The thioxotriazole copper (II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells

Journal of Biological Chemistry

Volumn 284, Issue 36, 2009, Pages 24306-24319

  Tardito, Saverio ^a   Isella, Claudio ^b   Medico, Enzo ^b   Marchiò, Luciano ^a   Bevilacqua, Elena ^c   Hatzoglou, Maria ^c   Bussolati, Ovidio ^a   Franchi Gazzola, Renata ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC; APOPTOTIC CELL DEATH; CASPASE ACTIVATION; CIS-PLATIN; COPPER COMPLEXES; CYCLOHEXIMIDES; CYTOTOXIC EFFECTS; DEATH PROCESS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION PROFILING; HT-1080 CELLS; HUMAN CANCER CELLS; MOUSE EMBRYONIC FIBROBLASTS; PARAPTOSIS; PROTEIN SYNTHESIS; REGULATED GENES; UBIQUITIN-PROTEASOME SYSTEM; UNFOLDED PROTEIN RESPONSE; VACUOLIZATION; WILD-TYPE CELLS;

CELL CULTURE; CELL DEATH; CELL MEMBRANES; COPPER COMPOUNDS; GENE EXPRESSION; HEAVY METALS; PHOSPHORYLATION; PLATINUM COMPOUNDS; PROTEINS;

COMPLEXATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENT; CISPLATIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PROTEASOME; PROTEIN P53; THIOXOTRIAZOLE COPPER; TRANSCRIPTION FACTOR; UBIQUITIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; EMBRYO; EMBRYO CELL; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; FIBROSARCOMA; GENE CONTROL; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; RNA SPLICING; SARCOMA CELL; UBIQUITINATION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CACO-2 CELLS; CISPLATIN; COPPER; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; MICE; NEOPLASM PROTEINS; NEOPLASMS; ORGANOMETALLIC COMPOUNDS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; UBIQUITIN; UBIQUITINATION;

EID: 69949155034     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.026583     Document Type: Article

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