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Volumn 4, Issue 3, 2013, Pages

Controversial view of a genetically altered mouse model of focal retinal degeneration

Author keywords

Age related macular degeneration; Animal model; Ccl2; Cx3cr1; rd8; TSG 6

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; LIPOFUSCIN; MEMBRANE COFACTOR PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1;

EID: 84877696645     PISSN: 19491018     EISSN: 19491026     Source Type: Journal    
DOI: 10.4161/bioe.22949     Document Type: Article
Times cited : (24)

References (34)
  • 1
    • 84862804838 scopus 로고    scopus 로고
    • Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model
    • PMID:22452753
    • Tuo J, Cao X, Shen D, Wang Y, Zhang J, Oh JY, et al. Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model. J Neuroinflammation 2012; 9:59; PMID:22452753; http://dx.doi.org/10.1186/1742-2094-9-59.
    • (2012) J Neuroinflammation , vol.9 , pp. 59
    • Tuo, J.1    Cao, X.2    Shen, D.3    Wang, Y.4    Zhang, J.5    Oh, J.Y.6
  • 2
    • 0344676389 scopus 로고    scopus 로고
    • An animal model of agerelated macular degeneration in senescent Ccl-2-or Ccr-2-deficient mice
    • PMID:14566334
    • Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, et al. An animal model of agerelated macular degeneration in senescent Ccl-2-or Ccr-2-deficient mice. Nat Med 2003; 9:1390-7; PMID:14566334; http://dx.doi.org/10.1038/nm950.
    • (2003) Nat Med , vol.9 , pp. 1390-1397
    • Ambati, J.1    Anand, A.2    Fernandez, S.3    Sakurai, E.4    Lynn, B.C.5    Kuziel, W.A.6
  • 3
    • 34948898131 scopus 로고    scopus 로고
    • CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
    • PMID:17909628
    • Combadière C, Feumi C, Raoul W, Keller N, Rodéro M, Pézard A, et al. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest 2007; 117:2920-8; PMID:17909628; http://dx.doi.org/10.1172/JCI31692.
    • (2007) J Clin Invest , vol.117 , pp. 2920-2928
    • Combadière, C.1    Feumi, C.2    Raoul, W.3    Keller, N.4    Rodéro, M.5    Pézard, A.6
  • 4
    • 79961159284 scopus 로고    scopus 로고
    • Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice
    • PMID:21850237
    • Chen M, Forrester JV, Xu H. Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS One 2011; 6:e22818; PMID:21850237; http:// dx.doi.org/10.1371/journal.pone.0022818.
    • (2011) PLoS One , vol.6
    • Chen, M.1    Forrester, J.V.2    Xu, H.3
  • 5
    • 42449093343 scopus 로고    scopus 로고
    • Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice
    • PMID:18421223
    • Raoul W, Feumi C, Keller N, Lavalette S, Houssier M, Behar-Cohen F, et al. Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice. Ophthalmic Res 2008; 40:115-9; PMID:18421223; http://dx.doi. org/10.1159/000119860.
    • (2008) Ophthalmic Res , vol.40 , pp. 115-119
    • Raoul, W.1    Feumi, C.2    Keller, N.3    Lavalette, S.4    Houssier, M.5    Behar-Cohen, F.6
  • 6
    • 34648846532 scopus 로고    scopus 로고
    • Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human agerelated macular degeneration
    • PMID:17652758
    • Tuo J, Bojanowski CM, Zhou M, Shen D, Ross RJ, Rosenberg KI, et al. Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human agerelated macular degeneration. Invest Ophthalmol Vis Sci 2007; 48:3827-36; PMID:17652758; http:// dx.doi.org/10.1167/iovs.07-0051.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3827-3836
    • Tuo, J.1    Bojanowski, C.M.2    Zhou, M.3    Shen, D.4    Ross, R.J.5    Rosenberg, K.I.6
  • 7
    • 77951254301 scopus 로고    scopus 로고
    • Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)
    • PMID:20206286
    • Ramkumar HL, Zhang J, Chan CC. Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res 2010; 29:169-90; PMID:20206286; http://dx.doi. org/10.1016/j.preteyeres.2010.02.002.
    • (2010) Prog Retin Eye Res , vol.29 , pp. 169-190
    • Ramkumar, H.L.1    Zhang, J.2    Chan, C.C.3
  • 8
    • 84863723643 scopus 로고    scopus 로고
    • The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes
    • PMID:22447858
    • Mattapallil MJ, Wawrousek EF, Chan CC, Zhao H, Roychoudhury J, Ferguson TA, et al. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 2012; 53:2921-7; PMID:22447858; http://dx.doi.org/10.1167/iovs.12-9662.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 2921-2927
    • Mattapallil, M.J.1    Wawrousek, E.F.2    Chan, C.C.3    Zhao, H.4    Roychoudhury, J.5    Ferguson, T.A.6
  • 9
    • 84860179093 scopus 로고    scopus 로고
    • Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling
    • PMID:22545116
    • Luhmann UF, Lange CA, Robbie S, Munro PM, Cowing JA, Armer HE, et al. Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. PLoS One 2012; 7:e35551; PMID:22545116; http://dx.doi.org/10.1371/journal. pone.0035551.
    • (2012) PLoS One , vol.7
    • Luhmann, U.F.1    Lange, C.A.2    Robbie, S.3    Munro, P.M.4    Cowing, J.A.5    Armer, H.E.6
  • 10
    • 0034964652 scopus 로고    scopus 로고
    • Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene
    • PMID:11389483
    • den Hollander AI, Heckenlively JR, van den Born LI, de Kok YJ, van der Velde-Visser SD, Kellner U, et al. Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene. Am J Hum Genet 2001; 69:198-203; PMID:11389483; http://dx.doi. org/10.1086/321263.
    • (2001) Am J Hum Genet , vol.69 , pp. 198-203
    • den Hollander, A.I.1    Heckenlively, J.R.2    van den Born, L.I.3    de Kok, Y.J.4    van der Velde-Visser, S.D.5    Kellner, U.6
  • 11
    • 10744224972 scopus 로고    scopus 로고
    • CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina
    • PMID:12915475
    • Mehalow AK, Kameya S, Smith RS, Hawes NL, Denegre JM, Young JA, et al. CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina. Hum Mol Genet 2003; 12:2179-89; PMID:12915475; http://dx.doi.org/10.1093/hmg/ddg232.
    • (2003) Hum Mol Genet , vol.12 , pp. 2179-2189
    • Mehalow, A.K.1    Kameya, S.2    Smith, R.S.3    Hawes, N.L.4    Denegre, J.M.5    Young, J.A.6
  • 12
    • 34648822766 scopus 로고    scopus 로고
    • Crb1 is a determinant of retinal apical Müller glia cell features
    • PMID:17705196
    • van de Pavert SA, Sanz AS, Aartsen WM, Vos RM, Versteeg I, Beck SC, et al. Crb1 is a determinant of retinal apical Müller glia cell features. Glia 2007; 55:1486-97; PMID:17705196; http://dx.doi. org/10.1002/glia.20561.
    • (2007) Glia , vol.55 , pp. 1486-1497
    • van de Pavert, S.A.1    Sanz, A.S.2    Aartsen, W.M.3    Vos, R.M.4    Versteeg, I.5    Beck, S.C.6
  • 13
    • 79955971116 scopus 로고    scopus 로고
    • Naloxone ameliorates retinal lesions in Ccl2/ Cx3cr1 double-deficient mice via modulation of microglia
    • PMID:21245403
    • Shen D, Cao X, Zhao L, Tuo J, Wong WT, Chan CC. Naloxone ameliorates retinal lesions in Ccl2/ Cx3cr1 double-deficient mice via modulation of microglia. Invest Ophthalmol Vis Sci 2011; 52:2897-904; PMID:21245403; http://dx.doi.org/10.1167/ iovs.10-6114.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 2897-2904
    • Shen, D.1    Cao, X.2    Zhao, L.3    Tuo, J.4    Wong, W.T.5    Chan, C.C.6
  • 14
    • 42449086469 scopus 로고    scopus 로고
    • Ccl2/Cx3cr1-deficient mice: An animal model for age-related macular degeneration
    • PMID:18421225
    • Chan CC, Ross RJ, Shen D, Ding X, Majumdar Z, Bojanowski CM, et al. Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res 2008; 40:124-8; PMID:18421225; http://dx.doi.org/10.1159/000119862.
    • (2008) Ophthalmic Res , vol.40 , pp. 124-128
    • Chan, C.C.1    Ross, R.J.2    Shen, D.3    Ding, X.4    Majumdar, Z.5    Bojanowski, C.M.6
  • 15
    • 0024151007 scopus 로고
    • Evolution of geographic atrophy of the retinal pigment epithelium
    • PMID:2476333
    • Sarks JP, Sarks SH, Killingsworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye (Lond) 1988; 2:552-77; PMID:2476333; http:// dx.doi.org/10.1038/eye.1988.106.
    • (1988) Eye (Lond) , vol.2 , pp. 552-577
    • Sarks, J.P.1    Sarks, S.H.2    Killingsworth, M.C.3
  • 16
    • 84863719879 scopus 로고    scopus 로고
    • Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration
    • PMID:22575354
    • Mettu PS, Wielgus AR, Ong SS, Cousins SW. Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration. Mol Aspects Med 2012; 33:376-98; PMID:22575354; http://dx.doi.org/10.1016/j. mam.2012.04.006.
    • (2012) Mol Aspects Med , vol.33 , pp. 376-398
    • Mettu, P.S.1    Wielgus, A.R.2    Ong, S.S.3    Cousins, S.W.4
  • 17
    • 0034086115 scopus 로고    scopus 로고
    • The lipofuscin fluorophore A2E mediates blue lightinduced damage to retinal pigmented epithelial cells
    • PMID:10845625
    • Sparrow JR, Nakanishi K, Parish CA. The lipofuscin fluorophore A2E mediates blue lightinduced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 2000; 41:1981-9; PMID:10845625.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 1981-1989
    • Sparrow, J.R.1    Nakanishi, K.2    Parish, C.A.3
  • 18
    • 33750814597 scopus 로고    scopus 로고
    • Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium
    • PMID:17060630
    • Zhou J, Jang YP, Kim SR, Sparrow JR. Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci U S A 2006; 103:16182-7; PMID:17060630; http://dx.doi.org/10.1073/ pnas.0604255103.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16182-16187
    • Zhou, J.1    Jang, Y.P.2    Kim, S.R.3    Sparrow, J.R.4
  • 19
    • 62649135260 scopus 로고    scopus 로고
    • Complement activation by bisretinoid constituents of RPE lipofuscin
    • PMID:19029031
    • Zhou J, Kim SR, Westlund BS, Sparrow JR. Complement activation by bisretinoid constituents of RPE lipofuscin. Invest Ophthalmol Vis Sci 2009; 50:1392-9; PMID:19029031; http://dx.doi. org/10.1167/iovs.08-2868.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1392-1399
    • Zhou, J.1    Kim, S.R.2    Westlund, B.S.3    Sparrow, J.R.4
  • 20
    • 33644763001 scopus 로고    scopus 로고
    • Age-related maculopathy and the impact of blue light hazard
    • PMID:16445433
    • Algvere PV, Marshall J, Seregard S. Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand 2006; 84:4-15; PMID:16445433; http://dx.doi.org/10.1111/j.1600-0420.2005.00627.x.
    • (2006) Acta Ophthalmol Scand , vol.84 , pp. 4-15
    • Algvere, P.V.1    Marshall, J.2    Seregard, S.3
  • 21
    • 41049102336 scopus 로고    scopus 로고
    • Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration
    • PMID:18308304
    • Ross RJ, Zhou M, Shen D, Fariss RN, Ding X, Bojanowski CM, et al. Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration. Exp Eye Res 2008; 86:675-83; PMID:18308304; http://dx.doi.org/10.1016/j.exer.2008.01.014.
    • (2008) Exp Eye Res , vol.86 , pp. 675-683
    • Ross, R.J.1    Zhou, M.2    Shen, D.3    Fariss, R.N.4    Ding, X.5    Bojanowski, C.M.6
  • 22
    • 68449094580 scopus 로고    scopus 로고
    • A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration
    • PMID:19608872
    • Tuo J, Ross RJ, Herzlich AA, Shen D, Ding X, Zhou M, et al. A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration. Am J Pathol 2009; 175:799-807; PMID:19608872; http://dx.doi.org/10.2353/ajpath.2009.090089.
    • (2009) Am J Pathol , vol.175 , pp. 799-807
    • Tuo, J.1    Ross, R.J.2    Herzlich, A.A.3    Shen, D.4    Ding, X.5    Zhou, M.6
  • 23
    • 82755194865 scopus 로고    scopus 로고
    • AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2(-/-)/Cx3cr1(-/-) mice
    • PMID:21397984
    • Tuo J, Pang JJ, Cao X, Shen D, Zhang J, Scaria A, et al. AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2(-/-)/Cx3cr1(-/-) mice. Neurobiol Aging 2012; 33:433, e1-10; PMID:21397984; http:// dx.doi.org/10.1016/j.neurobiolaging.2011.01.009.
    • (2012) Neurobiol Aging , vol.33
    • Tuo, J.1    Pang, J.J.2    Cao, X.3    Shen, D.4    Zhang, J.5    Scaria, A.6
  • 24
    • 61549104499 scopus 로고    scopus 로고
    • Cautionary insights on knockout mouse studies: The gene or not the gene?
    • PMID:18822367
    • Eisener-Dorman AF, Lawrence DA, Bolivar VJ. Cautionary insights on knockout mouse studies: the gene or not the gene? Brain Behav Immun 2009; 23:318-24; PMID:18822367; http://dx.doi. org/10.1016/j.bbi.2008.09.001.
    • (2009) Brain Behav Immun , vol.23 , pp. 318-324
    • Eisener-Dorman, A.F.1    Lawrence, D.A.2    Bolivar, V.J.3
  • 25
    • 0036453590 scopus 로고    scopus 로고
    • The role of aging, high fat diet and blue light exposure in an experimental mouse model for basal laminar deposit formation
    • PMID:12457866
    • Cousins SW, Espinosa-Heidmann DG, Alexandridou A, Sall J, Dubovy S, Csaky K. The role of aging, high fat diet and blue light exposure in an experimental mouse model for basal laminar deposit formation. Exp Eye Res 2002; 75:543-53; PMID:12457866; http://dx.doi.org/10.1006/exer.2002.2047.
    • (2002) Exp Eye Res , vol.75 , pp. 543-553
    • Cousins, S.W.1    Espinosa-Heidmann, D.G.2    Alexandridou, A.3    Sall, J.4    Dubovy, S.5    Csaky, K.6
  • 26
    • 0034767039 scopus 로고    scopus 로고
    • Murine high-fat diet and laser photochemical model of basal deposits in Bruch membrane
    • PMID:11709015
    • Dithmar S, Sharara NA, Curcio CA, Le NA, Zhang Y, Brown S, et al. Murine high-fat diet and laser photochemical model of basal deposits in Bruch membrane. Arch Ophthalmol 2001; 119:1643-9; PMID:11709015; http://dx.doi.org/10.1001/ archopht.119.11.1643.
    • (2001) Arch Ophthalmol , vol.119 , pp. 1643-1649
    • Dithmar, S.1    Sharara, N.A.2    Curcio, C.A.3    Le, N.A.4    Zhang, Y.5    Brown, S.6
  • 27
    • 33644661427 scopus 로고    scopus 로고
    • Exacerbation of retinal degeneration and choroidal neovascularization induced by subretinal injection of Matrigel in CCL2/MCP-1-deficient mice
    • PMID:16352919
    • Shen D, Wen R, Tuo J, Bojanowski CM, Chan CC. Exacerbation of retinal degeneration and choroidal neovascularization induced by subretinal injection of Matrigel in CCL2/MCP-1-deficient mice. Ophthalmic Res 2006; 38:71-3; PMID:16352919; http://dx.doi.org/10.1159/000090266.
    • (2006) Ophthalmic Res , vol.38 , pp. 71-73
    • Shen, D.1    Wen, R.2    Tuo, J.3    Bojanowski, C.M.4    Chan, C.C.5
  • 28
    • 79951911015 scopus 로고    scopus 로고
    • A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap
    • PMID:20538989
    • Cao J, Zhao L, Li Y, Liu Y, Xiao W, Song Y, et al. A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap. Invest Ophthalmol Vis Sci 2010; 51:6009-17; PMID:20538989; http://dx.doi.org/10.1167/ iovs.09-4956.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 6009-6017
    • Cao, J.1    Zhao, L.2    Li, Y.3    Liu, Y.4    Xiao, W.5    Song, Y.6
  • 29
    • 0031768434 scopus 로고    scopus 로고
    • Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model
    • PMID:9811357
    • Tobe T, Ortega S, Luna JD, Ozaki H, Okamoto N, Derevjanik NL, et al. Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model. Am J Pathol 1998; 153:1641-6; PMID:9811357; http://dx.doi. org/10.1016/S0002-9440(10)65753-7.
    • (1998) Am J Pathol , vol.153 , pp. 1641-1646
    • Tobe, T.1    Ortega, S.2    Luna, J.D.3    Ozaki, H.4    Okamoto, N.5    Derevjanik, N.L.6
  • 30
    • 0033882695 scopus 로고    scopus 로고
    • Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization
    • PMID:10880384
    • Spilsbury K, Garrett KL, Shen WY, Constable IJ, Rakoczy PE. Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. Am J Pathol 2000; 157:135-44; PMID:10880384; http://dx.doi.org/10.1016/S0002-9440(10)64525-7.
    • (2000) Am J Pathol , vol.157 , pp. 135-144
    • Spilsbury, K.1    Garrett, K.L.2    Shen, W.Y.3    Constable, I.J.4    Rakoczy, P.E.5
  • 31
    • 38949185692 scopus 로고    scopus 로고
    • Oxidative damage-induced inflammation initiates age-related macular degeneration
    • PMID:18223656
    • Hollyfield JG, Bonilha VL, Rayborn ME, Yang X, Shadrach KG, Lu L, et al. Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med 2008; 14:194-8; PMID:18223656; http://dx.doi.org/10.1038/nm1709.
    • (2008) Nat Med , vol.14 , pp. 194-198
    • Hollyfield, J.G.1    Bonilha, V.L.2    Rayborn, M.E.3    Yang, X.4    Shadrach, K.G.5    Lu, L.6
  • 32
    • 77955085670 scopus 로고    scopus 로고
    • A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration
    • PMID:20221855
    • Hollyfield JG, Perez VL, Salomon RG. A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration. Mol Neurobiol 2010; 41:290-8; PMID:20221855; http://dx.doi.org/10.1007/ s12035-010-8110-z.
    • (2010) Mol Neurobiol , vol.41 , pp. 290-298
    • Hollyfield, J.G.1    Perez, V.L.2    Salomon, R.G.3
  • 33
    • 67651155742 scopus 로고    scopus 로고
    • Para-inflammation in the aging retina
    • PMID:19560552
    • Xu H, Chen M, Forrester JV. Para-inflammation in the aging retina. Prog Retin Eye Res 2009; 28:348-68; PMID:19560552; http://dx.doi.org/10.1016/j. preteyeres.2009.06.001.
    • (2009) Prog Retin Eye Res , vol.28 , pp. 348-368
    • Xu, H.1    Chen, M.2    Forrester, J.V.3
  • 34
    • 42449105692 scopus 로고    scopus 로고
    • Immunopathological aspects of age-related macular degeneration
    • PMID:18299834
    • Patel M, Chan CC. Immunopathological aspects of age-related macular degeneration. Semin Immunopathol 2008; 30:97-110; PMID:18299834; http://dx.doi.org/10.1007/s00281-008-0112-9.
    • (2008) Semin Immunopathol , vol.30 , pp. 97-110
    • Patel, M.1    Chan, C.C.2


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