., Xu X., Xiong J., et al., Glucocorticoids facilitate astrocytic amyloid-β peptide deposition by increased expression of APP and BACE1 and decreasing the expression of amyloid-β-degrading proteases, Endocrinology, 2011, 152, 2704-2715
    • (2011) Endocrinology , vol.152 , pp. 2704-2715
    • Wang, Y.1    Li, M.2    Tang, J.3    Song, M.4    Xu, X.5    Xiong, J.6
  • 21
    • 84893642447 scopus 로고    scopus 로고
    • The neglected co-star in the dementia drama: The putative roles of astrocytes in the pathogenesis of major neurocognitive disorders
    • Jo W.K., Law A.C., Chung S.K., The neglected co-star in the dementia drama: the putative roles of astrocytes in the pathogenesis of major neurocognitive disorders, Mol. Psychiatry, 2014, 19, 159-167
    • (2014) Mol. Psychiatry , vol.19 , pp. 159-167
    • Jo, W.K.1    Law, A.C.2    Chung, S.K.3
  • 22
    • 79959945013 scopus 로고    scopus 로고
    • Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture
    • Garwood C.J., Pooler A.M., Atherton J., Hanger D.P., Noble W., Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture, Cell Death Dis., 2011, 2, e167
    • (2011) Cell Death Dis. , vol.2
    • Garwood, C.J.1    Pooler, A.M.2    Atherton, J.3    Hanger, D.P.4    Noble, W.5
  • 23
    • 84857770581 scopus 로고    scopus 로고
    • Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways
    • Zilka N., Kazmerova Z., Jadhav S., Neradil P., Madari A., Obetkova D., et al., Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways, J. Neuroinflammation, 2012, 9, 47
    • (2012) J. Neuroinflammation , vol.9 , pp. 47
    • Zilka, N.1    Kazmerova, Z.2    Jadhav, S.3    Neradil, P.4    Madari, A.5    Obetkova, D.6
  • 24
    • 0037336701 scopus 로고    scopus 로고
    • Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
    • Li Y, Liu L, Barger S.W., Grifin W.S., Interleukin-1 mediates pathological efects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway, J. Neurosci., 2003, 23, 1605-1611 (Pubitemid 36314715)
    • (2003) Journal of Neuroscience , vol.23 , Issue.5 , pp. 1605-1611
    • Li, Y.1    Liu, L.2    Barger, S.W.3    Griffin, W.S.T.4
  • 25
    • 77952312969 scopus 로고    scopus 로고
    • Regulation of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis
    • Radmark O., Samuelsson B., Regulation of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis, Biochem. Biophys. Res. Comm., 2010, 396, 105-110
    • (2010) Biochem. Biophys. Res. Comm. , vol.396 , pp. 105-110
    • Radmark, O.1    Samuelsson, B.2
  • 26
    • 84883239352 scopus 로고    scopus 로고
    • 5-lipoxygenase antagonist therapy: A new approach towards targeted cancer chemotherapy
    • Bishayee K., Khuda-Bukhsh A.R., 5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy, Acta Biochim. Sin. (Shanghai), 2013, 45, 709-719
    • (2013) Acta Biochim. Sin. (Shanghai) , vol.45 , pp. 709-719
    • Bishayee, K.1    Khuda-Bukhsh, A.R.2
  • 28
    • 34447565153 scopus 로고    scopus 로고
    • The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old
    • DOI 10.1016/j.neurobiolaging.2006.06.007, PII S0197458006002193
    • Chinnici C.M., Yao Y., Praticò D., The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old, Neurobiol. Aging, 2007, 28, 1457-1462 (Pubitemid 47081230)
    • (2007) Neurobiology of Aging , vol.28 , Issue.9 , pp. 1457-1462
    • Chinnici, C.M.1    Yao, Y.2    Pratico, D.3
  • 29
    • 56449106689 scopus 로고    scopus 로고
    • Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease
    • Ikonomovic M.D., Abrahamson E.E., Uz T., Manev H., Dekosky S.T., Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease, J. Histochem. Cytochem., 2008, 56, 1065-1073
    • (2008) J. Histochem. Cytochem. , vol.56 , pp. 1065-1073
    • Ikonomovic, M.D.1    Abrahamson, E.E.2    Uz, T.3    Manev, H.4    Dekosky, S.T.5
  • 30
    • 42049114647 scopus 로고    scopus 로고
    • 5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer's disease
    • DOI 10.1096/fj.07-9131.com
    • Firuzi O., Zhuo J., Chinnici C.M., Wisniewski T., Praticò, D., 5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer's disease, FASEB J., 2008, 22, 1169-1178 (Pubitemid 351519971)
    • (2008) FASEB Journal , vol.22 , Issue.4 , pp. 1169-1178
    • Firuzi, O.1    Zhuo, J.2    Chinnici, C.M.3    Wisniewski, T.4    Pratico, D.5
  • 31
    • 79953660461 scopus 로고    scopus 로고
    • Pharmacological blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase
    • Chu J., Praticò D., Pharmacological blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase, Am. J. Pathol., 2011, 178, 1762-1769
    • (2011) Am. J. Pathol. , vol.178 , pp. 1762-1769
    • Chu, J.1    Praticò, D.2
  • 32
    • 84855414647 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
    • Chu J., Giannopoulos P.F., Ceballos-Diaz C., Golde T.E., Praticò D., Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice, Mol. Neurodegener., 2012, 7, 1
    • (2012) Mol. Neurodegener. , vol.7 , pp. 1
    • Chu, J.1    Giannopoulos, P.F.2    Ceballos-Diaz, C.3    Golde, T.E.4    Praticò, D.5
  • 33
    • 79551473183 scopus 로고    scopus 로고
    • 5-Lipoxygenase as an endogenous modulator of amyloid β formation in vivo
    • Chu J., Praticò D., 5-Lipoxygenase as an endogenous modulator of amyloid β formation in vivo, Ann. Neurol., 2011, 69, 34-46
    • (2011) Ann. Neurol. , vol.69 , pp. 34-46
    • Chu, J.1    Praticò, D.2
  • 34
    • 79959944588 scopus 로고    scopus 로고
    • Γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: Disappointments and hopes
    • Imbimbo B.P., Giardina G.A., Γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes, Curr. Top. Med. Chem., 2011, 11, 15550-15570
    • (2011) Curr. Top. Med. Chem. , vol.11 , pp. 15550-15570
    • Imbimbo, B.P.1    Giardina, G.A.2
  • 35
    • 84867095666 scopus 로고    scopus 로고
    • 5-Lipoxygenase gene transfer worsens memory, amyloid and tau brain pathologies in a mouse model of Alzheimer's disease
    • Chu J., Giannopoulos P.F., Ceballos-Diaz C., Golde T.E., Praticò D., 5-Lipoxygenase gene transfer worsens memory, amyloid and tau brain pathologies in a mouse model of Alzheimer's disease, Ann. Neurol., 2012, 72, 442-454
    • (2012) Ann. Neurol. , vol.72 , pp. 442-454
    • Chu, J.1    Giannopoulos, P.F.2    Ceballos-Diaz, C.3    Golde, T.E.4    Praticò, D.5
  • 36
    • 84897110156 scopus 로고    scopus 로고
    • Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease
    • Giannopoulos P.F., Chu J., Joshi Y.B., Sperow M., Li J.G., Kirby L.G., et al., Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease, Mol. Psychiatry, 2014, 19, 511-518
    • (2014) Mol. Psychiatry , vol.19 , pp. 511-518
    • Giannopoulos, P.F.1    Chu, J.2    Joshi, Y.B.3    Sperow, M.4    Li, J.G.5    Kirby, L.G.6
  • 37
    • 84875271571 scopus 로고    scopus 로고
    • 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: Involvement of the cyclin-dependent kinase-5
    • Chu J., Praticò D., 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5, Neurobiol. Aging, 2013, 34, 1549-1554
    • (2013) Neurobiol. Aging , vol.34 , pp. 1549-1554
    • Chu, J.1    Praticò, D.2
  • 38
    • 84882256181 scopus 로고    scopus 로고
    • The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: In vivo and in vitro evidence
    • Chu J., Li J.G., Ceballos-Diaz C., Golde T., Praticò D., The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence, Biol. Psychiatry, 2013, 74, 321-328
    • (2013) Biol. Psychiatry , vol.74 , pp. 321-328
    • Chu, J.1    Li, J.G.2    Ceballos-Diaz, C.3    Golde, T.4    Praticò, D.5
  • 39
    • 84862239252 scopus 로고    scopus 로고
    • Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model
    • Chu J., Praticò D., Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model, J. Neuroinflmmation, 2012, 9, 127
    • (2012) J. Neuroinflmmation , vol.9 , pp. 127
    • Chu, J.1    Praticò, D.2
  • 40
    • 84893731765 scopus 로고    scopus 로고
    • Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase
    • Joshi Y.B., Giannopoulos P.F., Chu J., Praticò D., Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase, Neurobiol. Aging, 2014, 35, 1024-1031
    • (2014) Neurobiol. Aging , vol.35 , pp. 1024-1031
    • Joshi, Y.B.1    Giannopoulos, P.F.2    Chu, J.3    Praticò, D.4
  • 41
    • 77957357526 scopus 로고    scopus 로고
    • Reductions in amyloid-β-derived neuroinflammation, with minocycline, restore cognition but do not significantly afect tau hyperphosphorylation
    • Parachikova A., Vasilevko V., Cribbs D.H., LaFerla F.M., Green K.N., Reductions in amyloid-β-derived neuroinflammation, with minocycline, restore cognition but do not significantly afect tau hyperphosphorylation, J. Alzheimers Dis., 2010, 21, 527-542
    • (2010) J. Alzheimers Dis. , vol.21 , pp. 527-542
    • Parachikova, A.1    Vasilevko, V.2    Cribbs, D.H.3    LaFerla, F.M.4    Green, K.N.5
  • 42
    • 84874882726 scopus 로고    scopus 로고
    • Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model
    • Ghosh S., Wu M.D., Shaftel S.S., Kyrkanides S., LaFerla F.M., Olschowka J.A., et al., Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model, J. Neurosci., 12, 5053-5064
    • J. Neurosci. , vol.12 , pp. 5053-5064
    • Ghosh, S.1    Wu, M.D.2    Shaftel, S.S.3    Kyrkanides, S.4    LaFerla, F.M.5    Olschowka, J.A.6
  • 43
    • 84883540356 scopus 로고    scopus 로고
    • Amyloid-β peptides and tau protein as biomarkers in cerebrospinal and interstitial fluid following traumatic brain injury: A review of experimental and clinical studies
    • Tsitsopoulos P.P., Marklund N., Amyloid-β peptides and tau protein as biomarkers in cerebrospinal and interstitial fluid following traumatic brain injury: a review of experimental and clinical studies, Front. Neurol., 2013, 4, 79
    • (2013) Front. Neurol. , vol.4 , pp. 79
    • Tsitsopoulos, P.P.1    Marklund, N.2
  • 45
    • 84885783467 scopus 로고    scopus 로고
    • Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
    • Yanamandra K., Kfoury N., Jiang H., Mahan T.E., Ma S., Maloney S.E., et al., Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo, Neuron, 2013, 80, 402-414
    • (2013) Neuron , vol.80 , pp. 402-414
    • Yanamandra, K.1    Kfoury, N.2    Jiang, H.3    Mahan, T.E.4    Ma, S.5    Maloney, S.E.6
  • 46
    • 0012057211 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer P.L., Schulzer M., McGeer E.G., Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies, Neurology, 1996, 22, 1-4
    • (1996) Neurology , vol.22 , pp. 1-4
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 47
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart W.F., Kawas C., Corrada M., Metter E.J., Risk of Alzheimer's disease and duration of NSAID use, Neurology, 1997, 48, 626-632 (Pubitemid 27120096)
    • (1997) Neurology , vol.48 , Issue.3 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3    Metter, E.J.4
  • 48
    • 84861314593 scopus 로고    scopus 로고
    • Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease
    • Jaturapatporn D., Isaac M.G., McCleery J., Tablet N., Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease, Cochrane Database Syst. Rev., 2012, 2, CD006378
    • (2012) Cochrane Database Syst. Rev. , vol.2
    • Jaturapatporn, D.1    Isaac, M.G.2    McCleery, J.3    Tablet, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.