A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents

Oncotarget

Volumn 5, Issue 15, 2014, Pages 5978-5991

  Bortolozzi, Roberta ^a   Viola, Giampietro ^a   Porcù, Elena ^a   Consolaro, Francesca ^a   Marzano, Cristina ^a   Pellei, Maura ^b   Gandin, Valentina ^a   Basso, Giuseppe ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Acute lymphoblastic leukemia; Apoptosis; Copper complexes; ER stress

Indexed keywords

CASPASE 12; CASPASE 3; CASPASE 7; CASPASE 9; CELL EXTRACT; CHYMOTRYPSIN; COPPER DERIVATIVE; CYCLOHEXIMIDE; CYTARABINE; CYTOCHROME C; DAUNORUBICIN; DEXAMETHASONE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PHOSPHINE COPPER COMPLEX; PROTEASOME; TRYPSIN; UBIQUITIN; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; VINCRISTINE; X BOX BINDING PROTEIN 1; COORDINATION COMPOUND; COPPER; MONOVALENT CATION;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SENSITIZATION; DRUG UPTAKE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN SYNTHESIS; DRUG DELIVERY SYSTEM; DRUG EFFECTS; ENDOPLASMIC RETICULUM; METABOLISM; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TUMOR CELL LINE;

APOPTOSIS; CATIONS, MONOVALENT; CELL LINE, TUMOR; COORDINATION COMPLEXES; COPPER; DRUG DELIVERY SYSTEMS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMANS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 84906248776     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2027     Document Type: Article

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