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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 10, 2012, Pages 3492-3497

Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer

(6) Chen, Mo a Adeniji, Adegoke O a Twenter, Barry M b Winkler, Jeffrey D b Christianson, David W b Penning, Trevor M a

a UNIVERSITY OF PENNSYLVANIA (United States)

b UNIVERSITY OF PENNSYLVANIA (United States)

Author keywords

Adaptive androgen biosynthesis; Aldo keto reductase; Androgen receptor antagonist; Competitive inhibition; N Phenylanthranilic acids; Non steroidal anti inflammatory drugs (NSAIDs)

Indexed keywords

3 [(4 NITRONAPHTHALEN 1 YL)AMINO]BENZOIC ACID; 3 [[4 (TRIFLUOROMETHYL)PHENYL]AMINO]BENZOIC ACID; ALDO KETO REDUCTASE 1C3; ALDO KETO REDUCTASE 1C3 INHIBITOR; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ANTAGONIST; ANDROSTANOLONE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FLUFENAMIC ACID; ISOENZYME; N AMINOBENZOATE INHIBITOR; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ANDROGEN SYNTHESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CASTRATION RESISTANT PROSTATE CANCER; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IC 50; RECEPTOR DENSITY; REPORTER GENE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ALDEHYDE REDUCTASE; ANDROGEN ANTAGONISTS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MALE; MODELS, MOLECULAR; ORCHIECTOMY; PROSTATIC NEOPLASMS; PROTEIN CONFORMATION;

EID: 84860493930 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.03.085 Document Type: Article

Times cited : (54)

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