Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase

Neurobiology of Aging

Volumn 35, Issue 5, 2014, Pages 1024-1031

  Joshi, Yash B ^a   Giannopoulos, Phillip F ^a   Chu, Jin ^a   Praticò, Domenico ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid beta; Behavior; LPS; Neuroinflammation; Transgenic mouse models

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID BETA; BEHAVIOR; LPS; NEUROINFLAMMATION; TRANSGENIC MOUSE MODELS;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; AMYLOIDOGENIC PROTEINS; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CYCLIN-DEPENDENT KINASE 5; DISEASE MODELS, ANIMAL; INFLAMMATION; LIPOPOLYSACCHARIDES; MEMORY; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; TAU PROTEINS; UP-REGULATION;

EID: 84893731765     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.11.016     Document Type: Article

References (33)

1. Augustinack J.C., Sanders J.L., Tsai L.H., Hyman B.T. Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles. J.Neuropathol. Exp. Neurol. 2002, 61:557-564.
2. Balin B.J., Gerard H.C., Arkin E.J., Appelt D.M., Branigan P.J., Abrams J.T., Whittum-Hudson J.A., Hudson A.P. Identification and localization of Chlamydia pneumonieae in the Alzheimer's brain. Med. Microbiol. Immunol. 1998, 187:23-42.
3. Bard F., Cannon C., Barbour R., Games D., Grajeda H., Guido T., Hu K., Huan J., Johnson-Wood K., Khan K., Kholodenko D., Lee M., Lieberburg I., Motter R., Nguyen M., Soriano F., Vasquez N., Weiss K., Welch B., Seubert P., Schenk D., Yednock T. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 2000, 6:916-919.
4. Bitting L., Naidu A., Cordell B., Murphy G.M. Beta-amyloid peptide secretion by a microglial cell line is induced by beta-amyloid-(25-35) and lipopolysaccharide. J.Biol. Chem. 1996, 271:16804-16809.
5. Breitner J.C., Baker L.D., Montine T.J., Meinert C.L., Lyketsos C.G., Ashe K.H., Brandt J., Craft S., Evans D.E., Green R.C., Imsail M.S., Martin B.K., Mullan M.J., Sabbagh M., Tariot P.N. Extended results of the Alzheimer's disease anti-inflammatory prevention trial. Alzheimers Dement. 2011, 7:402-411. ADAPT Research Group.
6. Chinnici C.M., Yao Y., Pratico D. The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old. Neurobiol. Aging 2007, 28:1457-1462.
7. Chu J., Giannopoulos P.F., Ceballos-Diaz C., Golde T.E., Pratico D. 5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease. Ann. Neurol. 2012, 72:442-454.
8. Chu J., Pratico D. Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase. Am. J. Pathol. 2011, 178:1762-1769.
9. Chu J., Pratico D. 5-lipoxygenase pharmacological blockade decreases tau phosphorylation invivo: involvement of the cyclin-dependent kinase-5. Neurobiol. Aging 2013, 34:1549-1554.
10. Chu J., Pratico D. 5-lipoxygenase as an endogenous modulator of amyloid β invivo. Ann. Neurol. 2011, 69:34-36.
11. Erickson M.A., Hartvigson P.E., Morofuji Y., Owen J.B., Butterfield D.A., Banks W.A. Lipopolysaccharide impairs amyloid β efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood-brain barrier. J.Neuroinflammation 2012, 29:150.
12. Firuzi O., Zhuo J., Chinnici C.M., Wisniewski T., Pratico D. 5-lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease. FASEB J. 2008, 22:1169-1178.
13. Ghosh S., Wu M.D., Shaftel S.S., Kyrkanides S., LaFerla F.M., Olschowka J.A., O'Banion M.K. Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. J.Neurosci. 2013, 33:5053-5064.
14. Giannopoulos P.F., Chu J., Joshi Y.B., Sperow M., Li J.G., Kirby L.G., Pratico D. Gene knockout of 5-lipoxygenase rescues synaptyic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease. Mol. Psychiatry 2013, Epub ahead of print Mar 2013. 10.1038/mp.2013.23.
15. Goulet J.L., Snouwaert J.N., Latour A.M., Coffman T.M., Koller B.H. Altered inflammatory responses in leukotriene-deficient mice. Proc. Natl. Acad. U.S.A 1994, 91:12852-12856.
16. Griffin W.S., Stanley L.C., Ling C., White L., MacLeod V., Perrot L.J., White C.L., Araoz C. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A 1989, 86:7611-7615.
17. Hammond C.J., Hallock L.R., Howanski R.J., Appelt D.M., Little C.S., Balin B.J. Immunohistological detection of Chlamydia pneumonia in the Alzheimer's disease brain. BMC Neurosci. 2012, 11:121.
18. Ikonomovic M.D., Abrahamson E.E., Uz T., Manev H., Dekosky S.T. Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease. J.Histochem. Cytochem. 2008, 56:1065-1073.
19. Jaeger L.B., Dohgu S., Sultana R., Lynch J.L., Owen J.B., Erickson M.A., Shah G.N., Price T.O., Fleegal-Demotta M.A., Butterfield D.A., Banks W.A. Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease. Brain Behav. Immun. 2009, 23:507-517.
20. Joshi Y.B., Chu J., Pratico D. Stress hormone leads to memory deficits and altered tau phosphorylation in a model Alzheimer's disease. J.Alzheimers Dis. 2012, 31:167-176.
21. Joshi Y.B., Pratico D. The involvement of 5-lipoxygenase activating protein in anxiety-like behavior. J.Psychiatr. Res. 2013, 47:694-698.
22. Kimberly W.T., LaVoie M.J., Ostaszewski B.L., Ye W., Wolfe M.S., Selkoe D.J. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. Proc. Natl. Acad. Sci. U.S.A 2003, 100:6382-6387.
23. Kitazawa M., Oddo S., Yamasaki T.R., Green K.N., LaFerla F.M. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J.Neurosci. 2005, 25:8843-8853.
24. Kountouras J., Tsolaki M., Gavalas E., Boziki M., Zavos C., Karatzoglou P., Chatzopoulos D., Venizelos I. Relationship between helicobacter pylori infection and Alzheimer disease. Neurology 2006, 66:938-940.
25. Lee J.W., Lee Y.K., Yuk D.Y., Choi D.Y., Ban S.B., Oh K.W., Hong J.T. Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J.Neuroinflammation 2008, 5:37. 10.1186/1742-2094-5-37.
26. Nadler Y., Alexandrovich A., Grigoriadis N., Hartmann T., Rao K.S., Shohami E., Stein R. Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury. Glia 2008, 56:552-567.
27. Oddo S., Caccamo A., Shepherd J.D., Murphy M.P., Golde T.E., Kayed R., Metherate R., Mattson M.P., Akbari Y., LaFerla F.M. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular abeta and synaptic dysfunction. Neuron 2003, 39:409-421.
28. Parachikova A., Vasilevko V., Cribbs D.H., LaFerla F.M., Green K.N. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J.Alzheimers Dis. 2010, 21:527-542.
29. Radmark O., Samuelsson B. Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis. Biochem. Biophys. Res. Commun. 2010, 396:105-110.
30. Sheng J.G., Mrak R.E., Griffen W.S. Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+ microglia and S100beta+ astrocytes with neurofibrillary tangle stages. J.Neuropathol. Exp. Neurol. 1997, 56:285-290.
31. Sheng J.G., Mrak R.E., Griffin W.S. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol. 1997, 94:1-5.
32. Sy M., Kitazawa M., Medeiros R., Whitman L., Cheng D., Lane T.E., LaFerla F.M. Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am. J. Pathol. 2011, 178:2811-2822.
33. Wozniak M.A., Irzhaki R.F., Shipley S.J., Dobson C.B. Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation. Neurosci. Lett. 2007, 429:95-100.