메뉴 건너뛰기




Volumn 25, Issue 5-6, 2014, Pages 425-433

Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs

Author keywords

2 arachidonoyl glycerol; anandamide; anxiety; endocannabinoids; fatty acid amide hydrolase; monoacylglycerol lipase

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ACYLGLYCEROL LIPASE; ANANDAMIDE; ANXIOLYTIC AGENT; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR; CANNABIS; DRONABINOL; ENDOCANNABINOID; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1;

EID: 84906053208     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0000000000000073     Document Type: Article
Times cited : (35)

References (113)
  • 1
    • 80053082233 scopus 로고    scopus 로고
    • Animal models of obsessive-compulsive disorder: Exploring pharmacology and neural substrates
    • Albelda N, Joel D (2012). Animal models of obsessive-compulsive disorder: Exploring pharmacology and neural substrates. Neurosci Biobehav Rev 36:47-63.
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 47-63
    • Albelda, N.1    Joel, D.2
  • 2
    • 79957551226 scopus 로고    scopus 로고
    • Supply and demand for endocannabinoids
    • Alger BE, Kim J (2011). Supply and demand for endocannabinoids. Trends Neurosci 34:304-315.
    • (2011) Trends Neurosci , vol.34 , pp. 304-315
    • Alger, B.E.1    Kim, J.2
  • 3
    • 84863832862 scopus 로고    scopus 로고
    • The temporal dynamics of the effects of monoacylglycerol lipase blockade on locomotion, anxiety, and body temperature
    • Aliczki M, Balogh Z, Tulogdi A, Haller J (2012). The temporal dynamics of the effects of monoacylglycerol lipase blockade on locomotion, anxiety, and body temperature. Behav Pharmacol 23:348-357.
    • (2012) Behav Pharmacol , vol.23 , pp. 348-357
    • Aliczki, M.1    Balogh, Z.2    Tulogdi, A.3    Haller, J.4
  • 4
    • 84878246519 scopus 로고    scopus 로고
    • Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice
    • Aliczki M, Zelena D, Mikics E, Varga ZK, Pinter O, Bakos NV, et al. (2013). Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice. Horm Behav 63:752-758.
    • (2013) Horm Behav , vol.63 , pp. 752-758
    • Aliczki, M.1    Zelena, D.2    Mikics, E.3    Varga, Z.K.4    Pinter, O.5    Bakos, N.V.6
  • 5
    • 84879132067 scopus 로고    scopus 로고
    • Modulation of anxiety-like behavior by the endocannabinoid 2-Arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray
    • Almeida-Santos AF, Gobira PH, Rosa LC, Guimaraes FS, Moreira FA, Aguiar DC (2013). Modulation of anxiety-like behavior by the endocannabinoid 2-Arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray. Behav Brain Res 252:10-17.
    • (2013) Behav Brain Res , vol.252 , pp. 10-17
    • Almeida-Santos, A.F.1    Gobira, P.H.2    Rosa, L.C.3    Guimaraes, F.S.4    Moreira, F.A.5    Aguiar, D.C.6
  • 6
    • 0003472502 scopus 로고    scopus 로고
    • American Psychiatric Association. 5th ed. Arlington, VA: American Psychiatric Publishing
    • American Psychiatric Association. 2013 Diagnostic and statistical manual of mental disorders 5th ed. Arlington, VA: American Psychiatric Publishing.
    • (2013) Diagnostic and Statistical Manual of Mental Disorders
  • 7
    • 84899839975 scopus 로고    scopus 로고
    • Evidence-based pharmacological treatment of anxiety disorders, posttraumatic stress disorder and obsessive-compulsive disorder: A revision of the 2005 guidelines from the british association for psychopharmacology
    • Baldwin DS, Anderson IM, Nutt DJ, Allgulander C, Bandelow B, den Boer JA, et al. (2014). Evidence-based pharmacological treatment of anxiety disorders, posttraumatic stress disorder and obsessive-compulsive disorder: A revision of the 2005 guidelines from the British Association for Psychopharmacology. J Psychopharmacol 28:403-439.
    • (2014) J Psychopharmacol , vol.28 , pp. 403-439
    • Baldwin, D.S.1    Anderson, I.M.2    Nutt, D.J.3    Allgulander, C.4    Bandelow, B.5    Den Boer, J.A.6
  • 8
    • 84892678351 scopus 로고    scopus 로고
    • CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparations
    • Basavarajappa BS, Subbanna S (2014). CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparations. Hippocampus 24:178-188.
    • (2014) Hippocampus , vol.24 , pp. 178-188
    • Basavarajappa, B.S.1    Subbanna, S.2
  • 9
    • 0030865871 scopus 로고    scopus 로고
    • Functional role of high-Affinity anandamide transport, as revealed by selective inhibition
    • Beltramo M, Stella N, Calignano A, Lin SY, Makriyannis A, Piomelli D (1997). Functional role of high-Affinity anandamide transport, as revealed by selective inhibition. Science 277:1094-1097.
    • (1997) Science , vol.277 , pp. 1094-1097
    • Beltramo, M.1    Stella, N.2    Calignano, A.3    Lin, S.Y.4    Makriyannis, A.5    Piomelli, D.6
  • 11
    • 0036373043 scopus 로고    scopus 로고
    • Involvement of the opioid system in the anxiolytic-like effects induced by delta(9)-Tetrahydrocannabinol
    • Berrendero F, Maldonado R (2002). Involvement of the opioid system in the anxiolytic-like effects induced by delta(9)-Tetrahydrocannabinol. Psychopharmacology (Berl) 163:111-117.
    • (2002) Psychopharmacology (Berl) , vol.163 , pp. 111-117
    • Berrendero, F.1    Maldonado, R.2
  • 12
    • 53649087673 scopus 로고    scopus 로고
    • Facilitation of contextual fear memory extinction and anti-Anxiogenic effects of AM404 and cannabidiol in conditioned rats
    • Bitencourt RM, Pamplona FA, Takahashi RN (2008). Facilitation of contextual fear memory extinction and anti-Anxiogenic effects of AM404 and cannabidiol in conditioned rats. Eur Neuropsychopharmacol 18:849-859.
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 849-859
    • Bitencourt, R.M.1    Pamplona, F.A.2    Takahashi, R.N.3
  • 14
    • 33846014230 scopus 로고    scopus 로고
    • 5-HT1A receptors are involved in the anxiolytic effect of Delta9-Tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats
    • Braida D, Limonta V, Malabarba L, Zani A, Sala M (2007). 5-HT1A receptors are involved in the anxiolytic effect of Delta9-Tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats. Eur J Pharmacol 555:156-163.
    • (2007) Eur J Pharmacol , vol.555 , pp. 156-163
    • Braida, D.1    Limonta, V.2    Malabarba, L.3    Zani, A.4    Sala, M.5
  • 16
    • 84885295742 scopus 로고    scopus 로고
    • The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness
    • Campolongo P, Ratano P, Manduca A, Scattoni ML, Palmery M, Trezza V, Cuomo V (2012). The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness. Front Behav Neurosci 6:11.
    • (2012) Front Behav Neurosci , vol.6 , pp. 11
    • Campolongo, P.1    Ratano, P.2    Manduca, A.3    Scattoni, M.L.4    Palmery, M.5    Trezza, V.6    Cuomo, V.7
  • 17
    • 77950858464 scopus 로고    scopus 로고
    • Facilitation of endocannabinoid effects in the ventral hippocampus modulates anxiety-like behaviors depending on previous stress experience
    • Campos AC, Ferreira FR, Guimarães FS, Lemos JI (2010). Facilitation of endocannabinoid effects in the ventral hippocampus modulates anxiety-like behaviors depending on previous stress experience. Neuroscience 167:238-246.
    • (2010) Neuroscience , vol.167 , pp. 238-246
    • Campos, A.C.1    Ferreira, F.R.2    Guimarães, F.S.3    Lemos, J.I.4
  • 18
    • 84856060775 scopus 로고    scopus 로고
    • Opposing roles for cannabinoid receptor type-1 (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats
    • Casarotto PC, Terzian AL, Aguiar DC, Zangrossi H, Guimarães FS, Wotjak CT, Wotjak CT (2012). Opposing roles for cannabinoid receptor type-1 (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats. Neuropsychopharmacology 37: 478-486.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 478-486
    • Casarotto, P.C.1    Terzian, A.L.2    Aguiar, D.C.3    Zangrossi, H.4    Guimarães, F.S.5    Wotjak, C.T.6    Wotjak, C.T.7
  • 20
    • 13944267958 scopus 로고    scopus 로고
    • Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear
    • Chhatwal JP, Davis M, Maguschak KA, Ressler KJ (2005). Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear. Neuropsychopharmacology 30:516-524.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 516-524
    • Chhatwal, J.P.1    Davis, M.2    Maguschak, K.A.3    Ressler, K.J.4
  • 21
    • 0026592569 scopus 로고
    • Pharmacological profile of a series of bicyclic cannabinoid analogs: Classification as cannabimimetic agents
    • Compton DR, Johnson MR, Melvin LS, Martin BR (1992). Pharmacological profile of a series of bicyclic cannabinoid analogs: Classification as cannabimimetic agents. J Pharmacol Exp Ther 260:201-209.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 201-209
    • Compton, D.R.1    Johnson, M.R.2    Melvin, L.S.3    Martin, B.R.4
  • 25
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, et al. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946-1949.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3    Pertwee, R.G.4    Stevenson, L.A.5    Griffin, G.6
  • 28
    • 0019604393 scopus 로고
    • The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety
    • Fabre LF, McLendon D (1981). The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety. J Clin Pharmacol 21:377S-382S.
    • (1981) J Clin Pharmacol , vol.21
    • Fabre, L.F.1    McLendon, D.2
  • 30
    • 77954175874 scopus 로고    scopus 로고
    • Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance
    • Finn DP (2010). Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance. Immunobiology 215: 629-646.
    • (2010) Immunobiology , vol.215 , pp. 629-646
    • Finn, D.P.1
  • 31
    • 0043073239 scopus 로고    scopus 로고
    • Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats
    • Finn DP, Jhaveri MD, Beckett SR, Roe CH, Kendall DA, Marsden CA, Chapman V (2003). Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats. Neuropharmacology 45:594-604.
    • (2003) Neuropharmacology , vol.45 , pp. 594-604
    • Finn, D.P.1    Jhaveri, M.D.2    Beckett, S.R.3    Roe, C.H.4    Kendall, D.A.5    Marsden, C.A.6    Chapman, V.7
  • 32
    • 84876947593 scopus 로고    scopus 로고
    • Transport of endocannabinoids across the plasma membrane and within the cell
    • Fowler CJ (2013). Transport of endocannabinoids across the plasma membrane and within the cell. FEBS J 280:1895-1904.
    • (2013) FEBS J , vol.280 , pp. 1895-1904
    • Fowler, C.J.1
  • 33
    • 60349127390 scopus 로고    scopus 로고
    • The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD
    • Fraser GA (2009). The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD). CNS Neurosci Ther 15:84-88.
    • (2009) CNS Neurosci Ther , vol.15 , pp. 84-88
    • Fraser, G.A.1
  • 34
    • 0027467421 scopus 로고
    • Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent
    • Fride E, Mechoulam R (1993). Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent. Eur J Pharmacol 231: 313-314.
    • (1993) Eur J Pharmacol , vol.231 , pp. 313-314
    • Fride, E.1    Mechoulam, R.2
  • 36
    • 84879475262 scopus 로고    scopus 로고
    • Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activities in the elevated T-maze
    • Gobira PH, Aguiar DC, Moreira FA (2013). Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activities in the elevated T-maze. Pharmacol Biochem Behav 110:33-39.
    • (2013) Pharmacol Biochem Behav , vol.110 , pp. 33-39
    • Gobira, P.H.1    Aguiar, D.C.2    Moreira, F.A.3
  • 39
    • 80051799610 scopus 로고    scopus 로고
    • Pharmacological elevation of anandamide impairs short-Term memory by altering the neurophysiology in the hippocampus
    • Goonawardena AV, Sesay J, Sexton CA, Riedel G, Hampson RE (2011). Pharmacological elevation of anandamide impairs short-Term memory by altering the neurophysiology in the hippocampus. Neuropharmacology 61:1016-1025.
    • (2011) Neuropharmacology , vol.61 , pp. 1016-1025
    • Goonawardena, A.V.1    Sesay, J.2    Sexton, C.A.3    Riedel, G.4    Hampson, R.E.5
  • 40
    • 45849113264 scopus 로고    scopus 로고
    • Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders
    • Gorzalka BB, Hill MN, Hillard CJ (2008). Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders. Neurosci Biobehav Rev 32:1152-1160.
    • (2008) Neurosci Biobehav Rev , vol.32 , pp. 1152-1160
    • Gorzalka, B.B.1    Hill, M.N.2    Hillard, C.J.3
  • 41
    • 84863635267 scopus 로고    scopus 로고
    • Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-initiates 2-Arachidonoylglycerol formation and endocannabinoidmediated analgesia
    • Gregg LC, Jung KM, Spradley JM, Nyilas R, Suplita RL 2nd, Zimmer A, et al. (2012). Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-a initiates 2-Arachidonoylglycerol formation and endocannabinoidmediated analgesia. J Neurosci 32:9457-9468.
    • (2012) J Neurosci , vol.32 , pp. 9457-9468
    • Gregg, L.C.1    Jung, K.M.2    Spradley, J.M.3    Nyilas, R.4    Suplita, I.I.R.L.5    Zimmer, A.6
  • 42
    • 84883336698 scopus 로고    scopus 로고
    • 50 years of hurdles and hope in anxiolytic drug discovery
    • Griebel G, Holmes A (2013). 50 years of hurdles and hope in anxiolytic drug discovery. Nat Rev Drug Discov 12:667-687.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 667-687
    • Griebel, G.1    Holmes, A.2
  • 43
    • 84887406857 scopus 로고    scopus 로고
    • Amygdala faah and anandamide: Mediating protection and recovery from stress
    • Gunduz-Cinar O, Hill MN, McEwen BS, Holmes A (2013). Amygdala FAAH and anandamide: Mediating protection and recovery from stress. Trends Pharmacol Sci 34:637-644.
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 637-644
    • Gunduz-Cinar, O.1    Hill, M.N.2    McEwen, B.S.3    Holmes, A.4
  • 44
    • 84862150875 scopus 로고    scopus 로고
    • Endocannabinoid system and TRPV1 receptors in the dorsal hippocampus of the rats modulate anxiety-like behaviors
    • Hakimizadeh E, Oryan S, Hajizadeh Moghaddam A, Shamsizadeh A, Roohbakhsh A (2012). Endocannabinoid system and TRPV1 receptors in the dorsal hippocampus of the rats modulate anxiety-like behaviors. Iran J Basic Med Sci 15:795-802.
    • (2012) Iran J Basic Med Sci , vol.15 , pp. 795-802
    • Hakimizadeh, E.1    Oryan, S.2    Hajizadeh Moghaddam, A.3    Shamsizadeh, A.4    Roohbakhsh, A.5
  • 45
    • 0032517566 scopus 로고    scopus 로고
    • Adverse effects of cannabis
    • Hall W, Solowij N (1998). Adverse effects of cannabis. Lancet 352:1611-1616.
    • (1998) Lancet , vol.352 , pp. 1611-1616
    • Hall, W.1    Solowij, N.2
  • 46
    • 1842633508 scopus 로고    scopus 로고
    • Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice
    • Haller J, Varga B, Ledent C, Barna I, Freund TF (2004). Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice. Eur J Neurosci 19:1906-1912.
    • (2004) Eur J Neurosci , vol.19 , pp. 1906-1912
    • Haller, J.1    Varga, B.2    Ledent, C.3    Barna, I.4    Freund, T.F.5
  • 47
    • 67349253906 scopus 로고    scopus 로고
    • Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats
    • Haller J, Barna I, Barsvari B, Gyimesi Pelczer K, Yasar S, Panlilio LV, Goldberg S (2009). Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats. Psychopharmacology (Berl) 204:607-616.
    • (2009) Psychopharmacology (Berl) , vol.204 , pp. 607-616
    • Haller, J.1    Barna, I.2    Barsvari, B.3    Gyimesi Pelczer, K.4    Yasar, S.5    Panlilio, L.V.6    Goldberg, S.7
  • 50
    • 34247282023 scopus 로고    scopus 로고
    • Estrogen recruits the endocannabinoid system to modulate emotionality
    • Hill MN, Karacabeyli ES, Gorzalka BB (2007). Estrogen recruits the endocannabinoid system to modulate emotionality. Psychoneuroendocrinology 32:350-357.
    • (2007) Psychoneuroendocrinology , vol.32 , pp. 350-357
    • Hill, M.N.1    Karacabeyli, E.S.2    Gorzalka, B.B.3
  • 51
    • 69549116206 scopus 로고    scopus 로고
    • The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants
    • Hill MN, Hillard CJ, Bambico FR, Patel S, Gorzalka BB, Gobbi G (2009). The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants. Trends Pharmacol Sci 30:484-493.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 484-493
    • Hill, M.N.1    Hillard, C.J.2    Bambico, F.R.3    Patel, S.4    Gorzalka, B.B.5    Gobbi, G.6
  • 52
    • 24744469860 scopus 로고    scopus 로고
    • Conversion of acetaminophen to the bioactive N-Acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system
    • Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, et al. (2005). Conversion of acetaminophen to the bioactive N-Acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem 280: 31405-31412.
    • (2005) J Biol Chem , vol.280 , pp. 31405-31412
    • Högestätt, E.D.1    Jönsson, B.A.2    Ermund, A.3    Andersson, D.A.4    Björk, H.5    Alexander, J.P.6
  • 54
  • 56
    • 84862296984 scopus 로고    scopus 로고
    • N-Arachidonoyl-serotonin in the basolateral amygdale increases anxiolytic behavior in the elevated plus maze
    • John CS, Currie PJ (2012). N-Arachidonoyl-serotonin in the basolateral amygdale increases anxiolytic behavior in the elevated plus maze. Behav Brain Res 233:382-388.
    • (2012) Behav Brain Res , vol.233 , pp. 382-388
    • John, C.S.1    Currie, P.J.2
  • 57
    • 54349109924 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates
    • Justinova Z, Mangieri RA, Bortolato M, Chefer SI, Mukhin AG, Clapper JR, et al. (2008). Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. Biol Psychiatry 64:930-937.
    • (2008) Biol Psychiatry , vol.64 , pp. 930-937
    • Justinova, Z.1    Mangieri, R.A.2    Bortolato, M.3    Chefer, S.I.4    Mukhin, A.G.5    Clapper, J.R.6
  • 60
    • 79959705331 scopus 로고    scopus 로고
    • Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey
    • Kawahara H, Drew GM, Christie MJ, Vaughan CW (2011). Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey. Br J Pharmacol 163:1214-1222.
    • (2011) Br J Pharmacol , vol.163 , pp. 1214-1222
    • Kawahara, H.1    Drew, G.M.2    Christie, M.J.3    Vaughan, C.W.4
  • 62
    • 78650619344 scopus 로고    scopus 로고
    • Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay
    • Kinsey SG, O'Neal ST, Long JZ, Cravatt BF, Lichtman AH (2011). Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. Pharmacol Biochem Behav 98:21-27.
    • (2011) Pharmacol Biochem Behav , vol.98 , pp. 21-27
    • Kinsey, S.G.1    O'neal, S.T.2    Long, J.Z.3    Cravatt, B.F.4    Lichtman, A.H.5
  • 63
    • 49749128054 scopus 로고    scopus 로고
    • Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test
    • Lisboa SF, Resstel LB, Aguiar DC, Guimarães FS (2008). Activation of cannabinoid CB1 receptors in the dorsolateral periaqueductal gray induces anxiolytic effects in rats submitted to the Vogel conflict test. Eur J Pharmacol 593:73-78.
    • (2008) Eur J Pharmacol , vol.593 , pp. 73-78
    • Lisboa, S.F.1    Resstel, L.B.2    Aguiar, D.C.3    Guimarães, F.S.4
  • 65
    • 57749087828 scopus 로고    scopus 로고
    • Selective blockade of 2-Arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
    • Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, et al. (2009). Selective blockade of 2-Arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol 5:37-44.
    • (2009) Nat Chem Biol , vol.5 , pp. 37-44
    • Long, J.Z.1    Li, W.2    Booker, L.3    Burston, J.J.4    Kinsey, S.G.5    Schlosburg, J.E.6
  • 66
    • 73949109254 scopus 로고    scopus 로고
    • Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
    • Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, et al. (2009). Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci USA 106:20270-20275.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20270-20275
    • Long, J.Z.1    Nomura, D.K.2    Vann, R.E.3    Walentiny, D.M.4    Booker, L.5    Jin, X.6
  • 69
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 70
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, et al. (1995). Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50:83-90.
    • (1995) Biochem Pharmacol , vol.50 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3    Ligumsky, M.4    Kaminski, N.E.5    Schatz, A.R.6
  • 71
    • 58149461157 scopus 로고    scopus 로고
    • Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels
    • Micale V, Cristino L, Tamburella A, Petrosino S, Leggio GM, Drago F, Di Marzo V (2009). Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels. Neuropsychopharmacology 34:593-606.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 593-606
    • Micale, V.1    Cristino, L.2    Tamburella, A.3    Petrosino, S.4    Leggio, G.M.5    Drago, F.6    Di Marzo, V.7
  • 73
    • 67650504086 scopus 로고    scopus 로고
    • The psychiatric side-effects of rimonabant
    • Moreira FA, Crippa JA (2009). The psychiatric side-effects of rimonabant. Rev Bras Psiquiatr 31:145-153.
    • (2009) Rev Bras Psiquiatr , vol.31 , pp. 145-153
    • Moreira, F.A.1    Crippa, J.A.2
  • 74
    • 33846869741 scopus 로고    scopus 로고
    • Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray
    • Moreira FA, Aguiar DC, Guimarães FS (2007). Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray. Neuropharmacology 52:958-965.
    • (2007) Neuropharmacology , vol.52 , pp. 958-965
    • Moreira, F.A.1    Aguiar, D.C.2    Guimarães, F.S.3
  • 75
    • 37149050777 scopus 로고    scopus 로고
    • Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoiddegrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
    • Moreira FA, Kaiser N, Monory K, Lutz B (2008). Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoiddegrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology 54:141-150.
    • (2008) Neuropharmacology , vol.54 , pp. 141-150
    • Moreira, F.A.1    Kaiser, N.2    Monory, K.3    Lutz, B.4
  • 79
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S, Thomas KL, Abu-Shaar M (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 82
    • 0025331052 scopus 로고
    • Pharmacological characterization of cannabinoids in the elevated plus maze
    • Onaivi ES, Green MR, Martin BR (1990). Pharmacological characterization of cannabinoids in the elevated plus maze. J Pharmacol Exp Ther 253:1002-1009.
    • (1990) J Pharmacol Exp Ther , vol.253 , pp. 1002-1009
    • Onaivi, E.S.1    Green, M.R.2    Martin, B.R.3
  • 83
    • 33749544716 scopus 로고    scopus 로고
    • Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain
    • Onaivi ES, Ishiguro H, Gong JP, Patel S, Perchuk A, Meozzi PA, et al. (2006). Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann N Y Acad Sci 1074:514-536.
    • (2006) Ann N y Acad Sci , vol.1074 , pp. 514-536
    • Onaivi, E.S.1    Ishiguro, H.2    Gong, J.P.3    Patel, S.4    Perchuk, A.5    Meozzi, P.A.6
  • 85
    • 33745261630 scopus 로고    scopus 로고
    • Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: Further evidence for an anxiolytic role for endogenous cannabinoid signaling
    • Patel S, Hillard CJ (2006). Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: Further evidence for an anxiolytic role for endogenous cannabinoid signaling. J Pharmacol Exp Ther 318:304-311.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 304-311
    • Patel, S.1    Hillard, C.J.2
  • 86
    • 45149111341 scopus 로고    scopus 로고
    • Adaptations in endocannabinoid signaling in response to repeated homotypic stress: A novel mechanism for stress habituation
    • Patel S, Hillard CJ (2008). Adaptations in endocannabinoid signaling in response to repeated homotypic stress: A novel mechanism for stress habituation. Eur J Neurosci 27:2821-2829.
    • (2008) Eur J Neurosci , vol.27 , pp. 2821-2829
    • Patel, S.1    Hillard, C.J.2
  • 87
    • 9444277292 scopus 로고    scopus 로고
    • Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-Adrenal axis
    • Patel S, Roelke CT, Rademacher DJ, Cullinan WE, Hillard CJ (2004). Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-Adrenal axis. Endocrinology 145:5431-5438.
    • (2004) Endocrinology , vol.145 , pp. 5431-5438
    • Patel, S.1    Roelke, C.T.2    Rademacher, D.J.3    Cullinan, W.E.4    Hillard, C.J.5
  • 88
    • 43949121784 scopus 로고    scopus 로고
    • Ligands that target cannabinoid receptors in the brain: From THC to anandamide and beyond
    • Pertwee RG (2008). Ligands that target cannabinoid receptors in the brain: From THC to anandamide and beyond. Addict Biol 13:147-159.
    • (2008) Addict Biol , vol.13 , pp. 147-159
    • Pertwee, R.G.1
  • 89
    • 78650120798 scopus 로고    scopus 로고
    • union of basic and clinical pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB1 and CB2. Pharmacol Rev
    • Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR, et al. (2010). International union of basic and clinical pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB1 and CB2. Pharmacol Rev 62:588-631.
    • (2010) International , vol.62 , pp. 588-631
    • Pertwee, R.G.1    Howlett, A.C.2    Abood, M.E.3    Alexander, S.P.4    Di Marzo, V.5    Elphick, M.R.6
  • 90
    • 0242268553 scopus 로고    scopus 로고
    • The molecular logic of endocannabinoid signalling
    • Piomelli D (2003). The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873-884.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 873-884
    • Piomelli, D.1
  • 93
    • 44249113032 scopus 로고    scopus 로고
    • Activation of CB1 cannabinoid receptors in the dorsolateral periaqueductal gray reduces the expression of contextual fear conditioning in rats
    • Resstel LB, Lisboa SF, Aguiar DC, Corrêa FM, Guimarães FS (2008). Activation of CB1 cannabinoid receptors in the dorsolateral periaqueductal gray reduces the expression of contextual fear conditioning in rats. Psychopharmacology (Berl) 198:405-411.
    • (2008) Psychopharmacology (Berl) , vol.198 , pp. 405-411
    • Resstel, L.B.1    Lisboa, S.F.2    Aguiar, D.C.3    Corrêa, F.M.4    Guimarães, F.S.5
  • 94
    • 84867583020 scopus 로고    scopus 로고
    • Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission
    • Rey AA, Purrio M, Viveros MP, Lutz B (2012). Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission. Neuro Psychopharmacology 37: 2624-2634.
    • (2012) Neuro Psychopharmacology , vol.37 , pp. 2624-2634
    • Rey, A.A.1    Purrio, M.2    Viveros, M.P.3    Lutz, B.4
  • 95
    • 70350025072 scopus 로고    scopus 로고
    • Role of endocannabinoid system in the ventral hippocampus of rats in the modulation of anxiety-like behaviours
    • Roohbakhsh A, Keshavarz S, Hasanein P, Rezvani ME, Moghaddam AH (2009). Role of endocannabinoid system in the ventral hippocampus of rats in the modulation of anxiety-like behaviours. Basic Clin Pharmacol Toxicol 105: 333-338.
    • (2009) Basic Clin Pharmacol Toxicol , vol.105 , pp. 333-338
    • Roohbakhsh, A.1    Keshavarz, S.2    Hasanein, P.3    Rezvani, M.E.4    Moghaddam, A.H.5
  • 96
    • 34547872348 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral delta9-Tetrahydrocannabinol in rats
    • Rubino T, Sala M, Viganò D, Braida D, Castiglioni C, Limonta V, et al. (2007). Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral delta9-Tetrahydrocannabinol in rats. Neuropsychopharmacology 32:2036-2045.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2036-2045
    • Rubino, T.1    Sala, M.2    Viganò, D.3    Braida, D.4    Castiglioni, C.5    Limonta, V.6
  • 97
    • 44449151954 scopus 로고    scopus 로고
    • Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex
    • Rubino T, Realini N, Castiglioni C, Guidali C, Viganò D, Marras E, et al. (2008). Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex. Cereb Cortex 18:1292-1301.
    • (2008) Cereb Cortex , vol.18 , pp. 1292-1301
    • Rubino, T.1    Realini, N.2    Castiglioni, C.3    Guidali, C.4    Viganò, D.5    Marras, E.6
  • 98
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1a receptors
    • Russo EB, Burnett A, Hall B, Parker KK (2005). Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res 30:1037-1043.
    • (2005) Neurochem Res , vol.30 , pp. 1037-1043
    • Russo, E.B.1    Burnett, A.2    Hall, B.3    Parker, K.K.4
  • 99
    • 33646756221 scopus 로고    scopus 로고
    • Effects of cannabinoids on the anxietylike response in mice
    • Rutkowska M, Jamontt J, Gliniak H (2006). Effects of cannabinoids on the anxietylike response in mice. Pharmacol Rep 58:200-206.
    • (2006) Pharmacol Rep , vol.58 , pp. 200-206
    • Rutkowska, M.1    Jamontt, J.2    Gliniak, H.3
  • 100
    • 37449017773 scopus 로고    scopus 로고
    • The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition
    • Scherma M, Medalie J, Fratta W, Vadivel SK, Makriyannis A, Piomelli D, et al. (2008). The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology 54:129-140.
    • (2008) Neuropharmacology , vol.54 , pp. 129-140
    • Scherma, M.1    Medalie, J.2    Fratta, W.3    Vadivel, S.K.4    Makriyannis, A.5    Piomelli, D.6
  • 101
    • 84856246732 scopus 로고    scopus 로고
    • The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats
    • Scherma M, Justinov Z, Zanettini C, Panlilio LV, Mascia P, Fadda P, et al. (2012). The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. Br J Pharmacol 165:2539-2548.
    • (2012) Br J Pharmacol , vol.165 , pp. 2539-2548
    • Scherma, M.1    Justinov, Z.2    Zanettini, C.3    Panlilio, L.V.4    Mascia, P.5    Fadda, P.6
  • 102
    • 79959977058 scopus 로고    scopus 로고
    • Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-Arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats
    • Sciolino NR, Zhou W, Hohmann AG (2011). Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-Arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. Pharmacol Res 64:226-234.
    • (2011) Pharmacol Res , vol.64 , pp. 226-234
    • Sciolino, N.R.1    Zhou, W.2    Hohmann, A.G.3
  • 104
    • 33947697100 scopus 로고    scopus 로고
    • Biochemistry and pharmacology of endovanilloids
    • Starowicz K, Nigam S, Di Marzo V (2007). Biochemistry and pharmacology of endovanilloids. Pharmacol Ther 114:13-33.
    • (2007) Pharmacol Ther , vol.114 , pp. 13-33
    • Starowicz, K.1    Nigam, S.2    Di Marzo, V.3
  • 106
    • 0030561432 scopus 로고    scopus 로고
    • A community survey of adverse effects of cannabis use
    • Thomas H (1996). A community survey of adverse effects of cannabis use. Drug Alcohol Depend 42:201-207.
    • (1996) Drug Alcohol Depend , vol.42 , pp. 201-207
    • Thomas, H.1
  • 108
    • 0033952656 scopus 로고    scopus 로고
    • Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro
    • Vaughan CW, Connor M, Bagley EE, Christie MJ (2000). Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro. Mol Pharmacol 57:288-295.
    • (2000) Mol Pharmacol , vol.57 , pp. 288-295
    • Vaughan, C.W.1    Connor, M.2    Bagley, E.E.3    Christie, M.J.4
  • 109
    • 20444379218 scopus 로고    scopus 로고
    • Endocannabinoid system and stress and anxiety responses
    • Viveros MP, Marco EM, File SE (2005). Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav 81:331-342.
    • (2005) Pharmacol Biochem Behav , vol.81 , pp. 331-342
    • Viveros, M.P.1    Marco, E.M.2    File, S.E.3
  • 110
    • 84862092052 scopus 로고    scopus 로고
    • Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: An in vivo microdialysis study
    • Wiskerke J, Irimia C, Cravatt BF, De Vries TJ, Schoffelmeer AN, Pattij T, Parsons LH (2012). Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: An in vivo microdialysis study. ACS Chem Neurosci 3:407-417.
    • (2012) ACS Chem Neurosci , vol.3 , pp. 407-417
    • Wiskerke, J.1    Irimia, C.2    Cravatt, B.F.3    De Vries, T.J.4    Schoffelmeer, A.N.5    Pattij, T.6    Parsons, L.H.7
  • 112
    • 80052213796 scopus 로고    scopus 로고
    • Brain cannabinoid CB2 receptors modulate cocaine's actions in mice
    • Xi ZX, Peng XQ, Li X, Song R, Zhang HY, Liu QR, et al. (2011). Brain cannabinoid CB2 receptors modulate cocaine's actions in mice. Nat Neurosci 14: 1160-1166.
    • (2011) Nat Neurosci , vol.14 , pp. 1160-1166
    • Xi, Z.X.1    Peng, X.Q.2    Li, X.3    Song, R.4    Zhang, H.Y.5    Liu, Q.R.6
  • 113
    • 33846455132 scopus 로고    scopus 로고
    • TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons
    • Xing J, Li J (2007). TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons. J Neurophysiol 97: 503-511.
    • (2007) J Neurophysiol , vol.97 , pp. 503-511
    • Xing, J.1    Li, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.