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Volumn 23, Issue 7, 2009, Pages 1496-1508

Microvascular lesions of diabetic retinopathy: Clues towards understanding pathogenesis?

Author keywords

Blood flow; Diabetes; Diabetic retinopathy; Haemodynamics; Hypoxia; Ischaemia

Indexed keywords

PIMONIDAZOLE; VASCULOTROPIN;

EID: 67749088340     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/eye.2009.108     Document Type: Review
Times cited : (285)

References (105)
  • 1
    • 0031752685 scopus 로고    scopus 로고
    • Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections
    • King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998; 21(9): 1414-1431.
    • (1998) Diabetes Care , vol.21 , Issue.9 , pp. 1414-1431
    • King, H.1    Aubert, R.E.2    Herman, W.H.3
  • 2
    • 0024430867 scopus 로고
    • The Wisconsin Epidemiological Study of Diabetic Retinopathy: A review
    • Klein R, Klein BE, Moss SE. The Wisconsin Epidemiological Study of Diabetic Retinopathy: a review. Diabetes Metab Rev 1989; 5(7): 559-570. (Pubitemid 19272666)
    • (1989) Diabetes/Metabolism Reviews , vol.5 , Issue.7 , pp. 559-570
    • Klein, R.1    Klein, B.E.K.2    Moss, S.E.3
  • 3
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • DCCT The Diabetes Control and Complications Trial Research Group
    • DCCT. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993; 329(14): 977-986.
    • (1993) N Engl J Med , vol.329 , Issue.14 , pp. 977-986
  • 4
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
    • UKPDS UK Prospective Diabetes Study Group
    • UKPDS (UK Prospective Diabetes Study Group). Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 1998; 317(7160): 703-713.
    • (1998) BMJ , vol.317 , Issue.7160 , pp. 703-713
  • 6
    • 1542636997 scopus 로고    scopus 로고
    • Oscillatory potential analysis and ERGs of normal and diabetic rats
    • Hancock HA, Kraft TW. Oscillatory potential analysis and ERGs of normal and diabetic rats. Invest Ophthalmol Vis Sci 2004; 45(3): 1002-1008.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , Issue.3 , pp. 1002-1008
    • Hancock, H.A.1    Kraft, T.W.2
  • 7
    • 0032457359 scopus 로고    scopus 로고
    • Seeing beyond retinopathy in diabetes: Electrophysiological and psychophysical abnormalities and alterations in vision
    • Ewing FM, Deary IJ, Strachan MW, Frier BM. Seeing beyond retinopathy in diabetes: electrophysiological and psychophysical abnormalities and alterations in vision. Endocr Rev 1998; 19(4): 462-476.
    • (1998) Endocr Rev , vol.19 , Issue.4 , pp. 462-476
    • Ewing, F.M.1    Deary, I.J.2    Strachan, M.W.3    Frier, B.M.4
  • 8
    • 0038578086 scopus 로고    scopus 로고
    • Visual dysfunction, neurodegenerative diseases, and aging
    • DOI 10.1016/S0733-8619(02)00107-X
    • Jackson GR, Owsley C. Visual dysfunction, neurodegenerative diseases, and aging. Neurol Clin 2003; 21(3): 709-728. (Pubitemid 36754063)
    • (2003) Neurologic Clinics , vol.21 , Issue.3 , pp. 709-728
    • Jackson, G.R.1    Owsley, C.2
  • 12
    • 0141594635 scopus 로고    scopus 로고
    • Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina
    • Park SH, Park JW, Park SJ, Kim KY, Chung JW, Chun MH et al. Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina. Diabetologia 2003; 46(9): 1260-1268.
    • (2003) Diabetologia , vol.46 , Issue.9 , pp. 1260-1268
    • Park, S.H.1    Park, J.W.2    Park, S.J.3    Kim, K.Y.4    Chung, J.W.5    Chun, M.H.6
  • 13
    • 0022392234 scopus 로고
    • Alterations in the retinal dopaminergic neuronal system in rats with streptozotocin-induced diabetes
    • DOI 10.1111/j.1471-4159.1985.tb04008.x
    • Nishimura C, Kuriyama K. Alterations in the retinal dopaminergic neuronal system in rats with streptozotocin-induced diabetes. J Neurochem 1985; 45(2): 448-455. (Pubitemid 15233944)
    • (1985) Journal of Neurochemistry , vol.45 , Issue.2 , pp. 448-455
    • Nishimura, C.1    Kuriyama, K.2
  • 14
    • 0033921527 scopus 로고    scopus 로고
    • Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats
    • DOI 10.1017/S0952523800173122
    • Zeng XX, Ng YK, Ling EA. Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats. Vis Neurosci 2000; 17(3): 463-471. (Pubitemid 30451626)
    • (2000) Visual Neuroscience , vol.17 , Issue.3 , pp. 463-471
    • Zeng, X.-X.1    Ng, Y.-K.2    Ling, E.-A.3
  • 15
    • 0036175576 scopus 로고    scopus 로고
    • Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced diabetes
    • DOI 10.1076/ceyr.23.4.276.5459
    • Agardh E, Bruun A, Agardh CD. Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced diabetes. Curr Eye Res 2001; 23(4): 276-284. (Pubitemid 34161300)
    • (2001) Current Eye Research , vol.23 , Issue.4 , pp. 276-284
    • Agardh, E.1    Bruun, A.2    Agardh, C.-D.3
  • 16
    • 2442693140 scopus 로고    scopus 로고
    • Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase: A role in high glucose-induced apoptosis in retinal Muller cells
    • DOI 10.1167/iovs.03-1294
    • Kusner LL, Sarthy VP, Mohr S. Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase: a role in high glucose-induced apoptosis in retinal Muller cells. Invest Ophthalmol Vis Sci 2004; 45(5): 1553-1561. (Pubitemid 38859337)
    • (2004) Investigative Ophthalmology and Visual Science , vol.45 , Issue.5 , pp. 1553-1561
    • Kusner, L.L.1    Sarthy, V.P.2    Mohr, S.3
  • 17
    • 33644759517 scopus 로고    scopus 로고
    • Diabetes alters osmotic swelling characteristics and membrane conductance of glial cells in rat retina
    • Pannicke T, Iandiev I, Wurm A, Uckermann O, vom Hagen F, Reichenbach A et al. Diabetes alters osmotic swelling characteristics and membrane conductance of glial cells in rat retina. Diabetes 2006; 55(3): 633-639.
    • (2006) Diabetes , vol.55 , Issue.3 , pp. 633-639
    • Pannicke, T.1    Iandiev, I.2    Wurm, A.3    Uckermann, O.4    Vom Hagen, F.5    Reichenbach, A.6
  • 18
    • 0036981941 scopus 로고    scopus 로고
    • Diabetes-induced dysfunction of retinal Muller cells
    • Puro DG. Diabetes-induced dysfunction of retinal Muller cells. Trans Am Ophthalmol Soc 2002; 100: 339-352.
    • (2002) Trans Am Ophthalmol Soc , vol.100 , pp. 339-352
    • Puro, D.G.1
  • 19
    • 0031919598 scopus 로고    scopus 로고
    • Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy
    • DOI 10.2337/diabetes.47.5.815
    • Lieth E, Barber AJ, Xu B, Dice C, Ratz MJ, Tanase D et al. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes 1998; 47(5): 815-820. (Pubitemid 28201813)
    • (1998) Diabetes , vol.47 , Issue.5 , pp. 815-820
    • Lieth, E.1    Barber, A.J.2    Xu, B.3    Dice, C.4    Ratz, M.J.5    Tanase, D.6    Strother, J.M.7
  • 20
    • 33847261189 scopus 로고    scopus 로고
    • Arteriolar involvement in the microvascular lesions of diabetic retinopathy: Implications for pathogenesis
    • DOI 10.1080/10739680601072123, PII 769178547
    • Gardiner TA, Archer DB, Curtis TM, Stitt AW. Arteriolar involvement in the microvascular lesions of diabetic retinopathy: implications for pathogenesis. Microcirculation 2007; 14(1): 25-38. (Pubitemid 46321703)
    • (2007) Microcirculation , vol.14 , Issue.1 , pp. 25-38
    • Gardiner, T.A.1    Archer, D.B.2    Curtis, T.M.3    Stitt, A.W.4
  • 21
    • 0033802949 scopus 로고    scopus 로고
    • Regulatory mechanisms in the retinal and choroidal circulation
    • Delaey C, Van dV. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res 2000; 32(6): 249-256.
    • (2000) Ophthalmic Res , vol.32 , Issue.6 , pp. 249-256
    • Delaey, C.1    Van, D.V.2
  • 24
    • 0014516910 scopus 로고
    • Diameters of the retinal vessels in diabetic and normal subjects
    • Skovborg F, Nielsen AV, Lauritzen E, Hartkopp O. Diameters of the retinal vessels in diabetic and normal subjects. Diabetes 1969; 18(5): 292-298.
    • (1969) Diabetes , vol.18 , Issue.5 , pp. 292-298
    • Skovborg, F.1    Nielsen, A.V.2    Lauritzen, E.3    Hartkopp, O.4
  • 29
    • 0030770396 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: A potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy
    • Clermont AC, Aiello LP, Mori F, Aiello LM, Bursell SE. Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy. Am J Ophthalmol 1997; 124(4): 433-446. (Pubitemid 27425869)
    • (1997) American Journal of Ophthalmology , vol.124 , Issue.4 , pp. 433-446
    • Clermont, A.C.1    Aiello, L.P.2    Mori, F.3    Aiello, L.M.4    Bursell, S.-E.5
  • 30
    • 0026548652 scopus 로고
    • Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control
    • Grunwald JE, Riva CE, Baine J, Brucker AJ. Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control. Invest Ophthalmol Vis Sci 1992; 33(2): 356-363.
    • (1992) Invest Ophthalmol Vis Sci , vol.33 , Issue.2 , pp. 356-363
    • Grunwald, J.E.1    Riva, C.E.2    Baine, J.3    Brucker, A.J.4
  • 31
    • 0026706830 scopus 로고
    • Retinal blood flow in diabetic retinopathy
    • Patel V, Rassam S, Newsom R, Wiek J, Kohner E. Retinal blood flow in diabetic retinopathy. BMJ 1992; 305(6855): 678-683.
    • (1992) BMJ , vol.305 , Issue.6855 , pp. 678-683
    • Patel, V.1    Rassam, S.2    Newsom, R.3    Wiek, J.4    Kohner, E.5
  • 33
    • 0026506987 scopus 로고
    • Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats
    • Bursell SE, Clermont AC, Shiba T, King GL. Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats. Curr Eye Res 1992; 11(4): 287-295.
    • (1992) Curr Eye Res , vol.11 , Issue.4 , pp. 287-295
    • Bursell, S.E.1    Clermont, A.C.2    Shiba, T.3    King, G.L.4
  • 35
    • 33847271760 scopus 로고    scopus 로고
    • Retinal blood flow in diabetes
    • Clermont AC, Bursell SE. Retinal blood flow in diabetes. Microcirculation 2007; 14(1): 49-61.
    • (2007) Microcirculation , vol.14 , Issue.1 , pp. 49-61
    • Clermont, A.C.1    Bursell, S.E.2
  • 36
    • 33645670376 scopus 로고    scopus 로고
    • Advanced glycation and retinal pathology during diabetes
    • Stitt AW, Curtis TM. Advanced glycation and retinal pathology during diabetes. Pharmacol Rep 2005; 57(Suppl): 156-168.
    • (2005) Pharmacol Rep , vol.57 , Issue.SUPPL. , pp. 156-168
    • Stitt, A.W.1    Curtis, T.M.2
  • 37
    • 0024457571 scopus 로고
    • Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors
    • Tilton RG, Chang K, Pugliese G, Eades DM, Province MA, Sherman WR et al. Prevention of hemodynamlemma and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors. Diabetes 1989; 38(10): 1258-1270. (Pubitemid 19247421)
    • (1989) Diabetes , vol.38 , Issue.10 , pp. 1258-1270
    • Tilton, R.G.1    Chang, K.2    Pugliese, G.3    Eades, D.M.4    Province, M.A.5    Sherman, W.R.6    Kilo, C.7    Williamson, J.R.8
  • 38
    • 33750869527 scopus 로고    scopus 로고
    • A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy
    • DOI 10.2337/db06-0138
    • Sun W, Oates PJ, Coutcher JB, Gerhardinger C, Lorenzi M. A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Diabetes 2006; 55(10): 2757-2762. (Pubitemid 44923674)
    • (2006) Diabetes , vol.55 , Issue.10 , pp. 2757-2762
    • Sun, W.1    Oates, P.J.2    Coutcher, J.B.3    Gerhardinger, C.4    Lorenzi, M.5
  • 39
    • 1042291963 scopus 로고    scopus 로고
    • The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy
    • DOI 10.1002/dmrr.431
    • Curtis TM, Scholfield CN. The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy. Diabetes Metab Res Rev 2004; 20(1): 28-43. (Pubitemid 38196246)
    • (2004) Diabetes/Metabolism Research and Reviews , vol.20 , Issue.1 , pp. 28-43
    • Curtis, T.M.1    Scholfield, C.N.2
  • 40
    • 0034846788 scopus 로고    scopus 로고
    • Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats
    • DOI 10.1007/s001250100631
    • Obrosova IG, Minchenko AG, Marinescu V, Fathallah L, Kennedy A, Stockert CM et al. Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats. Diabetologia 2001; 44(9): 1102-1110. (Pubitemid 32835501)
    • (2001) Diabetologia , vol.44 , Issue.9 , pp. 1102-1110
    • Obrosova, I.G.1    Minchenko, A.G.2    Marinescu, V.3    Fathallah, L.4    Kennedy, A.5    Stockert, C.M.6    Frank, R.N.7    Stevens, M.J.8
  • 41
    • 33645964980 scopus 로고    scopus 로고
    • Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy
    • DOI 10.1167/iovs.05-1276
    • Kowluru RA, Atasi L, Ho YS. Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci 2006; 47(4): 1594-1599. (Pubitemid 46780770)
    • (2006) Investigative Ophthalmology and Visual Science , vol.47 , Issue.4 , pp. 1594-1599
    • Kowluru, R.A.1    Atasi, L.2    Ho, Y.-S.3
  • 42
    • 0033816582 scopus 로고    scopus 로고
    • Possible pathophysiological mechanisms for diabetic angiopathy in type 2 diabetes
    • DOI 10.1016/S1056-8727(00)00083-0, PII S1056872700000830
    • Tooke J. Possible pathophysiological mechanisms for diabetic angiopathy in type 2 diabetes. J Diabetes Complications 2000; 14(4): 197-200. (Pubitemid 30686255)
    • (2000) Journal of Diabetes and Its Complications , vol.14 , Issue.4 , pp. 197-200
    • Tooke, J.E.1
  • 43
    • 0033018576 scopus 로고    scopus 로고
    • Ocular blood flow and associated functional deviations in diabetic retinopathy
    • DOI 10.1007/s001250051171
    • Schmetterer L, Wolzt M. Ocular blood flow and associated functional deviations in diabetic retinopathy. Diabetologia 1999; 42(4): 387-405. (Pubitemid 29148397)
    • (1999) Diabetologia , vol.42 , Issue.4 , pp. 387-405
    • Schmetterer, L.1    Wolzt, M.2
  • 44
    • 0142122031 scopus 로고    scopus 로고
    • Angiotensin II receptor blockers and angiotensin converting enzyme inhibitors: Implication of radical scavenging and transition metal chelation in inhibition of advanced glycation end product formation
    • DOI 10.1016/j.abb.2003.08.010
    • Miyata T, van Ypersele de Strihou C. Angiotensin II receptor blockers and angiotensin converting enzyme inhibitors: implication of radical scavenging and transition metal chelation in inhibition of advanced glycation end product formation. Arch Biochem Biophys 2003; 419(1): 50-54. (Pubitemid 37272159)
    • (2003) Archives of Biochemistry and Biophysics , vol.419 , Issue.1 , pp. 50-54
    • Miyata, T.1    Van Ypersele De Strihou, C.2
  • 45
    • 41849096928 scopus 로고    scopus 로고
    • AGEs and RAGE inhibitors in the treatment of diabetic retinopathy
    • Bhatwadekar A, Stitt AW. AGEs and RAGE inhibitors in the treatment of diabetic retinopathy. Expert Rev Ophthalmol 2007; 2(1): 105-120.
    • (2007) Expert Rev Ophthalmol , vol.2 , Issue.1 , pp. 105-120
    • Bhatwadekar, A.1    Stitt, A.W.2
  • 46
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • DOI 10.2337/diabetes.47.6.859
    • Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes 1998; 47(6): 859-866. (Pubitemid 28255657)
    • (1998) Diabetes , vol.47 , Issue.6 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 47
    • 1042291963 scopus 로고    scopus 로고
    • The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy
    • DOI 10.1002/dmrr.431
    • Curtis TM, Scholfield CN. The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy. Diabetes Metab Res Rev 2004; 20(1): 28-43. (Pubitemid 38196246)
    • (2004) Diabetes/Metabolism Research and Reviews , vol.20 , Issue.1 , pp. 28-43
    • Curtis, T.M.1    Scholfield, C.N.2
  • 50
    • 33644842187 scopus 로고    scopus 로고
    • Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients
    • DOI 10.1167/iovs.05-0757
    • Aiello LP, Clermont A, Arora V, Davis MD, Sheetz MJ, Bursell SE. Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients. Invest Ophthalmol Vis Sci 2006; 47(1): 86-92. (Pubitemid 46780799)
    • (2006) Investigative Ophthalmology and Visual Science , vol.47 , Issue.1 , pp. 86-92
    • Aiello, L.P.1    Clermont, A.2    Arora, V.3    Davis, M.D.4    Sheetz, M.J.5    Bursell, S.-E.6
  • 51
    • 58249089758 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema
    • PKC-DRS2 Study Group
    • Davis MD, Sheetz MJ, Aiello LP, Milton RC, Danis RP, Zhi X et al. PKC-DRS2 Study Group. Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema. Invest Ophthalmol Vis Sci 2009; 50(1): 1-4.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , Issue.1 , pp. 1-4
    • Davis, M.D.1    Sheetz, M.J.2    Aiello, L.P.3    Milton, R.C.4    Danis, R.P.5    Zhi, X.6
  • 52
    • 33847254032 scopus 로고    scopus 로고
    • Cellular physiology of retinal and choroidal arteriolar smooth muscle cells
    • Scholfield CN, McGeown JG, Curtis TM. Cellular physiology of retinal and choroidal arteriolar smooth muscle cells. Microcirculation 2007; 14(1): 11-24.
    • (2007) Microcirculation , vol.14 , Issue.1 , pp. 11-24
    • Scholfield, C.N.1    McGeown, J.G.2    Curtis, T.M.3
  • 56
    • 0031031010 scopus 로고    scopus 로고
    • Partial reversal of protan and tritan colour defects with inhaled oxygen in insulin dependent diabetic subjects
    • Dean FM, Arden GB, Dornhorst A. Partial reversal of protan and tritan colour defects with inhaled oxygen in insulin dependent diabetic subjects. Br J Ophthalmol 1997; 81(1): 27-30.
    • (1997) Br J Ophthalmol , vol.81 , Issue.1 , pp. 27-30
    • Dean, F.M.1    Arden, G.B.2    Dornhorst, A.3
  • 59
    • 0028892978 scopus 로고
    • Quantitative evaluation of leukocyte dynamics in retinal microcirculation
    • Nishiwaki H, Ogura Y, Kimura H, Kiryu J, Honda Y. Quantitative evaluation of leukocyte dynamics in retinal microcirculation. Invest Ophthalmol Vis Sci 1995; 36(1): 123-130.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , Issue.1 , pp. 123-130
    • Nishiwaki, H.1    Ogura, Y.2    Kimura, H.3    Kiryu, J.4    Honda, Y.5
  • 61
    • 0025769620 scopus 로고
    • Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy
    • Schroder S, Palinski W, Schmid-Schonbein GW. Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. Am J Pathol 1991; 139(1): 81-100.
    • (1991) Am J Pathol , vol.139 , Issue.1 , pp. 81-100
    • Schroder, S.1    Palinski, W.2    Schmid-Schonbein, G.W.3
  • 62
    • 0033775426 scopus 로고    scopus 로고
    • A retinal-derived relaxing factor mediates the hypoxic vasodilation of retinal arteries
    • Delaey C, Boussery K, Van de Voorde J. A retinal-derived relaxing factor mediates the hypoxic vasodilation of retinal arteries. Invest Ophthalmol Vis Sci 2000; 41(11): 3555-3560. (Pubitemid 30774947)
    • (2000) Investigative Ophthalmology and Visual Science , vol.41 , Issue.11 , pp. 3555-3560
    • Delaey, C.1    Boussery, K.2    Van De Voorde, J.3
  • 63
    • 0020693320 scopus 로고
    • Retinal blood flow alterations during progression of diabetic retinopathy
    • Yoshida A, Feke GT, Morales-Stoppello J, Collas GD, Goger DG, McMeel JW. Retinal blood flow alterations during progression of diabetic retinopathy. Arch Ophthalmol 1983; 101(2): 225-227. (Pubitemid 13186764)
    • (1983) Archives of Ophthalmology , vol.101 , Issue.2 , pp. 225-227
    • Yoshida, A.1    Feke, G.T.2    Morales Stoppello, J.3
  • 65
    • 48649102056 scopus 로고    scopus 로고
    • Retinal arteriolar caliber predicts incident retinopathy: The Australian Diabetes, Obesity and Lifestyle (AusDiab) study
    • Rogers SL, Tikellis G, Cheung N, Tapp R, Shaw J, Zimmet PZ et al. Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study. Diabetes Care 2008; 31(4): 761-763.
    • (2008) Diabetes Care , vol.31 , Issue.4 , pp. 761-763
    • Rogers, S.L.1    Tikellis, G.2    Cheung, N.3    Tapp, R.4    Shaw, J.5    Zimmet, P.Z.6
  • 66
    • 0028790068 scopus 로고
    • Changes in organization and composition of the extracellular matrix underlying cultured endothelial cells exposed to laminar steady shear stress
    • Thoumine O, Nerem RM, Girard PR. Changes in organization and composition of the extracellular matrix underlying cultured endothelial cells exposed to laminar steady shear stress. Lab Invest 1995; 73(4): 565-576.
    • (1995) Lab Invest , vol.73 , Issue.4 , pp. 565-576
    • Thoumine, O.1    Nerem, R.M.2    Girard, P.R.3
  • 67
    • 33645404162 scopus 로고    scopus 로고
    • Noninvasive evaluation of wall shear stress on retinal microcirculation in humans
    • DOI 10.1167/iovs.05-0218
    • Nagaoka T, Yoshida A. Noninvasive evaluation of wall shear stress on retinal microcirculation in humans. Invest Ophthalmol Vis Sci 2006; 47(3): 1113-1119. (Pubitemid 46768347)
    • (2006) Investigative Ophthalmology and Visual Science , vol.47 , Issue.3 , pp. 1113-1119
    • Nagaoka, T.1    Yoshida, A.2
  • 68
    • 0028123510 scopus 로고
    • Diabetic retinopathy: Quantitative variation in capillary basement membrane thickening in arterial or venous environments
    • Stitt AW, Anderson HR, Gardiner TA, Archer DB. Diabetic retinopathy: quantitative variation in capillary basement membrane thickening in arterial or venous environments. Br J Ophthalmol 1994; 78(2): 133-137.
    • (1994) Br J Ophthalmol , vol.78 , Issue.2 , pp. 133-137
    • Stitt, A.W.1    Anderson, H.R.2    Gardiner, T.A.3    Archer, D.B.4
  • 69
    • 33750809382 scopus 로고
    • Retinal vascular patterns. IV. Diabetic retinopathy
    • Cogan DG, Toussaint D, Kuwabara T. Retinal vascular patterns. IV. Diabetic retinopathy. Arch Ophthalmol 1961; 66: 366-378.
    • (1961) Arch Ophthalmol , vol.66 , pp. 366-378
    • Cogan, D.G.1    Toussaint, D.2    Kuwabara, T.3
  • 70
    • 0036738046 scopus 로고    scopus 로고
    • Advanced glycation end products and diabetic complications
    • DOI 10.1517/13543784.11.9.1205
    • Stitt AW, Jenkins AJ, Cooper ME. Advanced glycation end products and diabetic complications. Expert Opin Investig Drugs 2002; 11(9): 1205-1223. (Pubitemid 35050074)
    • (2002) Expert Opinion on Investigational Drugs , vol.11 , Issue.9 , pp. 1205-1223
    • Stitt, A.W.1    Jenkins, A.J.2    Cooper, M.E.3
  • 71
    • 25444463573 scopus 로고    scopus 로고
    • Endothelial/pericyte interactions
    • Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circ Res 2005; 97(6): 512-523.
    • (2005) Circ Res , vol.97 , Issue.6 , pp. 512-523
    • Armulik, A.1    Abramsson, A.2    Betsholtz, C.3
  • 74
    • 0021807568 scopus 로고
    • A morphologic and autoradiographic study of cell death and regeneration in the retinal microvasculature of normal and diabetic rats
    • Sharma NK, Gardiner TA, Archer DB. A morphologic and autoradiographic study of cell death and regeneration in the retinal microvasculature of normal and diabetic rats. Am J Ophthalmol 1985; 100(1): 51-60.
    • (1985) Am J Ophthalmol , vol.100 , Issue.1 , pp. 51-60
    • Sharma, N.K.1    Gardiner, T.A.2    Archer, D.B.3
  • 76
    • 34047144378 scopus 로고    scopus 로고
    • Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells
    • DOI 10.2337/db06-1254
    • Caballero S, Sengupta N, Afzal A, Chang KH, Li Calzi S, Guberski DL et al. Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes 2007; 56(4): 960-967. (Pubitemid 46525067)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 960-967
    • Caballero, S.1    Sengupta, N.2    Afzal, A.3    Chang, K.-H.4    Li Calzi, S.5    Guberski, D.L.6    Kern, T.S.7    Grant, M.B.8
  • 77
    • 41949108995 scopus 로고    scopus 로고
    • Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: Implications for vasodegeneration in diabetic retinopathy
    • Bhatwadekar AD, Glenn JV, Li G, Curtis TM, Gardiner TA, Stitt AW. Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy. Investig Ophthalmol Vis Sci 2008; 49(3): 1232-1241.
    • (2008) Investig Ophthalmol Vis Sci , vol.49 , Issue.3 , pp. 1232-1241
    • Bhatwadekar, A.D.1    Glenn, J.V.2    Li, G.3    Curtis, T.M.4    Gardiner, T.A.5    Stitt, A.W.6
  • 78
    • 0032504745 scopus 로고    scopus 로고
    • Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: Involvement in suppression of apoptosis
    • Dimmeler S, Assmus B, Hermann C, Haendeler J, Zeiher AM. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ Res 1998; 83(3): 334-341. (Pubitemid 28371324)
    • (1998) Circulation Research , vol.83 , Issue.3 , pp. 334-341
    • Dimmeler, S.1    Assmus, B.2    Hermann, C.3    Haendeler, J.4    Zeiher, A.M.5
  • 80
    • 0028922544 scopus 로고
    • Histological and ultrastructural investigation of retinal microaneurysm development in diabetic patients
    • Stitt AW, Gardiner TA, Archer DB. Histological and ultrastructural investigation of retinal microaneurysm development in diabetic patients. Br J Ophthalmol 1995; 79(4): 362-367.
    • (1995) Br J Ophthalmol , vol.79 , Issue.4 , pp. 362-367
    • Stitt, A.W.1    Gardiner, T.A.2    Archer, D.B.3
  • 81
    • 0030016266 scopus 로고    scopus 로고
    • Precapillary patterns and perivascular cells in the retinal microvasculature. a scanning electron microscope study
    • Pannarale L, Onori P, Ripani M, Gaudio E. Precapillary patterns and perivascular cells in the retinal microvasculature. A scanning electron microscope study. J Anat 1996; 188(Part 3): 693-703. (Pubitemid 26232210)
    • (1996) Journal of Anatomy , vol.188 , Issue.3 , pp. 693-703
    • Pannarale, L.1    Onori, P.2    Ripani, M.3    Gaudio, E.4
  • 82
    • 0028998575 scopus 로고
    • Vascular lesions in diabetes are distributed non-uniformly within the retina
    • Kern TS, Engerman RL. Vascular lesions in diabetes are distributed non-uniformly within the retina. Exp Eye Res 1995; 60(5): 545-549.
    • (1995) Exp Eye Res , vol.60 , Issue.5 , pp. 545-549
    • Kern, T.S.1    Engerman, R.L.2
  • 83
    • 2642660702 scopus 로고
    • Arteriolar involvement in diabetic retinopathy
    • Ashton N. Arteriolar involvement in diabetic retinopathy. Br J Ophthalmol 1953; 37(5): 282-292.
    • (1953) Br J Ophthalmol , vol.37 , Issue.5 , pp. 282-292
    • Ashton, N.1
  • 84
    • 0029901097 scopus 로고    scopus 로고
    • Regional retinal blood flow and vascular autoregulation
    • Rassam SM, Patel V, Chen HC, Kohner EM. Regional retinal blood flow and vascular autoregulation. Eye 1996; 10(Part 3): 331-337. (Pubitemid 26241503)
    • (1996) Eye , vol.10 , Issue.3 , pp. 331-337
    • Rassam, S.M.B.1
  • 85
    • 0028896755 scopus 로고
    • The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XV. The long-term incidence of macular edema
    • Klein R, Klein BE, Moss SE, Cruickshanks KJ. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XV. The long-term incidence of macular edema. Ophthalmology 1995; 102(1): 7-16.
    • (1995) Ophthalmology , vol.102 , Issue.1 , pp. 7-16
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Cruickshanks, K.J.4
  • 87
    • 0025892104 scopus 로고
    • Early photocoagulation for diabetic retinopathy. ETDRS report number 9
    • ETDRS Early Treatment Diabetic Retinopathy Study Research Group
    • ETDRS. Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 1991; 98(5 Suppl): 766-785.
    • (1991) Ophthalmology , vol.98 , Issue.5 SUPPL. , pp. 766-785
  • 88
    • 0038243821 scopus 로고    scopus 로고
    • Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor
    • El-Remessy AB, Behzadian MA, Abou-Mohamed G, Franklin T, Caldwell RW, Caldwell RB. Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor. Am J Pathol 2003; 162(6): 1995-2004. (Pubitemid 36613056)
    • (2003) American Journal of Pathology , vol.162 , Issue.6 , pp. 1995-2004
    • El-Remessy, A.B.1    Ali Behzadian, M.2    Abou-Mohamed, G.3    Franklin, T.4    Caldwell, R.W.5    Caldwell, R.B.6
  • 90
    • 0031018867 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy
    • Amin RH, Frank RN, Kennedy A, Eliott D, Puklin JE, Abrams GW. Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 1997; 38(1): 36-47. (Pubitemid 27051522)
    • (1997) Investigative Ophthalmology and Visual Science , vol.38 , Issue.1 , pp. 36-47
    • Amin, R.H.1    Frank, R.N.2    Kennedy, A.3    Eliott, D.4    Puklin, J.E.5    Abrams, G.W.6
  • 91
    • 0033551811 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1: A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    • Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 1999; 274(33): 23463-23467. (Pubitemid 129529185)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.33 , pp. 23463-23467
    • Antonetti, D.A.1    Barber, A.J.2    Hollinger, L.A.3    Wolpert, E.B.4    Gardner, T.W.5
  • 92
    • 34247354628 scopus 로고    scopus 로고
    • Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes
    • DOI 10.1155/2007/51837, PII S1687521407518374
    • Canning P, Glenn JV, Hsu DK, Liu FT, Gardiner TA, Stitt AW. Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes. Exp Diabetes Res 2007; 2007: 51837. (Pubitemid 46630109)
    • (2007) Experimental Diabesity Research , vol.2007 , pp. 51837
    • Canning, P.1    Glenn, J.V.2    Hsu, D.K.3    Liu, F.-T.4    Gardiner, T.A.5    Stitt, A.W.6
  • 93
    • 0036517850 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression
    • Joussen AM, Poulaki V, Mitsiades N, Kirchhof B, Koizumi K, Dohmen S et al. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J 2002; 16(3): 438-440.
    • (2002) FASEB J , vol.16 , Issue.3 , pp. 438-440
    • Joussen, A.M.1    Poulaki, V.2    Mitsiades, N.3    Kirchhof, B.4    Koizumi, K.5    Dohmen, S.6
  • 94
    • 0036174019 scopus 로고    scopus 로고
    • Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo
    • Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ et al. Retinal vascular endothelial growth factor induces intercellular adhesionmolecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol 2002; 160(2): 501-509. (Pubitemid 34160327)
    • (2002) American Journal of Pathology , vol.160 , Issue.2 , pp. 501-509
    • Joussen, A.M.1    Poulaki, V.2    Qin, W.3    Kirchhof, B.4    Mitsiades, N.5    Wiegand, S.J.6    Rudge, J.7    Yancopoulos, G.D.8    Adamis, A.P.9
  • 95
    • 25844513658 scopus 로고    scopus 로고
    • A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    • Cunningham Jr ET, Adamis AP, Altaweel M, Aiello LP, Bressler NM, D'Amico DJ et al. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology 2005; 112(10): 1747-1757.
    • (2005) Ophthalmology , vol.112 , Issue.10 , pp. 1747-1757
    • Cunningham Jr., E.T.1    Adamis, A.P.2    Altaweel, M.3    Aiello, L.P.4    Bressler, N.M.5    D'Amico, D.J.6
  • 98
    • 0021191759 scopus 로고
    • The Wisconsin Epidemiologic Study of Diabetic Retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years
    • Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol 1984; 102(4): 527-532.
    • (1984) Arch Ophthalmol , vol.102 , Issue.4 , pp. 527-532
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Davis, M.D.4    DeMets, D.L.5
  • 99
    • 0021136256 scopus 로고
    • The Wisconsin Epidemiologic Study of Diabetic Retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years
    • Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol 1984; 102(4): 520-526.
    • (1984) Arch Ophthalmol , vol.102 , Issue.4 , pp. 520-526
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Davis, M.D.4    DeMets, D.L.5
  • 100
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331(22): 1480-1487.
    • (1994) N Engl J Med , vol.331 , Issue.22 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3    Keyt, B.A.4    Jampel, H.D.5    Shah, S.T.6
  • 102
    • 33646464279 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage
    • DOI 10.1097/00006982-200603000-00004, PII 0000698220060300000004
    • Spaide RF, Fisher YL. Intravitreal bevacizumab (Avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage. Retina 2006; 26(3): 275-278. (Pubitemid 44318179)
    • (2006) Retina , vol.26 , Issue.3 , pp. 275-278
    • Spaide, R.F.1    Fisher, Y.L.2
  • 103
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin LE, Hemo I, Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 1998; 125(9): 1591-1598. (Pubitemid 28256727)
    • (1998) Development , vol.125 , Issue.9 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 105
    • 56149103354 scopus 로고    scopus 로고
    • Endogenous VEGF is required for visual function: Evidence for a survival role on Muller cells and photoreceptors
    • Saint-Geniez M, Maharaj AS, Walshe TE, Tucker BA, Sekiyama E, Kurihara Tet al. Endogenous VEGF is required for visual function: evidence for a survival role on Muller cells and photoreceptors. PLoS ONE 2008; 3(11): e3554.
    • (2008) PLoS ONE , vol.3 , Issue.11
    • Saint-Geniez, M.1    Maharaj, A.S.2    Walshe, T.E.3    Tucker, B.A.4    Sekiyama, E.5    Kurihara, T.6


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