Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin

Journal of Biological Chemistry

Volumn 283, Issue 3, 2008, Pages 1257-1266

  Teghanemt, Athmane ^a   Re, Fabio ^d   Prohinar, Polonca ^a   Widstrom, Richard ^a   Gioannini, Theresa L ^a,c   Weiss, Jerrold P ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BINDING SITES; PROTEINS; STRUCTURAL PROPERTIES;

ENDOTOXIN (E); MAMMALIAN CELL; PROTEIN-PROTEIN INTERACTIONS;

CELLS;

CD14 ANTIGEN; ENDOTOXIN; MUTANT PROTEIN; PHENYLALANINE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; TYROSINE;

ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; WILD TYPE;

ANTIGENS, CD14; CELL LINE; CULTURE MEDIA; ENDOTOXINS; HUMANS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MUTANT PROTEINS; PHENYLALANINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 4; TRANSFECTION; TRITIUM; TYROSINE;

BACTERIA (MICROORGANISMS); MAMMALIA; NEGIBACTERIA;

EID: 38349186906     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705994200     Document Type: Article

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