Human cytosolic 3α-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3β-hydroxysteroid dehydrogenase activity: Implications for steroid hormone metabolism and action

Journal of Biological Chemistry

Volumn 279, Issue 11, 2004, Pages 10784-10795

  Steckelbroeck, Stephan ^a   Jin, Yi ^a   Gopishetty, Sridhar ^a   Oyesanmi, Busola ^a   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPUTER SIMULATION; DRUG DOSAGE; ENZYMES; HORMONES; ISOMERIZATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

MICROMOLAR CONCENTRATIONS; MOLECULAR DOCKING;

BIOCHEMISTRY;

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ALDEHYDE REDUCTASE; ANDROSTANOLONE; ESTROGEN RECEPTOR BETA; FLUFENAMIC ACID; HYDROXYSTEROID DEHYDROGENASE; NONSTEROID ANTIINFLAMMATORY AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID HORMONE; 3 (OR 17) BETA HYDROXYSTEROID DEHYDROGENASE; 3 (OR 17)-BETA-HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; COMPLEMENTARY DNA; ISOPROTEIN; LIGAND; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RECOMBINANT PROTEIN; STEROID;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; CYTOSOLIC FRACTION; ENZYME ACTIVITY; GLUCURONIDATION; HORMONE ACTION; HORMONE METABOLISM; HUMAN; HUMAN CELL; PHYLOGENY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SIMULATION; STEROIDOGENESIS; TARGET CELL; BIOLOGICAL MODEL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; CYTOSOL; ENZYMOLOGY; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERASE CHAIN REACTION; TIME;

17-HYDROXYSTEROID DEHYDROGENASES; ANDROGENS; CATALYSIS; CELL LINE; CYTOSOL; DNA, COMPLEMENTARY; FLUFENAMIC ACID; GABA ANTAGONISTS; HUMANS; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NADP; POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; RNA, MESSENGER; SOFTWARE; STEROIDS; TIME FACTORS;

EID: 1642305724     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313308200     Document Type: Article

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