RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 37, 2010, Pages 16125-16130

  Huo, Longfei ^a   Wang, Ying Nai ^a   Xia, Weiya ^a   Hsu, Sheng Chieh ^a   Lai, Chien Chen ^b   Li, Long Yuan ^b,c   Chang, Wei Chao ^d   Wang, Yan ^a   Hsu, Ming Chuan ^a   Yu, Ng Luen ^b,c   Huang, Tzu Hsuan ^a   Ding, Qingqing ^a   Chen, Chung Hsuan ^d   Tsai, Chang Hai ^b   Hung, Mien Chie ^a,b,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

Cyclin D1; Inducible nitric oxide synthase; Nuclear translocation; Transcription

Indexed keywords

CYCLIN D1; DNA BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; RNA HELICASE; RNA HELICASE A; UNCLASSIFIED DRUG; CCND1 PROTEIN, HUMAN; DNA; PROTEIN BINDING;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AT RICH SEQUENCE; BREAST CANCER; CANCER CELL; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; MEDIATOR; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; ACTIVE TRANSPORT; BREAST TUMOR; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; METABOLISM;

ACTIVE TRANSPORT, CELL NUCLEUS; BREAST NEOPLASMS; CELL NUCLEUS; CYCLIN D1; DNA; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA HELICASES; TRANSCRIPTIONAL ACTIVATION;

EID: 77958022249     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1000743107     Document Type: Article

References (41)

1. Linggi B, Carpenter G (2006) ErbB receptors: New insights on mechanisms and biology. Trends Cell Biol 16:649-656. (Pubitemid 44809890)
2. Lo HW, Hung MC (2006) Nuclear EGFR signalling network in cancers: Linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. Br J Cancer 94:184-188.
3. Mosesson Y, Mills GB, Yarden Y (2008) Derailed endocytosis: An emerging feature of cancer. Nat Rev Cancer 8:835-850.
4. Wang SC, Hung MC (2009) Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors. Clin Cancer Res 15 (21):6484-6489.
5. Das AK, et al. (2007) Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. Cancer Res 67:5267-5274.
6. Li C, Iida M, Dunn EF, Ghia AJ, Wheeler DL (2009) Nuclear EGFR contributes to acquired resistance to cetuximab. Oncogene 28:3801-3813.
7. Lo HW, et al. (2005) Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res 65:338-348.
8. Psyrri A, et al. (2005) Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin Cancer Res 11:5856-5862.
9. Hoshino M, et al. (2007) Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinoma. Pathobiology 74:15-21. (Pubitemid 46742314)
10. Edwards J, et al. (2006) The role of HER1-HER4 and EGFRvIII in hormone-refractory prostate cancer. Clin Cancer Res 12:123-130.
11. Xia W, et al. (2009) Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol Carcinog 48:610-617.
12. Wang SC, et al. (2006) Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol 8:1359-1368.
13. Lo HW, et al. (2005) Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell 7:575-589.
14. Hanada N, et al. (2006) Co-regulation of B-Myb expression by E2F1 and EGF receptor. Mol Carcinog 45:10-17. (Pubitemid 43122365)
15. Chen DJ, Nirodi CS (2007) The epidermal growth factor receptor: A role in repair of radiation-induced DNA damage. Clin Cancer Res 13:6555-6560. (Pubitemid 350206788)
16. Hung LY, et al. (2008) Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression. Nucleic Acids Res 36:4337-4351.
17. Lin SY, et al. (2001) Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3:802-808.
18. Hu S, et al. (2009) Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell 139:610-622.
19. Kuroda MI, Kernan MJ, Kreber R, Ganetzky B, Baker BS (1991) The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Cell 66:935-947.
20. Lee CG, Hurwitz J (1993) Human RNA helicase A is homologous to the maleless protein of Drosophila. J Biol Chem 268:16822-16830.
21. Lee CG, Eki T, Okumura K, da Costa Soares V, Hurwitz J (1998) Molecular analysis of the cDNA and genomic DNA encoding mouse RNA helicase A. Genomics 47:365-371.
22. Fuller-Pace FV (2006) DExD/H box RNA helicases: Multifunctional proteins with important roles in transcriptional regulation. Nucleic Acids Res 34:4206-4215.
23. Zhang S, Grosse F (1994) Nuclear DNA helicase II unwinds both DNA and RNA. Biochemistry 33:3906-3912. (Pubitemid 24125354)
24. Hung ML, Chao P, Chang KY (2003) dsRBM1 and a proline-rich domain of RNA helicase A can form a composite binder to recognize a specific dsDNA. Nucleic Acids Res 31:5741-5753. (Pubitemid 37441945)
25. Myöhänen S, Baylin SB (2001) Sequence-specific DNA binding activity of RNA helicase A to the p16INK4a promoter. J Biol Chem 276:1634-1642. (Pubitemid 32098014)
26. Lee CG, Reichman TW, Baik T, Mathews MB (2004) MLE functions as a transcriptional regulator of the roX2 gene. J Biol Chem 279:47740-47745. (Pubitemid 39540922)
27. Clarke N, Arenzana N, Hai T, Minden A, Prywes R (1998) Epidermal growth factor induction of the c-jun promoter by a Rac pathway. Mol Cell Biol 18:1065-1073.
28. Kayahara M, Wang X, Tournier C (2005) Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-O- tetradecanoylphorbol-13-acetate-responsive element and myocyte enhancer factor 2 binding sites. Mol Cell Biol 25:3784-3792.
29. Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316:1160-1166. (Pubitemid 46877472)
30. Beausoleil SA, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci USA 101:12130-12135.
31. Tetsuka T, et al. (2004) RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator. Eur J Biochem 271:3741-3751. (Pubitemid 39233616)
32. Hsu SC, Hung MC (2007) Characterization of a novel tripartite nuclear localization sequence in the EGFR family. J Biol Chem 282:10432-10440.
33. Hsu SC, Miller SA, Wang Y, Hung MC (2009) Nuclear EGFR is required for cisplatin resistance and DNA repair. American Journal of Translational Research 1:249-258.
34. Filmus J, Pollak MN, Cailleau R, Buick RN (1985) MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF. Biochem Biophys Res Commun 128:898-905.
35. Oksvold MP, Skarpen E, Lindeman B, Roos N, Huitfeldt HS (2000) Immunocytochemical localization of Shc and activated EGF receptor in early endosomes after EGF stimulation of HeLa cells. J Histochem Cytochem 48:21-33. (Pubitemid 30053563)
36. Carpenter G (2003) Nuclear localization and possible functions of receptor tyrosine kinases. Curr Opin Cell Biol 15:143-148.
37. Sorkin A, Goh LK (2009) Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res 315:683-696.
38. 111In-DTPA human epidermal growth factor. J Nucl Med 48:1562-1570.
39. 211At-EGF. Eur J Nucl Med Mol Imaging 30:1348-1356.
40. Carpenter G (2000) The EGF receptor: A nexus for trafficking and signaling. Bioessays 22:697-707.
41. Huang F, Khvorova A, Marshall W, Sorkin A (2004) Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem 279:16657-16661.