Calcineurin phosphatase in signal transduction: Lessons from fission yeast

Genes to Cells

Volumn 7, Issue 7, 2002, Pages 619-627

  Sugiura, Reiko ^a   Sio, Susie O ^a   Shuntoh, Hisato ^b   Kuno, Takayoshi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITOR; CALCIUM ION; CALMODULIN; CYCLOSPORIN A; GUANOSINE TRIPHOSPHATASE; IMMUNOSUPPRESSIVE AGENT; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN HEAVY CHAIN; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; RAB PROTEIN; SERINE; TACROLIMUS; THREONINE; CALCINEURIN PHOSPHATASE; PHOSPHATASE;

CALCIUM SIGNALING; CONTROLLED STUDY; CYTOKINESIS; ENZYME INHIBITION; ENZYME LOCALIZATION; GENETIC ANALYSIS; GENETIC CONSERVATION; MEDIATOR; MEMBRANE TRANSPORT; NERVOUS TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; YEAST; BIOLOGICAL MODEL; GENETICS; METABOLISM; SCHIZOSACCHAROMYCES;

CALCINEURIN; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; PHOSPHORIC MONOESTER HYDROLASES; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T;

SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 0035985031     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2002.00557.x     Document Type: Review

References (51)

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2. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
3. Lipid kinases are novel effectors of the GTPase Rac1
4. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
5. Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway
6. The structure and regulation of protein phosphatases
7. Signal transmission between the plasma membrane and nucleus of T lymphocytes
8. Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase
9. 2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone
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11. Genetic interaction between calcineurin and type 2 myosin and their involvement in the regulation of cytokinesis and chloride ion homeostasis in fission yeast
12. 2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase
13. Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis
14. Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation
15. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase
16. Calcineurin: A calcium-and calmodulin-binding protein of the nervous system
17. Purification of cyclic 3′,5′-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to Sepharose
18. cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae
19. The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway
20. The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B
21. Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals
22. Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae
23. The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae
24. Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast
25. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
26. Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions
27. Genetic evidence for the functional redundancy of the calcine
28. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
29. Regulation of calcineurin gene expression in Schizosaccharomyces pombe. Dependence on the ste11 transcription factor
30. Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization
31. Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe
32. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
33. + gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation
34. Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
35. The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase
36. Molecular genetic analysis of the calcineurin signaling pathways
37. The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch
38. +, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast
39. Prevention of cardiac hypertrophy in mice by calcineurin inhibition
40. Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin)
41. + gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway
42. + gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway
43. Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control
44. Regulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I
45. +-dependent association with the protein modulator of cyclic nucleotide phosphodiesterase
46. The genome sequence of Schizosaccharomyces pombe
47. Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis
48. + in fission yeast: Mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning
49. Spm1, a stress-activated MAP kinase that regulates morphogenesis in S. pombe
50. Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast
51. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1