-
2
-
-
78650510609
-
MTOR. From growth signal integration to cancer, diabetes and ageing
-
Zoncu, R., Efeyan, A., and Sabatini, D. M. (2011) mTOR. From growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21-35
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
3
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger, S., Loewith, R., and Hall, M. N. (2006) TOR signaling in growth and metabolism. Cell 124, 471-484
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
4
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
Han, J. M., Jeong, S. J., Park, M. C., Kim, G., Kwon, N. H., Kim, H. K., Ha, S. H., Ryu, S. H., and Kim, S. (2012) Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149, 410-424
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
Kim, G.4
Kwon, N.H.5
Kim, H.K.6
Ha, S.H.7
Ryu, S.H.8
Kim, S.9
-
5
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
Hara, K., Yonezawa, K., Weng, Q. P., Kozlowski, M. T., Belham, C., and Avruch, J. (1998) Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 273, 14484-14494
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
6
-
-
65649128580
-
Amino acid regulation of TOR complex 1
-
Avruch, J., Long, X., Ortiz-Vega, S., Rapley, J., Papageorgiou, A., and Dai, N. (2009) Amino acid regulation of TOR complex 1. Am. J. Physiol. Endocrinol. Metab. 296, E592-E602
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.296
-
-
Avruch, J.1
Long, X.2
Ortiz-Vega, S.3
Rapley, J.4
Papageorgiou, A.5
Dai, N.6
-
7
-
-
0037178786
-
MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163-175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
8
-
-
27544500981
-
Growing roles for the mTOR pathway
-
Sarbassov, D. D., Ali, S. M., and Sabatini, D. M. (2005) Growing roles for the mTOR pathway. Curr. Opin. Cell Biol. 17, 596-603
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 596-603
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sabatini, D.M.3
-
9
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., and Shaw, R. J. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30, 214-226
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
10
-
-
72949093349
-
The nuts and bolts of AGC protein kinases
-
Pearce, L. R., Komander, D., and Alessi, D. R. (2010) The nuts and bolts of AGC protein kinases. Nat. Rev. Mol. Cell Biol. 11, 9-22
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 9-22
-
-
Pearce, L.R.1
Komander, D.2
Alessi, D.R.3
-
11
-
-
47949125486
-
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
-
Facchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A., Gould, C., Lowry, C., Newton, A. C., Mao, Y., Miao, R. Q., Sessa, W. C., Qin, J., Zhang, P., Su, B., and Jacinto, E. (2008) The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 27, 1932-1943
-
(2008)
EMBO J.
, vol.27
, pp. 1932-1943
-
-
Facchinetti, V.1
Ouyang, W.2
Wei, H.3
Soto, N.4
Lazorchak, A.5
Gould, C.6
Lowry, C.7
Newton, A.C.8
Mao, Y.9
Miao, R.Q.10
Sessa, W.C.11
Qin, J.12
Zhang, P.13
Su, B.14
Jacinto, E.15
-
12
-
-
47949104258
-
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
-
Ikenoue, T., Inoki, K., Yang, Q., Zhou, X., and Guan, K. L. (2008) Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 27, 1919-1931
-
(2008)
EMBO J.
, vol.27
, pp. 1919-1931
-
-
Ikenoue, T.1
Inoki, K.2
Yang, Q.3
Zhou, X.4
Guan, K.L.5
-
13
-
-
78649712949
-
MTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
-
Oh, W. J., Wu, C. C., Kim, S. J., Facchinetti, V., Julien, L. A., Finlan, M., Roux, P. P., Su, B., and Jacinto, E. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 29, 3939-3951
-
(2010)
EMBO J.
, vol.29
, pp. 3939-3951
-
-
Oh, W.J.1
Wu, C.C.2
Kim, S.J.3
Facchinetti, V.4
Julien, L.A.5
Finlan, M.6
Roux, P.P.7
Su, B.8
Jacinto, E.9
-
14
-
-
81155123660
-
The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2
-
Chen, C. H., and Sarbassov Dos, D. (2011) The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2. J. Biol. Chem. 286, 40386-40394
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 40386-40394
-
-
Chen, C.H.1
Sarbassov Dos, D.2
-
15
-
-
33947264077
-
PRAS40 is an insulinregulated inhibitor of the mTORC1 protein kinase
-
Sancak, Y., Thoreen, C. C., Peterson, T. R., Lindquist, R. A., Kang, S. A., Spooner, E., Carr, S. A., and Sabatini, D. M. (2007) PRAS40 is an insulinregulated inhibitor of the mTORC1 protein kinase. Mol. Cell 25, 903-915
-
(2007)
Mol. Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
Carr, S.A.7
Sabatini, D.M.8
-
16
-
-
84555195843
-
Isolation of the mTOR complexes by affinity purification
-
Sarbassov Dos, D., Bulgakova, O., Bersimbaev, R. I., and Shaiken, T. (2012) Isolation of the mTOR complexes by affinity purification. Methods Mol. Biol. 821, 59-74
-
(2012)
Methods Mol. Biol.
, vol.821
, pp. 59-74
-
-
Sarbassov Dos, D.1
Bulgakova, O.2
Bersimbaev, R.I.3
Shaiken, T.4
-
17
-
-
79952119614
-
ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor
-
Chen, C. H., Shaikenov, T., Peterson, T. R., Aimbetov, R., Bissenbaev, A. K., Lee, S. W., Wu, J., Lin, H. K., and Sarbassov Dos, D. (2011) ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor. Sci. Signal. 4, ra10
-
(2011)
Sci. Signal.
, vol.4
-
-
Chen, C.H.1
Shaikenov, T.2
Peterson, T.R.3
Aimbetov, R.4
Bissenbaev, A.K.5
Lee, S.W.6
Wu, J.7
Lin, H.K.8
Sarbassov Dos, D.9
-
18
-
-
0035336970
-
Glucose-sensing mechanisms in eukaryotic cells
-
Rolland, F., Winderickx, J., and Thevelein, J. M. (2001) Glucose-sensing mechanisms in eukaryotic cells. Trends Biochem. Sci. 26, 310-317
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 310-317
-
-
Rolland, F.1
Winderickx, J.2
Thevelein, J.M.3
-
19
-
-
0032932192
-
Protein-damaging stresses activate c-Jun. N-terminal kinase via inhibition of its dephosphorylation. A novel pathway controlled by HSP72
-
Meriin, A. B., Yaglom, J. A., Gabai, V. L., Zon, L., Ganiatsas, S., Mosser, D. D., Zon, L., and Sherman, M. Y. (1999) Protein-damaging stresses activate c-Jun. N-terminal kinase via inhibition of its dephosphorylation. A novel pathway controlled by HSP72. Mol. Cell. Biol. 19, 2547-2555
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2547-2555
-
-
Meriin, A.B.1
Yaglom, J.A.2
Gabai, V.L.3
Zon, L.4
Ganiatsas, S.5
Mosser, D.D.6
Zon, L.7
Sherman, M.Y.8
-
20
-
-
0035798097
-
Mammalian TOR. A homeostatic ATP sensor
-
Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., and Thomas, G. (2001) Mammalian TOR. A homeostatic ATP sensor. Science 294, 1102-1105
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
21
-
-
21244458013
-
Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
-
Ali, S. M., and Sabatini, D. M. (2005) Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J. Biol. Chem. 280, 19445-19448
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19445-19448
-
-
Ali, S.M.1
Sabatini, D.M.2
-
22
-
-
34147097962
-
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling
-
Schroder, W. A., Buck, M., Cloonan, N., Hancock, J. F., Suhrbier, A., Sculley, T., and Bushell, G. (2007) Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. Cell. Signal. 19, 1279-1289
-
(2007)
Cell. Signal.
, vol.19
, pp. 1279-1289
-
-
Schroder, W.A.1
Buck, M.2
Cloonan, N.3
Hancock, J.F.4
Suhrbier, A.5
Sculley, T.6
Bushell, G.7
-
23
-
-
84859903360
-
Integrity of mTORC2 is dependent on the rictor Gly-934 site
-
Aimbetov, R., Chen, C. H., Bulgakova, O., Abetov, D., Bissenbaev, A. K., Bersimbaev, R. I., and Sarbassov, D. D. (2012) Integrity of mTORC2 is dependent on the rictor Gly-934 site. Oncogene 31, 2115-2220
-
(2012)
Oncogene
, vol.31
, pp. 2115-2220
-
-
Aimbetov, R.1
Chen, C.H.2
Bulgakova, O.3
Abetov, D.4
Bissenbaev, A.K.5
Bersimbaev, R.I.6
Sarbassov, D.D.7
-
24
-
-
33748471980
-
MSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
-
Frias, M. A., Thoreen, C. C., Jaffe, J. D., Schroder, W., Sculley, T., Carr, S. A., and Sabatini, D. M. (2006) mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr. Biol. 16, 1865-1870
-
(2006)
Curr. Biol.
, vol.16
, pp. 1865-1870
-
-
Frias, M.A.1
Thoreen, C.C.2
Jaffe, J.D.3
Schroder, W.4
Sculley, T.5
Carr, S.A.6
Sabatini, D.M.7
-
25
-
-
33749076673
-
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., and Su, B. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127, 125-137
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
Huang, Q.7
Qin, J.8
Su, B.9
-
26
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
Zinzalla, V., Stracka, D., Oppliger, W., and Hall, M. N. (2011) Activation of mTORC2 by association with the ribosome. Cell 144, 757-768
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
27
-
-
80052863830
-
Endoplasmic reticulum is a main localization site of mTORC2
-
Boulbés, D. R., Shaiken, T., and Sarbassov Dos, D. (2011) Endoplasmic reticulum is a main localization site of mTORC2. Biochem. Biophys. Res. Commun. 413, 46-52
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.413
, pp. 46-52
-
-
Boulbés, D.R.1
Shaiken, T.2
Sarbassov Dos, D.3
|