-
1
-
-
84890276779
-
Evidence for central regulation of glucose metabolism
-
Carey, M., Kehlenbrink, S., and Hawkins, M. (2013) Evidence for central regulation of glucose metabolism. J. Biol. Chem. 288, 34981-34988
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 34981-34988
-
-
Carey, M.1
Kehlenbrink, S.2
Hawkins, M.3
-
2
-
-
38649116056
-
Selective versus total insulin resistance: A pathogenic paradox
-
Brown, M. S., and Goldstein, J. L. (2008) Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 7, 95-96
-
(2008)
Cell Metab.
, vol.7
, pp. 95-96
-
-
Brown, M.S.1
Goldstein, J.L.2
-
3
-
-
0029933643
-
The cellular and molecular mechanisms of diabetic complications
-
King, G. L., and Brownlee, M. (1996) The cellular and molecular mechanisms of diabetic complications. Endocrinol. Metab. Clin. North Am. 25, 255-270
-
(1996)
Endocrinol. Metab. Clin. North Am.
, vol.25
, pp. 255-270
-
-
King, G.L.1
Brownlee, M.2
-
4
-
-
0032719024
-
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
-
Jiang, Z. Y., Lin, Y. W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., and King, G. L. (1999) Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J. Clin. Invest. 104, 447-457
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 447-457
-
-
Jiang, Z.Y.1
Lin, Y.W.2
Clemont, A.3
Feener, E.P.4
Hein, K.D.5
Igarashi, M.6
Yamauchi, T.7
White, M.F.8
King, G.L.9
-
5
-
-
84857401843
-
Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes
-
Cryer, P. E. (2012) Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. Endocrinology 153, 1039-1048
-
(2012)
Endocrinology
, vol.153
, pp. 1039-1048
-
-
Cryer, P.E.1
-
6
-
-
9244264963
-
Effects of type 2 diabetes on the regulation of hepatic glucose metabolism
-
Basu, A., Shah, P., Nielsen, M., Basu, R., and Rizza, R. A. (2004) Effects of type 2 diabetes on the regulation of hepatic glucose metabolism. J. Investig. Med. 52, 366-374
-
(2004)
J. Investig. Med.
, vol.52
, pp. 366-374
-
-
Basu, A.1
Shah, P.2
Nielsen, M.3
Basu, R.4
Rizza, R.A.5
-
7
-
-
78049259220
-
Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: Implications for therapy
-
Rizza, R. A. (2010) Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy. Diabetes 59, 2697-2707
-
(2010)
Diabetes
, vol.59
, pp. 2697-2707
-
-
Rizza, R.A.1
-
8
-
-
21344463062
-
Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis
-
Basu, R., Chandramouli, V., Dicke, B., Landau, B., and Rizza, R. (2005) Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis. Diabetes 54, 1942-1948
-
(2005)
Diabetes
, vol.54
, pp. 1942-1948
-
-
Basu, R.1
Chandramouli, V.2
Dicke, B.3
Landau, B.4
Rizza, R.5
-
9
-
-
34249674023
-
Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: Role of increased rates of gluconeogenesis
-
Bock, G., Chittilapilly, E., Basu, R., Toffolo, G., Cobelli, C., Chandramouli, V., Landau, B. R., and Rizza, R. A. (2007) Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis. Diabetes 56, 1703-1711
-
(2007)
Diabetes
, vol.56
, pp. 1703-1711
-
-
Bock, G.1
Chittilapilly, E.2
Basu, R.3
Toffolo, G.4
Cobelli, C.5
Chandramouli, V.6
Landau, B.R.7
Rizza, R.A.8
-
10
-
-
0026607988
-
Regulation of net hepatic glucose uptake in vivo
-
Pagliassotti, M. J., and Cherrington, A. D. (1992) Regulation of net hepatic glucose uptake in vivo. Annu. Rev. Physiol. 54, 847-860
-
(1992)
Annu. Rev. Physiol.
, vol.54
, pp. 847-860
-
-
Pagliassotti, M.J.1
Cherrington, A.D.2
-
11
-
-
0141566760
-
Regulation of hepatic and peripheral glucose disposal
-
Moore, M. C., Cherrington, A. D., and Wasserman, D. H. (2003) Regulation of hepatic and peripheral glucose disposal. Best Pract. Res. Clin. Endocrinol. Metab. 17, 343-364
-
(2003)
Best Pract. Res. Clin. Endocrinol. Metab.
, vol.17
, pp. 343-364
-
-
Moore, M.C.1
Cherrington, A.D.2
Wasserman, D.H.3
-
12
-
-
0036063775
-
Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans
-
Shah, P., Vella, A., Basu, A., Basu, R., Adkins, A., Schwenk, W. F., Johnson, C. M., Nair, K. S., Jensen, M. D., and Rizza, R. A. (2002) Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans. Diabetes 51, 301-310
-
(2002)
Diabetes
, vol.51
, pp. 301-310
-
-
Shah, P.1
Vella, A.2
Basu, A.3
Basu, R.4
Adkins, A.5
Schwenk, W.F.6
Johnson, C.M.7
Nair, K.S.8
Jensen, M.D.9
Rizza, R.A.10
-
13
-
-
0037223317
-
Elevated free fatty acids impair glucose metabolism in women: Decreased stimulation of muscle glucose uptake and suppression of splanchnic glucose production during combined hyperinsulinemia and hyperglycemia
-
Shah, P., Vella, A., Basu, A., Basu, R., Adkins, A., Schwenk, W. F., Johnson, C. M., Nair, K. S., Jensen, M. D., and Rizza, R. A. (2003) Elevated free fatty acids impair glucose metabolism in women: decreased stimulation of muscle glucose uptake and suppression of splanchnic glucose production during combined hyperinsulinemia and hyperglycemia. Diabetes 52, 38-42
-
(2003)
Diabetes
, vol.52
, pp. 38-42
-
-
Shah, P.1
Vella, A.2
Basu, A.3
Basu, R.4
Adkins, A.5
Schwenk, W.F.6
Johnson, C.M.7
Nair, K.S.8
Jensen, M.D.9
Rizza, R.A.10
-
14
-
-
57649133952
-
Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: Impact of physiological and pharmacological effectors
-
Anderka, O., Boyken, J., Aschenbach, U., Batzer, A., Boscheinen, O., and Schmoll, D. (2008) Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors. J. Biol. Chem. 283, 31333-31340
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 31333-31340
-
-
Anderka, O.1
Boyken, J.2
Aschenbach, U.3
Batzer, A.4
Boscheinen, O.5
Schmoll, D.6
-
16
-
-
0028338590
-
Shortterm control of glucokinase activity: A role of a regulatory protein
-
Van Schaftingen, E., Detheux, M., and Veiga da Cunha, M. (1994) Shortterm control of glucokinase activity: a role of a regulatory protein. FASEB J. 8, 414-419
-
(1994)
FASEB J.
, vol.8
, pp. 414-419
-
-
Van Schaftingen, E.1
Detheux, M.2
Veiga Da Cunha, M.3
-
17
-
-
0028101926
-
Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut
-
Jetton, T. L., Liang, Y., Pettepher, C. C., Zimmerman, E. C., Cox, F. G., Horvath, K., Matschinsky, F. M., and Magnuson, M. A. (1994) Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J. Biol. Chem. 269, 3641-3654
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 3641-3654
-
-
Jetton, T.L.1
Liang, Y.2
Pettepher, C.C.3
Zimmerman, E.C.4
Cox, F.G.5
Horvath, K.6
Matschinsky, F.M.7
Magnuson, M.A.8
-
18
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase
-
Postic, C., Shiota, M., Niswender, K. D., Jetton, T. L., Chen, Y., Moates, J. M., Shelton, K. D., Lindner, J., Cherrington, A. D., and Magnuson, M. A. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274, 305-315
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 305-315
-
-
Postic, C.1
Shiota, M.2
Niswender, K.D.3
Jetton, T.L.4
Chen, Y.5
Moates, J.M.6
Shelton, K.D.7
Lindner, J.8
Cherrington, A.D.9
Magnuson, M.A.10
-
19
-
-
80052914660
-
Defective glycogenesis contributes toward the inability to suppress hepatic glucose production in response to hyperglycemia and hyperinsulinemia in Zucker diabetic fatty rats
-
Torres, T. P., Fujimoto, Y., Donahue, E. P., Printz, R. L., Houseknecht, K. L., Treadway, J. L., and Shiota, M. (2011) Defective glycogenesis contributes toward the inability to suppress hepatic glucose production in response to hyperglycemia and hyperinsulinemia in Zucker diabetic fatty rats. Diabetes 60, 2225-2233
-
(2011)
Diabetes
, vol.60
, pp. 2225-2233
-
-
Torres, T.P.1
Fujimoto, Y.2
Donahue, E.P.3
Printz, R.L.4
Houseknecht, K.L.5
Treadway, J.L.6
Shiota, M.7
-
20
-
-
63249123500
-
Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in Zucker diabetic fatty rats
-
Torres, T. P., Catlin, R. L., Chan, R., Fujimoto, Y., Sasaki, N., Printz, R. L., Newgard, C. B., and Shiota, M. (2009) Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in Zucker diabetic fatty rats. Diabetes 58, 78-86
-
(2009)
Diabetes
, vol.58
, pp. 78-86
-
-
Torres, T.P.1
Catlin, R.L.2
Chan, R.3
Fujimoto, Y.4
Sasaki, N.5
Printz, R.L.6
Newgard, C.B.7
Shiota, M.8
-
21
-
-
33750585132
-
Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats
-
Fujimoto, Y., Torres, T. P., Donahue, E. P., and Shiota, M. (2006) Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats. Diabetes 55, 2479-2490
-
(2006)
Diabetes
, vol.55
, pp. 2479-2490
-
-
Fujimoto, Y.1
Torres, T.P.2
Donahue, E.P.3
Shiota, M.4
-
22
-
-
77956417607
-
A retrospective review of the roles of multifunctional glucose-6-phosphatase in blood glucose homeostasis: Genesis of the tuning/retuning hypothesis
-
Nordlie, R. C., and Foster, J. D. (2010) A retrospective review of the roles of multifunctional glucose-6-phosphatase in blood glucose homeostasis: genesis of the tuning/retuning hypothesis. Life Sci. 87, 339-349
-
(2010)
Life Sci.
, vol.87
, pp. 339-349
-
-
Nordlie, R.C.1
Foster, J.D.2
-
23
-
-
79956225940
-
Glucose-6-phosphatase deficiency
-
Froissart, R., Piraud, M., Boudjemline, A. M., Vianey-Saban, C., Petit, F., Hubert-Buron, A., Eberschweiler, P. T., Gajdos, V., and Labrune, P. (2011) Glucose-6-phosphatase deficiency. Orphanet. J. Rare Dis. 6, 27
-
(2011)
Orphanet. J. Rare Dis.
, vol.6
, pp. 27
-
-
Froissart, R.1
Piraud, M.2
Boudjemline, A.M.3
Vianey-Saban, C.4
Petit, F.5
Hubert-Buron, A.6
Eberschweiler, P.T.7
Gajdos, V.8
Labrune, P.9
-
24
-
-
0034034229
-
Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes
-
Clore, J. N., Stillman, J., and Sugerman, H. (2000) Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes. Diabetes 49, 969-974
-
(2000)
Diabetes
, vol.49
, pp. 969-974
-
-
Clore, J.N.1
Stillman, J.2
Sugerman, H.3
-
25
-
-
1942422572
-
Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ
-
Hornbuckle, L. A., Everett, C. A., Martin, C. C., Gustavson, S. S., Svitek, C. A., Oeser, J. K., Neal, D. W., Cherrington, A. D., and O'Brien, R. M. (2004) Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ. Am. J Physiol. Endocrinol. Metab. 286, E795-E808
-
(2004)
Am. J Physiol. Endocrinol. Metab.
, vol.286
-
-
Hornbuckle, L.A.1
Everett, C.A.2
Martin, C.C.3
Gustavson, S.S.4
Svitek, C.A.5
Oeser, J.K.6
Neal, D.W.7
Cherrington, A.D.8
O'Brien, R.M.9
-
26
-
-
67749142348
-
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with type 2 diabetes
-
Samuel, V. T., Beddow, S. A., Iwasaki, T., Zhang, X. M., Chu, X., Still, C. D., Gerhard, G. S., and Shulman, G. I. (2009) Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with type 2 diabetes. Proc. Natl. Acad. Sci. U. S. A. 106, 12121-12126
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 12121-12126
-
-
Samuel, V.T.1
Beddow, S.A.2
Iwasaki, T.3
Zhang, X.M.4
Chu, X.5
Still, C.D.6
Gerhard, G.S.7
Shulman, G.I.8
-
27
-
-
84855929671
-
Glycogen and its metabolism: Some new developments and old themes
-
Roach, P. J., Depaoli-Roach, A. A., Hurley, T. D., and Tagliabracci, V. S. (2012) Glycogen and its metabolism: some new developments and old themes. Biochem. J. 441, 763-787
-
(2012)
Biochem. J.
, vol.441
, pp. 763-787
-
-
Roach, P.J.1
Depaoli-Roach, A.A.2
Hurley, T.D.3
Tagliabracci, V.S.4
-
28
-
-
0025771284
-
Sources of carbon for hepatic glycogen synthesis in the conscious dog
-
Moore, M. C., Cherrington, A. D., Cline, G., Pagliassotti, M. J., Jones, E. M., Neal, D. W., Badet, C., and Shulman, G. I. (1991) Sources of carbon for hepatic glycogen synthesis in the conscious dog. J. Clin. Invest. 88, 578-587
-
(1991)
J. Clin. Invest.
, vol.88
, pp. 578-587
-
-
Moore, M.C.1
Cherrington, A.D.2
Cline, G.3
Pagliassotti, M.J.4
Jones, E.M.5
Neal, D.W.6
Badet, C.7
Shulman, G.I.8
-
29
-
-
0026530891
-
Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats
-
Giaccari, A., and Rossetti, L. (1992) Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. J. Clin. Invest. 89, 36-45
-
(1992)
J. Clin. Invest.
, vol.89
, pp. 36-45
-
-
Giaccari, A.1
Rossetti, L.2
-
30
-
-
33845437164
-
Impact of portal glucose delivery on glucose metabolism in conscious, unrestrained mice
-
Chueh, F. Y., Malabanan, C., and McGuinness, O. P. (2006) Impact of portal glucose delivery on glucose metabolism in conscious, unrestrained mice. Am. J. Physiol. Endocrinol. Metab. 291, E1206-E1211
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.291
-
-
Chueh, F.Y.1
Malabanan, C.2
McGuinness, O.P.3
-
31
-
-
78549264131
-
Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis
-
Ros, S., Zafra, D., Valles-Ortega, J., García-Rocha, M., Forrow, S., Domínguez, J., Calbó, J., and Guinovart, J. J. (2010) Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis. J. Biol. Chem. 285, 37170-37177
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 37170-37177
-
-
Ros, S.1
Zafra, D.2
Valles-Ortega, J.3
García-Rocha, M.4
Forrow, S.5
Domínguez, J.6
Calbó, J.7
Guinovart, J.J.8
-
32
-
-
80054121137
-
Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats
-
Ros, S., García-Rocha, M., Calbó, J., and Guinovart, J. (2011) Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats. Diabetologia 54, 2639-2648
-
(2011)
Diabetologia
, vol.54
, pp. 2639-2648
-
-
Ros, S.1
García-Rocha, M.2
Calbó, J.3
Guinovart, J.4
-
33
-
-
84870281398
-
Transcriptional regulation of pyruvate dehydrogenase kinase
-
Jeong, J. Y., Jeoung, N. H., Park, K. G., and Lee, I. K. (2012) Transcriptional regulation of pyruvate dehydrogenase kinase. Diabetes Metab. J. 36, 328-335
-
(2012)
Diabetes Metab. J.
, vol.36
, pp. 328-335
-
-
Jeong, J.Y.1
Jeoung, N.H.2
Park, K.G.3
Lee, I.K.4
-
34
-
-
84881097499
-
Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes
-
Tao, R., Xiong, X., Harris, R. A., White, M. F., and Dong, X. C. (2013) Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. PLoS ONE 8, e71997
-
(2013)
PLoS ONE
, vol.8
-
-
Tao, R.1
Xiong, X.2
Harris, R.A.3
White, M.F.4
Dong, X.C.5
-
35
-
-
0030798890
-
Fatty acid regulation of very low density lipoprotein production
-
Lewis, G. F. (1997) Fatty acid regulation of very low density lipoprotein production. Curr. Opin. Lipidol. 8, 146-153
-
(1997)
Curr. Opin. Lipidol.
, vol.8
, pp. 146-153
-
-
Lewis, G.F.1
-
36
-
-
34248203216
-
Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis
-
Chong, M. F. F., Fielding, B. A., and Frayn, K. N. (2007) Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis. Proc. Nutr. Soc. 66, 52-59
-
(2007)
Proc. Nutr. Soc.
, vol.66
, pp. 52-59
-
-
Chong, M.F.F.1
Fielding, B.A.2
Frayn, K.N.3
-
37
-
-
34548675572
-
Time trends and risk factors for diabetes mellitus in cats presented to veterinary teaching hospitals
-
Prahl, A., Guptill, L., Glickman, N. W., Tetrick, M., and Glickman, L. T. (2007) Time trends and risk factors for diabetes mellitus in cats presented to veterinary teaching hospitals. J. Feline Med. Surg. 9, 351-358
-
(2007)
J. Feline Med. Surg.
, vol.9
, pp. 351-358
-
-
Prahl, A.1
Guptill, L.2
Glickman, N.W.3
Tetrick, M.4
Glickman, L.T.5
-
38
-
-
0037195528
-
Pathogenesis of feline diabetes mellitus
-
O'Brien, T. D. (2002) Pathogenesis of feline diabetes mellitus. Mol. Cell. Endocrinol. 197, 213-219
-
(2002)
Mol. Cell. Endocrinol.
, vol.197
, pp. 213-219
-
-
O'Brien, T.D.1
-
39
-
-
77951212602
-
Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice
-
Irimia, J. M., Meyer, C. M., Peper, C. L., Zhai, L., Bock, C. B., Previs, S. F., McGuinness, O. P., DePaoli-Roach, A., and Roach, P. J. (2010) Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. J. Biol. Chem. 285, 12851-12861
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 12851-12861
-
-
Irimia, J.M.1
Meyer, C.M.2
Peper, C.L.3
Zhai, L.4
Bock, C.B.5
Previs, S.F.6
McGuinness, O.P.7
DePaoli-Roach, A.8
Roach, P.J.9
-
40
-
-
45849094471
-
Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a
-
Bandsma, R. H., Prinsen, B. H., van der Velden Mde, S., Rake, J. P., Boer, T., Smit, G. P., Reijngoud, D. J., and Kuipers, F. (2008) Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a. Pediatr. Res. 63, 702-707
-
(2008)
Pediatr. Res.
, vol.63
, pp. 702-707
-
-
Bandsma, R.H.1
Prinsen, B.H.2
Van Velden Der Mde, S.3
Rake, J.P.4
Boer, T.5
Smit, G.P.6
Reijngoud, D.J.7
Kuipers, F.8
-
41
-
-
73249136971
-
Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo
-
Edgerton, D. S., Ramnanan, C. J., Grueter, C. A., Johnson, K. M. S., Lautz, M., Neal, D. W., Williams, P. E., and Cherrington, A. D. (2009) Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Diabetes 58, 2766-2775
-
(2009)
Diabetes
, vol.58
, pp. 2766-2775
-
-
Edgerton, D.S.1
Ramnanan, C.J.2
Grueter, C.A.3
Johnson, K.M.S.4
Lautz, M.5
Neal, D.W.6
Williams, P.E.7
Cherrington, A.D.8
-
42
-
-
77953216482
-
Molecular characterization of insulinmediated suppression of hepatic glucose production in vivo
-
Ramnanan, C. J., Edgerton, D. S., Rivera, N., Irimia-Dominguez, J., Farmer, B., Neal, D. W., Lautz, M., Donahue, E. P., Meyer, C. M., Roach, P. J., and Cherrington, A. D. (2010) Molecular characterization of insulinmediated suppression of hepatic glucose production in vivo. Diabetes 59, 1302-1311
-
(2010)
Diabetes
, vol.59
, pp. 1302-1311
-
-
Ramnanan, C.J.1
Edgerton, D.S.2
Rivera, N.3
Irimia-Dominguez, J.4
Farmer, B.5
Neal, D.W.6
Lautz, M.7
Donahue, E.P.8
Meyer, C.M.9
Roach, P.J.10
Cherrington, A.D.11
-
43
-
-
33947580628
-
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
-
Burgess, S. C., He, T., Yan, Z., Lindner, J., Sherry, A. D., Malloy, C. R., Browning, J. D., and Magnuson, M. A. (2007) Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab. 5, 313-320
-
(2007)
Cell Metab.
, vol.5
, pp. 313-320
-
-
Burgess, S.C.1
He, T.2
Yan, Z.3
Lindner, J.4
Sherry, A.D.5
Malloy, C.R.6
Browning, J.D.7
Magnuson, M.A.8
-
44
-
-
37349000335
-
Canine diabetes mellitus: From phenotype to genotype
-
Catchpole, B., Kennedy, L. J., Davison, L. J., and Ollier, W. E. R. (2008) Canine diabetes mellitus: from phenotype to genotype. J. Small Anim. Pract. 49, 4-10
-
(2008)
J. Small Anim. Pract.
, vol.49
, pp. 4-10
-
-
Catchpole, B.1
Kennedy, L.J.2
Davison, L.J.3
Ollier, W.E.R.4
-
45
-
-
0026600946
-
Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans
-
Jungas, R. L., Halperin, M. L., and Brosnan, J. T. (1992) Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans. Physiol. Rev. 72, 419-448
-
(1992)
Physiol. Rev.
, vol.72
, pp. 419-448
-
-
Jungas, R.L.1
Halperin, M.L.2
Brosnan, J.T.3
-
46
-
-
0033758124
-
Metabolic complications of obesity
-
Grundy, S. M. (2000) Metabolic complications of obesity. Endocrine 13, 155-165
-
(2000)
Endocrine
, vol.13
, pp. 155-165
-
-
Grundy, S.M.1
-
47
-
-
0018364379
-
Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia
-
Grundy, S. M., Mok, H. Y., Zech, L., Steinberg, D., and Berman, M. (1979) Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia. J. Clin. Invest. 63, 1274-1283
-
(1979)
J. Clin. Invest.
, vol.63
, pp. 1274-1283
-
-
Grundy, S.M.1
Mok, H.Y.2
Zech, L.3
Steinberg, D.4
Berman, M.5
-
48
-
-
38649111018
-
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
-
Fabbrini, E., Mohammed, B. S., Magkos, F., Korenblat, K. M., Patterson, B. W., and Klein, S. (2008) Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 134, 424-431
-
(2008)
Gastroenterology
, vol.134
, pp. 424-431
-
-
Fabbrini, E.1
Mohammed, B.S.2
Magkos, F.3
Korenblat, K.M.4
Patterson, B.W.5
Klein, S.6
-
49
-
-
33646035836
-
Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states
-
Barrows, B. R., and Parks, E. J. (2006) Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states. J. Clin. Endocrinol. Metab. 91, 1446-1452
-
(2006)
J. Clin. Endocrinol. Metab.
, vol.91
, pp. 1446-1452
-
-
Barrows, B.R.1
Parks, E.J.2
-
50
-
-
84859159458
-
Postprandial metabolism of meal triglyceride in humans
-
Lambert, J. E., and Parks, E. J. (2012) Postprandial metabolism of meal triglyceride in humans. Biochim. Biophys. Acta 1821, 721-726
-
(2012)
Biochim. Biophys. Acta
, vol.1821
, pp. 721-726
-
-
Lambert, J.E.1
Parks, E.J.2
-
51
-
-
24144475456
-
Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men
-
Timlin, M. T., Barrows, B. R., and Parks, E. J. (2005) Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men. Diabetes 54, 2694-2701
-
(2005)
Diabetes
, vol.54
, pp. 2694-2701
-
-
Timlin, M.T.1
Barrows, B.R.2
Parks, E.J.3
-
52
-
-
80053541911
-
Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women
-
Stanhope, K. L., Bremer, A. A., Medici, V., Nakajima, K., Ito, Y., Nakano, T., Chen, G., Fong, T. H., Lee, V., Menorca, R. I., Keim, N. L., and Havel, P. J. (2011) Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. J. Clin. Endocrinol. Metab. 96, E1596-E1605
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
-
-
Stanhope, K.L.1
Bremer, A.A.2
Medici, V.3
Nakajima, K.4
Ito, Y.5
Nakano, T.6
Chen, G.7
Fong, T.H.8
Lee, V.9
Menorca, R.I.10
Keim, N.L.11
Havel, P.J.12
-
53
-
-
33845587374
-
Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans
-
Vedala, A., Wang, W., Neese, R. A., Christiansen, M. P., and Hellerstein, M. K. (2006) Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans. J. Lipid Res. 47, 2562-2574
-
(2006)
J. Lipid Res.
, vol.47
, pp. 2562-2574
-
-
Vedala, A.1
Wang, W.2
Neese, R.A.3
Christiansen, M.P.4
Hellerstein, M.K.5
-
54
-
-
77952863834
-
Genetic control of de novo lipogenesis: Role in diet-induced obesity
-
Strable, M. S., and Ntambi, J. M. (2010) Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit. Rev. Biochem. Mol. Biol. 45, 199-214
-
(2010)
Crit. Rev. Biochem. Mol. Biol.
, vol.45
, pp. 199-214
-
-
Strable, M.S.1
Ntambi, J.M.2
-
55
-
-
84855303466
-
2O quantification
-
2O quantification. Am. J. Physiol. Endocrinol. Metab. 302, E209-E217
-
(2012)
Am. J. Physiol. Endocrinol. Metab.
, vol.302
-
-
Jensen, K.K.1
Previs, S.F.2
Zhu, L.3
Herath, K.4
Wang, S.-P.5
Bhat, G.6
Hu, G.7
Miller, P.L.8
McLaren, D.G.9
Shin, M.K.10
Vogt, T.F.11
Wang, L.12
Wong, K.K.13
Roddy, T.P.14
Johns, D.G.15
Hubbard, B.K.16
-
56
-
-
0032965030
-
De novo lipogenesis in humans: Metabolic and regulatory aspects
-
Hellerstein, M. K. (1999) De novo lipogenesis in humans: metabolic and regulatory aspects. Eur. J Clin. Nutr. 53, Suppl. 1, S53-S65
-
(1999)
Eur. J Clin. Nutr.
, vol.53
, Issue.SUPPL. 1
-
-
Hellerstein, M.K.1
-
57
-
-
58849119766
-
A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes
-
Beysen, C., Murphy, E. J., Nagaraja, H., Decaris, M., Riiff, T., Fong, A., Hellerstein, M. K., and Boyle, P. J. (2008) A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes. J. Lipid Res. 49, 2657-2663
-
(2008)
J. Lipid Res.
, vol.49
, pp. 2657-2663
-
-
Beysen, C.1
Murphy, E.J.2
Nagaraja, H.3
Decaris, M.4
Riiff, T.5
Fong, A.6
Hellerstein, M.K.7
Boyle, P.J.8
-
58
-
-
84879864004
-
Reciprocal regulation of hepatic and adipose lipogenesis by liverXreceptors in obesity and insulin resistance
-
Beaven, S. W., Matveyenko, A., Wroblewski, K., Chao, L., Wilpitz, D., Hsu, T. W., Lentz, J., Drew, B., Hevener, A. L., and Tontonoz, P. (2013) Reciprocal regulation of hepatic and adipose lipogenesis by liverXreceptors in obesity and insulin resistance. Cell Metab. 18, 106-117
-
(2013)
Cell Metab.
, vol.18
, pp. 106-117
-
-
Beaven, S.W.1
Matveyenko, A.2
Wroblewski, K.3
Chao, L.4
Wilpitz, D.5
Hsu, T.W.6
Lentz, J.7
Drew, B.8
Hevener, A.L.9
Tontonoz, P.10
-
59
-
-
0033598749
-
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
-
Shimomura, I., Bashmakov, Y., Ikemoto, S., Horton, J. D., Brown, M. S., and Goldstein, J. L. (1999) Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc. Natl. Acad. Sci. U. S. A. 96, 13656-13661
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 13656-13661
-
-
Shimomura, I.1
Bashmakov, Y.2
Ikemoto, S.3
Horton, J.D.4
Brown, M.S.5
Goldstein, J.L.6
-
60
-
-
84859480317
-
-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions
-
-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. J. Biol. Chem. 287, 12578-12588
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 12578-12588
-
-
Abu-Elheiga, L.1
Wu, H.2
Gu, Z.3
Bressler, R.4
Wakil, S.J.5
-
61
-
-
0042337449
-
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets
-
Abu-Elheiga, L., Oh, W., Kordari, P., and Wakil, S. J. (2003) Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc. Natl. Acad. Sci. U. S. A. 100, 10207-10212
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 10207-10212
-
-
Abu-Elheiga, L.1
Oh, W.2
Kordari, P.3
Wakil, S.J.4
-
62
-
-
77952213776
-
Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake
-
Olson, D. P., Pulinilkunnil, T., Cline, G. W., Shulman, G. I., and Lowell, B. B. (2010) Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc. Natl. Acad. Sci. U. S. A. 107, 7598-7603
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 7598-7603
-
-
Olson, D.P.1
Pulinilkunnil, T.2
Cline, G.W.3
Shulman, G.I.4
Lowell, B.B.5
-
63
-
-
84871709488
-
The role of the carbohydrate response element-binding protein in male fructose-fed rats
-
Erion, D. M., Popov, V., Hsiao, J. J., Vatner, D., Mitchell, K., Yonemitsu, S., Nagai, Y., Kahn, M., Gillum, M. P., Dong, J., Murray, S. F., Manchem, V. P., Bhanot, S., Cline, G. W., Shulman, G. I., and Samuel, V. T. (2013) The role of the carbohydrate response element-binding protein in male fructose-fed rats. Endocrinology 154, 36-44
-
(2013)
Endocrinology
, vol.154
, pp. 36-44
-
-
Erion, D.M.1
Popov, V.2
Hsiao, J.J.3
Vatner, D.4
Mitchell, K.5
Yonemitsu, S.6
Nagai, Y.7
Kahn, M.8
Gillum, M.P.9
Dong, J.10
Murray, S.F.11
Manchem, V.P.12
Bhanot, S.13
Cline, G.W.14
Shulman, G.I.15
Samuel, V.T.16
-
64
-
-
33749370739
-
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
-
Dentin, R., Benhamed, F., Hainault, I., Fauveau, V., Foufelle, F., Dyck, J. R., Girard, J., and Postic, C. (2006) Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes 55, 2159-2170
-
(2006)
Diabetes
, vol.55
, pp. 2159-2170
-
-
Dentin, R.1
Benhamed, F.2
Hainault, I.3
Fauveau, V.4
Foufelle, F.5
Dyck, J.R.6
Girard, J.7
Postic, C.8
-
65
-
-
84874600898
-
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
-
Eissing, L., Scherer, T., Tödter, K., Knippschild, U., Greve, J. W., Buurman, W. A., Pinnschmidt, H. O., Rensen, S. S., Wolf, A. M., Bartelt, A., Heeren, J., Buettner, C., and Scheja, L. (2013) De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health. Nat. Commun. 4, 1528
-
(2013)
Nat. Commun.
, vol.4
, pp. 1528
-
-
Eissing, L.1
Scherer, T.2
Tödter, K.3
Knippschild, U.4
Greve, J.W.5
Buurman, W.A.6
Pinnschmidt, H.O.7
Rensen, S.S.8
Wolf, A.M.9
Bartelt, A.10
Heeren, J.11
Buettner, C.12
Scheja, L.13
-
66
-
-
0017177024
-
Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats
-
Stansbie, D., Brownsey, R. W., Crettaz, M., and Denton, R. M. (1976) Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. Biochem. J. 160, 413-416
-
(1976)
Biochem. J.
, vol.160
, pp. 413-416
-
-
Stansbie, D.1
Brownsey, R.W.2
Crettaz, M.3
Denton, R.M.4
-
67
-
-
84905376402
-
Liver but not adipose tissue is responsive to the pattern of enteral feeding
-
Otero, Y. F., Lundblad, T. M., Ford, E. A., House, L. M., and McGuinness, O. P. (2014) Liver but not adipose tissue is responsive to the pattern of enteral feeding. Physiol. Rep. 2, e00250
-
(2014)
Physiol. Rep.
, vol.2
-
-
Otero, Y.F.1
Lundblad, T.M.2
Ford, E.A.3
House, L.M.4
McGuinness, O.P.5
-
68
-
-
77955763276
-
Hypoglycemia in type 1 diabetes mellitus
-
Cryer, P. E. (2010) Hypoglycemia in type 1 diabetes mellitus. Endocrinol. Metab. Clin. North Am. 39, 641-654
-
(2010)
Endocrinol. Metab. Clin. North Am.
, vol.39
, pp. 641-654
-
-
Cryer, P.E.1
-
69
-
-
79954996869
-
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
-
Jornayvaz, F. R., Birkenfeld, A. L., Jurczak, M. J., Kanda, S., Guigni, B. A., Jiang, D. C., Zhang, D., Lee, H.-Y., Samuel, V. T., and Shulman, G. I. (2011) Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proc. Natl. Acad. Sci. U. S. A. 108, 5748-5752
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 5748-5752
-
-
Jornayvaz, F.R.1
Birkenfeld, A.L.2
Jurczak, M.J.3
Kanda, S.4
Guigni, B.A.5
Jiang, D.C.6
Zhang, D.7
Lee, H.-Y.8
Samuel, V.T.9
Shulman, G.I.10
-
70
-
-
34347235098
-
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
-
Monetti, M., Levin, M. C., Watt, M. J., Sajan, M. P., Marmor, S., Hubbard, B. K., Stevens, R. D., Bain, J. R., Newgard, C. B., Farese, R. V., Sr., Hevener, A. L., and Farese, R. V., Jr. (2007) Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 6, 69-78
-
(2007)
Cell Metab.
, vol.6
, pp. 69-78
-
-
Monetti, M.1
Levin, M.C.2
Watt, M.J.3
Sajan, M.P.4
Marmor, S.5
Hubbard, B.K.6
Stevens, R.D.7
Bain, J.R.8
Newgard, C.B.9
Farese Sr., R.V.10
Hevener, A.L.11
Farese Jr., R.V.12
-
71
-
-
34547946930
-
Suppression of diacylglycerol acyltransferase-2(DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
-
Choi, C. S., Savage, D. B., Kulkarni, A., Yu, X. X., Liu, Z. X., Morino, K., Kim, S., Distefano, A., Samuel, V. T., Neschen, S., Zhang, D., Wang, A., Zhang, X. M., Kahn, M., Cline, G. W., Pandey, S. K., Geisler, J. G., Bhanot, S., Monia, B. P., and Shulman, G. I. (2007) Suppression of diacylglycerol acyltransferase-2(DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem. 282, 22678-22688
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 22678-22688
-
-
Choi, C.S.1
Savage, D.B.2
Kulkarni, A.3
Yu, X.X.4
Liu, Z.X.5
Morino, K.6
Kim, S.7
Distefano, A.8
Samuel, V.T.9
Neschen, S.10
Zhang, D.11
Wang, A.12
Zhang, X.M.13
Kahn, M.14
Cline, G.W.15
Pandey, S.K.16
Geisler, J.G.17
Bhanot, S.18
Monia, B.P.19
Shulman, G.I.20
more..
-
72
-
-
82355171896
-
Targeting acyl-CoA: Diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases
-
Cao, J., Zhou, Y., Peng, H., Huang, X., Stahler, S., Suri, V., Qadri, A., Gareski, T., Jones, J., Hahm, S., Perreault, M., McKew, J., Shi, M., Xu, X., Tobin, J. F., and Gimeno, R. E. (2011) Targeting acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J. Biol. Chem. 286, 41838-41851
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 41838-41851
-
-
Cao, J.1
Zhou, Y.2
Peng, H.3
Huang, X.4
Stahler, S.5
Suri, V.6
Qadri, A.7
Gareski, T.8
Jones, J.9
Hahm, S.10
Perreault, M.11
McKew, J.12
Shi, M.13
Xu, X.14
Tobin, J.F.15
Gimeno, R.E.16
-
73
-
-
4143116960
-
Hypoglycemia in type 2 diabetes
-
Banarer, S., and Cryer, P. E. (2004) Hypoglycemia in type 2 diabetes. Med. Clin. North Am. 88, 1107-1116
-
(2004)
Med. Clin. North Am.
, vol.88
, pp. 1107-1116
-
-
Banarer, S.1
Cryer, P.E.2
-
74
-
-
84865523163
-
Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia
-
Sparks, J. D., Sparks, C. E., and Adeli, K. (2012) Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia. Arterioscler. Thromb. Vasc. Biol. 32, 2104-2112
-
(2012)
Arterioscler. Thromb. Vasc. Biol.
, vol.32
, pp. 2104-2112
-
-
Sparks, J.D.1
Sparks, C.E.2
Adeli, K.3
-
75
-
-
77954925939
-
Impairedinactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoprotein
-
Wu, K., Cappel, D., Martinez, M., and Stafford, J. M. (2010) Impairedinactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoprotein. Endocrinology 151, 3566-3576
-
(2010)
Endocrinology
, vol.151
, pp. 3566-3576
-
-
Wu, K.1
Cappel, D.2
Martinez, M.3
Stafford, J.M.4
-
76
-
-
45749133797
-
FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice
-
Kamagate, A., Qu, S., Perdomo, G., Su, D., Kim, D. H., Slusher, S., Meseck, M., and Dong, H. H. (2008) FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J. Clin. Invest. 118, 2347-2364
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2347-2364
-
-
Kamagate, A.1
Qu, S.2
Perdomo, G.3
Su, D.4
Kim, D.H.5
Slusher, S.6
Meseck, M.7
Dong, H.H.8
-
77
-
-
53149150247
-
ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice
-
Chen, Z., Newberry, E. P., Norris, J. Y., Xie, Y., Luo, J., Kennedy, S. M., and Davidson, N. O. (2008) ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. J. Lipid Res. 49, 2013-2022
-
(2008)
J. Lipid Res.
, vol.49
, pp. 2013-2022
-
-
Chen, Z.1
Newberry, E.P.2
Norris, J.Y.3
Xie, Y.4
Luo, J.5
Kennedy, S.M.6
Davidson, N.O.7
-
78
-
-
79958222144
-
New lipid modulating drugs: The role of microsomal transport protein inhibitors
-
Rizzo, M., and Wierzbicki, A. S. (2011) New lipid modulating drugs: the role of microsomal transport protein inhibitors. Curr. Pharm. Des. 17, 943-949
-
(2011)
Curr. Pharm. Des.
, vol.17
, pp. 943-949
-
-
Rizzo, M.1
Wierzbicki, A.S.2
-
79
-
-
0031731373
-
Hyperglycemia-induced inhibition of splanchnic fatty acid oxidation increases hepatic triacylglycerol secretion
-
Sidossis, L. S., Mittendorfer, B., Walser, E., Chinkes, D., and Wolfe, R. R. (1998) Hyperglycemia-induced inhibition of splanchnic fatty acid oxidation increases hepatic triacylglycerol secretion. Am. J. Physiol. 275, E798-E805
-
(1998)
Am. J. Physiol.
, vol.275
-
-
Sidossis, L.S.1
Mittendorfer, B.2
Walser, E.3
Chinkes, D.4
Wolfe, R.R.5
-
80
-
-
0037376827
-
VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: Effects of sex and obesity
-
Mittendorfer, B., Patterson, B. W., Klein, S., and Sidossis, L. S. (2003) VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity. Am. J. Physiol. Endocrinol. Metab. 284, E708-E715
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.284
-
-
Mittendorfer, B.1
Patterson, B.W.2
Klein, S.3
Sidossis, L.S.4
-
81
-
-
80052881506
-
Increased VLDL-triglyceride secretion precedes impaired control of endogenous glucose production in obese, normoglycemic men
-
Sørensen, L. P., Søndergaard, E., Nellemann, B., Christiansen, J. S., Gormsen, L. C., and Nielsen, S. (2011) Increased VLDL-triglyceride secretion precedes impaired control of endogenous glucose production in obese, normoglycemic men. Diabetes 60, 2257-2264
-
(2011)
Diabetes
, vol.60
, pp. 2257-2264
-
-
Sørensen, L.P.1
Søndergaard, E.2
Nellemann, B.3
Christiansen, J.S.4
Gormsen, L.C.5
Nielsen, S.6
-
82
-
-
84881486253
-
One day of mixed meal overfeeding reduces hepatic insulin sensitivity and increases VLDL particle but not VLDLtriglyceride secretion in overweight and obese men
-
Smith, G. I., Magkos, F., Reeds, D. N., Okunade, A. L., Patterson, B. W., and Mittendorfer, B. (2013) One day of mixed meal overfeeding reduces hepatic insulin sensitivity and increases VLDL particle but not VLDLtriglyceride secretion in overweight and obese men. J. Clin. Endocrinol. Metab. 98, 3454-3462
-
(2013)
J. Clin. Endocrinol. Metab.
, vol.98
, pp. 3454-3462
-
-
Smith, G.I.1
Magkos, F.2
Reeds, D.N.3
Okunade, A.L.4
Patterson, B.W.5
Mittendorfer, B.6
-
83
-
-
0028839110
-
Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans
-
Lewis, G. F., Uffelman, K. D., Szeto, L. W., Weller, B., and Steiner, G. (1995) Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J. Clin. Invest. 95, 158-166
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 158-166
-
-
Lewis, G.F.1
Uffelman, K.D.2
Szeto, L.W.3
Weller, B.4
Steiner, G.5
-
84
-
-
84861783237
-
Multiorgan insulin sensitivity in lean and obese subjects
-
Conte, C., Fabbrini, E., Kars, M., Mittendorfer, B., Patterson, B. W., and Klein, S. (2012) Multiorgan insulin sensitivity in lean and obese subjects. Diabetes Care 35, 1316-1321
-
(2012)
Diabetes Care
, vol.35
, pp. 1316-1321
-
-
Conte, C.1
Fabbrini, E.2
Kars, M.3
Mittendorfer, B.4
Patterson, B.W.5
Klein, S.6
-
85
-
-
65949123793
-
Effects of type 2 diabetes on insulin secretion, insulin action, glucose effectiveness, and postprandial glucose metabolism
-
Basu, A., Dalla Man, C., Basu, R., Toffolo, G., Cobelli, C., and Rizza, R. A. (2009) Effects of type 2 diabetes on insulin secretion, insulin action, glucose effectiveness, and postprandial glucose metabolism. Diabetes Care 32, 866-872
-
(2009)
Diabetes Care
, vol.32
, pp. 866-872
-
-
Basu, A.1
Man, D.C.2
Basu, R.3
Toffolo, G.4
Cobelli, C.5
Rizza, R.A.6
-
86
-
-
0037339730
-
Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: Effects of insulin sensitization therapy
-
Miles, J. M., Wooldridge, D., Grellner, W. J., Windsor, S., Isley, W. L., Klein, S., and Harris, W. S. (2003) Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy. Diabetes 52, 675-681
-
(2003)
Diabetes
, vol.52
, pp. 675-681
-
-
Miles, J.M.1
Wooldridge, D.2
Grellner, W.J.3
Windsor, S.4
Isley, W.L.5
Klein, S.6
Harris, W.S.7
-
87
-
-
0042333279
-
Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in rats
-
Bandsma, R. H. J., Wiegman, C. H., Herling, A. W., Burger, H.-J., ter Harmsel, A., Meijer, A. J., Romijn, J. A., Reijngoud, D.-J., and Kuipers, F. (2001) Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in rats. Diabetes 50, 2591-2597
-
(2001)
Diabetes
, vol.50
, pp. 2591-2597
-
-
Bandsma, R.H.J.1
Wiegman, C.H.2
Herling, A.W.3
Burger, H.-J.4
Harmsel, T.A.5
Meijer, A.J.6
Romijn, J.A.7
Reijngoud, D.-J.8
Kuipers, F.9
-
88
-
-
79951672283
-
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas
-
Mutel, E., Abdul-Wahed, A., Ramamonjisoa, N., Stefanutti, A., Houberdon, I., Cavassila, S., Pilleul, F., Beuf, O., Gautier-Stein, A., Penhoat, A., Mithieux, G., and Rajas, F. (2011) Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas. J. Hepatol. 54, 529-537
-
(2011)
J. Hepatol.
, vol.54
, pp. 529-537
-
-
Mutel, E.1
Abdul-Wahed, A.2
Ramamonjisoa, N.3
Stefanutti, A.4
Houberdon, I.5
Cavassila, S.6
Pilleul, F.7
Beuf, O.8
Gautier-Stein, A.9
Penhoat, A.10
Mithieux, G.11
Rajas, F.12
-
89
-
-
61749100743
-
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
-
Semple, R. K., Sleigh, A., Murgatroyd, P. R., Adams, C. A., Bluck, L., Jackson, S., Vottero, A., Kanabar, D., Charlton-Menys, V., Durrington, P., Soos, M. A., Carpenter, T. A., Lomas, D. J., Cochran, E. K., Gorden, P., O'Rahilly, S., and Savage, D. B. (2009) Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. J. Clin. Invest. 119, 315-322
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 315-322
-
-
Semple, R.K.1
Sleigh, A.2
Murgatroyd, P.R.3
Adams, C.A.4
Bluck, L.5
Jackson, S.6
Vottero, A.7
Kanabar, D.8
Charlton-Menys, V.9
Durrington, P.10
Soos, M.A.11
Carpenter, T.A.12
Lomas, D.J.13
Cochran, E.K.14
Gorden, P.15
O'Rahilly, S.16
Savage, D.B.17
-
90
-
-
79952303537
-
A dual sugar challenge test for lipogenic sensitivity to dietary fructose
-
Hudgins, L. C., Parker, T. S., Levine, D. M., and Hellerstein, M. K. (2011) A dual sugar challenge test for lipogenic sensitivity to dietary fructose. J. Clin. Endocrinol. Metab. 96, 861-868
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
, pp. 861-868
-
-
Hudgins, L.C.1
Parker, T.S.2
Levine, D.M.3
Hellerstein, M.K.4
-
91
-
-
66749181719
-
Fructose consumption: Considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans
-
Stanhope, K. L., and Havel, P. J. (2009) Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans. J. Nutr. 139, 1236S-1241S
-
(2009)
J. Nutr.
, vol.139
-
-
Stanhope, K.L.1
Havel, P.J.2
-
92
-
-
0034873371
-
Insulin-regulated gene expression
-
O'Brien, R. M., Streeper, R. S., Ayala, J. E., Stadelmaier, B. T., and Hornbuckle, L. A. (2001) Insulin-regulated gene expression. Biochem. Soc. Trans. 29, 552-558
-
(2001)
Biochem. Soc. Trans.
, vol.29
, pp. 552-558
-
-
O'Brien, R.M.1
Streeper, R.S.2
Ayala, J.E.3
Stadelmaier, B.T.4
Hornbuckle, L.A.5
-
93
-
-
70350417158
-
Akt2 is required for hepatic lipid accumulation in models of insulin resistance
-
Leavens, K. F., Easton, R. M., Shulman, G. I., Previs, S. F., and Birnbaum, M. J. (2009) Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab. 10, 405-418
-
(2009)
Cell Metab.
, vol.10
, pp. 405-418
-
-
Leavens, K.F.1
Easton, R.M.2
Shulman, G.I.3
Previs, S.F.4
Birnbaum, M.J.5
-
94
-
-
77649251207
-
MTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
-
Laplante, M., and Sabatini, D. M. (2010) mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. Proc. Natl. Acad. Sci. U. S. A. 107, 3281-3282
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 3281-3282
-
-
Laplante, M.1
Sabatini, D.M.2
-
95
-
-
77649264504
-
Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
-
Li, S., Brown, M. S., and Goldstein, J. L. (2010) Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc. Natl. Acad. Sci. U. S. A. 107, 3441-3446
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 3441-3446
-
-
Li, S.1
Brown, M.S.2
Goldstein, J.L.3
-
96
-
-
84865503043
-
Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2
-
Yuan, M., Pino, E., Wu, L., Kacergis, M., and Soukas, A. A. (2012) Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. J. Biol. Chem. 287, 29579-29588
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 29579-29588
-
-
Yuan, M.1
Pino, E.2
Wu, L.3
Kacergis, M.4
Soukas, A.A.5
-
97
-
-
84862023939
-
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression
-
Haas, J. T., Miao, J., Chanda, D., Wang, Y., Zhao, E., Haas, M. E., Hirschey, M., Vaitheesvaran, B., Farese, R. V., Jr., Kurland, I. J., Graham, M., Crooke, R., Foufelle, F., and Biddinger, S. B. (2012) Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 15, 873-884
-
(2012)
Cell Metab.
, vol.15
, pp. 873-884
-
-
Haas, J.T.1
Miao, J.2
Chanda, D.3
Wang, Y.4
Zhao, E.5
Haas, M.E.6
Hirschey, M.7
Vaitheesvaran, B.8
Farese Jr., R.V.9
Kurland, I.J.10
Graham, M.11
Crooke, R.12
Foufelle, F.13
Biddinger, S.B.14
-
98
-
-
79958266213
-
Cross-regulation of hepatic glucose metabolism via ChREBP and nuclear receptors
-
Poupeau, A., and Postic, C. (2011) Cross-regulation of hepatic glucose metabolism via ChREBP and nuclear receptors. Biochim. Biophys. Acta 1812, 995-1006
-
(2011)
Biochim. Biophys. Acta
, vol.1812
, pp. 995-1006
-
-
Poupeau, A.1
Postic, C.2
-
99
-
-
84861809881
-
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
-
Benhamed, F., Denechaud, P. D., Lemoine, M., Robichon, C., Moldes, M., Bertrand-Michel, J., Ratziu, V., Serfaty, L., Housset, C., Capeau, J., Girard, J., Guillou, H., and Postic, C. (2012) The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J. Clin. Invest. 122, 2176-2194
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 2176-2194
-
-
Benhamed, F.1
Denechaud, P.D.2
Lemoine, M.3
Robichon, C.4
Moldes, M.5
Bertrand-Michel, J.6
Ratziu, V.7
Serfaty, L.8
Housset, C.9
Capeau, J.10
Girard, J.11
Guillou, H.12
Postic, C.13
-
100
-
-
2442435802
-
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
-
Iizuka, K., Bruick, R. K., Liang, G., Horton, J. D., and Uyeda, K. (2004) Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc. Natl. Acad. Sci. U. S. A. 101, 7281-7286
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 7281-7286
-
-
Iizuka, K.1
Bruick, R.K.2
Liang, G.3
Horton, J.D.4
Uyeda, K.5
-
101
-
-
22544480378
-
"New" hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis
-
Chakravarthy, M. V., Pan, Z., Zhu, Y., Tordjman, K., Schneider, J. G., Coleman, T., Turk, J., and Semenkovich, C. F. (2005) "New" hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab. 1, 309-322
-
(2005)
Cell Metab.
, vol.1
, pp. 309-322
-
-
Chakravarthy, M.V.1
Pan, Z.2
Zhu, Y.3
Tordjman, K.4
Schneider, J.G.5
Coleman, T.6
Turk, J.7
Semenkovich, C.F.8
-
102
-
-
0037372412
-
Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity
-
Mittendorfer, B., Patterson, B. W., and Klein, S. (2003) Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity. Am. J. Physiol. Endocrinol. Metab. 284, E549-E556
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.284
-
-
Mittendorfer, B.1
Patterson, B.W.2
Klein, S.3
-
103
-
-
84861573124
-
Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease
-
Sullivan, S., Kirk, E. P., Mittendorfer, B., Patterson, B. W., and Klein, S. (2012) Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology 55, 1738-1745
-
(2012)
Hepatology
, vol.55
, pp. 1738-1745
-
-
Sullivan, S.1
Kirk, E.P.2
Mittendorfer, B.3
Patterson, B.W.4
Klein, S.5
-
104
-
-
84873040492
-
Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance
-
Zhu, L., Brown, W. C., Cai, Q., Krust, A., Chambon, P., McGuinness, O. P., and Stafford, J. M. (2013) Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance. Diabetes 62, 424-434
-
(2013)
Diabetes
, vol.62
, pp. 424-434
-
-
Zhu, L.1
Brown, W.C.2
Cai, Q.3
Krust, A.4
Chambon, P.5
McGuinness, O.P.6
Stafford, J.M.7
|