-
1
-
-
34547426963
-
Biosynthesis and metabolism of leukotrienes
-
10.1042/BJ20070289, 17623009
-
Murphy RC, Gijon MA. Biosynthesis and metabolism of leukotrienes. Biochem J 2007, 405:379-395. 10.1042/BJ20070289, 17623009.
-
(2007)
Biochem J
, vol.405
, pp. 379-395
-
-
Murphy, R.C.1
Gijon, M.A.2
-
2
-
-
2342503757
-
The membrane organization of leukotriene synthesis
-
10.1073/pnas.0308523101, 404089, 15084748
-
Mandal AK, Skoch J, Bacskai BJ, Hyman BT, Christmas P, Miller D, Yamin TT, Xu S, Wisniewski D, Evans JF, Soberman RJ. The membrane organization of leukotriene synthesis. Proc Natl Acad Sci USA 2004, 101:6587-6592. 10.1073/pnas.0308523101, 404089, 15084748.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6587-6592
-
-
Mandal, A.K.1
Skoch, J.2
Bacskai, B.J.3
Hyman, B.T.4
Christmas, P.5
Miller, D.6
Yamin, T.T.7
Xu, S.8
Wisniewski, D.9
Evans, J.F.10
Soberman, R.J.11
-
3
-
-
34447565153
-
The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old
-
10.1016/j.neurobiolaging.2006.06.007, 16930777
-
Chinnici CM, Yao Y, Praticò D. The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old. Neurobiol Aging 2007, 28:1457-1462. 10.1016/j.neurobiolaging.2006.06.007, 16930777.
-
(2007)
Neurobiol Aging
, vol.28
, pp. 1457-1462
-
-
Chinnici, C.M.1
Yao, Y.2
Praticò, D.3
-
4
-
-
56449106689
-
Increased 5-lipooxygenase imunoreactivity in hippocampus of patients with Alzheimer' diseases
-
10.1369/jhc.2008.951855, 2583907, 18678882
-
Ikonomovic MD, Abrahamson EE, Uz T, Manev H, Dekosky ST. Increased 5-lipooxygenase imunoreactivity in hippocampus of patients with Alzheimer' diseases. J Histochem Cytochem 2008, 56:1065-1073. 10.1369/jhc.2008.951855, 2583907, 18678882.
-
(2008)
J Histochem Cytochem
, vol.56
, pp. 1065-1073
-
-
Ikonomovic, M.D.1
Abrahamson, E.E.2
Uz, T.3
Manev, H.4
Dekosky, S.T.5
-
5
-
-
42049114647
-
5-lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer's disease
-
2698428, 17998412
-
Firuzi O, Zhuo J, Chinnici CM, Wisniewski T, Praticò D. 5-lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer's disease. FASEB J 2008, 22:1169-1178. 2698428, 17998412.
-
(2008)
FASEB J
, vol.22
, pp. 1169-1178
-
-
Firuzi, O.1
Zhuo, J.2
Chinnici, C.M.3
Wisniewski, T.4
Praticò, D.5
-
6
-
-
0028821025
-
The effect of MK-591, a novel 5-lipoxygenase-activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo
-
10.1016/S0091-6749(95)70151-6, 7822663
-
Diamant Z, Timmers MC, van der Veen H, Friedman BS, De Smet M, Depré M, Hilliard D, Bel EH, Sterk PJ. The effect of MK-591, a novel 5-lipoxygenase-activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo. J Allergy Clin Immunol 1995, 95:42-51. 10.1016/S0091-6749(95)70151-6, 7822663.
-
(1995)
J Allergy Clin Immunol
, vol.95
, pp. 42-51
-
-
Diamant, Z.1
Timmers, M.C.2
van der Veen, H.3
Friedman, B.S.4
De Smet, M.5
Depré, M.6
Hilliard, D.7
Bel, E.H.8
Sterk, P.J.9
-
7
-
-
0035875690
-
Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer's disease
-
Praticò D, Uryu K, Leight S, Trojanowski J, Lee V. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer's disease. J Neurosci 2001, 21(12):4183-4187.
-
(2001)
J Neurosci
, vol.21
, Issue.12
, pp. 4183-4187
-
-
Praticò, D.1
Uryu, K.2
Leight, S.3
Trojanowski, J.4
Lee, V.5
-
8
-
-
78049423493
-
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase
-
Yang H, Zhuo J, Chu J, Chinnici C, Praticò D. Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Biol Psych 2010, 68(10):922-929.
-
(2010)
Biol Psych
, vol.68
, Issue.10
, pp. 922-929
-
-
Yang, H.1
Zhuo, J.2
Chu, J.3
Chinnici, C.4
Praticò, D.5
-
9
-
-
84855414647
-
Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
-
10.1186/1750-1326-7-1, 3277480, 22222029
-
Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Praticò D. Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice. Mol Neurodegener 2012, 7:1. 10.1186/1750-1326-7-1, 3277480, 22222029.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 1
-
-
Chu, J.1
Giannopoulos, P.F.2
Ceballos-Diaz, C.3
Golde, T.E.4
Praticò, D.5
-
10
-
-
79551473183
-
5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo
-
10.1002/ana.22234, 3051361, 21280074
-
Chu J, Praticò D. 5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo. Ann Neurol 2011, 69:34-46. 10.1002/ana.22234, 3051361, 21280074.
-
(2011)
Ann Neurol
, vol.69
, pp. 34-46
-
-
Chu, J.1
Praticò, D.2
-
11
-
-
0035710746
-
Analysis of relative gene expression data using real time quantitative PCR and the 2-ΔΔCt method
-
Kenneth JL, Thomas DS. Analysis of relative gene expression data using real time quantitative PCR and the 2-ΔΔCt method. Methods 2002, 25:402-408.
-
(2002)
Methods
, vol.25
, pp. 402-408
-
-
Kenneth, J.L.1
Thomas, D.S.2
-
12
-
-
0035863055
-
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Hsiao Ashe K, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 2001, 21(2):372-381.
-
(2001)
J Neurosci
, vol.21
, Issue.2
, pp. 372-381
-
-
Kawarabayashi, T.1
Younkin, L.H.2
Saido, T.C.3
Shoji, M.4
Hsiao Ashe, K.5
Younkin, S.G.6
-
13
-
-
0346101885
-
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
10.1016/S0896-6273(03)00787-6, 14687544
-
Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sunh X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 2003, 40:1087-1093. 10.1016/S0896-6273(03)00787-6, 14687544.
-
(2003)
Neuron
, vol.40
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
Walsh, D.M.4
Wu, X.5
Sunh, X.6
Frosch, M.P.7
Selkoe, D.J.8
-
14
-
-
10744232186
-
Mechanisms of Abeta clearance and catabolism
-
10.1385/NMM:4:3:147, 14716023
-
Guenette SY. Mechanisms of Abeta clearance and catabolism. Neuromolecular Med 2003, 4:147-160. 10.1385/NMM:4:3:147, 14716023.
-
(2003)
Neuromolecular Med
, vol.4
, pp. 147-160
-
-
Guenette, S.Y.1
-
15
-
-
18044392303
-
Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis
-
10.1186/1742-2094-1-21, 527877, 15500684
-
Yao Y, Chinnici C, Tang H, Trojanowski J, Lee V, Praticò D. Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis. J Neuroinflammation 2004, 1:21. 10.1186/1742-2094-1-21, 527877, 15500684.
-
(2004)
J Neuroinflammation
, vol.1
, pp. 21
-
-
Yao, Y.1
Chinnici, C.2
Tang, H.3
Trojanowski, J.4
Lee, V.5
Praticò, D.6
-
16
-
-
0025021789
-
Identification and isolation of a membrane protein necessary for leukotriene production
-
10.1038/343278a0, 2300172
-
Miller DK, Gillard JW, Vickers PJ, Sadowski S, Léveillé C, Mancini JA, Charleson P, Dixon RA, Ford-Hutchinson AW, Fortin R. Identification and isolation of a membrane protein necessary for leukotriene production. Nature 1990, 343:278-281. 10.1038/343278a0, 2300172.
-
(1990)
Nature
, vol.343
, pp. 278-281
-
-
Miller, D.K.1
Gillard, J.W.2
Vickers, P.J.3
Sadowski, S.4
Léveillé, C.5
Mancini, J.A.6
Charleson, P.7
Dixon, R.A.8
Ford-Hutchinson, A.W.9
Fortin, R.10
-
17
-
-
0025022489
-
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
-
10.1038/343282a0, 2300173
-
Dixon RAF, Diehl RE, Opas E, Rands E, Vickers PJ, Evans JF, Gillard JW, Miller DK. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 1990, 343:282-284. 10.1038/343282a0, 2300173.
-
(1990)
Nature
, vol.343
, pp. 282-284
-
-
Dixon, R.A.F.1
Diehl, R.E.2
Opas, E.3
Rands, E.4
Vickers, P.J.5
Evans, J.F.6
Gillard, J.W.7
Miller, D.K.8
-
18
-
-
0025823424
-
5-lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors
-
Evans JF, Lévillé C, Mancini JA, Prasit P, Thérien M, Zamboni R, Gauthier JY, Fortin R, Charleson P, MacIntyre DE, Luell S, Bach TJ, Meurer R, Guay J, Vickers PJ, Rouzer CA, Gillard JW, Miller DK. 5-lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors. Mol Pharmacol 1991, 40:22-27.
-
(1991)
Mol Pharmacol
, vol.40
, pp. 22-27
-
-
Evans, J.F.1
Lévillé, C.2
Mancini, J.A.3
Prasit, P.4
Thérien, M.5
Zamboni, R.6
Gauthier, J.Y.7
Fortin, R.8
Charleson, P.9
MacIntyre, D.E.10
Luell, S.11
Bach, T.J.12
Meurer, R.13
Guay, J.14
Vickers, P.J.15
Rouzer, C.A.16
Gillard, J.W.17
Miller, D.K.18
-
19
-
-
79953660461
-
Pharmacological blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model
-
10.1016/j.ajpath.2010.12.032, 3078454, 21435457
-
Chu J, Pratico D. Pharmacological blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model. Am J Pathol 2011, 178(4):1762-1769. 10.1016/j.ajpath.2010.12.032, 3078454, 21435457.
-
(2011)
Am J Pathol
, vol.178
, Issue.4
, pp. 1762-1769
-
-
Chu, J.1
Pratico, D.2
-
20
-
-
34547560098
-
Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein
-
10.1126/science.1144346, 17600184
-
Ferguson AD, McKeever BM, Xu S, Wisniewski D, Miller DK, Yamin TT, Spencer RH, Chu L, Ujjainwalla F, Cunningham BR, Evans JF, Becker JW. Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. Science 2007, 317:510-512. 10.1126/science.1144346, 17600184.
-
(2007)
Science
, vol.317
, pp. 510-512
-
-
Ferguson, A.D.1
McKeever, B.M.2
Xu, S.3
Wisniewski, D.4
Miller, D.K.5
Yamin, T.T.6
Spencer, R.H.7
Chu, L.8
Ujjainwalla, F.9
Cunningham, B.R.10
Evans, J.F.11
Becker, J.W.12
-
21
-
-
0037424275
-
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1
-
10.1074/jbc.C200648200, 12522139
-
Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem 2003, 278:7850-7854. 10.1074/jbc.C200648200, 12522139.
-
(2003)
J Biol Chem
, vol.278
, pp. 7850-7854
-
-
Luo, W.J.1
Wang, H.2
Li, H.3
Kim, B.S.4
Shah, S.5
Lee, H.J.6
Thinakaran, G.7
Kim, T.W.8
Yu, G.9
Xu, H.10
-
22
-
-
32044466055
-
Transcriptional regulation of Pen-2, a key component of the γ-secretase complex, by CREB
-
10.1128/MCB.26.4.1347-1354.2006, 1367199, 16449647
-
Wang R, Zhang YW, Sun P, Liu R, Zhang X, Zhang X, Xia K, Xia J, Xu H, Zhang Z. Transcriptional regulation of Pen-2, a key component of the γ-secretase complex, by CREB. Mol Cell Biol 2006, 26:1347-1354. 10.1128/MCB.26.4.1347-1354.2006, 1367199, 16449647.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 1347-1354
-
-
Wang, R.1
Zhang, Y.W.2
Sun, P.3
Liu, R.4
Zhang, X.5
Zhang, X.6
Xia, K.7
Xia, J.8
Xu, H.9
Zhang, Z.10
-
23
-
-
84856146554
-
Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments
-
10.1002/ana.22625, 22275252
-
Chu J, Zhuo JM, Pratico D. Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments. Ann Neurol 2012, 71(1):57-67. 10.1002/ana.22625, 22275252.
-
(2012)
Ann Neurol
, vol.71
, Issue.1
, pp. 57-67
-
-
Chu, J.1
Zhuo, J.M.2
Pratico, D.3
-
24
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
10.1126/science.1072994, 12130773
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356. 10.1126/science.1072994, 12130773.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
25
-
-
46749097518
-
Inhibition and modulation of γ-secretase for Alzheimer's disease
-
10.1016/j.nurt.2008.05.010, 2572079, 18625450
-
Wolfe MS. Inhibition and modulation of γ-secretase for Alzheimer's disease. Neurotherapeutics 2008, 5:391-398. 10.1016/j.nurt.2008.05.010, 2572079, 18625450.
-
(2008)
Neurotherapeutics
, vol.5
, pp. 391-398
-
-
Wolfe, M.S.1
-
26
-
-
0036023971
-
A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
-
10.1093/embo-reports/kvf124, 1084181, 12101103
-
Geling A, Steiner H, Willem M, Bally-Cuif L, Haas C. A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep 2002, 3:688-694. 10.1093/embo-reports/kvf124, 1084181, 12101103.
-
(2002)
EMBO Rep
, vol.3
, pp. 688-694
-
-
Geling, A.1
Steiner, H.2
Willem, M.3
Bally-Cuif, L.4
Haas, C.5
-
27
-
-
0242412482
-
Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional γ-secretase inhibitor
-
10.1074/jbc.M307757200, 12949072
-
Searfoss GH, Jordan WH, Calligaro DO, Galbreath EJ, Schirtzinger LM, Berridge BR, Gao H, Higgins MA, May PC, Ryan TP. Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional γ-secretase inhibitor. J Biol Chem 2003, 278:46107-46116. 10.1074/jbc.M307757200, 12949072.
-
(2003)
J Biol Chem
, vol.278
, pp. 46107-46116
-
-
Searfoss, G.H.1
Jordan, W.H.2
Calligaro, D.O.3
Galbreath, E.J.4
Schirtzinger, L.M.5
Berridge, B.R.6
Gao, H.7
Higgins, M.A.8
May, P.C.9
Ryan, T.P.10
|