In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 798-808

  Marzano, Cristina ^a   Gandin, Valentina ^a   Pellei, Maura ^b   Colavito, Davide ^c   Papini, Grazia ^b   Lobbia, Giancarlo Gioia ^b   Del Giudice, Elda ^c   Porchia, Marina ^d   Tisato, Francesco ^d   Santini, Carlo ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c Research and Innovation SpA   (Italy)

^d CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 BIS[BIS(HYDROXYMETHYL)PHOSPHINOLETHANE; CISPLATIN; CUPROUS ION; PHOSPHINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRIHYDROXYMETHYLPHOSPHINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYDROPHILICITY; LYSOSOME; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIDRUG RESISTANCE; PHENOTYPE; STAINING; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHELATING AGENTS; COPPER; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGANDS; ORGANOMETALLIC COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 39749139466     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701146c     Document Type: Article

References (45)