An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis

Structure

Volumn 20, Issue 9, 2012, Pages 1528-1539

  Mazhab Jafari, Mohammad T ^a,b   Marshall, Christopher B ^a,b   Ishiyama, Noboru ^a,b   Ho, Jason ^a,b   Di Palma, Vanessa ^a,b   Stambolic, Vuk ^a,b   Ikura, Mitsuhiko ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GUANOSINE TRIPHOSPHATE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RHEB PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; GUANOSINE TRIPHOSPHATE; HEK293 CELLS; HELA CELLS; HOMEOSTASIS; HUMANS; HYDROGEN BONDING; HYDROLYSIS; KINETICS; MICE; MODELS, MOLECULAR; MONOMERIC GTP-BINDING PROTEINS; MUTAGENESIS, SITE-DIRECTED; NEUROPEPTIDES; PROTEIN BINDING; PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; THERMODYNAMICS;

MAMMALIA;

EID: 84865800800     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2012.06.013     Document Type: Article

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