The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis

Genes and Development

Volumn 27, Issue 23, 2013, Pages 2543-2548

  Liu, Mingzhu ^a,b   Roth, Anna ^c,d   Yu, Min ^a,b   Morris, Robert ^a   Bersani, Francesca ^a,b   Rivera, Miguel N ^a   Lu, Jun ^e,f   Shioda, Toshihiro ^a   Vasudevan, Shobha ^a   Ramaswamy, Sridhar ^a   Maheswaran, Shyamala ^a   Diederichs, Sven ^a,c,d   Haber, Daniel A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fetal promoters; IGF2; Nuclear miRNA; Transcription

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GENOMIC DNA; MICRORNA; MICRORNA 483; RNA HELICASE; SOMATOMEDIN B; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ADRENAL CORTEX CARCINOMA; ADULT; ADULT DISEASE; ARTICLE; BINDING SITE; CARCINOGENESIS; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; DNA BASE COMPOSITION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE INTERACTION; GENE OVEREXPRESSION; GENE POOL; GENETIC ASSOCIATION; GENOME IMPRINTING; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRON; MALE; NEPHROBLASTOMA; POSITIVE FEEDBACK; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA PROCESSING; RNA PURIFICATION; RNA TRANSCRIPTION; SARCOMA CELL; SCHOOL CHILD; UPREGULATION;

FETAL PROMOTERS; IGF2; NUCLEAR MIRNA; TRANSCRIPTION;

5' UNTRANSLATED REGIONS; CARCINOGENESIS; CELL LINE; CELL NUCLEUS; DEAD-BOX RNA HELICASES; FETUS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN-LIKE GROWTH FACTOR II; INTRONS; MICRORNAS; NEOPLASM PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA, MESSENGER;

EID: 84888869374     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.224170.113     Document Type: Article

References (26)

1. Allo M, Buggiano V, Fededa JP, Petrillo E, Schor I, de la Mata M, Agirre E, Plass M, Eyras E, Elela SA, et al. 2009. Control of alternative splicing through siRNA-mediated transcriptional gene silencing. Nat Struct Mol Biol 16: 717-724.
2. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT. 2008. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet 40: 43-50.
3. Dahan O, Gingold H, Pilpel Y. 2011. Regulatory mechanisms and networks couple the different phases of gene expression. Trends Genet 27: 316-322.
4. Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, Inoue K, Enright AJ, Schier AF. 2006. Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312: 75-79.
5. Han K, Gennarino VA, Lee Y, Pang K, Hashimoto-Torii K, Choufani S, Raju CS, Oldham MC, Weksberg R, Rakic P, et al. 2013. Humanspecific regulation ofMeCP2 levels in fetal brains by microRNA miR-483-5p. Genes Dev 27: 485-490.
6. Huff V. 2011. Wilms' tumours: About tumour suppressor genes, an oncogene and a chameleon gene. Nat Rev Cancer 11: 111-121.
7. Jelinic P, Shaw P. 2007. Loss of imprinting and cancer. J Pathol 211: 261-268.
8. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. 2012. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem 287: 3976-3986.
9. Keniry A, Oxley D, Monnier P, Kyba M, Dandolo L, Smits G, Reik W. 2012. The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nat Cell Biol 14: 659-665.
10. Lal A, Thomas MP, Altschuler G, Navarro F, O'Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, et al. 2011. Capture of microRNAbound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet 7: e1002363.
11. Ma N, Wang X, Qiao Y, Li F, Hui Y, Zou C, Jin J, Lv G, Peng Y, Wang L, et al. 2011. Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner. Mol Cell Endocrinol 333: 96-101.
12. Ma N, Li F, Li D, Hui Y, Wang X, Qiao Y, Zhang Y, Xiang Y, Zhou J, Zhou L, et al. 2012. Igf2-derived intronic miR-483 promotes mouse hepatocellular carcinoma cell proliferation. Mol Cell Biochem 361: 337-343.
13. Monk D, Sanches R, Arnaud P, Apostolidou S, Hills FA, Abu-Amero S, Murrell A, Friess H, Reik W, Stanier P, et al. 2006. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human. Hum Mol Genet 15: 1259-1269.
14. Moore T, Haig D. 1991. Genomic imprinting in mammalian development: A parental tug-of-war. Trends Genet 7: 45-49.
15. Newman MA, Thomson JM, Hammond SM. 2008. Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 14: 1539-1549.
16. Padmanabhan K, Robles MS, Westerling T, Weitz CJ. 2012. Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science 337: 599-602.
17. Patterson EE, Holloway AK, Weng J, Fojo T, Kebebew E. 2011. MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy. Cancer 117: 1630-1639.
18. Pollak M. 2008. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 8: 915-928.
19. Qiao Y, Ma N, Wang X, Hui Y, Li F, Xiang Y, Zhou J, Zou C, Jin J, Lv G, et al. 2011. miR-483-5p controls angiogenesis in vitro and targets serum response factor. FEBS Lett 585: 3095-3100.
20. Robb GB, Rana TM. 2007. RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol Cell 26: 523-537.
21. Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szasz AM, Wang ZC, Brock JE, Richardson AL, Weinberg RA. 2009. A pleiotropically acting micro-RNA, miR-31, inhibits breast cancer metastasis. Cell 137: 1032-1046.
22. Veronese A, Lupini L, Consiglio J, Visone R, Ferracin M, Fornari F, Zanesi N, Alder H, D'Elia G, Gramantieri L, et al. 2010. Oncogenic role of miR-483-3p at the IGF2/483 locus. Cancer Res 70: 3140-3149.
23. Wang L, Shi M, Hou S, Ding B, Liu L, Ji X, Zhang J, Deng Y. 2012. miR-483-5p suppresses the proliferation of glioma cells via directly targeting ERK1. FEBS Lett 586: 1312-1317.
24. Watson JA, Bryan K, Williams R, Popov S, Vujanic G, Coulomb A, Boccon-Gibod L, Graf N, Pritchard-Jones K, O'Sullivan M. 2013. miRNA profiles as a predictor of chemoresponsiveness in Wilms' tumor blastema. PLoS ONE 8: e53417.
25. Wisniewski D, Lambek CL, Liu C, Strife A, Veach DR, Nagar B, Young MA, Schindler T, Bornmann WG, Bertino JR, et al. 2002. Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Res 62: 4244-4255.
26. Yoon JH, Abdelmohsen K, Srikantan S, Yang X, Martindale JL, De S, Huarte M, Zhan M, Becker KG, Gorospe M. 2012. LincRNA-p21 suppresses target mRNA translation. Mol Cell 47: 648-655.