Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

Nature Neuroscience

Volumn 16, Issue 9, 2013, Pages 1291-1298

  Hermanson, Daniel J ^a   Hartley, Nolan D ^a   Gamble George, Joyonna ^a   Brown, Naoko ^a   Shonesy, Brian C ^a   Kingsley, Phillip J ^a   Colbran, Roger J ^a   Reese, Jeffrey ^a   Marnett, Lawrence J ^a   Patel, Sachin ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACYLGLYCEROL LIPASE; ARACHIDONIC ACID; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ENDOCANNABINOID; ESTERASE INHIBITOR; FATTY ACID AMIDASE INHIBITOR; INDOMETACIN; JZL 184; LIPID; LM 4131; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PF 3845; PROSTAGLANDIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; IN VIVO STUDY; LIPOGENESIS; MALE; MOUSE; NONHUMAN; PHARMACOLOGICAL PROCEDURES; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SIGNAL TRANSDUCTION;

ADAPTATION, OCULAR; AMIDOHYDROLASES; ANIMALS; ANXIETY; BENZOXAZINES; BODY TEMPERATURE; CALCIUM CHANNEL BLOCKERS; CANNABINOID RECEPTOR AGONISTS; CANNABINOID RECEPTOR ANTAGONISTS; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DISEASE MODELS, ANIMAL; ENDOCANNABINOIDS; EXPLORATORY BEHAVIOR; FREEZING REACTION, CATALEPTIC; HUMANS; INDOLES; MALE; MAZE LEARNING; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; MORPHOLINES; NAPHTHALENES; RECEPTOR, CANNABINOID, CB1; SIGNAL TRANSDUCTION;

EID: 84883466059     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3480     Document Type: Article

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