메뉴 건너뛰기




Volumn 19, Issue 20, 2013, Pages 5613-5625

Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; NUCLEAR RECEPTOR COACTIVATOR; PROTEIN AKR1C3; UNCLASSIFIED DRUG;

EID: 84886413827     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-1151     Document Type: Article
Times cited : (101)

References (32)
  • 1
    • 50449085844 scopus 로고    scopus 로고
    • Optimizing treatment for men with advanced prostate cancer: Expert recommendations and the multidisciplinary approach
    • Fitzpatrick JM, Anderson J, Sternberg CN, Fleshner N, Fizazi K, Rebillard X, et al. Optimizing treatment for men with advanced prostate cancer: expert recommendations and the multidisciplinary approach. Crit Rev Oncol Hematol 2008;68 Suppl 1:S9-22.
    • (2008) Crit Rev Oncol Hematol , vol.68 , Issue.SUPPL. 1
    • Fitzpatrick, J.M.1    Anderson, J.2    Sternberg, C.N.3    Fleshner, N.4    Fizazi, K.5    Rebillard, X.6
  • 2
    • 80755169423 scopus 로고    scopus 로고
    • New and emerging agents for the treatment of castration-resistant prostate cancer
    • Higano CS, Crawford ED. New and emerging agents for the treatment of castration-resistant prostate cancer. Urol Oncol 2011;29:S1-8.
    • (2011) Urol Oncol , vol.29
    • Higano, C.S.1    Crawford, E.D.2
  • 3
    • 79960979238 scopus 로고    scopus 로고
    • Increased androgen receptor transcription: A cause of castration-resistant prostate cancer and a possible therapeutic target
    • Shiota M, Yokomizo A, Naito S. Increased androgen receptor transcription: a cause of castration-resistant prostate cancer and a possible therapeutic target. J Mol Endocrinol 2011;47:R25-41.
    • (2011) J Mol Endocrinol , vol.47
    • Shiota, M.1    Yokomizo, A.2    Naito, S.3
  • 5
    • 58049196759 scopus 로고    scopus 로고
    • Mechanisms mediating androgen receptor reactivation after castration
    • Yuan X, Balk SP. Mechanisms mediating androgen receptor reactivation after castration. Urol Oncol 2009;27:36-41.
    • (2009) Urol Oncol , vol.27 , pp. 36-41
    • Yuan, X.1    Balk, S.P.2
  • 6
    • 79951511609 scopus 로고    scopus 로고
    • Blockade of testicular and adrenal androgens in prostate cancer treatment
    • Labrie F. Blockade of testicular and adrenal androgens in prostate cancer treatment. Nat Rev Urol 2011;8:73-85.
    • (2011) Nat Rev Urol , vol.8 , pp. 73-85
    • Labrie, F.1
  • 8
    • 80054021222 scopus 로고    scopus 로고
    • Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    • Cai C, Chen S, Ng P, Bubley GJ, Nelson PS, Mostaghel EA, et al. Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res 2011;71:6503-13.
    • (2011) Cancer Res , vol.71 , pp. 6503-6513
    • Cai, C.1    Chen, S.2    Ng, P.3    Bubley, G.J.4    Nelson, P.S.5    Mostaghel, E.A.6
  • 9
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res 2006;66:2815-25.
    • (2006) Cancer Res , vol.66 , pp. 2815-2825
    • Stanbrough, M.1    Bubley, G.J.2    Ross, K.3    Golub, T.R.4    Rubin, M.A.5    Penning, T.M.6
  • 11
    • 79957965751 scopus 로고    scopus 로고
    • Inhibitors of aldo-keto reductases AKR1C1-AKR1C4
    • Brozic P, Turk S, Rizner TL, Gobec S. Inhibitors of aldo-keto reductases AKR1C1-AKR1C4. Curr Med Chem 2011;18:2554-65.
    • (2011) Curr Med Chem , vol.18 , pp. 2554-2565
    • Brozic, P.1    Turk, S.2    Rizner, T.L.3    Gobec, S.4
  • 12
  • 14
    • 18044371228 scopus 로고    scopus 로고
    • Androgen receptor-cofactor interactions as targets for new drug discovery
    • ChangCY, McDonnell DP. Androgen receptor-cofactor interactions as targets for new drug discovery. Trends Pharmacol Sci 2005;26:225-8.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 225-228
    • Chang, C.Y.1    McDonnell, D.P.2
  • 15
    • 76549097089 scopus 로고    scopus 로고
    • Discovery and mechanistic characterization of a novel selective nuclear androgen receptor exporter for the treatment of prostate cancer
    • Narayanan R, Yepuru M, Szafran AT, Szwarc M, Bohl CE, Young NL, et al. Discovery and mechanistic characterization of a novel selective nuclear androgen receptor exporter for the treatment of prostate cancer. Cancer Res 2010;70:842-51.
    • (2010) Cancer Res , vol.70 , pp. 842-851
    • Narayanan, R.1    Yepuru, M.2    Szafran, A.T.3    Szwarc, M.4    Bohl, C.E.5    Young, N.L.6
  • 16
    • 78049285751 scopus 로고    scopus 로고
    • IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis
    • Yang CH, Yue J, Fan M, Pfeffer LM. IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis. Cancer Res 2010;70:8108-16.
    • (2010) Cancer Res , vol.70 , pp. 8108-8116
    • Yang, C.H.1    Yue, J.2    Fan, M.3    Pfeffer, L.M.4
  • 17
    • 80655125015 scopus 로고    scopus 로고
    • MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells
    • Yang CH, Yue J, Pfeffer SR, Handorf CR, Pfeffer LM. MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells. J Biol Chem 2011;286:39172-8.
    • (2011) J Biol Chem , vol.286 , pp. 39172-39178
    • Yang, C.H.1    Yue, J.2    Pfeffer, S.R.3    Handorf, C.R.4    Pfeffer, L.M.5
  • 18
    • 55049091779 scopus 로고    scopus 로고
    • Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways
    • Narayanan R, Coss CC, Yepuru M, Kearbey JD, Miller DD, Dalton JT. Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways. Mol Endocrinol 2008;22:2448-65.
    • (2008) Mol Endocrinol , vol.22 , pp. 2448-2465
    • Narayanan, R.1    Coss, C.C.2    Yepuru, M.3    Kearbey, J.D.4    Miller, D.D.5    Dalton, J.T.6
  • 22
    • 33751304953 scopus 로고    scopus 로고
    • Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    • Agoulnik IU, Vaid A, Nakka M, Alvarado M, Bingman WE III, Erdem H, et al. Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. Cancer Res 2006;66:10594-602.
    • (2006) Cancer Res , vol.66 , pp. 10594-10602
    • Agoulnik, I.U.1    Vaid, A.2    Nakka, M.3    Alvarado, M.4    Bingman III, W.E.5    Erdem, H.6
  • 23
    • 3042829462 scopus 로고    scopus 로고
    • Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: Critical androgen regulation in human peripheral tissues
    • Qiu W, Zhou M, Labrie F, Lin SX. Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues. Mol Endocrinol 2004;18: 1798-807.
    • (2004) Mol Endocrinol , vol.18 , pp. 1798-1807
    • Qiu, W.1    Zhou, M.2    Labrie, F.3    Lin, S.X.4
  • 24
    • 59049089110 scopus 로고    scopus 로고
    • Type 5 17beta-hydroxysteroid dehydrogenase/ prostaglandin F synthase (AKR1C3): Role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs
    • Byrns MC, Penning TM. Type 5 17beta-hydroxysteroid dehydrogenase/ prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact 2009;178:221-7.
    • (2009) Chem Biol Interact , vol.178 , pp. 221-227
    • Byrns, M.C.1    Penning, T.M.2
  • 26
    • 0019979722 scopus 로고
    • The role of androgen metabolism in the control of androgen action in the rat prostate
    • Tenniswood M, Bird CE, Clark AF. The role of androgen metabolism in the control of androgen action in the rat prostate. Mol Cell Endocrinol 1982;27:89-96.
    • (1982) Mol Cell Endocrinol , vol.27 , pp. 89-96
    • Tenniswood, M.1    Bird, C.E.2    Clark, A.F.3
  • 27
    • 79955788943 scopus 로고    scopus 로고
    • An ADIOLERbeta-CtBP transrepression pathway negatively regulates microgliamediated inflammation
    • Saijo K, Collier JG, Li AC, Katzenellenbogen JA, Glass CK. An ADIOLERbeta-CtBP transrepression pathway negatively regulates microgliamediated inflammation. Cell 2011;145:584-95.
    • (2011) Cell , vol.145 , pp. 584-595
    • Saijo, K.1    Collier, J.G.2    Li, A.C.3    Katzenellenbogen, J.A.4    Glass, C.K.5
  • 28
    • 80053567168 scopus 로고    scopus 로고
    • The changing therapeutic landscape of castration-resistant prostate cancer
    • Yap TA, Zivi A, Omlin A, de Bono JS. The changing therapeutic landscape of castration-resistant prostate cancer. Nat Rev Clin Oncol 2011;8:597-610.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 597-610
    • Yap, T.A.1    Zivi, A.2    Omlin, A.3    De Bono, J.S.4
  • 29
  • 30
    • 79951838692 scopus 로고    scopus 로고
    • Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer
    • Mohler JL, Titus MA, Bai S, Kennerley BJ, Lih FB, Tomer KB, et al. Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer. Cancer Res 2011;71:1486-96.
    • (2011) Cancer Res , vol.71 , pp. 1486-1496
    • Mohler, J.L.1    Titus, M.A.2    Bai, S.3    Kennerley, B.J.4    Lih, F.B.5    Tomer, K.B.6
  • 31
    • 80052846905 scopus 로고    scopus 로고
    • Potential prostate cancer drug target: Bioactivation of androstanediol by conversion to dihydrotestosterone
    • Mohler JL, TitusMA, Wilson EM. Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone. Clin Cancer Res 2011;17:5844-9.
    • (2011) Clin Cancer Res , vol.17 , pp. 5844-5849
    • Mohler, J.L.1    Titus, M.A.2    Wilson, E.M.3
  • 32
    • 0037439967 scopus 로고    scopus 로고
    • The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the noncyclooxygenase- dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs
    • Desmond JC, Mountford JC, Drayson MT, Walker EA, Hewison M, Ride JP, et al. The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the noncyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs. Cancer Res 2003;63:505-12.
    • (2003) Cancer Res , vol.63 , pp. 505-512
    • Desmond, J.C.1    Mountford, J.C.2    Drayson, M.T.3    Walker, E.A.4    Hewison, M.5    Ride, J.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.