Glucocorticoids facilitate astrocytic amyloid-β peptide deposition by increasing the expression of APP and BACE1 and decreasing the expression of amyloid-β-degrading proteases

Endocrinology

Volumn 152, Issue 7, 2011, Pages 2704-2715

  Wang, Yanyan ^a   Li, Maoquan ^b   Tang, Jun ^a   Song, Min ^a   Xu, Xueqing ^a   Xiong, Jiaxiang ^a   Li, Junxia ^a   Bai, Yun ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHENGDU MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; GELATINASE B; GLUCOCORTICOID; INSULINASE;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; CELL CULTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; IMMUNOFLUORESCENCE; IN VITRO STUDY; MALE; MOLECULAR MECHANICS; MOUSE; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; ASTROCYTES; CELLS, CULTURED; CEREBRAL CORTEX; CORTICOSTERONE; DEXAMETHASONE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HIPPOCAMPUS; INSULYSIN; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; RANDOM ALLOCATION; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 79959444286     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2011-0145     Document Type: Article

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