-
1
-
-
0020597565
-
Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation
-
Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220 (1983) 568-575
-
(1983)
Science
, vol.220
, pp. 568-575
-
-
Samuelsson, B.1
-
2
-
-
33644815175
-
Treatment of asthma with antileukotrienes: first line or last resort therapy?
-
Dahlen S.E. Treatment of asthma with antileukotrienes: first line or last resort therapy?. Eur. J. Pharmacol. 533 (2006) 40-56
-
(2006)
Eur. J. Pharmacol.
, vol.533
, pp. 40-56
-
-
Dahlen, S.E.1
-
4
-
-
0030736867
-
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity
-
(Published erratum appears in Nat. Struct. Biol. 5(3) (1998) 242)
-
Gillmor S.A., Villasenor A., Fletterick R., et al. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat. Struct. Biol. 4 (1997) 1003-1009 (Published erratum appears in Nat. Struct. Biol. 5(3) (1998) 242)
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 1003-1009
-
-
Gillmor, S.A.1
Villasenor, A.2
Fletterick, R.3
-
5
-
-
0037066761
-
Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase
-
Kulkarni S., Das S., Funk C.D., et al. Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase. J. Biol. Chem. 277 (2002) 13167-13174
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13167-13174
-
-
Kulkarni, S.1
Das, S.2
Funk, C.D.3
-
6
-
-
18144399317
-
Structural organization of the regulatory domain of human 5-lipoxygenase
-
Allard J.B., and Brock T.G. Structural organization of the regulatory domain of human 5-lipoxygenase. Curr. Protein Pept. Sci. 6 (2005) 125-131
-
(2005)
Curr. Protein Pept. Sci.
, vol.6
, pp. 125-131
-
-
Allard, J.B.1
Brock, T.G.2
-
7
-
-
58149487199
-
Human Dicer C-terminus functions as a 5-lipoxygenase binding domain
-
Dincbas-Renqvist V., Pepin G., Rakonjac M., et al. Human Dicer C-terminus functions as a 5-lipoxygenase binding domain. Biochim. Biophys. Acta 1789 (2009) 99-108
-
(2009)
Biochim. Biophys. Acta
, vol.1789
, pp. 99-108
-
-
Dincbas-Renqvist, V.1
Pepin, G.2
Rakonjac, M.3
-
8
-
-
34347397335
-
5-Lipoxygenase: regulation of expression and enzyme activity
-
Rådmark O., Werz O., Steinhilber D., et al. 5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem. Sci. 32 (2007) 332-341
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 332-341
-
-
Rådmark, O.1
Werz, O.2
Steinhilber, D.3
-
9
-
-
0345008359
-
On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors
-
Rouzer C.A., and Samuelsson B. On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors. Proc. Natl. Acad. Sci. USA 82 (1985) 6040-6044
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 6040-6044
-
-
Rouzer, C.A.1
Samuelsson, B.2
-
10
-
-
0034624019
-
The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity
-
Hammarberg T., Provost P., Persson B., et al. The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity. J. Biol. Chem. 275 (2000) 38787-38793
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 38787-38793
-
-
Hammarberg, T.1
Provost, P.2
Persson, B.3
-
11
-
-
72449124354
-
Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102
-
Esser J., Rakonjac M., Hofmann B., et al. Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102. Biochem. J. 425 (2010) 265-274
-
(2010)
Biochem. J.
, vol.425
, pp. 265-274
-
-
Esser, J.1
Rakonjac, M.2
Hofmann, B.3
-
12
-
-
0035808471
-
The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation
-
Chen X.S., and Funk C.D. The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation. J. Biol. Chem. 276 (2001) 811-818
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 811-818
-
-
Chen, X.S.1
Funk, C.D.2
-
13
-
-
0942276361
-
Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium
-
Walther M., Wiesner R., and Kuhn H. Investigations into calcium-dependent membrane association of 15-lipoxygenase-1. Mechanistic roles of surface-exposed hydrophobic amino acids and calcium. J. Biol. Chem. 279 (2004) 3717-3725
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 3717-3725
-
-
Walther, M.1
Wiesner, R.2
Kuhn, H.3
-
14
-
-
8744267513
-
Modulation of human 5-lipoxygenase activity by membrane lipids
-
Pande A.H., Moe D., Nemec K.N., et al. Modulation of human 5-lipoxygenase activity by membrane lipids. Biochemistry 43 (2004) 14653-14666
-
(2004)
Biochemistry
, vol.43
, pp. 14653-14666
-
-
Pande, A.H.1
Moe, D.2
Nemec, K.N.3
-
15
-
-
22244452942
-
Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase
-
Pande A.H., Qin S., and Tatulian S.A. Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase. Biophys. J. 88 (2005) 4084-4094
-
(2005)
Biophys. J.
, vol.88
, pp. 4084-4094
-
-
Pande, A.H.1
Qin, S.2
Tatulian, S.A.3
-
16
-
-
0035844240
-
5-Lipoxygenase Interacts with Coactosin-like protein
-
Provost P., Doucet J., Hanmmarberg T., et al. 5-Lipoxygenase Interacts with Coactosin-like protein. J. Biol. Chem. 276 (2001) 16520-16527
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16520-16527
-
-
Provost, P.1
Doucet, J.2
Hanmmarberg, T.3
-
17
-
-
33748348405
-
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production
-
Rakonjac M., Fischer L., Provost P., et al. Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc. Natl. Acad. Sci. USA 103 (2006) 13150-13155
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 13150-13155
-
-
Rakonjac, M.1
Fischer, L.2
Provost, P.3
-
18
-
-
68549132365
-
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo
-
Feisst C., Pergola C., Rakonjac M., et al. Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. Cell. Mol. Life Sci. 66 (2009) 2759-2771
-
(2009)
Cell. Mol. Life Sci.
, vol.66
, pp. 2759-2771
-
-
Feisst, C.1
Pergola, C.2
Rakonjac, M.3
-
19
-
-
5144223918
-
Structural flexibility of the N-terminal beta-barrel domain of 15-lipoxygenase-1 probed by small angle X-ray scattering. Functional consequences for activity regulation and membrane binding
-
Hammel M., Walther M., Prassl R., et al. Structural flexibility of the N-terminal beta-barrel domain of 15-lipoxygenase-1 probed by small angle X-ray scattering. Functional consequences for activity regulation and membrane binding. J. Mol. Biol. 343 (2004) 917-929
-
(2004)
J. Mol. Biol.
, vol.343
, pp. 917-929
-
-
Hammel, M.1
Walther, M.2
Prassl, R.3
-
22
-
-
33750102847
-
Therapeutic options for 5-lipoxygenase inhibitors
-
Werz O., and Steinhilber D. Therapeutic options for 5-lipoxygenase inhibitors. Pharmacol. Ther. 112 (2006) 701-718
-
(2006)
Pharmacol. Ther.
, vol.112
, pp. 701-718
-
-
Werz, O.1
Steinhilber, D.2
-
23
-
-
38749113897
-
What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases
-
Evans J.F., Ferguson A.D., Mosley R.T., et al. What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. Trends Pharmacol. Sci. 29 (2008) 72-78
-
(2008)
Trends Pharmacol. Sci.
, vol.29
, pp. 72-78
-
-
Evans, J.F.1
Ferguson, A.D.2
Mosley, R.T.3
-
24
-
-
7244239214
-
Multiple nuclear localization sequences allow modulation of 5-lipoxygenase nuclear import
-
Luo M., Pang C.W., Gerken A.E., et al. Multiple nuclear localization sequences allow modulation of 5-lipoxygenase nuclear import. Traffic 5 (2004) 847-854
-
(2004)
Traffic
, vol.5
, pp. 847-854
-
-
Luo, M.1
Pang, C.W.2
Gerken, A.E.3
-
25
-
-
0030972551
-
Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence
-
Brock T.G., McNish R.W., Bailie M.B., et al. Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence. J. Biol. Chem. 272 (1997) 8276-8280
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 8276-8280
-
-
Brock, T.G.1
McNish, R.W.2
Bailie, M.B.3
-
26
-
-
58649091333
-
Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export
-
Flamand N., Luo M., Peters-Golden M., et al. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. J. Biol. Chem. 284 (2009) 306-313
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 306-313
-
-
Flamand, N.1
Luo, M.2
Peters-Golden, M.3
-
28
-
-
0036464591
-
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes
-
Werz O., Bürkert E., Samuelsson B., et al. Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. Blood 99 (2002) 1044-1052
-
(2002)
Blood
, vol.99
, pp. 1044-1052
-
-
Werz, O.1
Bürkert, E.2
Samuelsson, B.3
-
29
-
-
0036719157
-
Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes
-
Werz O., Burkert E., Fischer L., et al. Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes. FASEB J. 16 (2002) 1441-1443
-
(2002)
FASEB J.
, vol.16
, pp. 1441-1443
-
-
Werz, O.1
Burkert, E.2
Fischer, L.3
-
30
-
-
0035871688
-
Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes
-
Werz O., Klemm J., Samuelsson B., et al. Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes. Blood 97 (2001) 2487-2495
-
(2001)
Blood
, vol.97
, pp. 2487-2495
-
-
Werz, O.1
Klemm, J.2
Samuelsson, B.3
-
31
-
-
24344468621
-
2+ mobilisation in polymorphonuclear leukocytes involving Src family kinases
-
2+ mobilisation in polymorphonuclear leukocytes involving Src family kinases. Biochim. Biophys. Acta 1736 (2005) 109-119
-
(2005)
Biochim. Biophys. Acta
, vol.1736
, pp. 109-119
-
-
Fischer, L.1
Poeckel, D.2
Buerkert, E.3
-
32
-
-
28844492469
-
Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase
-
Luo M., Jones S.M., Flamand N., et al. Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase. J. Biol. Chem. 280 (2005) 40609-40616
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40609-40616
-
-
Luo, M.1
Jones, S.M.2
Flamand, N.3
-
33
-
-
0036076153
-
Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils
-
Flamand N., Surette M.E., Picard S., et al. Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils. Mol. Pharmacol. 62 (2002) 250-256
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 250-256
-
-
Flamand, N.1
Surette, M.E.2
Picard, S.3
-
34
-
-
33644857422
-
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils
-
Flamand N., Lefebvre J., Surette M.E., et al. Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils. J. Biol. Chem. 281 (2006) 129-136
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 129-136
-
-
Flamand, N.1
Lefebvre, J.2
Surette, M.E.3
-
35
-
-
42549138031
-
Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids
-
Brock T.G. Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids. Lipids 43 (2008) 161-169
-
(2008)
Lipids
, vol.43
, pp. 161-169
-
-
Brock, T.G.1
-
36
-
-
2342503757
-
The membrane organization of leukotriene synthesis
-
(Epub 2004 Apr 14)
-
Mandal A.K., Skoch J., Bacskai B.J., et al. The membrane organization of leukotriene synthesis. Proc. Natl. Acad. Sci. USA 101 (2004) 6587-6592 (Epub 2004 Apr 14)
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6587-6592
-
-
Mandal, A.K.1
Skoch, J.2
Bacskai, B.J.3
-
37
-
-
30044446862
-
5-Lipoxygenase activating protein homodimer in human neutrophils. Evidence for a role in leukotriene synthesis
-
Plante H., Picard S., Mancini J., et al. 5-Lipoxygenase activating protein homodimer in human neutrophils. Evidence for a role in leukotriene synthesis. Biochem. J. 393 (2006) 211-218
-
(2006)
Biochem. J.
, vol.393
, pp. 211-218
-
-
Plante, H.1
Picard, S.2
Mancini, J.3
-
38
-
-
34547560098
-
Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein
-
Ferguson A.D., McKeever B.M., Xu S., et al. Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. Science 317 (2007) 510-512
-
(2007)
Science
, vol.317
, pp. 510-512
-
-
Ferguson, A.D.1
McKeever, B.M.2
Xu, S.3
-
39
-
-
58149511977
-
The nuclear membrane organization of leukotriene synthesis
-
Mandal A.K., Jones P.B., Bair A.M., et al. The nuclear membrane organization of leukotriene synthesis. Proc. Natl. Acad. Sci. USA 105 (2008) 20434-20439
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 20434-20439
-
-
Mandal, A.K.1
Jones, P.B.2
Bair, A.M.3
-
40
-
-
33947365144
-
Leukotriene synthesis in response to A23187 is inhibited by methyl-beta-cyclodextrin in RBL-2H3 cells
-
You H.J., Seo J.M., Moon J.Y., et al. Leukotriene synthesis in response to A23187 is inhibited by methyl-beta-cyclodextrin in RBL-2H3 cells. Mol. Cell 23 (2007) 57-63
-
(2007)
Mol. Cell
, vol.23
, pp. 57-63
-
-
You, H.J.1
Seo, J.M.2
Moon, J.Y.3
-
41
-
-
71049123949
-
Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma
-
Boyd R.S., Jukes-Jones R., Walewska R., et al. Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma. Mol. Cell. Proteomics 8 (2009) 1501-1515
-
(2009)
Mol. Cell. Proteomics
, vol.8
, pp. 1501-1515
-
-
Boyd, R.S.1
Jukes-Jones, R.2
Walewska, R.3
-
42
-
-
58149398605
-
ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma
-
Pergola C., Dodt G., Rossi A., et al. ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma. Proc. Natl. Acad. Sci. USA 105 (2008) 19881-19886
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19881-19886
-
-
Pergola, C.1
Dodt, G.2
Rossi, A.3
-
43
-
-
67349265997
-
Leukocyte lipid bodies - biogenesis and functions in inflammation
-
Bozza P.T., Magalhaes K.G., and Weller P.F. Leukocyte lipid bodies - biogenesis and functions in inflammation. Biochim. Biophys. Acta 1791 (2009) 540-551
-
(2009)
Biochim. Biophys. Acta
, vol.1791
, pp. 540-551
-
-
Bozza, P.T.1
Magalhaes, K.G.2
Weller, P.F.3
-
44
-
-
59649083719
-
Cell and molecular biology of nuclear actin
-
Hofmann W.A. Cell and molecular biology of nuclear actin. Int. Rev. Cell Mol. Biol. 273 (2009) 219-263
-
(2009)
Int. Rev. Cell Mol. Biol.
, vol.273
, pp. 219-263
-
-
Hofmann, W.A.1
|