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Volumn 21, Issue 4, 2014, Pages

Androgen biosynthesis in castration-resistant prostate cancer

Author keywords

Androgen receptor; Androgen receptor antagonists; Enzyme inhibitors; Intratumoral androgen biosynthesis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 5ALPHA OXIDOREDUCTASE 1; ABIRATERONE; ANDROSTANOLONE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME P450 17; CYTOCHROME P450 17A1; CYTOCHROME P450 17ALPHA HYDROXYLASE; DEOXYCORTICOSTERONE; ENZALUTAMIDE; STEROID 17ALPHA MONOOXYGENASE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE 2; STEROID 5ALPHA REDUCTASE 3; STERYL SULFATASE; TESTOSTERONE; TRANSFERASE; UNCLASSIFIED DRUG; URIDINE GLUCURONSYL TRANSFERASE; ENZYME INHIBITOR;

EID: 84905968578     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-14-0109     Document Type: Review
Times cited : (38)

References (98)
  • 1
    • 84905970987 scopus 로고    scopus 로고
    • Plasma steroid concentrations in male rhesus monkeys following treatment with the P450c17 (CYP) inhibitors VT-464 and abiraterone acetate. A comparison to human 17,20-lyase (lyase) and combined lyase/17α-hydroxylase (hydroxylase) deficiencies
    • Abbott D, Einser JR, Bird IM, Raffrety SW, Moore WR & Schotzinger RJ 2012 Plasma steroid concentrations in male rhesus monkeys following treatment with the P450c17 (CYP) inhibitors VT-464 and abiraterone acetate. A comparison to human 17,20-lyase (lyase) and combined lyase/17α-hydroxylase (hydroxylase) deficiencies. Endocrine Reviews 33 SAT-256.
    • (2012) Endocrine Reviews , vol.33
    • Abbott, D.1    Einser, J.R.2    Bird, I.M.3    Raffrety, S.W.4    Moore, W.R.5    Schotzinger, R.J.6
  • 3
    • 84863230589 scopus 로고    scopus 로고
    • Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships
    • doi:10.1021/jm201547v
    • Adeniji A, Twenter BM, Byrns MC, Jin Y, Chen M, Winkler JD & Penning TM 2012 Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl- aminobenzoates and their structure-activity relationships. Journal of Medicinal Chemistry 55 2311-2323. (doi:10.1021/jm201547v)
    • (2012) Journal of Medicinal Chemistry , vol.55 , pp. 2311-2323
    • Adeniji, A.1    Twenter, B.M.2    Byrns, M.C.3    Jin, Y.4    Chen, M.5    Winkler, J.D.6    Penning, T.M.7
  • 7
    • 67449119425 scopus 로고    scopus 로고
    • Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven
    • doi:10.1158/0008-5472.CAN-08-4531
    • Attard G, Reid AH, Olmos D & de Bono JS 2009 Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven. Cancer Research 69 4937-4940. (doi:10.1158/0008-5472. CAN-08-4531)
    • (2009) Cancer Research , vol.69 , pp. 4937-4940
    • Attard, G.1    Reid, A.H.2    Olmos, D.3    De Bono, J.S.4
  • 9
    • 7444233759 scopus 로고    scopus 로고
    • The backdoor pathway to dihydrotestosterone
    • doi:10.1016/j.tem.2004. 09.004
    • Auchus RJ 2004 The backdoor pathway to dihydrotestosterone. Trends in Endocrinology and Metabolism 15 432-438. (doi:10.1016/j.tem.2004. 09.004)
    • (2004) Trends in Endocrinology and Metabolism , vol.15 , pp. 432-438
    • Auchus, R.J.1
  • 10
    • 84866994988 scopus 로고    scopus 로고
    • Defects in androgen biosynthesis causing 46, XY disorders of sexual development
    • doi:10.1055/s-0032-1324726
    • Auchus RJ & Miller WL 2012 Defects in androgen biosynthesis causing 46, XY disorders of sexual development. Seminars in Reproductive Medicine 30 417-426. (doi:10.1055/s-0032-1324726)
    • (2012) Seminars in Reproductive Medicine , vol.30 , pp. 417-426
    • Auchus, R.J.1    Miller, W.L.2
  • 11
    • 0036545464 scopus 로고    scopus 로고
    • Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia
    • doi:10.1007/s00345-002-0248-5
    • Bartsch G, Rittmaster RS & Klocker H 2002 Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia. World Journal of Urology 19 413-425. (doi:10.1007/s00345-002-0248-5)
    • (2002) World Journal of Urology , vol.19 , pp. 413-425
    • Bartsch, G.1    Rittmaster, R.S.2    Klocker, H.3
  • 12
    • 33751509661 scopus 로고    scopus 로고
    • Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer
    • doi:10.1210/en.2006-0627
    • Bauman DR, Steckelbroeck S, Peehl DM & Penning TM 2006α Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer. Endocrinology 147 5806-5816. (doi:10.1210/en.2006-0627)
    • (2006) Endocrinology , vol.147 , pp. 5806-5816
    • Bauman, D.R.1    Steckelbroeck, S.2    Peehl, D.M.3    Penning, T.M.4
  • 13
    • 31444440675 scopus 로고    scopus 로고
    • Identification of the major oxidative 3α-hydroxysteroid dehydrogenase in human prostate that converts 5α-andostane-3α, 17β-diol to 5α-dihydrotestosterone. A potential therapeutic target for androgen dependent disease
    • doi:10.1210/ me.2005-0287
    • Bauman D, Steckelbroeck S, Williams MV, Peehl DM & Penning TM 2006b Identification of the major oxidative 3α-hydroxysteroid dehydrogenase in human prostate that converts 5α-andostane-3α,17β-diol to 5α-dihydrotestosterone. A potential therapeutic target for androgen dependent disease. Molecular Endocrinology 20 444-458. (doi:10.1210/ me.2005-0287)
    • (2006) Molecular Endocrinology , vol.20 , pp. 444-458
    • Bauman, D.1    Steckelbroeck, S.2    Williams, M.V.3    Peehl, D.M.4    Penning, T.M.5
  • 14
    • 54049128964 scopus 로고    scopus 로고
    • 17α-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response
    • doi:10.1158/1535-7163.MCT-08-0336
    • Bruno R, Gover TD, Burger AM, Brodie AM & Njar VC 2008 17α-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response. Molecular Cancer Therapeutics 7 2828-2836. (doi:10.1158/1535-7163.MCT-08-0336)
    • (2008) Molecular Cancer Therapeutics , vol.7 , pp. 2828-2836
    • Bruno, R.1    Gover, T.D.2    Burger, A.M.3    Brodie, A.M.4    Njar, V.C.5
  • 16
    • 79957722662 scopus 로고    scopus 로고
    • Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): Overview and structural insights
    • doi:10.1016/j.jsbmb.2010.11.004
    • Byrns M, Jin Y & Penning TM 2011 Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights. Journal of Steroid Biochemistry and Molecular Biology 125 95-104. (doi:10.1016/j.jsbmb.2010.11.004)
    • (2011) Journal of Steroid Biochemistry and Molecular Biology , vol.125 , pp. 95-104
    • Byrns, M.1    Jin, Y.2    Penning, T.M.3
  • 17
    • 84858036972 scopus 로고    scopus 로고
    • Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride
    • doi:10.1016/j.jsbmb.2011.12.012
    • Byrns M, Mindnich R, Duan L & Penning TM 2012 Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride. Journal of Steroid Biochemistry and Molecular Biology 130 7-15. (doi:10.1016/j.jsbmb.2011.12.012)
    • (2012) Journal of Steroid Biochemistry and Molecular Biology , vol.130 , pp. 7-15
    • Byrns, M.1    Mindnich, R.2    Duan, L.3    Penning, T.M.4
  • 18
    • 80054021222 scopus 로고    scopus 로고
    • Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    • doi:10.1158/0008-5472.CAN-11-0532
    • Cai C, Chen S, Ng P, Bubley GJ, Nelson PS, Mostaghel EA, Marck B, Matsumoto AM, Simon NI, Wang H et al. 2011 Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Research 71 6503-6513. (doi:10.1158/0008-5472.CAN-11-0532)
    • (2011) Cancer Research , vol.71 , pp. 6503-6513
    • Cai, C.1    Chen, S.2    Ng, P.3    Bubley, G.J.4    Nelson, P.S.5    Mostaghel, E.A.6    Marck, B.7    Matsumoto, A.M.8    Simon, N.I.9    Wang, H.10
  • 19
    • 77955057089 scopus 로고    scopus 로고
    • SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder
    • doi:10.1016/ j.cell.2010.06.001
    • Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E et al. 2010 SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142 203-217. (doi:10.1016/ j.cell.2010.06.001)
    • (2010) Cell , vol.142 , pp. 203-217
    • Cantagrel, V.1    Lefeber, D.J.2    Ng, B.G.3    Guan, Z.4    Silhavy, J.L.5    Bielas, S.L.6    Lehle, L.7    Hombauer, H.8    Adamowicz, M.9    Swiezewska, E.10
  • 21
    • 85047676302 scopus 로고    scopus 로고
    • Expression of different 17β-hydroxysteroid dehydrogenase types and their activities in human prostate cancer cells
    • doi:10.1210/endo.138.11.5497
    • Castagnetta LA, Carruba G, Traina A, Granata OM, Markus M, Pavone-Macaluso M, Blomquist CH & Adamski J 1997 Expression of different 17β-hydroxysteroid dehydrogenase types and their activities in human prostate cancer cells. Endocrinology 138 4876-4882. (doi:10.1210/endo.138.11. 5497)
    • (1997) Endocrinology , vol.138 , pp. 4876-4882
    • Castagnetta, L.A.1    Carruba, G.2    Traina, A.3    Granata, O.M.4    Markus, M.5    Pavone-Macaluso, M.6    Blomquist, C.H.7    Adamski, J.8
  • 22
    • 80051963331 scopus 로고    scopus 로고
    • Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
    • doi:10.1073/pnas.1107898108
    • Chang K-H, Li R, Papari-Zareei M, Watumull L, Zhao YD, Auchus RJ & Sharifi N 2011 Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer. PNAS 108 13728-13733. (doi:10.1073/pnas. 1107898108)
    • (2011) PNAS , vol.108 , pp. 13728-13733
    • Chang, K.-H.1    Li, R.2    Papari-Zareei, M.3    Watumull, L.4    Zhao, Y.D.5    Auchus, R.J.6    Sharifi, N.7
  • 23
    • 84883367616 scopus 로고    scopus 로고
    • A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer
    • doi:10.1016/j.cell.2013.07.029
    • Chang K-H, Li R, Kuri B, Lotan Y, Roehrborn CG, Liu J, Vessella R, Nelson R, Kapur P, Guo X et al. 2013 A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer. Cell 154 1074-1084. (doi:10.1016/j.cell. 2013.07.029)
    • (2013) Cell , vol.154 , pp. 1074-1084
    • Chang, K.-H.1    Li, R.2    Kuri, B.3    Lotan, Y.4    Roehrborn, C.G.5    Liu, J.6    Vessella, R.7    Nelson, R.8    Kapur, P.9    Guo, X.10
  • 24
    • 84860493930 scopus 로고    scopus 로고
    • Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
    • doi:10.1016/j.bmcl.2012.03.085
    • Chen M, Adeniji AO, Twenter BM, Winkler JD, Christianson DW & Penning TM 2012 Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer. Bioorganic and Medicinal Chemistry Letters 22 3492-3497. (doi:10.1016/j.bmcl.2012.03.085)
    • (2012) Bioorganic and Medicinal Chemistry Letters , vol.22 , pp. 3492-3497
    • Chen, M.1    Adeniji, A.O.2    Twenter, B.M.3    Winkler, J.D.4    Christianson, D.W.5    Penning, T.M.6
  • 25
    • 0012293592 scopus 로고
    • Cytochrome P450c17 (steroid 17 α-hydroxylase/17,20 lyase): Cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues
    • doi:10.1073/ pnas.84.2.407
    • Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE & Miller WL 1987 Cytochrome P450c17 (steroid 17 α-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues. PNAS 84 407-411. (doi:10.1073/ pnas.84.2.407)
    • (1987) PNAS , vol.84 , pp. 407-411
    • Chung, B.C.1    Picado-Leonard, J.2    Haniu, M.3    Bienkowski, M.4    Hall, P.F.5    Shively, J.E.6    Miller, W.L.7
  • 27
    • 84856477784 scopus 로고    scopus 로고
    • Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001
    • doi:10.1038/nature10743
    • DeVore NM & Scott EE 2012 Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001. Nature 482 116-119. (doi:10.1038/nature10743)
    • (2012) Nature , vol.482 , pp. 116-119
    • DeVore, N.M.1    Scott, E.E.2
  • 28
    • 84865469114 scopus 로고    scopus 로고
    • Crystal structures of three classes of non-steroidal antiinflammatory drugs in complex with aldo-keto reductase 1C3
    • doi:10.1371/journal.pone.0043965
    • Flanagan JU, Yosaatmadja Y, Teague RM, Chai MZ, Turnbull AP & Squire CJ 2012 Crystal structures of three classes of non-steroidal antiinflammatory drugs in complex with aldo-keto reductase 1C3. PLoS ONE 7 e43965. (doi:10.1371/journal.pone.0043965)
    • (2012) PLoS ONE , vol.7
    • Flanagan, J.U.1    Yosaatmadja, Y.2    Teague, R.M.3    Chai, M.Z.4    Turnbull, A.P.5    Squire, C.J.6
  • 29
    • 80051664435 scopus 로고    scopus 로고
    • Why boys will be boys: Two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation
    • doi:10.1016/j.ajhg.2011.06.009
    • Fluck C, Meyer-Boni M, Pandey AV, Kempna P, Miller WL, Schoenle EJ & Biason-Lauber A 2011 Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation. American Journal of Human Genetics 89 201-218. (doi:10.1016/j.ajhg.2011.06.009)
    • (2011) American Journal of Human Genetics , vol.89 , pp. 201-218
    • Fluck, C.1    Meyer-Boni, M.2    Pandey, A.V.3    Kempna, P.4    Miller, W.L.5    Schoenle, E.J.6    Biason-Lauber, A.7
  • 30
    • 33646127626 scopus 로고    scopus 로고
    • Discovery and clinical development of dutasteride, a potent dual 5a-reductase inhibitor
    • doi:10.2174/156802606776743101
    • Frye SV 2006 Discovery and clinical development of dutasteride, a potent dual 5a-reductase inhibitor. Current Topics in Medicinal Chemistry 6 405-421. (doi:10.2174/156802606776743101)
    • (2006) Current Topics in Medicinal Chemistry , vol.6 , pp. 405-421
    • Frye, S.V.1
  • 31
    • 33645987281 scopus 로고    scopus 로고
    • Increased expression of type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with the androgen receptor in prostate carcinoma
    • doi:10.1677/erc.1.01048
    • Fung K-M, Shea-Samara EH, Wong C, Krin R, Jones AM, Bane B, Liu CZ, Yang JT, Pitha JV, Culkin DJ et al. 2006 Increased expression of type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with the androgen receptor in prostate carcinoma. Endocrine-Related Cancer 13 169-180. (doi:10.1677/erc.1. 01048)
    • (2006) Endocrine-Related Cancer , vol.13 , pp. 169-180
    • Fung, K.-M.1    Shea-Samara, E.H.2    Wong, C.3    Krin, R.4    Jones, A.M.5    Bane, B.6    Liu, C.Z.7    Yang, J.T.8    Pitha, J.V.9    Culkin, D.J.10
  • 33
    • 84890285742 scopus 로고    scopus 로고
    • Androgen glucuronidation: An unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications
    • doi:10.1158/0008-5472.CAN-13-1462
    • Grosse L, Pâquet S, Caron P, Fazli L, Rennie PS, Bélanger A & Barbier O 2013 Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications. Cancer Research 73 6963-6971. (doi:10.1158/0008-5472.CAN-13-1462)
    • (2013) Cancer Research , vol.73 , pp. 6963-6971
    • Grosse, L.1    Pâquet, S.2    Caron, P.3    Fazli, L.4    Rennie, P.S.5    Bélanger, A.6    Barbier, O.7
  • 34
    • 20444457578 scopus 로고    scopus 로고
    • The androgen derivative 5α-androstane-3β,17β-diol inhibits prostate cancer cell migration through activation of the estrogen receptor β subtype
    • doi:10.1158/0008-5472.CAN-04-1941
    • Guerini V, Sau D, Scaccianoce E, Rusmini P, Ciana P, Maggi A, Martini PG, Katzenellenbogen BS, Martini L, Motta M et al. 2005 The androgen derivative 5α-androstane-3β,17β-diol inhibits prostate cancer cell migration through activation of the estrogen receptor β subtype. Cancer Research 65 5445-5453. (doi:10.1158/0008-5472.CAN-04-1941)
    • (2005) Cancer Research , vol.65 , pp. 5445-5453
    • Guerini, V.1    Sau, D.2    Scaccianoce, E.3    Rusmini, P.4    Ciana, P.5    Maggi, A.6    Martini, P.G.7    Katzenellenbogen, B.S.8    Martini, L.9    Motta, M.10
  • 35
    • 0030991972 scopus 로고    scopus 로고
    • Differential regulation of two uridine diphospho- glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells
    • doi:10.1210/endo.138.7.5226
    • Guillemette C, Lévesque E, Beaulieu M, Turgeon D, Hum DW & Bélanger A 1997 Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells. Endocrinology 138 2998-3005. (doi:10.1210/endo.138.7.5226)
    • (1997) Endocrinology , vol.138 , pp. 2998-3005
    • Guillemette, C.1    Lévesque, E.2    Beaulieu, M.3    Turgeon, D.4    Hum, D.W.5    Bélanger, A.6
  • 36
    • 84872256884 scopus 로고    scopus 로고
    • Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castrationresistant prostate cancer
    • doi:10.2119/molmed.2012.00296
    • Hamid A, Pfeiffer MJ, Verhaegh GW, Schaafsma E, Brandt A, Sweep FC, Sedelaar JP & Schalken JA 2012 Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castrationresistant prostate cancer. Molecular Medicine 18 1449-1455. (doi:10.2119/molmed.2012.00296)
    • (2012) Molecular Medicine , vol.18 , pp. 1449-1455
    • Hamid, A.1    Pfeiffer, M.J.2    Verhaegh, G.W.3    Schaafsma, E.4    Brandt, A.5    Sweep, F.C.6    Sedelaar, J.P.7    Schalken, J.A.8
  • 37
    • 34548099697 scopus 로고    scopus 로고
    • Determination of prostatic androgens in 10 mg of tissue using liquid chromatography-tandem mass spectrometry with charged derivatization
    • doi:10.1007/s00216-005-3233-1
    • Higashi T, Yamauchi A, Shimada K, Koh E, Mizokami A & Namiki M 2005 Determination of prostatic androgens in 10 mg of tissue using liquid chromatography-tandem mass spectrometry with charged derivatization. Analytical and Bioanalytical Chemistry 382 1035-1043. (doi:10.1007/s00216-005-3233-1)
    • (2005) Analytical and Bioanalytical Chemistry , vol.382 , pp. 1035-1043
    • Higashi, T.1    Yamauchi, A.2    Shimada, K.3    Koh, E.4    Mizokami, A.5    Namiki, M.6
  • 38
    • 33749998934 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometric assay of androstenediol in prostatic tissue: Influence of androgen deprivation therapy on its level
    • doi:10.1016/j.steroids.2006.08.003
    • Higashi T, Takayama N, Kyutoku M, Shimada K, Koh E & Namiki M 2006 Liquid chromatography-mass spectrometric assay of androstenediol in prostatic tissue: influence of androgen deprivation therapy on its level. Steroids 71 1007-1013. (doi:10.1016/j.steroids.2006.08.003)
    • (2006) Steroids , vol.71 , pp. 1007-1013
    • Higashi, T.1    Takayama, N.2    Kyutoku, M.3    Shimada, K.4    Koh, E.5    Namiki, M.6
  • 40
    • 84863979005 scopus 로고    scopus 로고
    • Distinct transcriptional programsmediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
    • doi:10.1158/0008-5472.CAN-11-3892
    • Hu R, Lu C, Mostaghel EA, Yegnasubramanian S, Gurel M, Tannahill C, Edwards J, Isaacs WB, Nelson PS, Bluemn E et al. 2012 Distinct transcriptional programsmediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Research 72 3457-3462. (doi:10.1158/0008-5472.CAN-11-3892)
    • (2012) Cancer Research , vol.72 , pp. 3457-3462
    • Hu, R.1    Lu, C.2    Mostaghel, E.A.3    Yegnasubramanian, S.4    Gurel, M.5    Tannahill, C.6    Edwards, J.7    Isaacs, W.B.8    Nelson, P.S.9    Bluemn, E.10
  • 41
    • 0013794946 scopus 로고
    • Two principles in endocrine therapy of cancers: Hormone deprival and hormone interference
    • Huggins CB 1965 Two principles in endocrine therapy of cancers: hormone deprival and hormone interference. Cancer Research 25 1163-1167.
    • (1965) Cancer Research , vol.25 , pp. 1163-1167
    • Huggins, C.B.1
  • 42
    • 84928580276 scopus 로고
    • Studies on prostatic cancer 1. Effect of castration, estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins CB & Hodges CV 1941 Studies on prostatic cancer 1. Effect of castration, estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Research 1 293-397.
    • (1941) Cancer Research , vol.1 , pp. 293-397
    • Huggins, C.B.1    Hodges, C.V.2
  • 43
    • 33751096178 scopus 로고    scopus 로고
    • Multiple steps determine the overall rate of the reduction of 5α-dihydrotestosterone catalyzed by human type 3 3α-hydroxysteroid dehydrogenase: Implications for the elimination of androgens
    • doi:10.1021/bi060591r
    • Jin Y & Penning TM 2006 Multiple steps determine the overall rate of the reduction of 5α-dihydrotestosterone catalyzed by human type 3 3α-hydroxysteroid dehydrogenase: implications for the elimination of androgens. Biochemistry 45 13054-13063. (doi:10.1021/bi060591r)
    • (2006) Biochemistry , vol.45 , pp. 13054-13063
    • Jin, Y.1    Penning, T.M.2
  • 44
    • 0035964182 scopus 로고    scopus 로고
    • Crystal structure of human type III 3α-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADPC and ursodeoxycholate
    • doi:10.1021/bi010919a
    • Jin Y, Stayrook SE, Albert RH, Palackal NT, Penning TM & Lewis M 2001 Crystal structure of human type III 3α-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADPC and ursodeoxycholate. Biochemistry 40 10161-10168. (doi:10.1021/bi010919a)
    • (2001) Biochemistry , vol.40 , pp. 10161-10168
    • Jin, Y.1    Stayrook, S.E.2    Albert, R.H.3    Palackal, N.T.4    Penning, T.M.5    Lewis, M.6
  • 45
    • 0026033434 scopus 로고
    • Use of the nonsteroidal anti-androgen Casodex in advanced prostatic carcinoma
    • Kennealey GT & Furr BJ 1991 Use of the nonsteroidal anti-androgen Casodex in advanced prostatic carcinoma. Urologic Clinics of North America 18 99-110.
    • (1991) Urologic Clinics of North America , vol.18 , pp. 99-110
    • Kennealey, G.T.1    Furr, B.J.2
  • 46
    • 77952554163 scopus 로고    scopus 로고
    • Partners in crime: Deregulation of AR activity and androgen synthesis in prostate cancer
    • doi:10.1016/j.tem.2010.01.002
    • Knudsen K & Penning TM 2010 Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer. Trends in Endocrinology and Metabolism 21 315-324. (doi:10.1016/j.tem.2010.01.002)
    • (2010) Trends in Endocrinology and Metabolism , vol.21 , pp. 315-324
    • Knudsen, K.1    Penning, T.M.2
  • 50
    • 84863304593 scopus 로고    scopus 로고
    • Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: A rationale for increasing drug exposure in castration-resistant prostate cancer
    • doi:10.1158/1078-0432.CCR-12-0908
    • Li R, Evaul K, Sharma KK, Chang KH, Yoshimoto J, Liu J, Auchus RJ & Sharifi N 2012 Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer. Clinical Cancer Research 18 3571-3579. (doi:10.1158/1078-0432.CCR-12-0908)
    • (2012) Clinical Cancer Research , vol.18 , pp. 3571-3579
    • Li, R.1    Evaul, K.2    Sharma, K.K.3    Chang, K.H.4    Yoshimoto, J.5    Liu, J.6    Auchus, R.J.7    Sharifi, N.8
  • 51
    • 84875751054 scopus 로고    scopus 로고
    • Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer
    • doi:10.1021/jm3017656
    • Liedtke AJ, Adeniji AO, Chen M, Byrns MC, Jin Y, Christianson DW, Marnett LJ & Penning TM 2013 Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. Journal of Medicinal Chemistry 56 2429-2446. (doi:10.1021/jm3017656)
    • (2013) Journal of Medicinal Chemistry , vol.56 , pp. 2429-2446
    • Liedtke, A.J.1    Adeniji, A.O.2    Chen, M.3    Byrns, M.C.4    Jin, Y.5    Christianson, D.W.6    Marnett, L.J.7    Penning, T.M.8
  • 52
    • 0030784509 scopus 로고    scopus 로고
    • Expression and characterization of recombinant type 2 3α-hydroxysteroid dehydrogenase (HSD) from human prostate: Demonstration of bifunctional 3α/17β-HSD activity and cellular distribution
    • doi:10.1210/mend.11.13.0026
    • Lin H-K, Jez JM, Schlegel BP, Peehl DM, Pachter JA & Penning TM 1997 Expression and characterization of recombinant type 2 3α-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3α/17β-HSD activity and cellular distribution. Molecular Endocrinology 11 1971-1984. (doi:10.1210/mend.11.13.0026)
    • (1997) Molecular Endocrinology , vol.11 , pp. 1971-1984
    • Lin, H.-K.1    Jez, J.M.2    Schlegel, B.P.3    Peehl, D.M.4    Pachter, J.A.5    Penning, T.M.6
  • 53
    • 9944264069 scopus 로고    scopus 로고
    • Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3α-hydroxysteroid dehydrogenase/type 5 17β- hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate
    • doi:10.1016/j.steroids.2004.09.014
    • Lin HK, Steckelbroeck S, Fung KM, Jones AN & Penning TM 2004 Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate. Steroids 69 795-801. (doi:10.1016/j.steroids.2004.09.014)
    • (2004) Steroids , vol.69 , pp. 795-801
    • Lin, H.K.1    Steckelbroeck, S.2    Fung, K.M.3    Jones, A.N.4    Penning, T.M.5
  • 54
    • 84927652789 scopus 로고    scopus 로고
    • Safety, tolerability and anti-tumor activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: Multi-centre phase I/II study
    • In Press. (doi:10.1007/s10637-014-0101-x)
    • Loriot Y, Fizazi K, Jones RJ, Van den Brande J, Molife RL, Omlin A, James ND, Baskin-Bey E, Heeringa M, Baron B et al. 2014 Safety, tolerability and anti-tumor activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study. Investigational New Drugs (In Press). (doi:10.1007/s10637-014-0101-x)
    • (2014) Investigational New Drugs
    • Loriot, Y.1    Fizazi, K.2    Jones, R.J.3    Van Den Brande, J.4    Molife, R.L.5    Omlin, A.6    James, N.D.7    Baskin-Bey, E.8    Heeringa, M.9    Baron, B.10
  • 55
    • 1642357433 scopus 로고    scopus 로고
    • 2 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin
    • doi:10.1158/0008-5472.CAN-03-2847
    • 2 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Research 64 1802-1810. (doi:10.1158/0008-5472.CAN-03-2847)
    • (2004) Cancer Research , vol.64 , pp. 1802-1810
    • Lovering, A.L.1    Ride, J.P.2    Bunce, C.M.3    Desmond, J.C.4    Cummings, S.M.5    White, S.A.6
  • 56
    • 0024375357 scopus 로고
    • Full length cDNA structure and deduced amino acid sequence of human 3 β-hydroxy-5-ene steroid dehydrogenase
    • doi:10.1210/mend-3-8-1310
    • Luu The V, Lachance Y, Labrie C, Leblanc G, Thomas JL, Strickler RC & Labrie F 1989 Full length cDNA structure and deduced amino acid sequence of human 3 β-hydroxy-5-ene steroid dehydrogenase. Molecular Endocrinology 3 1310-1312. (doi:10.1210/mend-3-8-1310)
    • (1989) Molecular Endocrinology , vol.3 , pp. 1310-1312
    • Luu The, V.1    Lachance, Y.2    Labrie, C.3    Leblanc, G.4    Thomas, J.L.5    Strickler, R.C.6    Labrie, F.7
  • 57
    • 84870336847 scopus 로고    scopus 로고
    • Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors
    • doi:10.1158/0008-5472.CAN-12-1335
    • Mitsiades N, Sung CC, Schultz N, Danila DC, He B, Eedunuri VK, Fleisher M, Sander C, Sawyers CL & Scher HI 2012 Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors. Cancer Research 72 6142-6152. (doi:10.1158/0008-5472.CAN-12-1335)
    • (2012) Cancer Research , vol.72 , pp. 6142-6152
    • Mitsiades, N.1    Sung, C.C.2    Schultz, N.3    Danila, D.C.4    He, B.5    Eedunuri, V.K.6    Fleisher, M.7    Sander, C.8    Sawyers, C.L.9    Scher, H.I.10
  • 58
    • 80052846905 scopus 로고    scopus 로고
    • Potential prostate cancer drug target: Bioactivation of androstanediol by conversion to dihydrotestosterone
    • doi:10.1158/1078-0432.CCR-11-0644
    • Mohler JL, Titus MA & Wilson EM 2011 Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone. Clinical Cancer Research 17 5844-5849. (doi:10.1158/1078-0432.CCR-11-0644)
    • (2011) Clinical Cancer Research , vol.17 , pp. 5844-5849
    • Mohler, J.L.1    Titus, M.A.2    Wilson, E.M.3
  • 59
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    • doi:10.1158/0008-5472.CAN-08-0249
    • Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higian CS, True LD & Nelson PS 2008 Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Research 68 4447-4454. (doi:10.1158/0008-5472.CAN-08-0249)
    • (2008) Cancer Research , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5    Higian, C.S.6    True, L.D.7    Nelson, P.S.8
  • 60
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castrate-resistance prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
    • doi:10.1158/1078-0432.CCR-11-0728
    • Mostaghel EA, March BT, Plymate SR, Vessella RL, Balk S, Mastsumoto AM, Nelson PS & Montgomery RB 2011 Resistance to CYP17A1 inhibition with abiraterone in castrate-resistance prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clinical Cancer Research 17 5913-5925. (doi:10.1158/1078-0432.CCR-11-0728)
    • (2011) Clinical Cancer Research , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1    March, B.T.2    Plymate, S.R.3    Vessella, R.L.4    Balk, S.5    Mastsumoto, A.M.6    Nelson, P.S.7    Montgomery, R.B.8
  • 61
    • 80052528869 scopus 로고    scopus 로고
    • Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer
    • doi:10.1210/jc.2011-1049
    • Nadeau G, Bellemare J, Audet-Walsh É, Flageole C, Huang SP, Bao BY, Douville P, Caron P, Fradet Y, Lacombe L et al. 2011 Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer. Journal of Clinical Endocrinology and Metabolism 96 1550-1557. (doi:10.1210/jc.2011-1049)
    • (2011) Journal of Clinical Endocrinology and Metabolism , vol.96 , pp. 1550-1557
    • Nadeau, G.1    Bellemare, J.2    Audet-Walsh, É.3    Flageole, C.4    Huang, S.P.5    Bao, B.Y.6    Douville, P.7    Caron, P.8    Fradet, Y.9    Lacombe, L.10
  • 62
    • 0019887951 scopus 로고
    • Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of a C21 steroid side-chain cleavage system (17 α-hydroxylase- C17,20 lyase)
    • Nakajin S & Hall PF 1981 Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of a C21 steroid side-chain cleavage system (17 α-hydroxylase-C17,20 lyase). Journal of Biological Chemistry 256 3871-3876.
    • (1981) Journal of Biological Chemistry , vol.256 , pp. 3871-3876
    • Nakajin, S.1    Hall, P.F.2
  • 63
    • 0019874673 scopus 로고
    • Microsomal cytochrome P-450 from neonatal pig testis: Two enzymatic activities (17α-hydroxylase and c17,20-lyase) associated with one protein
    • doi:10.1021/bi00517a014
    • Nakajin S, Shively JE, Yuan PM & Hall PF 1981 Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17α-hydroxylase and c17,20-lyase) associated with one protein. Biochemistry 20 4037-4042. (doi:10.1021/bi00517a014)
    • (1981) Biochemistry , vol.20 , pp. 4037-4042
    • Nakajin, S.1    Shively, J.E.2    Yuan, P.M.3    Hall, P.F.4
  • 64
    • 0032587401 scopus 로고    scopus 로고
    • Inhibitors of 17α-hydroxylase/17,20-lyase (CYP17): Potential agents for the treatment of prostate cancer
    • Njar VC & Brodie AM 1999 Inhibitors of 17α-hydroxylase/17,20- lyase (CYP17): potential agents for the treatment of prostate cancer. Current Pharmaceutical Design 5 163-180. (Pubitemid 29159609)
    • (1999) Current Pharmaceutical Design , vol.5 , Issue.3 , pp. 163-180
    • Njar, V.C.O.1    Brodie, A.M.H.2
  • 65
    • 0034287545 scopus 로고    scopus 로고
    • Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
    • doi:10.1042/0264-6021:3510067
    • Penning TM, Burczynski ME, Jez JM, Hung C-F, Lin H-K, Ma H, Moore M, Palackal N & Ratnam K 2000 Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Biochemical Journal 351 67-77. (doi:10.1042/0264-6021:3510067)
    • (2000) Biochemical Journal , vol.351 , pp. 67-77
    • Penning, T.M.1    Burczynski, M.E.2    Jez, J.M.3    Hung, C.-F.4    Lin, H.-K.5    Ma, H.6    Moore, M.7    Palackal, N.8    Ratnam, K.9
  • 66
    • 79960738374 scopus 로고    scopus 로고
    • Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer
    • doi:10.2119/molmed.2010.00143
    • Pfeiffer MJ, Smit FP, Sedelaar JP & Schalken JA 2011 Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer. Molecular Medicine 17 657-664. (doi:10.2119/molmed.2010.00143)
    • (2011) Molecular Medicine , vol.17 , pp. 657-664
    • Pfeiffer, M.J.1    Smit, F.P.2    Sedelaar, J.P.3    Schalken, J.A.4
  • 67
    • 0029114308 scopus 로고
    • Inactivation of steroid sulfatase by an active site-directed inhibitor, estrone-3-O-sulfamate
    • doi:10.1021/ bi00036a025
    • Purohit A, Williams GJ, Howarth NM, Potter BV & Reed MJ 1995 Inactivation of steroid sulfatase by an active site-directed inhibitor, estrone-3-O-sulfamate. Biochemistry 34 11508-11514. (doi:10.1021/ bi00036a025)
    • (1995) Biochemistry , vol.34 , pp. 11508-11514
    • Purohit, A.1    Williams, G.J.2    Howarth, N.M.3    Potter, B.V.4    Reed, M.J.5
  • 68
    • 0029904709 scopus 로고    scopus 로고
    • In vivo activity of 4-methylcoumarin-7-O-sulfamate, a nonsteroidal, nonestrogenic steroid sulfatase inhibitor
    • Purohit A, Woo LW, Singh A, Winterborn CJ, Potter BV & Reed MJ 1996 In vivo activity of 4-methylcoumarin-7-O-sulfamate, a nonsteroidal, nonestrogenic steroid sulfatase inhibitor. Cancer Research 56 4950-4955. (Pubitemid 26374434)
    • (1996) Cancer Research , vol.56 , Issue.21 , pp. 4950-4955
    • Purohit, A.1    Woo, L.W.L.2    Singh, A.3    Winterborn, C.J.4    Potter, B.V.L.5    Reed, M.J.6
  • 70
    • 0026893712 scopus 로고
    • Congenital adrenal hyperplasia due to point mutations in the type II 3 β-hydroxysteroid dehydrogenase gene
    • doi:10.1038/ng0792-239
    • Rheaume E, Simard J, Morel Y, Mebarki F, Zachmann M, Forest MG, New MI & Labrie F 1992 Congenital adrenal hyperplasia due to point mutations in the type II 3 β-hydroxysteroid dehydrogenase gene. Nature Genetics 1 239-245. (doi:10.1038/ng0792-239)
    • (1992) Nature Genetics , vol.1 , pp. 239-245
    • Rheaume, E.1    Simard, J.2    Morel, Y.3    Mebarki, F.4    Zachmann, M.5    Forest, M.G.6    New, M.I.7    Labrie, F.8
  • 71
    • 0027971610 scopus 로고
    • Molecular basis of congenital adrenal hyperplasia in two siblings with classical nonsalt-losing 3 β-hydroxysteroid dehydrogenase deficiency
    • doi:10.1210/jcem.79.4.7962268
    • Rheaume E, Sanchez R, Simard J, Chang YT, Wang J, Pang S & Labrie F 1994 Molecular basis of congenital adrenal hyperplasia in two siblings with classical nonsalt-losing 3 β-hydroxysteroid dehydrogenase deficiency. Journal of Clinical Endocrinology and Metabolism 79 1012-1018. (doi:10.1210/jcem.79.4.7962268)
    • (1994) Journal of Clinical Endocrinology and Metabolism , vol.79 , pp. 1012-1018
    • Rheaume, E.1    Sanchez, R.2    Simard, J.3    Chang, Y.T.4    Wang, J.5    Pang, S.6    Labrie, F.7
  • 72
    • 84888370246 scopus 로고    scopus 로고
    • Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism
    • doi:10.1016/j.steroids.2013.10.012
    • Rizner TL & Penning TM 2013 Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism. Steroids 79 49-63. (doi:10.1016/j.steroids.2013.10.012)
    • (2013) Steroids , vol.79 , pp. 49-63
    • Rizner, T.L.1    Penning, T.M.2
  • 73
    • 0037661059 scopus 로고    scopus 로고
    • Human type 3 3α-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells
    • doi:10.1210/en.2002-0032
    • Rizner TL, Lin HK, Peehl DM, Steckelbroeck S, Bauman DR & Penning TM 2003 Human type 3 3α-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. Endocrinology 144 2922-2932. (doi:10.1210/en.2002-0032)
    • (2003) Endocrinology , vol.144 , pp. 2922-2932
    • Rizner, T.L.1    Lin, H.K.2    Peehl, D.M.3    Steckelbroeck, S.4    Bauman, D.R.5    Penning, T.M.6
  • 74
    • 0028173882 scopus 로고
    • Steroid 5α-reductase: Two genes/two enzymes
    • doi:10.1146/ annurev.bi.63.070194.000325
    • Russell DW & Wilson JD 1994 Steroid 5α-reductase: two genes/two enzymes. Annual Review of Biochemistry 63 25-61. (doi:10.1146/ annurev.bi.63.070194.000325)
    • (1994) Annual Review of Biochemistry , vol.63 , pp. 25-61
    • Russell, D.W.1    Wilson, J.D.2
  • 77
    • 0018608521 scopus 로고
    • Steroid sulfatase deficiency and X-linked ichthyosis
    • doi:10.1016/S0009-9120(79)80096-X
    • Shapiro LJ 1979 Steroid sulfatase deficiency and X-linked ichthyosis. Clinical Biochemistry 12 205. (doi:10.1016/S0009-9120(79)80096-X)
    • (1979) Clinical Biochemistry , vol.12 , pp. 205
    • Shapiro, L.J.1
  • 78
    • 0021903338 scopus 로고
    • Steroid sulfatase deficiency and the genetics of the short arm of the human X chromosome
    • doi:10.1007/978-1-4615-9400-0-5
    • Shapiro LJ 1985 Steroid sulfatase deficiency and the genetics of the short arm of the human X chromosome. Advances in Human Genetics 14 331-381. (doi:10.1007/978-1-4615-9400-0-5)
    • (1985) Advances in Human Genetics , vol.14 , pp. 331-381
    • Shapiro, L.J.1
  • 79
    • 0029764411 scopus 로고    scopus 로고
    • Leuprolide acetate 22.5 mg 12-week depot formulation in the treatment of patients with advanced prostate cancer
    • doi:10.1016/S0149-2918(96)80215-3
    • Sharifi R, Bruskewitz RC, Gittleman MC, Graham SD Jr, Hudson PB & Stein B 1996 Leuprolide acetate 22.5 mg 12-week depot formulation in the treatment of patients with advanced prostate cancer. Clinical Therapeutics 18 647-657. (doi:10.1016/S0149-2918(96)80215-3)
    • (1996) Clinical Therapeutics , vol.18 , pp. 647-657
    • Sharifi, R.1    Bruskewitz, R.C.2    Gittleman, M.C.3    Graham Jr., S.D.4    Hudson, P.B.5    Stein, B.6
  • 80
    • 33645921663 scopus 로고    scopus 로고
    • Role of the alternate pathway of dihydrotestosterone formation in virilization of the Wolffian ducts of the tammar wallaby, Macropus eugenii
    • doi:10.1210/en.2005-1251
    • Shaw G, Fenelon J, Sichlau M, Auchus RJ, Wilson JD & Renfree MB 2006 Role of the alternate pathway of dihydrotestosterone formation in virilization of the Wolffian ducts of the tammar wallaby, Macropus eugenii. Endocrinology 147 2368-2373. (doi:10.1210/en.2005-1251)
    • (2006) Endocrinology , vol.147 , pp. 2368-2373
    • Shaw, G.1    Fenelon, J.2    Sichlau, M.3    Auchus, R.J.4    Wilson, J.D.5    Renfree, M.B.6
  • 81
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • doi:10.1158/0008-5472.CAN-05-4000
    • Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, Febbo PG & Balk SP 2006 Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Research 66 2815-2825. (doi:10.1158/0008-5472.CAN-05-4000)
    • (2006) Cancer Research , vol.66 , pp. 2815-2825
    • Stanbrough, M.1    Bubley, G.J.2    Ross, K.3    Golub, T.R.4    Rubin, M.A.5    Penning, T.M.6    Febbo, P.G.7    Balk, S.P.8
  • 82
    • 1642305724 scopus 로고    scopus 로고
    • Human cytosolic 3α-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3β-hydroxysteroid dehydrogenase activity: Implications for steroid hormone metabolism and action
    • doi:10.1074/ jbc.M313308200
    • Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B & Penning TM 2004 Human cytosolic 3α-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3β-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. Journal of Biological Chemistry 279 10784-10795. (doi:10.1074/ jbc.M313308200)
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 10784-10795
    • Steckelbroeck, S.1    Jin, Y.2    Gopishetty, S.3    Oyesanmi, B.4    Penning, T.M.5
  • 83
    • 84884518447 scopus 로고    scopus 로고
    • Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum
    • doi:10.1016/j.jsbmb.2013.06.014
    • Tamae D, Byrns M, Marck B, Mostaghel EA, Nelson PS, Lange P, Lin D, Taplin ME, Balk S, Ellis W et al. 2013 Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum. Journal of Steroid Biochemistry and Molecular Biology 138C 281-289. (doi:10.1016/j.jsbmb.2013.06. 014)
    • (2013) Journal of Steroid Biochemistry and Molecular Biology , vol.138 C , pp. 281-289
    • Tamae, D.1    Byrns, M.2    Marck, B.3    Mostaghel, E.A.4    Nelson, P.S.5    Lange, P.6    Lin, D.7    Taplin, M.E.8    Balk, S.9    Ellis, W.10
  • 85
    • 0037044852 scopus 로고    scopus 로고
    • Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3β-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity
    • doi:10.1074/jbc.M208537200
    • Thomas JL, Mason JI, Brandt S, Spencer BR Jr & Norris W 2002a Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3β-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. Journal of Biological Chemistry 277 42795-42801. (doi:10.1074/jbc.M208537200)
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 42795-42801
    • Thomas, J.L.1    Mason, J.I.2    Brandt, S.3    Spencer Jr., B.R.4    Norris, W.5
  • 86
    • 12244280833 scopus 로고    scopus 로고
    • Differences in substrate and inhibitor kinetics of human type 1 and type 2 3β-hydroxysteroid dehydrogenase are explained by the type 1 mutant, H156Y
    • doi:10.1081/ERC-120016825
    • Thomas JL, Mason JI, Brandt S & Norris W 2002b Differences in substrate and inhibitor kinetics of human type 1 and type 2 3β- hydroxysteroid dehydrogenase are explained by the type 1 mutant, H156Y. Endocrine Research 28 471-475. (doi:10.1081/ERC-120016825)
    • (2002) Endocrine Research , vol.28 , pp. 471-475
    • Thomas, J.L.1    Mason, J.I.2    Brandt, S.3    Norris, W.4
  • 91
    • 36949000088 scopus 로고    scopus 로고
    • Novel 5α-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
    • doi:10.1111/j.1349-7006.2007.00656.x
    • Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y & Nakagawa H 2008 Novel 5α-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Science 99 81-86. (doi:10.1111/j.1349-7006.2007.00656.x)
    • (2008) Cancer Science , vol.99 , pp. 81-86
    • Uemura, M.1    Tamura, K.2    Chung, S.3    Honma, S.4    Okuyama, A.5    Nakamura, Y.6    Nakagawa, H.7
  • 93
    • 53349101498 scopus 로고    scopus 로고
    • Androgen receptor inactivation contributes to antitumor efficacy of 17α- hydroxylase/17, 20-lyase inhibitor 3β-hydroxy-17-(1H- benzimidazole-1-yl)androsta-5, 16-diene in prostate cancer
    • doi:10.1158/1535-7163.MCT-08-0230
    • Vasaitis T, Belosay A, Schayowitz A, Khandelwal A, Chopra P, Gediya LK, Guo Z, Fang HB, Njar VC & Brodie AM 2008 Androgen receptor inactivation contributes to antitumor efficacy of 17α- hydroxylase/17, 20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5, 16-diene in prostate cancer. Molecular Cancer Therapeutics 7 2348-2357. (doi:10.1158/1535- 7163.MCT-08-0230)
    • (2008) Molecular Cancer Therapeutics , vol.7 , pp. 2348-2357
    • Vasaitis, T.1    Belosay, A.2    Schayowitz, A.3    Khandelwal, A.4    Chopra, P.5    Gediya, L.K.6    Guo, Z.7    Fang, H.B.8    Njar, V.C.9    Brodie, A.M.10
  • 95
    • 84881373109 scopus 로고    scopus 로고
    • Discovery of 2-methyl- 1-{1-[(5-methyl-1 H-indol-2-yl)carbonyl]piperidin- 4-yl}propan-2-ol: A novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor
    • doi:10.1016/j.bmc.2013.06.025
    • Watanabe K, Kakefuda A, Yasuda M, Enjo K, Kikuchi A, Furutani T, Naritomi Y, Otsuka Y, Okada M & Ohta M 2013 Discovery of 2-methyl- 1-{1-[(5-methyl-1 H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: a novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor. Bioorganic and Medicinal Chemistry 21 5261-5270. (doi:10.1016/j.bmc.2013.06.025)
    • (2013) Bioorganic and Medicinal Chemistry , vol.21 , pp. 5261-5270
    • Watanabe, K.1    Kakefuda, A.2    Yasuda, M.3    Enjo, K.4    Kikuchi, A.5    Furutani, T.6    Naritomi, Y.7    Otsuka, Y.8    Okada, M.9    Ohta, M.10
  • 96
    • 0037317265 scopus 로고    scopus 로고
    • 5α-androstane-3α,17β-diol is formed in tammar wallaby pouch young testes by a pathway involving 5α-pregnane-3α,17α- diol-20-one as a key intermediate
    • doi:10.1210/en.2002-220721
    • Wilson JD, Auchus RJ, Leihy MW, Guryev OL, Estabrook RW, Osborn SM, Shaw G & Renfree MB 2003 5α-androstane-3α,17β-diol is formed in tammar wallaby pouch young testes by a pathway involving 5α-pregnane- 3α,17α-diol-20-one as a key intermediate. Endocrinology 144 575-580. (doi:10.1210/en.2002-220721)
    • (2003) Endocrinology , vol.144 , pp. 575-580
    • Wilson, J.D.1    Auchus, R.J.2    Leihy, M.W.3    Guryev, O.L.4    Estabrook, R.W.5    Osborn, S.M.6    Shaw, G.7    Renfree, M.B.8
  • 97
    • 0023662270 scopus 로고
    • Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: Implications for X-Y interchange
    • doi:10.1016/0092-8674(87) 90447-8
    • Yen PH, Allen E, Marsh B, Mohandas T, Wang N, Taggart RT & Shapiro LJ 1987 Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange. Cell 49 443-454. (doi:10.1016/0092-8674(87) 90447-8)
    • (1987) Cell , vol.49 , pp. 443-454
    • Yen, P.H.1    Allen, E.2    Marsh, B.3    Mohandas, T.4    Wang, N.5    Taggart, R.T.6    Shapiro, L.J.7


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