메뉴 건너뛰기




Volumn 289, Issue 31, 2014, Pages 21727-21737

Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent Protein Kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; ENZYME ACTIVITY; GLUCOSE; PHOSPHORYLATION; PIGMENTS; YEAST;

EID: 84905393009     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.573824     Document Type: Article
Times cited : (39)

References (63)
  • 1
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • Wullschleger, S., Loewith, R., and Hall, M. N. (2006) TOR signaling in growth and metabolism. Cell 124, 471-484 (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 2
    • 79953207023 scopus 로고    scopus 로고
    • A brief history of TOR
    • Loewith, R. (2011) A brief history of TOR. Biochem. Soc. Trans. 39, 437-442
    • (2011) Biochem. Soc. Trans. , vol.39 , pp. 437-442
    • Loewith, R.1
  • 3
    • 70449900928 scopus 로고    scopus 로고
    • TOR complex 2: A signaling pathway of its own
    • Cybulski, N., and Hall, M. N. (2009) TOR complex 2: a signaling pathway of its own. Trends Biochem. Sci. 34, 620-627
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 620-627
    • Cybulski, N.1    Hall, M.N.2
  • 4
    • 40549111629 scopus 로고    scopus 로고
    • Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control
    • Ikeda, K., Morigasaki, S., Tatebe, H., Tamanoi, F., and Shiozaki, K. (2008) Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle 7, 358 -364
    • (2008) Cell Cycle , vol.7 , pp. 358-364
    • Ikeda, K.1    Morigasaki, S.2    Tatebe, H.3    Tamanoi, F.4    Shiozaki, K.5
  • 5
    • 0037600512 scopus 로고    scopus 로고
    • Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases
    • DOI 10.1093/emboj/cdg298
    • Matsuo, T., Kubo, Y., Watanabe, Y., and Yamamoto, M. (2003) Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. EMBO J. 22, 3073-3083 (Pubitemid 36758627)
    • (2003) EMBO Journal , vol.22 , Issue.12 , pp. 3073-3083
    • Matsuo, T.1    Kubo, Y.2    Watanabe, Y.3    Yamamoto, M.4
  • 6
    • 68949145880 scopus 로고    scopus 로고
    • TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions
    • Schonbrun, M., Laor, D., López-Maury, L., Bähler, J., Kupiec, M., and Weisman, R. (2009) TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions. Mol. Cell. Biol. 29, 4584-4594
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 4584-4594
    • Schonbrun, M.1    Laor, D.2    López-Maury, L.3    Bähler, J.4    Kupiec, M.5    Weisman, R.6
  • 7
    • 0035831446 scopus 로고    scopus 로고
    • The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine
    • Weisman, R., and Choder, M. (2001) The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine. J. Biol. Chem. 276, 7027-7032
    • (2001) J. Biol. Chem. , vol.276 , pp. 7027-7032
    • Weisman, R.1    Choder, M.2
  • 8
    • 36749055217 scopus 로고    scopus 로고
    • Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits
    • DOI 10.1111/j.1365-2443.2007.01141.x
    • Hayashi, T., Hatanaka, M., Nagao, K., Nakaseko, Y., Kanoh, J., Kokubu, A., Ebe, M., and Yanagida, M. (2007) Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells 12, 1357-1370 (Pubitemid 350215139)
    • (2007) Genes to Cells , vol.12 , Issue.12 , pp. 1357-1370
    • Hayashi, T.1    Hatanaka, M.2    Nagao, K.3    Nakaseko, Y.4    Kanoh, J.5    Kokubu, A.6    Ebe, M.7    Yanagida, M.8
  • 9
    • 35748973557 scopus 로고    scopus 로고
    • TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases
    • DOI 10.1038/ncb1646, PII NCB1646
    • Petersen, J., and Nurse, P. (2007) TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases. Nat. Cell Biol. 9, 1263-1272 (Pubitemid 350042358)
    • (2007) Nature Cell Biology , vol.9 , Issue.11 , pp. 1263-1272
    • Petersen, J.1    Nurse, P.2
  • 11
    • 15544376264 scopus 로고    scopus 로고
    • + in Schizosaccharomyces pombe is sensitive to rapamycin
    • DOI 10.1534/genetics.104.034983
    • Weisman, R., Roitburg, I., Nahari, T., and Kupiec, M. (2005) Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin. Genetics 169, 539-550 (Pubitemid 40404292)
    • (2005) Genetics , vol.169 , Issue.2 , pp. 539-550
    • Weisman, R.1    Roitburg, I.2    Nahari, T.3    Kupiec, M.4
  • 12
    • 84880078363 scopus 로고    scopus 로고
    • TORC2 is required to maintain genome stability during S phase in fission yeast
    • Schonbrun, M., Kolesnikov, M., Kupiec, M., and Weisman, R. (2013) TORC2 is required to maintain genome stability during S phase in fission yeast. J. Biol. Chem. 288, 19649-19660
    • (2013) J. Biol. Chem. , vol.288 , pp. 19649-19660
    • Schonbrun, M.1    Kolesnikov, M.2    Kupiec, M.3    Weisman, R.4
  • 14
    • 34147207884 scopus 로고    scopus 로고
    • Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast
    • DOI 10.1128/MCB.01039-06
    • Matsuo, T., Otsubo, Y., Urano, J., Tamanoi, F., and Yamamoto, M. (2007) Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol. Cell. Biol. 27, 3154-3164 (Pubitemid 46581326)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.8 , pp. 3154-3164
    • Matsuo, T.1    Otsubo, Y.2    Urano, J.3    Tamanoi, F.4    Yamamoto, M.5
  • 15
    • 84863110536 scopus 로고    scopus 로고
    • The Vam6 and Gtr1- Gtr2 pathway activates TORC1 in response to amino acids in fission yeast
    • Valbuena, N., Guan, K. L., and Moreno, S. (2012) The Vam6 and Gtr1- Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. J. Cell Sci. 125, 1920-1928
    • (2012) J. Cell Sci. , vol.125 , pp. 1920-1928
    • Valbuena, N.1    Guan, K.L.2    Moreno, S.3
  • 18
    • 81055140318 scopus 로고    scopus 로고
    • The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe
    • Ikai, N., Nakazawa, N., Hayashi, T., and Yanagida, M. (2011) The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe. Open Biol. 1, 110007
    • (2011) Open Biol. , vol.1 , pp. 110007
    • Ikai, N.1    Nakazawa, N.2    Hayashi, T.3    Yanagida, M.4
  • 19
    • 81055137239 scopus 로고    scopus 로고
    • Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases
    • Yanagida, M., Ikai, N., Shimanuki, M., and Sajiki, K. (2011) Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 3508-3520
    • (2011) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.366 , pp. 3508-3520
    • Yanagida, M.1    Ikai, N.2    Shimanuki, M.3    Sajiki, K.4
  • 20
    • 14644435106 scopus 로고    scopus 로고
    • Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe
    • Hoffman, C. S. (2005) Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe. Biochem. Soc. Trans. 33, 257-260
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 257-260
    • Hoffman, C.S.1
  • 21
    • 0033786755 scopus 로고    scopus 로고
    • Glucose monitoring in fission yeast via the Gpa2 Gα, the git5 Gβ and the git3 putative glucose receptor
    • Welton, R. M., and Hoffman, C. S. (2000) Glucose monitoring in fission yeast via the Gpa2 Gα, the git5 Gβ and the git3 putative glucose receptor. Genetics 156, 513-521
    • (2000) Genetics , vol.156 , pp. 513-521
    • Welton, R.M.1    Hoffman, C.S.2
  • 23
    • 0036132655 scopus 로고    scopus 로고
    • Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast
    • DOI 10.1128/MCB.22.1.1-11.2002
    • Higuchi, T., Watanabe, Y., and Yamamoto, M. (2002) Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast. Mol. Cell. Biol. 22, 1-11 (Pubitemid 33144251)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.1 , pp. 1-11
    • Higuchi, T.1    Watanabe, Y.2    Yamamoto, M.3
  • 24
    • 84856688493 scopus 로고    scopus 로고
    • Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe
    • Matsuzawa, T., Fujita, Y., Tohda, H., and Takegawa, K. (2012) Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe. Eukaryot. Cell 11, 159-167
    • (2012) Eukaryot. Cell , vol.11 , pp. 159-167
    • Matsuzawa, T.1    Fujita, Y.2    Tohda, H.3    Takegawa, K.4
  • 25
    • 84865000275 scopus 로고    scopus 로고
    • AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast
    • Valbuena, N., and Moreno, S. (2012) AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. J. Cell Sci. 125, 2655-2664
    • (2012) J. Cell Sci. , vol.125 , pp. 2655-2664
    • Valbuena, N.1    Moreno, S.2
  • 26
    • 39149107076 scopus 로고    scopus 로고
    • Activation of the cell integrity pathway is channelled through diverse signalling elements in fission yeast
    • Yeast Physiology Group
    • Barba, G., Soto, T., Madrid, M., Núñez, A., Vicente, J., Gacto, M., Cansado, J., and Yeast Physiology Group (2008) Activation of the cell integrity pathway is channelled through diverse signalling elements in fission yeast. Cell. Signal. 20, 748-757
    • (2008) Cell. Signal. , vol.20 , pp. 748-757
    • Barba, G.1    Soto, T.2    Madrid, M.3    Núñez, A.4    Vicente, J.5    Gacto, M.6    Cansado, J.7
  • 28
    • 33644865142 scopus 로고    scopus 로고
    • Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe
    • DOI 10.1074/jbc.M506467200
    • Madrid, M., Soto, T., Khong, H. K., Franco, A., Vicente, J., Pérez, P., Gacto, M., and Cansado, J. (2006) Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe. J. Biol. Chem. 281, 2033-2043 (Pubitemid 43845791)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.4 , pp. 2033-2043
    • Madrid, M.1    Soto, T.2    Hou, K.K.3    Franco, A.4    Vicente, J.5    Perez, P.6    Gacto, M.7    Cansado, J.8
  • 29
    • 0031001506 scopus 로고    scopus 로고
    • Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe
    • Sengar, A. S., Markley, N. A., Marini, N. J., and Young, D. (1997) Mkh1, a MEKkinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe. Mol. Cell. Biol. 17, 3508-3519 (Pubitemid 27281827)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.7 , pp. 3508-3519
    • Sengar, A.S.1    Markley, N.A.2    Marini, N.J.3    Young, D.4
  • 31
    • 0026025891 scopus 로고
    • Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
    • Moreno, S., Klar, A., and Nurse, P. (1991) Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194, 795- 823
    • (1991) Methods Enzymol. , vol.194 , pp. 795-823
    • Moreno, S.1    Klar, A.2    Nurse, P.3
  • 32
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • DOI 10.1002/(SICI)1097-0061(199807)14:10<953::AID
    • Longtine, M. S., McKenzie, A., 3rd, Demarini, D. J., Shah, N. G., Wach, A., Brachat, A., Philippsen, P., and Pringle, J. R. (1998) Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14, 953-961 (Pubitemid 28328001)
    • (1998) Yeast , vol.14 , Issue.10 , pp. 953-961
    • Longtine, M.S.1    McKenzie III, A.2    Demarini, D.J.3    Shah, N.G.4    Wach, A.5    Brachat, A.6    Philippsen, P.7    Pringle, J.R.8
  • 33
    • 0030800386 scopus 로고    scopus 로고
    • Rapamycin specifically interferes with the developmental response of fission yeast to starvation
    • Weisman, R., Choder, M., and Koltin, Y. (1997) Rapamycin specifically interferes with the developmental response of fission yeast to starvation. J. Bacteriol. 179, 6325-6334 (Pubitemid 27443913)
    • (1997) Journal of Bacteriology , vol.179 , Issue.20 , pp. 6325-6334
    • Weisman, R.1    Choder, M.2    Koltin, Y.3
  • 35
    • 78649316549 scopus 로고    scopus 로고
    • Rab-family GTPase regulates TOR complex 2 signaling in fission yeast
    • Tatebe, H., Morigasaki, S., Murayama, S., Zeng, C. T., and Shiozaki, K. (2010) Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Curr. Biol. 20, 1975-1982
    • (2010) Curr. Biol. , vol.20 , pp. 1975-1982
    • Tatebe, H.1    Morigasaki, S.2    Murayama, S.3    Zeng, C.T.4    Shiozaki, K.5
  • 36
    • 84864292157 scopus 로고    scopus 로고
    • TORC1 of fission yeast is rapamycin-sensitive
    • Takahara, T., and Maeda, T. (2012) TORC1 of fission yeast is rapamycin-sensitive. Genes Cells 17, 698-708
    • (2012) Genes Cells , vol.17 , pp. 698-708
    • Takahara, T.1    Maeda, T.2
  • 37
    • 84880513351 scopus 로고    scopus 로고
    • TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
    • Rallis, C., Codlin, S., and Bähler, J. (2013) TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast. Aging Cell 12, 563-573
    • (2013) Aging Cell , vol.12 , pp. 563-573
    • Rallis, C.1    Codlin, S.2    Bähler, J.3
  • 38
    • 0035985031 scopus 로고    scopus 로고
    • Calcineurin phosphatase in signal transduction: Lessons from fission yeast
    • DOI 10.1046/j.1365-2443.2002.00557.x
    • Sugiura, R., Sio, S. O., Shuntoh, H., and Kuno, T. (2002) Calcineurin phosphatase in signal transduction: lessons from fission yeast. Genes Cells 7, 619-627 (Pubitemid 34814754)
    • (2002) Genes to Cells , vol.7 , Issue.7 , pp. 619-627
    • Sugiura, R.1    Sio, S.O.2    Shuntoh, H.3    Kuno, T.4
  • 39
    • 0013804549 scopus 로고
    • Effect of 2-deoxyglucose on Schizosaccharomyces pombe
    • Megnet, R. (1965) Effect of 2-deoxyglucose on Schizosaccharomyces pombe. J. Bacteriol. 90, 1032-1035
    • (1965) J. Bacteriol. , vol.90 , pp. 1032-1035
    • Megnet, R.1
  • 40
    • 0026742292 scopus 로고
    • Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast
    • Mochizuki, N., and Yamamoto, M. (1992) Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast. Mol. Gen. Genet. 233, 17-24
    • (1992) Mol. Gen. Genet. , vol.233 , pp. 17-24
    • Mochizuki, N.1    Yamamoto, M.2
  • 41
    • 77953248612 scopus 로고    scopus 로고
    • Global fitness profiling of fission yeast deletion strains by barcode sequencing
    • Han, T. X., Xu, X. Y., Zhang, M. J., Peng, X., and Du, L. L. (2010) Global fitness profiling of fission yeast deletion strains by barcode sequencing. Genome Biol. 11, R60
    • (2010) Genome Biol. , vol.11
    • Han, T.X.1    Xu, X.Y.2    Zhang, M.J.3    Peng, X.4    Du, L.L.5
  • 42
    • 33845429658 scopus 로고    scopus 로고
    • Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast
    • DOI 10.1091/mbc.E06-08-0688
    • Ma, Y., Kuno, T., Kita, A., Asayama, Y., and Sugiura, R. (2006) Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast. Mol. Biol. Cell 17, 5028-5037 (Pubitemid 44907348)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.12 , pp. 5028-5037
    • Ma, Y.1    Kuno, T.2    Kita, A.3    Asayama, Y.4    Sugiura, R.5
  • 43
    • 2942670792 scopus 로고    scopus 로고
    • Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe
    • DOI 10.1128/EC.3.3.610-619.2004
    • Stiefel, J., Wang, L., Kelly, D. A., Janoo, R. T., Seitz, J., Whitehall, S. K., and Hoffman, C. S. (2004) Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe . Eukaryot. Cell 3, 610-619 (Pubitemid 38763850)
    • (2004) Eukaryotic Cell , vol.3 , Issue.3 , pp. 610-619
    • Stiefel, J.1    Wang, L.2    Kelly, D.A.3    Janoo, R.T.K.4    Seitz, J.5    Whitehall, S.K.6    Hoffman, C.S.7
  • 44
    • 77954791051 scopus 로고    scopus 로고
    • Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae
    • Busti, S., Coccetti, P., Alberghina, L., and Vanoni, M. (2010) Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae. Sensors 10, 6195-6240
    • (2010) Sensors , vol.10 , pp. 6195-6240
    • Busti, S.1    Coccetti, P.2    Alberghina, L.3    Vanoni, M.4
  • 45
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • DOI 10.1038/ncb1183
    • Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., and Hall, M. N. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128 (Pubitemid 39468014)
    • (2004) Nature Cell Biology , vol.6 , Issue.11 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 46
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • DOI 10.1016/j.cub.2004.06.054, PII S0960982204004713
    • Sarbassov, D. D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302 (Pubitemid 38991819)
    • (2004) Current Biology , vol.14 , Issue.14 , pp. 1296-1302
    • Dos, D.S.1    Ali, S.M.2    Kim, D.-H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 47
    • 53149083731 scopus 로고    scopus 로고
    • Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCα-dependent manner in endothelial cells
    • Partovian, C., Ju, R., Zhuang, Z. W., Martin, K. A., and Simons, M. (2008) Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCα-dependent manner in endothelial cells. Mol. Cell 32, 140-149
    • (2008) Mol. Cell , vol.32 , pp. 140-149
    • Partovian, C.1    Ju, R.2    Zhuang, Z.W.3    Martin, K.A.4    Simons, M.5
  • 48
    • 84890130657 scopus 로고    scopus 로고
    • Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition
    • Hálová, L., Du, W., Kirkham, S., Smith, D. L., and Petersen, J. (2013) Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition. J. Cell Biol. 203 595-604
    • (2013) J. Cell Biol. , vol.203 , pp. 595-604
    • Hálová, L.1    Du, W.2    Kirkham, S.3    Smith, D.L.4    Petersen, J.5
  • 49
    • 34249054108 scopus 로고    scopus 로고
    • Opposite effects of Tor1 and Tor2 on nitrogen starvation responses in fission yeast
    • DOI 10.1534/genetics.106.064170
    • Weisman, R., Roitburg, I., Schonbrun, M., Harari, R., and Kupiec, M. (2007) Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics 175, 1153-1162 (Pubitemid 46798220)
    • (2007) Genetics , vol.175 , Issue.3 , pp. 1153-1162
    • Weisman, R.1    Roitburg, I.2    Schonbrun, M.3    Harari, R.4    Kupiec, M.5
  • 52
    • 84892178191 scopus 로고    scopus 로고
    • Crosstalk between mTOR complexes
    • Xie, J., and Proud, C. G. (2013) Crosstalk between mTOR complexes. Nat. Cell Biol. 15, 1263-1265
    • (2013) Nat. Cell Biol. , vol.15 , pp. 1263-1265
    • Xie, J.1    Proud, C.G.2
  • 55
    • 37549000623 scopus 로고    scopus 로고
    • Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity
    • Kumar, A., Harris, T. E., Keller, S. R., Choi, K. M., Magnuson, M. A., and Lawrence, J. C., Jr. (2008) Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity. Mol. Cell. Biol. 28, 61-70
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 61-70
    • Kumar, A.1    Harris, T.E.2    Keller, S.R.3    Choi, K.M.4    Magnuson, M.A.5    Lawrence Jr., J.C.6
  • 58
    • 0035856598 scopus 로고    scopus 로고
    • Regulation and physiological roles of serum-and glucocorticoid-induced protein kinase isoforms
    • Lang, F., and Cohen, P. (2001) Regulation and physiological roles of serum-and glucocorticoid-induced protein kinase isoforms. Sci. STKE 2001, re17
    • (2001) Sci. STKE , vol.2001
    • Lang, F.1    Cohen, P.2
  • 59
    • 33749500123 scopus 로고    scopus 로고
    • (Patho)physiological significance of the serum- and glucocorticoid- inducible kinase isoforms
    • DOI 10.1152/physrev.00050.2005
    • Lang, F., Böhmer, C., Palmada, M., Seebohm, G., Strutz-Seebohm, N., and Vallon, V. (2006) (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol. Rev. 86, 1151-1178 (Pubitemid 44521650)
    • (2006) Physiological Reviews , vol.86 , Issue.4 , pp. 1151-1178
    • Lang, F.1    Bohmer, C.2    Palmada, M.3    Seebohm, G.4    Strutz-Seebohm, N.5    Vallon, V.6
  • 60
    • 0032531881 scopus 로고    scopus 로고
    • Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
    • DOI 10.1038/27234
    • Kato, Y., Tapping, R. I., Huang, S., Watson, M. H., Ulevitch, R. J., and Lee, J. D. (1998) Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature 395, 713-716 (Pubitemid 28475970)
    • (1998) Nature , vol.395 , Issue.6703 , pp. 713-716
    • Kato, Y.1    Tapping, R.I.2    Huang, S.3    Watson, M.H.4    Ulevitch, R.J.5    Lee, J.-D.6
  • 61
    • 0035937718 scopus 로고    scopus 로고
    • BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase
    • Hayashi, M., Tapping, R. I., Chao, T. H., Lo, J. F., King, C. C., Yang, Y., and Lee, J. D. (2001) BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. J. Biol. Chem. 276, 8631-8634
    • (2001) J. Biol. Chem. , vol.276 , pp. 8631-8634
    • Hayashi, M.1    Tapping, R.I.2    Chao, T.H.3    Lo, J.F.4    King, C.C.5    Yang, Y.6    Lee, J.D.7
  • 62
    • 25644452031 scopus 로고    scopus 로고
    • The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
    • DOI 10.1038/nature03966, PII N03966
    • Dodge-Kafka, K. L., Soughayer, J., Pare, G. C., Carlisle Michel, J. J., Langeberg, L. K., Kapiloff, M. S., and Scott, J. D. (2005) The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 437, 574-578 (Pubitemid 41613557)
    • (2005) Nature , vol.437 , Issue.7058 , pp. 574-578
    • Dodge-Kafka, K.L.1    Soughayer, J.2    Pare, G.C.3    Carlisle, M.J.J.4    Langeberg, L.K.5    Kapiloff, M.S.6    Scott, J.D.7
  • 63
    • 0029012096 scopus 로고
    • sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase
    • Jin, M., Fujita, M., Culley, B. M., Apolinario, E., Yamamoto, M., Maundrell, K., and Hoffman, C. S. (1995) sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase. Genetics 140, 457-467
    • (1995) Genetics , vol.140 , pp. 457-467
    • Jin, M.1    Fujita, M.2    Culley, B.M.3    Apolinario, E.4    Yamamoto, M.5    Maundrell, K.6    Hoffman, C.S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.