Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray

Neuropharmacology

Volumn 52, Issue 3, 2007, Pages 958-965

  Moreira, Fabrício Araújo ^a   Aguiar, Daniele Cristina ^a   Guimarães, Francisco Silveira ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anandamide; Anxiety; Cannabinoid receptor; Cannabinoids; Endocannabinoids; Periaqueductal gray

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; ANANDAMIDE; ARACHIDONYL 2 CHLOROETHYLAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR AGONIST; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HISTOLOGY; MALE; MAZE TEST; MESENCEPHALON; NEUROANATOMY; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANXIETY; ARACHIDONIC ACIDS; BEHAVIOR, ANIMAL; CANNABINOIDS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MAZE LEARNING; PERIAQUEDUCTAL GRAY; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1;

EID: 33846869741     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.10.013     Document Type: Article

References (43)

1. Baldwin H.A., Rassnick S., Rivier J., Koob G.F., and Britton K.T. CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat. Psychopharmacology 103 (1991) 227-232
2. Bandler R., Keay K.A., Floyd N., and Price J. Central circuits mediating patterned autonomic activity during active vs. passive emotional coping. Brain Research Bulletin 53 (2000) 95-104
3. Barros D.M., Carlis V., Maidana M., Silva E.S., Baisch A.L., Ramirez M.R., and Izquierdo I. Interactions between anandamide-induced anterograde amnesia and post-training memory modulatory systems. Brain Research 1016 (2004) 66-71
4. Beltramo M., de Fonseca F.R., Navarro M., Calignano A., Gorriti M.A., Grammatikopoulos G., Sadile A.G., Giuffrida A., and Piomelli D. Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitor. Journal of Neuroscience 20 (2000) 3401-3407
5. Beltramo M., Stella N., Calignano A., Lin S.Y., Makriyannis A., and Piomelli D. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 (1997) 1094-1097
6. Berrendero F., and Maldonado R. Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol. Psychopharmacology 163 (2002) 111-117
7. Bortolato M., Campolongo P., Mangieri R.A., Scattoni M.L., Frau R., Trezza V., La Rana G., Russo R., Calignano A., Gessa G.L., Cuomo V., and Piomelli D. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology 31 (2006) 2652-2659
8. Calignano A., La Rana G., Beltramo M., Makriyannis A., and Piomelli D. Potentiation of anandamide hypotension by the transport inhibitor, AM404. European Journal of Pharmacology 337 (1997) R1-R2
9. Carobrez A.P., and Bertoglio L.J. Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on. Neuroscience and Biobehavioral Reviews 29 (2005) 1193-1205
10. Chakrabarti A., Ekuta J.E., and Onaivi E.S. Neurobehavioral effects of anandamide and cannabinoid receptor gene expression in mice. Brain Research Bulletin 45 (1998) 67-74
11. Chhatwal J.P., Davis M., Maguschak K.A., and Ressler K.J. Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear. Neuropsychopharmacology 30 (2005) 516-524
12. Cole B.J., Hillmann M., Seidelmann D., Klewer M., and Jones G.H. Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat. Psychopharmacology 121 (1995) 118-126
13. Di Marzo V., Bisogno T., and De Petrocellis L. Anandamide: some like it hot. Trends in Pharmacological Sciences 22 (2001) 346-349
14. Di Marzo V., Fontana A., Cadas H., Schinelli S., Cimino G., Schwartz J.C., and Piomelli D. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372 (1994) 686-691
15. Egertova M., Cravatt B.F., and Elphick M.R. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience 119 (2003) 481-496
16. Finn D.P., Jhaveri M.D., Beckett S.R., Roe C.H., Kendall D.A., Marsden C.A., and Chapman V. Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats. Neuropharmacology 45 (2003) 594-604
17. Giuffrida A., Beltramo M., and Piomelli D. Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. Journal of Pharmacology and Experimental Therapeutics 298 (2001) 7-14
18. Griebel G., Stemmelin J., and Scatton B. Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents. Biological Psychiatry 57 (2005) 261-267
19. Guimarães F.S., Carobrez A.P., De Aguiar J.C., and Graeff F.G. Anxiolytic effect in the elevated plus-maze of the NMDA receptor antagonist AP7 microinjected into the dorsal periaqueductal grey. Psychopharmacology 103 (1991) 91-94
20. Hall W., and Solowij N. Adverse effects of Cannabis. Lancet 352 (1998) 1611-1616
21. Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., and Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. Journal of Neuroscience 11 (1991) 563-583
22. Hillard C.J., Manna S., Greenberg M.J., Dicamelli R., Ross R.A., Stevenson L.A., Murphy V., Pertwee R.G., and Campbell W.B. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). Journal of Pharmacology and Experimental Therapeutics 289 (1999) 1427-1433
23. Hohmann A.G., Suplita R.L., Bolton N.M., Neely M.H., Fegley D., Mangieri R., Krey J.F., Walker J.M., Holmes P.V., Crystal J.D., Duranti A., Tontini A., Mor M., Tarzia G., and Piomelli D. An endocannabinoid mechanism for stress-induced analgesia. Nature 435 (2005) 1108-1112
24. Howlett A.C., Barth F., Bonner T.I., Cabral G., Casellas P., Devane W.A., Felder C.C., Herkenham M., Mackie K., Martin B.R., Mechoulam R., and Pertwee R.G. International union of pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological Reviews 54 (2002) 161-202
25. Kathuria S., Gaetani S., Fegley D., Valino F., Duranti A., Tontini A., Mor M., Tarzia G., La Rana G., Calignano A., Giustino A., Tattoli M., Palmery M., Cuomo V., and Piomelli D. Modulation of anxiety through blockade of anandamide hydrolysis. Nature Medicine 9 (2003) 76-81
26. Maione S., Bisogno T., de Novellis V., Palazzo E., Cristino L., Valenti M., Petrosino S., Guglielmotti V., Rossi F., and Di Marzo V. Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. Journal of Pharmacology and Experimental Therapeutics 316 (2006) 969-982
27. Martin W.J., Patrick S.L., Coffin P.O., Tsou K., and Walker J.M. An examination of the central sites of action of cannabinoid-induced antinociception in the rat. Life Sciences 56 (1995) 2103-2109
28. de Oliveira Alvares L., de Oliveira L.F., Camboim C., Diehl F., Genro B.P., Lanziotti V.B., and Quillfeldt J.A. Amnestic effect of intrahippocampal AM251, a CB1-selective blocker, in the inhibitory avoidance, but not in the open field habituation task, in rats. Neurobiology of Learning and Memory 83 (2005) 119-124
29. Onaivi E.S., Chakrabarti A., Gwebu E.T., and Chaudhuri G. Neurobehavioral effects of delta 9-THC and cannabinoid (CB1) receptor gene expression in mice. Behavioral Brain Research 72 (1995) 115-125
30. Onaivi E.S., Green M.R., and Martin B.R. Pharmacological characterization of cannabinoids in the elevated plus maze. Journal of Pharmacology and Experimental Therapeutics 253 (1990) 1002-1009
31. Padovan C.M., and Guimarães F.S. Restraint-induced hypoactivity in an elevated plus-maze. Brazilian Journal of Medical and Biological Research 33 (2000) 79-83
32. Patel S., and Hillard C.J. Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signalling. Journal of Pharmacology and Experimental Therapeutics 318 (2006) 304-311
33. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. third ed. (1997), Academic Press, San Diego
34. Piomelli D., Beltramo M., Glasnapp S., Lin S.Y., Goutopoulos A., Xie X.Q., and Makriyannis A. Structural determinants for recognition and translocation by the anandamide transporter. Proceedings of the National Academy of Sciences of the United States of America 96 (1999) 5802-5807
35. Rodgers R.J., Evans P.M., and Murphy A. Anxiogenic profile of AM-251, a selective cannabinoid CB1 receptor antagonist, in plus-maze-naive and plus-maze-experienced mice. Behavioural Pharmacology 16 (2005) 405-413
36. Russo A.S., Guimarães F.S., De Aguiar J.C., and Graeff F.G. Role of benzodiazepine receptors located in the dorsal periaqueductal grey of rats in anxiety. Psychopharmacology 110 (1993) 198-202
37. Schutz M.T., de Aguiar J.C., and Graeff F.G. Anti-aversive role of serotonin in the dorsal periaqueductal gray. Psychopharmacology 85 (1986) 340-345
38. Vaughan C.W., Connor M., Bagley E.E., and Christie M.J. Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro. Molecular Pharmacology 57 (2000) 288-295
39. Viveros M.P., Marco E.M., and File S.E. Endocannabinoid system and stress and anxiety responses. Pharmacology, Biochemistry and Behavior 81 (2005) 331-342
40. Walker J.M., Huang S.M., Strangman N.M., Tsou K., and Sanudo-Pena M.C. Pain modulation by release of the endogenous cannabinoid anandamide. Proceedings of the National Academy of Sciences of the United States of America 96 (1999) 12198-12203
41. Wilson R.I., and Nicoll R.A. Endocannabinoid signaling in the brain. Science 296 (2002) 678-682
42. Zuardi A.W., Shirakawa I., Finkelfarb E., and Karniol I.G. Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology 76 (1982) 245-250
43. Zygmunt P.M., Chuang H., Movahed P., Julius D., and Hogestatt E.D. The anandamide transport inhibitor AM404 activates vanilloid receptors. European Journal of Pharmacology 396 (2000) 39-42