Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins

Immunologic Research

Volumn 59, Issue 1-3, 2014, Pages 3-11

  Gioannini, Theresa L ^a,b   Teghanemt, Athmane ^a   Zhang, DeSheng ^a   Esparza, Gregory ^a,c   Yu, Liping ^a   Weiss, Jerrold ^a,b,c  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Endotoxin recognition proteins; Lipopolysaccharides; MD 2; Nuclear magnetic resonance spectroscopy; Radioiodination; Toll like receptors

Indexed keywords

ENDOTOXIN; LIGAND; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; LY96 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

CELL ACTIVATION; COMPLEX FORMATION; GRAM NEGATIVE BACTERIUM; INNATE IMMUNITY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; RADIOIODINATION; REVIEW; STRUCTURE ANALYSIS; ANIMAL; ART; CHEMISTRY; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; PROTEIN QUATERNARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ENDOTOXINS; GRAM-NEGATIVE BACTERIA; HUMANS; LYMPHOCYTE ANTIGEN 96; PORTRAITS AS TOPIC; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 4;

EID: 84905757424     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-014-8543-y     Document Type: Review

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