Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA B receptors in the balance of gabaergic and glutamatergic neurotransmission

Neuropsychopharmacology

Volumn 37, Issue 12, 2012, Pages 2624-2634

  Rey, Alejandro Aparisi ^a   Purrio, Martin ^a   Viveros, Maria Paz ^b   Lutz, Beat ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

anxiety; CB1 receptor; CP 55,940; GABA; glutamate; GS 39783

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 AMINOBUTYRIC ACID B RECEPTOR; CANNABINOID 1 RECEPTOR; CANNABINOID DERIVATIVE; GLUTAMATE RECEPTOR; N,N' DICYCLOPENTYL 2 METHYLTHIO 5 NITRO 4,6 PYRIMIDINEDIAMINE;

ALLOSTERISM; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANXIETY DISORDER; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; ELEVATED PLUS MAZE; EXPERIMENTAL TEST; FEMALE; FOREBRAIN; GABAERGIC TRANSMISSION; GLUTAMATERGIC NEUROTRANSMISSION; HOLEBOARD; LOCOMOTION; LOW DRUG DOSE; MALE; MAZE TEST; MOUSE; MOUSE MUTANT; NERVE CELL; NERVE ENDING; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANQUILIZING ACTIVITY; WILD TYPE;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; CANNABINOIDS; CYCLOHEXANOLS; CYCLOPENTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; PYRIMIDINES; RECEPTOR, CANNABINOID, CB1; RECEPTORS, GABA-B; SYNAPTIC TRANSMISSION;

EID: 84867583020     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2012.123     Document Type: Article

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