-
1
-
-
84869051280
-
Mitochondrial disorders as windows into an ancient organelle
-
Vafai, S. B., and Mootha, V. K. (2012) Mitochondrial disorders as windows into an ancient organelle. Nature 491, 374-383
-
(2012)
Nature
, vol.491
, pp. 374-383
-
-
Vafai, S.B.1
Mootha, V.K.2
-
2
-
-
34547877924
-
Mitochondrial medicine: Pharmacological targeting of mitochondria in disease
-
Armstrong, J. S. (2007) Mitochondrial medicine: pharmacological targeting of mitochondria in disease. Br. J. Pharmacol. 151, 1154-1165
-
(2007)
Br. J. Pharmacol.
, vol.151
, pp. 1154-1165
-
-
Armstrong, J.S.1
-
3
-
-
34548379435
-
The significance of mitochondrial toxicity testing in drug development
-
Dykens, J. A., and Will, Y. (2007) The significance of mitochondrial toxicity testing in drug development. Drug Discov. Today 12, 777-785
-
(2007)
Drug Discov. Today
, vol.12
, pp. 777-785
-
-
Dykens, J.A.1
Will, Y.2
-
4
-
-
77749298746
-
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
-
Gohil, V. M., Sheth, S. A., Nilsson, R., Wojtovich, A. P., Lee, J. H., Perocchi, F., Chen, W., Clish, C. B., Ayata, C., Brookes, P. S., and Mootha, V. K. (2010) Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat. Biotechnol. 28, 249-255
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 249-255
-
-
Gohilv, M.1
Sheth, S.A.2
Nilsson, R.3
Wojtovich, A.P.4
Lee, J.H.5
Perocchi, F.6
Chen, W.7
Clish, C.B.8
Ayata, C.9
Brookes, P.S.10
Mootha, V.K.11
-
5
-
-
78650572673
-
Meclizine is neuroprotective in models of Huntington's disease
-
Gohil, V. M., Offner, N., Walker, J. A., Sheth, S. A., Fossale, E., Gusella, J. F., MacDonald, M. E., Neri, C., and Mootha, V. K. (2011) Meclizine is neuroprotective in models of Huntington's disease. Hum. Mol. Genet. 20, 294-300
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 294-300
-
-
Gohil, V.M.1
Offner, N.2
Walker, J.A.3
Sheth, S.A.4
Fossale, E.5
Gusella, J.F.6
Macdonald, M.E.7
Neri, C.8
Mootha, V.K.9
-
6
-
-
0015383241
-
Meclizine and placebo in treating vertigo of vestibular origin. Relative efficacy in a double-blind study
-
Cohen, B., and DeJong, J. M. (1972) Meclizine and placebo in treating vertigo of vestibular origin. Relative efficacy in a double-blind study. Arch. Neurol. 27, 129-135
-
(1972)
Arch. Neurol.
, vol.27
, pp. 129-135
-
-
Cohen, B.1
Dejong, J.M.2
-
7
-
-
0023096152
-
Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assay
-
Kubo, N., Shirakawa, O., Kuno, T., and Tanaka, C. (1987) Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay. Jpn. J. Pharmacol. 43, 277-282
-
(1987)
Jpn. J. Pharmacol.
, vol.43
, pp. 277-282
-
-
Kubo, N.1
Shirakawa, O.2
Kuno, T.3
Tanaka, C.4
-
8
-
-
5044237671
-
Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR
-
Huang, W., Zhang, J., Wei, P., Schrader, W. T., and Moore, D. D. (2004) Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol. Endocrinol. 18, 2402-2408
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 2402-2408
-
-
Huang, W.1
Zhang, J.2
Wei, P.3
Schrader, W.T.4
Moore, D.D.5
-
9
-
-
76549086505
-
Aplasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells
-
Shaham, O., Slate, N. G., Goldberger, O., Xu, Q., Ramanathan, A., Souza, A. L., Clish, C. B., Sims, K. B., and Mootha, V. K. (2010)Aplasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells. Proc. Natl. Acad. Sci. U.S.A. 107, 1571-1575
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 1571-1575
-
-
Shaham, O.1
Slate, N.G.2
Goldberger, O.3
Xu, Q.4
Ramanathan, A.5
Souza, A.L.6
Clish, C.B.7
Sims, K.B.8
Mootha, V.K.9
-
10
-
-
84864076985
-
Targeted metabolomics
-
Unit 30.2.
-
Roberts, L. D., Souza, A. L., Gerszten, R. E., and Clish, C. B. (2012) Targeted metabolomics. Curr. Protoc. Mol. Biol. Chapter 30, Unit 30.2.1-24
-
(2012)
Curr. Protoc. Mol. Biol. Chapter
, vol.30
, pp. 1-24
-
-
Roberts, L.D.1
Souza, A.L.2
Gerszten, R.E.3
Clish, C.B.4
-
11
-
-
67649742844
-
Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1
-
Zhu, L., Johnson, C., and Bakovic, M. (2008) Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1. J. Lipid Res. 49, 2197-2211
-
(2008)
J. Lipid Res.
, vol.49
, pp. 2197-2211
-
-
Zhu, L.1
Johnson, C.2
Bakovic, M.3
-
12
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
Bligh, E. G., and Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917
-
(1959)
Can. J. Biochem. Physiol.
, vol.37
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
13
-
-
34948859084
-
Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties
-
Tie, A., and Bakovic, M. (2007) Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties. J. Lipid Res. 48, 2172-2181
-
(2007)
J. Lipid Res.
, vol.48
, pp. 2172-2181
-
-
Tie, A.1
Bakovic, M.2
-
14
-
-
33646033137
-
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
-
Moffat, J., Grueneberg, D. A., Yang, X., Kim, S. Y., Kloepfer, A. M., Hinkle, G., Piqani, B., Eisenhaure, T. M., Luo, B., Grenier, J. K., Carpenter, A. E., Foo, S. Y., Stewart, S. A., Stockwell, B. R., Hacohen, N., Hahn, W. C., Lander, E. S., Sabatini, D. M., and Root, D. E. (2006) A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-1298
-
(2006)
Cell
, vol.124
, pp. 1283-1298
-
-
Moffat, J.1
Grueneberg, D.A.2
Yang, X.3
Kim, S.Y.4
Kloepfer, A.M.5
Hinkle, G.6
Piqani, B.7
Eisenhaure, T.M.8
Luo, B.9
Grenier, J.K.10
Carpenter, A.E.11
Foo, S.Y.12
Stewart, S.A.13
Stockwell, B.R.14
Hacohen, N.15
Hahn, W.C.16
Lander, E.S.17
Sabatini, D.M.18
Root, D.E.19
-
15
-
-
77951587107
-
Mitochondrial and nuclear genomic responses to loss of LRPPRC expression
-
Gohil, V. M., Nilsson, R., Belcher-Timme, C. A., Luo, B., Root, D. E., and Mootha, V. K. (2010) Mitochondrial and nuclear genomic responses to loss of LRPPRC expression. J. Biol. Chem. 285, 13742-13747
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 13742-13747
-
-
Gohil, V.M.1
Nilsson, R.2
Belcher-Timme, C.A.3
Luo, B.4
Root, D.E.5
Mootha, V.K.6
-
16
-
-
34147159979
-
Analysis of mitochondrial function using phosphorescent oxygen-sensitive probes
-
Will, Y., Hynes, J., Ogurtsov, V. I., and Papkovsky, D. B. (2006) Analysis of mitochondrial function using phosphorescent oxygen-sensitive probes. Nat. Protoc. 1, 2563-2572
-
(2006)
Nat. Protoc.
, vol.1
, pp. 2563-2572
-
-
Will, Y.1
Hynes, J.2
Ogurtsov, V.I.3
Papkovsky, D.B.4
-
17
-
-
70449158340
-
A simple method for the isolation and purification of total lipids from animal tissues
-
Folch, J., Lees, M., and Sloane Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509
-
(1957)
J. Biol. Chem.
, vol.226
, pp. 497-509
-
-
Folch, J.1
Lees, M.2
Stanley, S.G.H.3
-
18
-
-
70449246528
-
Phosphorus assay in column chromatography
-
Bartlett, G.R. (1959) Phosphorus assay in column chromatography. J. Biol. Chem. 234, 466-468
-
(1959)
J. Biol. Chem.
, vol.234
, pp. 466-468
-
-
Bartlett, G.R.1
-
19
-
-
83755180488
-
Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation
-
Webhofer, C., Gormanns, P., Tolstikov, V., Zieglgänsberger, W., Sillaber, I., Holsboer, F., and Turck, C. W. (2011) Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation. Transl. Psychiatry 1, e58
-
(2011)
Transl. Psychiatry
, vol.1
-
-
Webhofer, C.1
Gormanns, P.2
Tolstikov, V.3
Zieglgänsberger, W.4
Sillaber, I.5
Holsboer, F.6
Turck, C.W.7
-
20
-
-
0036624293
-
Metabolomics and biochemical profiling in drug discovery and development
-
Watkins, S. M., and German, J. B. (2002) Metabolomics and biochemical profiling in drug discovery and development. Curr. Opin. Mol. Ther. 4, 224-228
-
(2002)
Curr. Opin. Mol. Ther.
, vol.4
, pp. 224-228
-
-
Watkins, S.M.1
German, J.B.2
-
21
-
-
50949084838
-
Phosphatidylserine and phosphatidylethanolamine in mammalian cells: Two metabolically related aminophospholipids
-
Vance, J. E. (2008) Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids. J. Lipid Res. 49, 1377-1387
-
(2008)
J. Lipid Res.
, vol.49
, pp. 1377-1387
-
-
Vance, J.E.1
-
22
-
-
84875114132
-
Regulation of phosphatidylethanolamine homeostasis - The critical role of CTP: Phosphoethanolamine cytidylyltransferase (Pcyt2)
-
Pavlovic, Z., and Bakovic, M. (2013) Regulation of phosphatidylethanolamine homeostasis - the critical role of CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). Int. J. Mol. Sci. 14, 2529-2550
-
(2013)
Int. J. Mol. Sci.
, vol.14
, pp. 2529-2550
-
-
Pavlovic, Z.1
Bakovic, M.2
-
23
-
-
1642564368
-
Ethanolamine and phosphoethanolamine inhibit mitochondrial function in vitro: Implications for mitochondrial dysfunction hypothesis in depression and bipolar disorder
-
Modica-Napolitano, J. S., and Renshaw, P. F. (2004) Ethanolamine and phosphoethanolamine inhibit mitochondrial function in vitro: implications for mitochondrial dysfunction hypothesis in depression and bipolar disorder. Biol. Psychiatry 55, 273-277
-
(2004)
Biol. Psychiatry
, vol.55
, pp. 273-277
-
-
Modica-Napolitano, J.S.1
Renshaw, P.F.2
-
24
-
-
84873671181
-
Phosphatidylethanolamine deficiency in mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology
-
Tasseva, G., Bai, H. D., Davidescu, M., Haromy, A., Michelakis, E., and Vance, J. E. (2013) Phosphatidylethanolamine deficiency in mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology. J. Biol. Chem. 288, 4158-4173
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 4158-4173
-
-
Tasseva, G.1
Bai, H.D.2
Davidescu, M.3
Haromy, A.4
Michelakis, E.5
Vance, J.E.6
-
25
-
-
70350002081
-
The development of a metabolic disease phenotype in CTP: phosphoethanolamine cytidylyltransferase-deficient mice
-
Fullerton, M. D., Hakimuddin, F., Bonen, A., and Bakovic, M. (2009) The development of a metabolic disease phenotype in CTP:phosphoethanolamine cytidylyltransferase-deficient mice. J. Biol. Chem. 284, 25704-25713
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 25704-25713
-
-
Fullerton, M.D.1
Hakimuddin, F.2
Bonen, A.3
Bakovic, M.4
-
26
-
-
27444446738
-
Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae
-
Gohil, V. M., Thompson, M. N., and Greenberg, M. L. (2005) Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae. J. Biol. Chem. 280, 35410-35416
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35410-35416
-
-
Gohil, V.M.1
Thompson, M.N.2
Greenberg, M.L.3
-
27
-
-
0034698098
-
Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function
-
Jiang, F., Ryan, M. T., Schlame, M., Zhao, M., Gu, Z., Klingenberg, M., Pfanner, N., and Greenberg, M. L. (2000) Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J. Biol. Chem. 275, 22387-22394
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 22387-22394
-
-
Jiang, F.1
Ryan, M.T.2
Schlame, M.3
Zhao, M.4
Gu, Z.5
Klingenberg, M.6
Pfanner, N.7
Greenberg, M.L.8
-
28
-
-
28844440297
-
Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects
-
Steenbergen, R., Nanowski, T. S., Beigneux, A., Kulinski, A., Young, S. G., and Vance, J. E. (2005) Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects. J. Biol. Chem. 280, 40032-40040
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40032-40040
-
-
Steenbergen, R.1
Nanowski, T.S.2
Beigneux, A.3
Kulinski, A.4
Young, S.G.5
Vance, J.E.6
-
29
-
-
35349002700
-
The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species
-
Bleijerveld, O. B., Brouwers, J. F., Vaandrager, A. B., Helms, J. B., and Houweling, M. (2007) The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species. J. Biol. Chem. 282, 28362-28372
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 28362-28372
-
-
Bleijerveld, O.B.1
Brouwers, J.F.2
Vaandrager, A.B.3
Helms, J.B.4
Houweling, M.5
-
30
-
-
84867579830
-
Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes
-
Böttinger, L., Horvath, S. E., Kleinschroth, T., Hunte, C., Daum, G., Pfanner, N., and Becker, T. (2012) Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes. J. Mol. Biol. 423, 677-686
-
(2012)
J. Mol. Biol.
, vol.423
, pp. 677-686
-
-
Böttinger, L.1
Horvath, S.E.2
Kleinschroth, T.3
Hunte, C.4
Daum, G.5
Pfanner, N.6
Becker, T.7
-
31
-
-
36249031068
-
Recognizing and exploiting differences between RNAi and small-molecule inhibitors
-
Weiss, W. A., Taylor, S. S., and Shokat, K. M. (2007) Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nat. Chem. Biol. 3, 739-744
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 739-744
-
-
Weiss, W.A.1
Taylor, S.S.2
Shokat, K.M.3
-
32
-
-
84855711904
-
Anticancer effects of synthetic phosphoethanolamine on Ehrlich ascites tumor: An experimental study
-
Ferreira, A. K., Meneguelo, R., Pereira, A., Mendonça Filho, O., Chierice, G. O., and Maria, D. A. (2012) Anticancer effects of synthetic phosphoethanolamine on Ehrlich ascites tumor: An experimental study. Anticancer Res. 32, 95-104
-
(2012)
Anticancer Res.
, vol.32
, pp. 95-104
-
-
Ferreira, A.K.1
Meneguelo, R.2
Pereira, A.3
Mendonça Filho, O.4
Chierice, G.O.5
Maria, D.A.6
-
33
-
-
78649323182
-
Ethanolamine is a novel STAT-3 dependent cardioprotective agent
-
Kelly, R. F., Lamont, K. T., Somers, S., Hacking, D., Lacerda, L., Thomas, P., Opie, L. H., and Lecour, S. (2010) Ethanolamine is a novel STAT-3 dependent cardioprotective agent. Basic Res. Cardiol. 105, 763-770
-
(2010)
Basic Res. Cardiol.
, vol.105
, pp. 763-770
-
-
Kelly, R.F.1
Lamont, K.T.2
Somers, S.3
Hacking, D.4
Lacerda, L.5
Thomas, P.6
Opie, L.H.7
Lecour, S.8
-
34
-
-
70350146496
-
The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei
-
Gibellini, F., Hunter, W. N., and Smith, T. K. (2009) The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei. Mol. Microbiol. 73, 826-843
-
(2009)
Mol. Microbiol.
, vol.73
, pp. 826-843
-
-
Gibellini, F.1
Hunter, W.N.2
Smith, T.K.3
-
35
-
-
84873035441
-
Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active
-
Maheshwari, S., Lavigne, M., Contet, A., Alberge, B., Pihan, E., Kocken, C., Wengelnik, K., Douguet, D., Vial, H., and Cerdan, R. (2013) Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active. Biochem. J. 450, 159-167
-
(2013)
Biochem. J.
, vol.450
, pp. 159-167
-
-
Maheshwari, S.1
Lavigne, M.2
Contet, A.3
Alberge, B.4
Pihan, E.5
Kocken, C.6
Wengelnik, K.7
Douguet, D.8
Vial, H.9
Cerdan, R.10
-
36
-
-
84866024324
-
Meclizine metabolism and pharmacokinetics: Formulation on its absorption
-
Wang, Z., Lee, B., Pearce, D., Qian, S., Wang, Y., Zhang, Q., and Chow, M. S. (2012) Meclizine metabolism and pharmacokinetics: formulation on its absorption. J. Clin. Pharmacol. 52, 1343-1349.
-
(2012)
J. Clin. Pharmacol.
, vol.52
, pp. 1343-1343
-
-
Wang, Z.1
Lee, B.2
Pearce, D.3
Qian, S.4
Wang, Y.5
Zhang, Q.6
Chow, M.S.7
|