Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner

Journal of Biological Chemistry

Volumn 289, Issue 33, 2014, Pages 22798-22814

  Lee, Teresa ^a   Di Paola, Domenic ^a   Malina, Abba ^a   Mills, John R ^a,f   Kreps, Amina ^a   Grosse, Frank ^b   Tang, Hengli ^c   Zannis Hadjopoulos, Maria ^a,d   Larsson, Ola ^e   Pelletier, Jerry ^a,d  

^a MCGILL UNIVERSITY   (Canada)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c FLORIDA STATE UNIVERSITY   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e KAROLINSKA INSTITUTE   (Sweden)

^f MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DNA; FIBROBLASTS; GENE EXPRESSION; REPAIR;

CELL-CYCLE PROGRESSION; CELLULAR FUNCTION; GENOME STABILITY; HUMAN DIPLOID FIBROBLASTS; HUMAN FIBROBLAST; MORPHOLOGICAL DEFECTS; SIGNALING PATHWAYS; TRANSLATIONAL REGULATION;

NUCLEIC ACIDS;

BETA GALACTOSIDASE; DEXH BOX HELICASE; DNA; DXH9 HELICASE; HELICASE; PROTEIN P53; UNCLASSIFIED DRUG; DEAD BOX PROTEIN; DHX9 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; TUMOR PROTEIN;

ARTICLE; CELL AGING; CELL CYCLE PROGRESSION; CELL GROWTH; CELL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIPLOIDY; DNA REPLICATION; ENZYME ACTIVITY; ENZYME REPRESSION; FIBROBLAST; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION; TELOMERE; CELL CYCLE CHECKPOINT; CYTOLOGY; GENETICS; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY;

BETA-GALACTOSIDASE; CELL AGING; CELL CYCLE CHECKPOINTS; DEAD-BOX RNA HELICASES; DIPLOIDY; DNA REPLICATION; FIBROBLASTS; HEK293 CELLS; HUMANS; NEOPLASM PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84905970341     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.568535     Document Type: Article

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