-
1
-
-
0035528888
-
The role of 5alpha-reduction in steroid hormone physiology
-
Wilson JD,. The role of 5alpha-reduction in steroid hormone physiology. Reprod Fertil Dev 2001; 13 (7-8): 673-678.
-
(2001)
Reprod Fertil Dev
, vol.13
, Issue.78
, pp. 673-678
-
-
Wilson, J.D.1
-
2
-
-
33646127626
-
Discovery and clinical development of dutasteride, a potent dual 5alpha-reductase inhibitor
-
Frye SV,. Discovery and clinical development of dutasteride, a potent dual 5alpha-reductase inhibitor. Curr Top Med Chem 2006; 6 (5): 405-421.
-
(2006)
Curr Top Med Chem
, vol.6
, Issue.5
, pp. 405-421
-
-
Frye, S.V.1
-
3
-
-
0025275489
-
Effects of finasteride (MK-906), a 5 alpha-reductase inhibitor, on circulating androgens in male volunteers
-
Gormley GJ, Stoner E, Rittmaster RS, Gregg H, Thompson DL, Lasseter KC, Vlasses PH, Stein EA,. Effects of finasteride (MK-906), a 5 alpha-reductase inhibitor, on circulating androgens in male volunteers. J Clin Endocrinol Metab 1990; 70 (4): 1136-1141.
-
(1990)
J Clin Endocrinol Metab
, vol.70
, Issue.4
, pp. 1136-1141
-
-
Gormley, G.J.1
Stoner, E.2
Rittmaster, R.S.3
Gregg, H.4
Thompson, D.L.5
Lasseter, K.C.6
Vlasses, P.H.7
Stein, E.A.8
-
4
-
-
0345672747
-
Selectivity of finasteride as an in vivo inhibitor of 5alpha-reductase isozyme enzymatic activity in the human prostate
-
Span PN, Voller MC, Smals AG, Sweep FG, Schalken JA, Feneley MR, Kirby RS,. Selectivity of finasteride as an in vivo inhibitor of 5alpha-reductase isozyme enzymatic activity in the human prostate. J Urol 1999; 161 (1): 332-337.
-
(1999)
J Urol
, vol.161
, Issue.1
, pp. 332-337
-
-
Span, P.N.1
Voller, M.C.2
Smals, A.G.3
Sweep, F.G.4
Schalken, J.A.5
Feneley, M.R.6
Kirby, R.S.7
-
5
-
-
2442545242
-
Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor
-
Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S,. Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. J Clin Endocrinol Metab 2004. 89 (5): 2179-2184.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, Issue.5
, pp. 2179-2184
-
-
Clark, R.V.1
Hermann, D.J.2
Cunningham, G.R.3
Wilson, T.H.4
Morrill, B.B.5
Hobbs, S.6
-
6
-
-
52949132642
-
Effect of dutasteride on intraprostatic androgen levels in men with benign prostatic hyperplasia or prostate cancer
-
Rittmaster R, Hahn RG, Ray P, Shannon JB, Wurzel R,. Effect of dutasteride on intraprostatic androgen levels in men with benign prostatic hyperplasia or prostate cancer. Urology 2008; 72 (4): 808-812.
-
(2008)
Urology
, vol.72
, Issue.4
, pp. 808-812
-
-
Rittmaster, R.1
Hahn, R.G.2
Ray, P.3
Shannon, J.B.4
Wurzel, R.5
-
7
-
-
0037812658
-
The influence of finasteride on the development of prostate cancer
-
Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, Lieber MM, Cespedes RD, Atkins JN, Lippman SM, Carlin SM, Ryan A, Szczepanek CM, Crowley JJ, Coltman CAJ,. The influence of finasteride on the development of prostate cancer. N Engl J Med 2003; 349 (3): 215-224.
-
(2003)
N Engl J Med
, vol.349
, Issue.3
, pp. 215-224
-
-
Thompson, I.M.1
Goodman, P.J.2
Tangen, C.M.3
Lucia, M.S.4
Miller, G.J.5
Ford, L.G.6
Lieber, M.M.7
Cespedes, R.D.8
Atkins, J.N.9
Lippman, S.M.10
Carlin, S.M.11
Ryan, A.12
Szczepanek, C.M.13
Crowley, J.J.14
Coltman, C.A.J.15
-
8
-
-
77950498003
-
Effect of dutasteride on the risk of prostate cancer
-
Andriole GL, Bostwick DG, Brawley OW, Gomella LG, Marberger M, Montorsi F, Pettaway CA, Tammela TL, Teloken C, Tindall DJ, Somerville MC, Wilson TH, Fowler IL, Rittmaster RS,. Effect of dutasteride on the risk of prostate cancer. N Engl J Med 2010; 362 (13): 1192-1202.
-
(2010)
N Engl J Med
, vol.362
, Issue.13
, pp. 1192-1202
-
-
Andriole, G.L.1
Bostwick, D.G.2
Brawley, O.W.3
Gomella, L.G.4
Marberger, M.5
Montorsi, F.6
Pettaway, C.A.7
Tammela, T.L.8
Teloken, C.9
Tindall, D.J.10
Somerville, M.C.11
Wilson, T.H.12
Fowler, I.L.13
Rittmaster, R.S.14
-
9
-
-
4143136459
-
Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor regression in prostate cancer
-
Andriole GL, Humphrey P, Ray P, Gleave ME, Trachtenberg J, Thomas LN, Lazier CB, Rittmaster RS,. Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor regression in prostate cancer. J Urol 2004; 172 (3): 915-919.
-
(2004)
J Urol
, vol.172
, Issue.3
, pp. 915-919
-
-
Andriole, G.L.1
Humphrey, P.2
Ray, P.3
Gleave, M.E.4
Trachtenberg, J.5
Thomas, L.N.6
Lazier, C.B.7
Rittmaster, R.S.8
-
10
-
-
77950510825
-
Chemoprevention of prostate cancer
-
Walsh PC,. Chemoprevention of prostate cancer. N Engl J Med 2010; 362 (13): 1237-1238.
-
(2010)
N Engl J Med
, vol.362
, Issue.13
, pp. 1237-1238
-
-
Walsh, P.C.1
-
11
-
-
0028843851
-
Treatment with finasteride following radical prostatectomy for prostate cancer
-
Andriole G, Lieber M, Smith J, Soloway M, Schroeder F, Kadmon D, DeKernion J, Rajfer J, Boake R, Crawford D, Ramsey E, Perreault J, Trachtenberg J, Fradet Y, Block N, Middelton R, Ng J, Ferguson D, Gormley G,. Treatment with finasteride following radical prostatectomy for prostate cancer. Urology 1995; 45 (3): 491-497.
-
(1995)
Urology
, vol.45
, Issue.3
, pp. 491-497
-
-
Andriole, G.1
Lieber, M.2
Smith, J.3
Soloway, M.4
Schroeder, F.5
Kadmon, D.6
Dekernion, J.7
Rajfer, J.8
Boake, R.9
Crawford, D.10
Ramsey, E.11
Perreault, J.12
Trachtenberg, J.13
Fradet, Y.14
Block, N.15
Middelton, R.16
Ng, J.17
Ferguson, D.18
Gormley, G.19
-
12
-
-
58149203191
-
Phase II study of dutasteride for recurrent prostate cancer during androgen deprivation therapy
-
Shah SK, Trump DL, Sartor O, Tan W, Wilding GE, Mohler JL,. Phase II study of dutasteride for recurrent prostate cancer during androgen deprivation therapy. J Urol 2009. 181 (2): 621-626.
-
(2009)
J Urol
, vol.181
, Issue.2
, pp. 621-626
-
-
Shah, S.K.1
Trump, D.L.2
Sartor, O.3
Tan, W.4
Wilding, G.E.5
Mohler, J.L.6
-
13
-
-
0026744010
-
Response of rat and human prostatic cancers to the novel 5 alpha-reductase inhibitor, SK&F 105657
-
Lamb JC, Levy MA, Johnson RK, Isaacs JT,. Response of rat and human prostatic cancers to the novel 5 alpha-reductase inhibitor, SK&F 105657. Prostate 1992; 21 (1): 15-34.
-
(1992)
Prostate
, vol.21
, Issue.1
, pp. 15-34
-
-
Lamb, J.C.1
Levy, M.A.2
Johnson, R.K.3
Isaacs, J.T.4
-
14
-
-
70350441994
-
Effects of the 5 alpha-reductase inhibitor dutasteride on gene expression in prostate cancer xenografts
-
Schmidt LJ, Regan KM, Anderson SK, Sun Z, Ballman KV, Tindall DJ,. Effects of the 5 alpha-reductase inhibitor dutasteride on gene expression in prostate cancer xenografts. Prostate 2009; 69 (16): 1730-1743.
-
(2009)
Prostate
, vol.69
, Issue.16
, pp. 1730-1743
-
-
Schmidt, L.J.1
Regan, K.M.2
Anderson, S.K.3
Sun, Z.4
Ballman, K.V.5
Tindall, D.J.6
-
15
-
-
33746047132
-
Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
-
Xu Y, Dalrymple SL, Becker RE, Denmeade SR, Isaacs JT,. Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Clin Cancer Res 2006; 12 (13): 4072-4079.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.13
, pp. 4072-4079
-
-
Xu, Y.1
Dalrymple, S.L.2
Becker, R.E.3
Denmeade, S.R.4
Isaacs, J.T.5
-
16
-
-
0034750057
-
Unexpected virilization in male mice lacking steroid 5 alpha-reductase enzymes
-
Mahendroo MS, Cala KM, Hess DL, Russell DW,. Unexpected virilization in male mice lacking steroid 5 alpha-reductase enzymes. Endocrinology 2001; 142 (11): 4652-4662.
-
(2001)
Endocrinology
, vol.142
, Issue.11
, pp. 4652-4662
-
-
Mahendroo, M.S.1
Cala, K.M.2
Hess, D.L.3
Russell, D.W.4
-
17
-
-
79955796493
-
5alpha-Reductase type 3 expression in human benign and malignant tissues: A comparative analysis during prostate cancer progression
-
Godoy A, Kawinski E, Li Y, Oka D, Alexiev B, Azzouni F, Titus MA, Mohler JL,. 5alpha-Reductase type 3 expression in human benign and malignant tissues: A comparative analysis during prostate cancer progression. Prostate 2011; 71 (10): 1033-1046.
-
(2011)
Prostate
, vol.71
, Issue.10
, pp. 1033-1046
-
-
Godoy, A.1
Kawinski, E.2
Li, Y.3
Oka, D.4
Alexiev, B.5
Azzouni, F.6
Titus, M.A.7
Mohler, J.L.8
-
18
-
-
0027248515
-
Characterization of Chinese hamster ovary cell lines expressing human steroid 5 alpha-reductase isozymes
-
Thigpen AE, Cala KM, Russell DW,. Characterization of Chinese hamster ovary cell lines expressing human steroid 5 alpha-reductase isozymes. J Biol Chem 1993; 268 (23): 17404-17412.
-
(1993)
J Biol Chem
, vol.268
, Issue.23
, pp. 17404-17412
-
-
Thigpen, A.E.1
Cala, K.M.2
Russell, D.W.3
-
19
-
-
20444476601
-
Steroid 5alpha-reductase isozymes i and II in recurrent prostate cancer
-
Titus MA, Gregory CW, Ford OHr, Schell MJ, Maygarden SJ, Mohler JL,. Steroid 5alpha-reductase isozymes I and II in recurrent prostate cancer. Clin Cancer Res 2005; 11 (12): 4365-4371.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.12
, pp. 4365-4371
-
-
Titus, M.A.1
Gregory, C.W.2
Ford, O.3
Schell, M.J.4
Maygarden, S.J.5
Mohler, J.L.6
-
20
-
-
34249989027
-
The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia
-
Wurzel R, Ray P, Major-Walker K, Shannon J, Rittmaster R,. The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia. Prostate Cancer Prostatic Dis 2007; 10 (2): 149-154.
-
(2007)
Prostate Cancer Prostatic Dis
, vol.10
, Issue.2
, pp. 149-154
-
-
Wurzel, R.1
Ray, P.2
Major-Walker, K.3
Shannon, J.4
Rittmaster, R.5
-
21
-
-
0032871043
-
Separation by thin-layer chromatography of the most common androgen-derived C19 steroids formed by mammalian cells
-
Godin C, Provost PR, Poirier D, Blomquist CH, Tremblay Y,. Separation by thin-layer chromatography of the most common androgen-derived C19 steroids formed by mammalian cells. Steroids 1999; 64 (11): 767-769.
-
(1999)
Steroids
, vol.64
, Issue.11
, pp. 767-769
-
-
Godin, C.1
Provost, P.R.2
Poirier, D.3
Blomquist, C.H.4
Tremblay, Y.5
-
22
-
-
77954628404
-
Atmospheric pressure photoionization tandem mass spectrometry of androgens in prostate cancer
-
Lih FB, Titus MA, Mohler JL, Tomer KB,. Atmospheric pressure photoionization tandem mass spectrometry of androgens in prostate cancer. Anal Chem 2010; 82 (14): 6000-6007.
-
(2010)
Anal Chem
, vol.82
, Issue.14
, pp. 6000-6007
-
-
Lih, F.B.1
Titus, M.A.2
Mohler, J.L.3
Tomer, K.B.4
-
23
-
-
65449183191
-
Central quadrant procurement of radical prostatectomy specimens
-
Morrison C, Cheney R, Johnson CS, Smith G, Mohler JL,. Central quadrant procurement of radical prostatectomy specimens. Prostate 2009; 69 (7): 770-773.
-
(2009)
Prostate
, vol.69
, Issue.7
, pp. 770-773
-
-
Morrison, C.1
Cheney, R.2
Johnson, C.S.3
Smith, G.4
Mohler, J.L.5
-
24
-
-
0025300293
-
Evaluation of radical prostatectomy capsular margins of resection. the significance of margins designated as negative, closely approaching, and positive
-
Epstein JI,. Evaluation of radical prostatectomy capsular margins of resection. The significance of margins designated as negative, closely approaching, and positive. Am J Surg Pathol 1990; 14 (7): 626-632.
-
(1990)
Am J Surg Pathol
, vol.14
, Issue.7
, pp. 626-632
-
-
Epstein, J.I.1
-
25
-
-
84865823502
-
Sequential transformation of 4-androstenedione into dihydrotestosterone in prostate carcinoma (DU-145) cells indicates that 4-androstenedione and not testosterone is the substrate of 5alpha-reductase
-
Samson M, Labrie F, Luu-The V,. Sequential transformation of 4-androstenedione into dihydrotestosterone in prostate carcinoma (DU-145) cells indicates that 4-androstenedione and not testosterone is the substrate of 5alpha-reductase. Horm Mol Biol Clin Invest 2010; 1 (2): 67-72.
-
(2010)
Horm Mol Biol Clin Invest
, vol.1
, Issue.2
, pp. 67-72
-
-
Samson, M.1
Labrie, F.2
Luu-The, V.3
-
26
-
-
80051963331
-
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
-
Chang KH, Li R, Papari-Zareei M, Watumull L, Zhao YD, Auchus RJ, Sharifi N,. Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer. Proc Natl Acad Sci USA 2011; 108 (33): 13728-13733.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.33
, pp. 13728-13733
-
-
Chang, K.H.1
Li, R.2
Papari-Zareei, M.3
Watumull, L.4
Zhao, Y.D.5
Auchus, R.J.6
Sharifi, N.7
-
27
-
-
51049098138
-
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
-
Locke JA, Guns ES, Lubik AA, Adomat HH, Hendy SC, Wood CA, Ettinger SL, Gleave ME, Nelson CC,. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res 2008; 68 (15): 6407-6415.
-
(2008)
Cancer Res
, vol.68
, Issue.15
, pp. 6407-6415
-
-
Locke, J.A.1
Guns, E.S.2
Lubik, A.A.3
Adomat, H.H.4
Hendy, S.C.5
Wood, C.A.6
Ettinger, S.L.7
Gleave, M.E.8
Nelson, C.C.9
-
28
-
-
0018079192
-
Steroidal inhibitors of prostatic 5a-reductase: Structure activity relationship
-
Dupuy GM, Roberts KD, Bleau G, Chapdelaine A,. Steroidal inhibitors of prostatic 5a-reductase: Structure activity relationship. J Steroid Biochem Mol Biol 1978; 9: 1043-1047.
-
(1978)
J Steroid Biochem Mol Biol
, vol.9
, pp. 1043-1047
-
-
Dupuy, G.M.1
Roberts, K.D.2
Bleau, G.3
Chapdelaine, A.4
-
29
-
-
84856774377
-
Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer
-
Attard G, Reid AH, Auchus RJ, Hughes BA, Cassidy AM, Thompson E, Oommen NB, Folkerd E, Dowsett M, Arlt W, de Bono JS,. Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer. J Clin Endocrinol Metab 2012; 97 (2): 507-516.
-
(2012)
J Clin Endocrinol Metab
, vol.97
, Issue.2
, pp. 507-516
-
-
Attard, G.1
Reid, A.H.2
Auchus, R.J.3
Hughes, B.A.4
Cassidy, A.M.5
Thompson, E.6
Oommen, N.B.7
Folkerd, E.8
Dowsett, M.9
Arlt, W.10
De Bono, J.S.11
-
30
-
-
7444233759
-
The backdoor pathway to dihydrotestosterone
-
Auchus RJ,. The backdoor pathway to dihydrotestosterone. Trends Endocrinol Metab 2004; 15 (9): 432-438.
-
(2004)
Trends Endocrinol Metab
, vol.15
, Issue.9
, pp. 432-438
-
-
Auchus, R.J.1
-
31
-
-
36949000088
-
Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
-
Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H,. Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci 2008; 99 (1): 81-86.
-
(2008)
Cancer Sci
, vol.99
, Issue.1
, pp. 81-86
-
-
Uemura, M.1
Tamura, K.2
Chung, S.3
Honma, S.4
Okuyama, A.5
Nakamura, Y.6
Nakagawa, H.7
-
32
-
-
77951977749
-
Evolution of steroid-5alpha-reductases and comparison of their function with 5beta-reductase
-
Langlois VS, Zhang D, Cooke GM, Trudeau VL,. Evolution of steroid-5alpha-reductases and comparison of their function with 5beta-reductase. Gen Comp Endocrinol 2010; 166 (3): 489-497.
-
(2010)
Gen Comp Endocrinol
, vol.166
, Issue.3
, pp. 489-497
-
-
Langlois, V.S.1
Zhang, D.2
Cooke, G.M.3
Trudeau, V.L.4
-
33
-
-
77955057089
-
SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder
-
Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blumel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG,. SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 2010; 142 (2): 203-217.
-
(2010)
Cell
, vol.142
, Issue.2
, pp. 203-217
-
-
Cantagrel, V.1
Lefeber, D.J.2
Ng, B.G.3
Guan, Z.4
Silhavy, J.L.5
Bielas, S.L.6
Lehle, L.7
Hombauer, H.8
Adamowicz, M.9
Swiezewska, E.10
De Brouwer, A.P.11
Blumel, P.12
Sykut-Cegielska, J.13
Houliston, S.14
Swistun, D.15
Ali, B.R.16
Dobyns, W.B.17
Babovic-Vuksanovic, D.18
Van Bokhoven, H.19
Wevers, R.A.20
Raetz, C.R.21
Freeze, H.H.22
Morava, E.23
Al-Gazali, L.24
Gleeson, J.G.25
more..
-
34
-
-
0141651675
-
5alpha-reduced C21 steroids are substrates for human cytochrome P450c17
-
Gupta MK, Guryev OL, Auchus RJ,. 5alpha-reduced C21 steroids are substrates for human cytochrome P450c17. Arch Biochem Biophys 2003; 418 (2): 151-160.
-
(2003)
Arch Biochem Biophys
, vol.418
, Issue.2
, pp. 151-160
-
-
Gupta, M.K.1
Guryev, O.L.2
Auchus, R.J.3
-
35
-
-
31444440675
-
Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: A potential therapeutic target for androgen-dependent disease
-
Bauman DR, Steckelbroeck S, Williams MV, Peehl DM, Penning TM,. Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: A potential therapeutic target for androgen-dependent disease. Mol Endocrinol 2006; 20 (2): 444-458.
-
(2006)
Mol Endocrinol
, vol.20
, Issue.2
, pp. 444-458
-
-
Bauman, D.R.1
Steckelbroeck, S.2
Williams, M.V.3
Peehl, D.M.4
Penning, T.M.5
-
36
-
-
49249119358
-
Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
-
Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, True LD, Nelson PS,. Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth. Cancer Res 2008; 68 (11): 4447-4454.
-
(2008)
Cancer Res
, vol.68
, Issue.11
, pp. 4447-4454
-
-
Montgomery, R.B.1
Mostaghel, E.A.2
Vessella, R.3
Hess, D.L.4
Kalhorn, T.F.5
Higano, C.S.6
True, L.D.7
Nelson, P.S.8
-
37
-
-
84870336847
-
Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors
-
Mitsiades N, Sung CC, Schultz N, Danila DC, He B, Eedunuri VK, Fleisher M, Sander C, Sawyers CL, Scher HI,. Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors. Cancer Res 2012; 72 (23): 6142-6152.
-
(2012)
Cancer Res
, vol.72
, Issue.23
, pp. 6142-6152
-
-
Mitsiades, N.1
Sung, C.C.2
Schultz, N.3
Danila, D.C.4
He, B.5
Eedunuri, V.K.6
Fleisher, M.7
Sander, C.8
Sawyers, C.L.9
Scher, H.I.10
-
38
-
-
77953623874
-
Enzyme promiscuity: A mechanistic and evolutionary perspective
-
Khersonsky O, Tawfik DS,. Enzyme promiscuity: A mechanistic and evolutionary perspective. Annu Rev Biochem 2010; 79: 471-505.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 471-505
-
-
Khersonsky, O.1
Tawfik, D.S.2
-
39
-
-
0028174647
-
17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase 1
-
Tian G, Stuart JD, Moss ML, Domanico PL, Bramson HN, Patel IR, Kadwell SH, Overton LK, Kost TA, Mook RAJ, Frye SV, Batchelor KW, Wiseman JS,. 17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase 1. Biochemistry 1994; 33 (8): 2291-2296.
-
(1994)
Biochemistry
, vol.33
, Issue.8
, pp. 2291-2296
-
-
Tian, G.1
Stuart, J.D.2
Moss, M.L.3
Domanico, P.L.4
Bramson, H.N.5
Patel, I.R.6
Kadwell, S.H.7
Overton, L.K.8
Kost, T.A.9
Mook, R.A.J.10
Frye, S.V.11
Batchelor, K.W.12
Wiseman, J.S.13
-
40
-
-
0028807269
-
Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: Toward perfection of rates of time-dependent inhibition by using ligand-binding energies
-
Tian G, Mook RAJ, Moss ML, Frye SV,. Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: Toward perfection of rates of time-dependent inhibition by using ligand-binding energies. Biochemistry 1995; 34 (41): 13453-13459.
-
(1995)
Biochemistry
, vol.34
, Issue.41
, pp. 13453-13459
-
-
Tian, G.1
Mook, R.A.J.2
Moss, M.L.3
Frye, S.V.4
-
41
-
-
0025278610
-
Mechanistic studies with solubilized rat liver steroid 5 alpha-reductase: Elucidation of the kinetic mechanism
-
Levy MA, Brandt M, Greway AT,. Mechanistic studies with solubilized rat liver steroid 5 alpha-reductase: Elucidation of the kinetic mechanism. Biochemistry 1990; 29 (11): 2808-2815.
-
(1990)
Biochemistry
, vol.29
, Issue.11
, pp. 2808-2815
-
-
Levy, M.A.1
Brandt, M.2
Greway, A.T.3
-
42
-
-
17644362707
-
Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer
-
Thomas LN, Lazier CB, Gupta R, Norman RW, Troyer DA, O'Brien SP, Rittmaster RS,. Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer. Prostate 2005; 63 (3): 231-239.
-
(2005)
Prostate
, vol.63
, Issue.3
, pp. 231-239
-
-
Thomas, L.N.1
Lazier, C.B.2
Gupta, R.3
Norman, R.W.4
Troyer, D.A.5
O'Brien, S.P.6
Rittmaster, R.S.7
-
43
-
-
0141676080
-
Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: Implications for finasteride therapy of prostate carcinoma
-
Luo J, Dunn TA, Ewing CM, Walsh PC, Isaacs WB,. Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: Implications for finasteride therapy of prostate carcinoma. Prostate 2003; 57 (2): 134-139.
-
(2003)
Prostate
, vol.57
, Issue.2
, pp. 134-139
-
-
Luo, J.1
Dunn, T.A.2
Ewing, C.M.3
Walsh, P.C.4
Isaacs, W.B.5
-
44
-
-
0029664519
-
Characterization of 17beta-hydroxysteroid dehydrogenase isoenzyme expression in benign and malignant human prostate
-
Elo JP, Akinola LA, Poutanen M, Vihko P, Kyllonen AP, Lukkarinen O, Vihko R,. Characterization of 17beta-hydroxysteroid dehydrogenase isoenzyme expression in benign and malignant human prostate. Int J Cancer 1996; 66 (1): 37-41.
-
(1996)
Int J Cancer
, vol.66
, Issue.1
, pp. 37-41
-
-
Elo, J.P.1
Akinola, L.A.2
Poutanen, M.3
Vihko, P.4
Kyllonen, A.P.5
Lukkarinen, O.6
Vihko, R.7
-
45
-
-
33645056171
-
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
-
Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, Febbo PG, Balk SP,. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res 2006; 66 (5): 2815-2825.
-
(2006)
Cancer Res
, vol.66
, Issue.5
, pp. 2815-2825
-
-
Stanbrough, M.1
Bubley, G.J.2
Ross, K.3
Golub, T.R.4
Rubin, M.A.5
Penning, T.M.6
Febbo, P.G.7
Balk, S.P.8
-
46
-
-
4544248276
-
Chemoprevention of prostate cancer in men at high risk: Rationale and design of the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial
-
Andriole G, Bostwick D, Brawley O, Gomella L, Marberger M, Tindall D, Breed S, Somerville M, Rittmaster R,. Chemoprevention of prostate cancer in men at high risk: Rationale and design of the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial. J Urol 2004; 172 (4 Pt 1): 1314-1317.
-
(2004)
J Urol
, vol.172
, Issue.4 PART 1
, pp. 1314-1317
-
-
Andriole, G.1
Bostwick, D.2
Brawley, O.3
Gomella, L.4
Marberger, M.5
Tindall, D.6
Breed, S.7
Somerville, M.8
Rittmaster, R.9
-
47
-
-
9144254440
-
Phase i and clinical pharmacology of a type i and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: Elevation of estradiol as possible mechanism of action
-
Eisenberger MA, Laufer M, Vogelzang NJ, Sartor O, Thornton D, Neubauer BL, Sinibaldi V, Lieskovsky G, Carducci MA, Zahurak M, Raghavan D,. Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: Elevation of estradiol as possible mechanism of action. Urology 2004; 63 (1): 114-119.
-
(2004)
Urology
, vol.63
, Issue.1
, pp. 114-119
-
-
Eisenberger, M.A.1
Laufer, M.2
Vogelzang, N.J.3
Sartor, O.4
Thornton, D.5
Neubauer, B.L.6
Sinibaldi, V.7
Lieskovsky, G.8
Carducci, M.A.9
Zahurak, M.10
Raghavan, D.11
-
48
-
-
27644452640
-
Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
-
Titus MA, Schell MJ, Lih FB, Tomer KB, Mohler JL,. Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clin Cancer Res 2005; 11 (13): 4653-4657.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.13
, pp. 4653-4657
-
-
Titus, M.A.1
Schell, M.J.2
Lih, F.B.3
Tomer, K.B.4
Mohler, J.L.5
-
49
-
-
0842311632
-
The androgen axis in recurrent prostate cancer
-
Mohler JL, Gregory CW, Ford OHr, Kim D, Weaver CM, Petrusz P, Wilson EM, French FS,. The androgen axis in recurrent prostate cancer. Clin Cancer Res 2004; 10 (2): 440-448.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.2
, pp. 440-448
-
-
Mohler, J.L.1
Gregory, C.W.2
Ford, O.3
Kim, D.4
Weaver, C.M.5
Petrusz, P.6
Wilson, E.M.7
French, F.S.8
-
50
-
-
0034287545
-
Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
-
Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K,. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Biochem J 2000; 351 (Pt 1): 67-77.
-
(2000)
Biochem J
, vol.351
, Issue.PART 1
, pp. 67-77
-
-
Penning, T.M.1
Burczynski, M.E.2
Jez, J.M.3
Hung, C.F.4
Lin, H.K.5
Ma, H.6
Moore, M.7
Palackal, N.8
Ratnam, K.9
-
51
-
-
80052846905
-
Potential prostate cancer drug target: Bioactivation of androstanediol by conversion to dihydrotestosterone
-
Mohler JL, Titus MA, Wilson EM,. Potential prostate cancer drug target: Bioactivation of androstanediol by conversion to dihydrotestosterone. Clin Cancer Res 2011; 17 (18): 5844-5849.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.18
, pp. 5844-5849
-
-
Mohler, J.L.1
Titus, M.A.2
Wilson, E.M.3
|