Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum

Journal of Steroid Biochemistry and Molecular Biology

Volumn 138, Issue , 2013, Pages 281-289

  Tamae, Daniel ^a   Byrns, Michael ^a   Marck, Brett ^b   Mostaghel, Elahe A ^b,c   Nelson, Peter S ^b,c   Lange, Paul ^d   Lin, Daniel ^d   Taplin, Mary Ellen ^e   Balk, Steven ^e   Ellis, William ^d   True, Larry ^c   Vessella, Robert ^d   Montgomery, Bruce ^c   Blair, Ian A ^a   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b USA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Androgen metabolome; Mass spectrometry; Prostate cancer

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; ANDROSTERONE; BICALUTAMIDE; DUTASTERIDE; EPITESTOSTERONE; GLUCURONIDE; GOSERELIN; HYDROXYLAMINE; PRASTERONE; PRASTERONE SULFATE; STABLE ISOTOPE; TESTOSTERONE;

ANDROGEN BLOOD LEVEL; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN TISSUE; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; MALE; PROSTATE CANCER; TANDEM MASS SPECTROMETRY;

Δ(4)-AD; Δ(4)-ANDROSTENE-3,17-DIONE; 5Α-ANDROSTANE-3,17-DIONE; 5Α-DIHYDROTESTOSTERONE; A; ADIONE; ADT; ANDROGEN DEPRIVATION THERAPY; ANDROGEN METABOLOME; ANDROSTERONE; CASTRATION RESISTANT PROSTATE CANCER; CD-FBS; CHARCOAL DEXTRAN STRIPPED FETAL BOVINE SERUM; COEFFICIENT OF VARIATION; CRPC; CV; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE GLUCURONIDE; DEHYDROEPIANDROSTERONE SULFATE; DHEA; DHEA-G; DHEA-S; DHT; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPI-T; EPITESTOSTERONE; GNRH; GONADOTROPIN RELEASING HORMONE; HSD; HYDROXYSTEROID DEHYDROGENASE; LC; LIQUID CHROMATOGRAPHY; LLOQ; LOWER LIMIT OF QUANTIFICATION; M/Z; MASS SPECTROMETRY; MASS TO CHARGE RATIO; ND; NOT DETECTED; NOT SIGNIFICANT; NS; PROSTATE CANCER; PROSTATE SPECIFIC ANTIGEN; PSA; QC; QUALITY CONTROL; RADIOIMMUNOASSAY; RIA; SID-LC/ESI/SRM/MS; STABLE ISOTOPE DILUTION LIQUID CHROMATOGRAPHY ELECTROSPRAY IONIZATION SELECTED REACTION MONITORING MASS SPECTROMETRY; T; TAPS; TARGETED ANDROGEN PATHWAY SUPPRESSION CLINICAL TRIAL; TESTOSTERONE; TFA; TRIFLUOROACETIC ACID; UDP GLUCURONOSYLTRANSFERASE; UGT;

ANDROGENS; CHROMATOGRAPHY, LIQUID; HUMANS; MALE; MASS SPECTROMETRY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84884518447     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.06.014     Document Type: Article

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