Associations of fibroblast growth factor 21 gene 3′ untranslated region single-nucleotide polymorphisms with metabolic syndrome, obesity, and diabetes in a Han Chinese population

DNA and Cell Biology

Volumn 31, Issue 4, 2012, Pages 547-552

  Zhang, Mei ^a   Zeng, Li ^a   Wang, You Juan ^a   An, Zhen Mei ^a   Ying, Bin Wu ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

3' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; BODY MASS; CHINESE; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CONCENTRATION (PARAMETERS); DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; ORAL GLUCOSE TOLERANCE TEST; POPULATION GENETICS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX RATIO; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

3' UNTRANSLATED REGIONS; CHINA; DIABETES MELLITUS, TYPE 2; FIBROBLAST GROWTH FACTORS; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METABOLIC SYNDROME X; OBESITY; ODDS RATIO; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA;

EID: 84859754680     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2011.1302     Document Type: Article

References (26)

1. Adams, B.D., Furneaux, H., and White, B.A. (2007). The microribonucleic acid (miRNA) miR-206 targets the human estrogen receptor alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol 21, 1132-1147.
2. Badman, M.K., Pissios, P., Kennedy, A.R., Koukos, G., Flier, J.S., and Maratos-Flier, E. (2007). Hepatic fibroblast growth factor-21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5, 426-437.
3. Bartel, D.P. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
4. Chen, K., and Rajewsky, N. (2006). Natural selection on human microRNA binding sites inferred from SNP data. Nat Genet 38, 1452-1456.
5. Chen, W.W., Li, L., Yang, G.Y., Li, K., Qi, X.Y., Zhu, W., Tang, Y., Liu, H., and Boden, G. (2008). Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 116, 65-68.
6. Choi, H.J., Cho, Y.M., Moon, M.K., Choi, H.H., Shin, H.D., Jang, H.C., Kim, S.Y., Lee, H.K., and Park, K.S. (2006). Polymorphisms in the Ghrelin gene are associated with serum highdensity lipoprotein cholesterol level and not with type 2 diabetes mellitus in Koreans. J Clin Endocrinol Metab 91, 4657-4663.
7. Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.M., Eychenne, F., Larzul, C., Laville, E., Meish, F., Milenkovic, D., Tobin, J., Charlier, C., and Georges, M. (2006). A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nat Genet 38, 813-818.
8. Dongxia, L., Qi, H., Lisong, L., and Jincheng, G. (2008). Association of peroxisome proliferator-activated receptor g gene Pro12Ala and C161T polymorphisms with metabolic syndrome. Circ J 72, 551-557.
9. Ford, E.S., Giles, W.H., and Dietz, W.H. (2002). Prevalence of the metabolic syndrome among U.S. adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287, 356-359.
10. Gu, D., Reynolds, K., Wu, X., Chen, J., Duan, X., Reynolds, R.F., Whelton, P.K., and He, J. (2005). Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 365, 1398-1405.
11. Kaess, B.M., Barnes, T.A., Stark, K., Charchar, F.J., Waterworth, D., Song, K., Wang, W.Y., and Vollenweider, P. (2010). FGF21 signalling pathway and metabolic traits-genetic association analysis. Eur J Hum Genet 18, 1344-1348.
12. Kharitonenkov, A., Shiyanova, T.L., Koester, A., Ford, A.M., Micanovic, R., Galbreath, E.J., Sandusky, G.E., Hammond, L.J., Moyers, J.S., Owens, R.A., Gromada, J., Brozinick, J.T., Hawkins, E.D., Wroblewski, V.J., Li, D.S., Mehrbod, F., Jaskunas, S.R., and Shanafelt, A.B. (2005). FGF-21 as a novel metabolic regulator. J Clin Invest 115, 1627-1635.
13. Kharitonenkov, A., Wroblewski, V.J., Koeste, R A., Chen, Y.F., Clutinger, C.K., Tigno, X.T., Hansen, B.C., Shanafelt, A.B., and Etgen, G.J. (2007). The metabolic state of diabetic monkeys is regulated by FGF-21. Endocrinology 148, 774-781.
14. Landi, D., Gemignani, F., Barale, R., and Landi, S. (2008). A catalog of polymorphisms falling in microRNA-binding regions of cancer genes. DNA Cell Biol 27, 35-43.
15. Liu, J., Gao, J.Y., Zhang, J.P., Li, P.Q., Liu, J.X., Liu, J., and Xie, X.D. (2008). Evaluation of the association between retinal binding protein 4 polymorphisms and type 2 diabetes in Chinese by DHPLC. Endocrine 34, 23-28.
16. Mashili, F.L., Austin, R.L., Deshmukh, A.S., Fritz, T., Caidahl, K., Bergdahl, K., Zierath, J.R., Chibalin, A.V., Moller, D.E., Kharitonenkov, A., and Krook, A. (2011). Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes Metab Res Rev 27, 286-297.
17. Mishra, P.J., Humeniuk, R., Mishra, P.J., Longo-Sorbello, G.S., Banerjee, D., and Bertino, J.R. (2007). A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance. Proc Natl Acad Sci U S A 104, 13513-13518.
18. Rankinen, T., Zuberi, A., Chagnon, Y.C., Weisnagel, S.J., Argyropoulos, G., Walts, B., Pérusse, L., and Bouchard, C. (2006). The human obesity gene map: the 2005 update. Obesity 14, 529-644.
19. Saxena, R., Voight, B.F., Lyssenko, V., Burtt, N.P., de Bakker, P.I., Chen, H., Roix, J.J., Kathiresan, S., Hirschhorn, J.N., Daly, M.J., Hughes, T.E., Groop, L., Altshuler, D., Almgren, P., Florez, J.C, Meyer, J., Ardlie, K., Bengtsson Boström, K., Isomaa, B., Lettre, G., Lindblad, U., Lyon, H.N., Melander, O., Newton-Cheh, C., Nilsson, P., Orho-Melander, M., Råstam, L., Speliotes, E.K., Taskinen, M.R., Tuomi, T., Guiducci, C., Berglund, A., Carlson, J., Gianniny, L., Hackett, R., Hall, L., Holmkvist, J., Laurila, E., Sjögren, M., Sterner, M., Surti, A., Svensson, M., Svensson, M., Tewhey, R., Blumenstiel, B., Parkin, M., Defelice, M., Barry, R., Brodeur, W., Camarata, J., Chia, N., Fava, M., Gibbons, J., Handsaker, B., Healy, C., Nguyen, K., Gates, C., Sougnez, C., Gage, D., Nizzari, M., Gabriel, SB., Chirn, GW., Ma, Q., Parikh, H., Richardson, D., Ricke, D., and Purcell, S. (2007). Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316, 1331-1336.
20. Sethupathy, P., and Collins, F.S. (2008). MicroRNA target site polymorphisms and human disease. Trends Genet 24, 489-497.
21. Shih, P.A., Wang, L., Chiron, S., Wen, G., Nievergelt, C., Mahata, M., Khandrika, S., Rao, F., Fung, M.M., Mahata, S.K., Hamilton, B.A., and O'Connor, D.T. (2009). Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. J Clin Endocrinol Metab 94, 4557-4566.
22. Wang, H., Qiang, L., and Farmer, S.R. (2008). Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Mol Cell Biol 28, 188-200.
23. Wong, K.C., and Wang, Z. (2006). Prevalence of type 2 diabetes mellitus of Chinese populations in Mainland China, Hong Kong, and Taiwan. Diabetes Res Clin Pract 73, 126-134.
24. Xu, J., Lloyd, D.J., Hale, C, Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.S., Lindberg, R.A., Chen, J.L., Jung, D.Y., Zhang, Z., Ko, H.J., Kim, J.K., and Véniant, M.M. (2009). Fibroblast growth factor-21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58, 250-259.
25. Yang, W.S., Yang, Y.C., Chen, C.L., Wu, I.L., Lu, J.Y., Lu, F.H., Tai, T.Y., and Chang, C.J. (2007). Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly. Am J Clin Nutr 86, 509-513.
26. Zhang, X., Yeung, D.C., Karpisek, M., Stejskal, D., Zhou, Z.G., Liu, F., Wong, R.L., Chow, W.S., Tso, A.W., Lam, K.S., and Xu, A. (2008). Serum FGF-21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 57, 1246-1253.