A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for toll-like receptor 4

Journal of Biological Chemistry

Volumn 279, Issue 33, 2004, Pages 34698-34704

  Kennedy, Margaret N ^a   Mullen, Gregory E D ^a,b   Leifer, Cynthia A ^a   Lee, ChangWoo ^a   Mazzoni, Alessandra ^a   Dileepan, Kottarappat N ^c   Segal, David M ^a,d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; PROTEINS; SYNTHESIS (CHEMICAL);

ENDOPLASMIC RETICULUM; LIPOPOLYSACCHARIDES;

POLYSACCHARIDES;

GLYCOPROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPID A; LIPOPOLYSACCHARIDE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; CD14 ANTIGEN; CELL SURFACE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; LY96 PROTEIN, HUMAN; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR;

ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; TIME; BIOLOGICAL MODEL; CELL LINE; CELL MEMBRANE; ENDOPLASMIC RETICULUM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE VECTOR; INFLAMMATION; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; TEMPERATURE;

ANTIGENS, CD14; ANTIGENS, SURFACE; CELL LINE; CELL MEMBRANE; ENDOPLASMIC RETICULUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC VECTORS; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; LIGANDS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; NF-KAPPA B; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; TEMPERATURE; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 4544250809     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405444200     Document Type: Article

References (29)

1. Beutler, B., and Rietschel, E. T. (2003) Nat. Rev. Immunol. 3, 169-176
2. Alexander, C., and Rietschel, E. T. (2001) J. Endotoxin Res. 7, 167-202
3. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., and Beutler, B. (1998) Science 282, 2085-2088
4. Schromm, A. B., Lien, E., Henneke, P., Chow, J. C., Yoshimura, A., Heine, H., Latz, E., Monks, B. G., Schwartz, D. A., Miyake, K., and Golenbock, D. T. (2001) J. Exp. Med. 194, 79-88
5. Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M., and Miyake, K. (2002) Nat. Immunol. 3, 667-672
6. Takeda, K., Kaisho, T., and Akira, S. (2003) Annu. Rev. Immunol. 21, 335-376
7. Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., and Kimoto, M. (1999) J. Exp. Med. 189, 1777-1782
8. Visintin, A., Mazzoni, A., Spitzer, J. A., and Segal, D. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 12156-12161
9. Viriyakosol, S., Tobias, P. S., Kitchens, R. L., and Kirkland, T. N. (2001) J. Biol. Chem. 276, 38044-38051
10. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., and Akira, S. (1999) J. Immunol. 162, 3749-3752
11. Lien, E., Means, T. K., Heine, H., Yoshimura, A., Kusumoto, S., Fukase, K., Fenton, M. J., Oikawa, M., Qureshi, N., Monks, B., Finberg, R. W., Ingalls, R. R., and Golenbock, D. T. (2000) J. Clin. Investig. 105, 497-504
12. Poltorak, A., Ricciardi-Castagnoli, P., Citterio, S., and Beutler, B. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2163-2167
13. Hajjar, A. M., Ernst, R. K., Tsai, J. H., Wilson, C. B., and Miller, S. I. (2002) Nat. Immunol. 3, 354-359
14. Muroi, M., Ohnishi, T., and Tanamoto, K. (2002) Infect. Immun. 70, 3546-3550
15. Akashi, S., Nagai, Y., Ogata, H., Oikawa, M., Fukase, K., Kusumoto, S., Kawasaki, K., Nishijima, M., Hayashi, S., Kimoto, M., and Miyake, K. (2001) Int. Immunol. 13, 1595-1599
16. Kawasaki, K., Gomi, K., and Nishijima, M. (2001) J. Immunol. 166, 11-14
17. da Silva Correia, J., Soldau, K., Christen, U., Tobias, P. S., and Ulevitch, R. J. (2001) J. Biol. Chem. 276, 21129-21135
18. Visintin, A., Latz, E., Monks, B. G., Espevik, T., and Golenbock, D. T. (2003) J. Biol. Chem. 278, 48313-48320
19. Akashi, S., Saitoh, S., Wakabayashi, Y., Kikuchi, T., Takamura, N., Nagai, Y., Kusumoto, Y., Fukase, K., Kusumoto, S., Adachi, Y., Kosugi, A., and Miyake, K. (2003) J. Exp. Med. 198, 1035-1042
20. Gioannini, T. L., Teghanemt, A., Zhang, D., Coussens, N. P., Dockstader, W., Ramaswamy, S., and Weiss, J. P. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 4186-4191
21. Talreja, J., Dileepan, K., Filla, M., Dileepan, K. N., and Stechschulte, D. J. (2003) FASEB J. 17, C57
22. Visintin, A., Mazzoni, A., Spitzer, J. H., Wyllie, D. H., Dower, S. K., and Segal, D. M. (2001) J. Immunol. 166, 249-255
23. Mazzoni, A., Young, H. A., Spitzer, J. H., Visintin, A., and Segal, D. M. (2001) J. Clin. Investig. 108, 1865-1873
24. Abreu, M. T., Arnold, E. T., Thomas, L. S., Gonsky, R., Zhou, Y., Hu, B., and Arditi, M. (2002) J. Biol. Chem. 277, 20431-20437
25. Haziot, A., Ferrero, E., Kontgen, F., Hijiya, N., Yamamoto, S., Silver, J., Stewart, C. L., and Goyert, S. M. (1996) Immunity 4, 407-414
26. Hoffmann, J. A. (2003) Nature 426, 33-38
27. Weber, A. N., Tauszig-Delamasure, S., Hoffmann, J. A., Lelievre, E., Gascan, H., Ray, K. P., Morse, M. A., Imler, J. L., and Gay, N. J. (2003) Nat. Immunol. 4, 794-800
28. Bell, J. K., Mullen, G. E., Leifer, C. A., Mazzoni, A., Davies, D. R., and Segal, D. M. (2003) Trends Immunol. 24, 528-533
29. Abreu, M. T., Thomas, L. S., Arnold, E. T., Lukasek, K., Michelsen, K. S., and Arditi, M. (2003) J. Endotoxin Res. 9, 322-330