Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 284, Issue 3 47-3, 2003, Pages

  Mittendorfer, Bettina ^a   Patterson, Bruce W ^a   Klein, Samuel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fatty acids; Lipolysis; Lipoprotein

Indexed keywords

APOLIPOPROTEIN B100; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DISSOCIATION; FEMALE; HUMAN; KINETICS; OBESITY; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN SECRETION; WEIGHT REDUCTION;

EID: 0037372412     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00379.2002     Document Type: Article

References (54)

1. Årsland A, Chinkes D, and Wolfe RR. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J Clin Invest 98: 2008-2017, 1996.
2. Austin MA. Plasma triglyceride as a risk factor for cardiovascular disease. Can J Cardiol 14, Suppl B: 14B-17B, 1998.
3. Austin MA, Hokanson JE, and Edwards KL. Hypertriglyceridemia as cardiovascular risk factor. Am J Cardiol 81: 7B-12B, 1998.
4. Barter PJ and Nestel PJ. Precursors of plasma triglyceride fatty acids in obesity. Metabolism 22: 779-783, 1973.
5. Bergman RN, Van Citters GW, Mittelman SD, Dea MK, Hamilton-Wessler M, Kim SP, and Ellmerer M. Central role of the adipocyte in the metabolic syndrome. J Investig Med 49: 119-26, 2001.
6. Boden G. Free fatty acids (FFA), a link between obesity and insulin resistance. Front Biosci 3: D169-D175, 1998.
7. Boer P. Estimated lean body mass as an index for normalization of body fluid volumes in humans. Am J Physiol Renal Fluid Electrolyte Physiol 247: F632-F636, 1984.
8. Cambien F, Jacqueson A, Richard JL, Warnet JM, Ducimetiere P, and Claude JR. Is the level of serum triglyceride a significant predictor of coronary death in "normocholesterolemic" subjects? The Paris Prospective Study. Am J Epidemiol 124: 624-632, 1986.
9. Castelli WP. Cholesterol and lipids in the risk of coronary artery disease - the Framingham Heart Study. Can J Cardiol 4, Suppl A: 5A-10A, 1988.
10. Chan DC, Watts GF, Redgrave TG, Mori TA, and Barrett PH. Apolipoprotein B-100 kinetics in visceral obesity: association with plasma apolipoprotein C-III concentration. Metabolism 51: 1041-1046, 2002.
11. Converse CA and Skinner ER. Lipoprotein Analysis: A Practical Approach. New York: Oxford University Press, 1992.
12. Cullen P. Evidence that triglycerides are an independent coronary heart disease risk factor. Am J Cardiol 86: 943-949, 2000.
13. Egusa G, Beltz WF, Grundy SM, and Howard BV. Influence of obesity on the metabolism of apolipoprotein B in humans. J Clin Invest 76: 596-603, 1985.
14. Elias N, Patterson BW, and Schonfeld G. In vivo metabolism of ApoB, ApoA-I, and VLDL triglycerides in a form of hypobetalipoproteinemia not linked to the ApoB gene. Arterioscler Thromb Vasc Biol 20: 1309-1315, 2000.
15. Gaw A, Packard CJ, Murray EF, Lindsay GM, Griffin BA, Caslake MJ, Vallance BD, Lorimer AR, and Shepherd J. Effects of simvastatin on apoB metabolism and LDL subfraction distribution. Arterioscler Thromb 13: 170-189, 1993.
16. Ginsberg HN, Le NA, and Gibson JC. Regulation of the production and catabolism of plasma low density lipoproteins in hypertriglyceridemic subjects. Effect of weight loss. J Clin Invest 75: 614-623, 1985.
17. Goodpaster BH, Kelley DE, Wing RR, Meier A, and Thaete FL. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48: 839-847, 1999.
18. Hales CN and Randle PJ. Immunoassay of insulin with insulin antibody precipitate. Biochem J 88: 137-146, 1963.
19. Horowitz JF and Klein S. Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women. Am J Physiol Endocrinol Metab 278: E1144-E1152, 2000.
20. Jourdan M, Margen S, and Bradfield RB. The turnover rate of serum glycerides in the lipoproteins of fasting obese women during weight loss. Am J Clin Nutr 27: 850-858, 1974.
21. Kelley DE, Goodpaster B, Wing RR, and Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol Endocrinol Metab 277: E1130-E1141, 1999.
22. Kelley DE, Mokan M, Simoneau JA, and Mandarino LJ. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92: 91-98, 1993.
23. Kelley DE, Wing R, Buonocore C, Sturis J, Polonsky K, and Fitzsimmons M. Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 77: 1287-1293, 1993.
24. Klein RL and Zilversmit DB. Direct determination of human and rabbit apolipoprotein B selectively precipitated with butanol-isopropyl ether. J Lipid Res 25: 1380-1386, 1984.
25. Klein S, Luu K, Gasic S, and Green A. Effect of weight loss on whole body and cellular lipid metabolism in severely obese humans. Am J Physiol Endocrinol Metab 270: E739-E745, 1996.
26. Lamon-Fava S, Wilson PW, and Schaefer EJ. Impact of body mass index on coronary heart disease risk factors in men and women. The Framingham Offspring Study. Arterioscler Thromb Vasc Biol 16: 1509-1515, 1996.
27. Latour MA, Patterson BW, Pulai J, Chen Z, and Schonfeld G. Metabolism of apolipoprotein B-100 in a kindred with familial hypobetalipoproteinemia without a truncated form of apoB. J Lipid Res 38: 592-599, 1997.
28. Lewis GF. Fatty acid regulation of very low density lipoprotein production. Curr Opin Lipidol 8: 146-156, 1997.
29. Lewis GF, Uffelman KD, Szeto LW, and Steiner G. Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes 42: 833-842, 1993.
30. Lewis GF, Uffelman KD, Szeto LW, Weller B, and Steiner G. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest 95: 158-166, 1995.
31. Marques-Lopes I, Ansorena D, Astiasaran I, Forga L, and Martinez JA. Postprandial de novo lipogenesis and metabolic changes induced by a high-carbohydrate, low-fat meal in lean and overweight men. Am J Clin Nutr 73: 253-261, 2001.
32. Mauriege P, Imbeault P, Langin D, Lacaille M, Almeras N, Tremblay A, and Despres JP. Regional and gender variations in adipose tissue lipolysis in response to weight loss. J Lipid Res 40: 1559-1571, 1999.
33. McDonald-Gibson RG and Young M. The use of an automatic solids injection system for quantitative determination of plasma long-chain nonesterified fatty acids by gas-lipid chromatography. Clin Chim Acta 53: 117-126, 1974.
34. Melish J, Le NA, Ginsberg H, Steinberg D, and Brown WV. Dissociation of apoprotein B and triglyceride production in verylow-density lipoproteins. Am J Physiol Endocrinol Metab 239: E354-E362, 1980.
35. Metropolitan LIC. 1983 Metropolitan height and weight tables. Stat Bull Metrop Life Found 64: 3-9, 1983.
36. Mittendorfer B, Horowitz JF, and Klein S. Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects. Am J Physiol Endocrinol Metab 283: E58-E65, 2002.
37. Mittendorfer B, Patterson BW, and Klein S. Effect of sex and obesity on basal very-low density lipoprotein triacylglycerol kinetics. Am J Clin Nutr. In press.
38. Muscelli E, Camastra S, Catalano C, Galvan AQ, Ciociaro D, Baldi S, and Ferrannini E. Metabolic and cardiovascular assessment in moderate obesity: effect of weight loss. J Clin Endocrinol Metab 82: 2937-2943, 1997.
39. Nicklas BJ, Rogus EM, Berman DM, Dennis KE, and Goldberg AP. Responses of adipose tissue lipoprotein lipase to weight loss affect lipid levels and weight regain in women. Am J Physiol Endocrinol Metab 279: E1012-E1019, 2000.
40. Olefsky J, Reaven GM, and Farquhar JW. Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects. J Clin Invest 53: 64-76, 1974.
41. Parks EJ, Krauss RM, Christiansen MP, Neese RA, and Hellerstein MK. Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance. J Clin Invest 104: 1087-1096, 1999.
42. Patterson BW, Carraro F, and Wolfe RR. Measurement of 15N enrichment in multiple amino acids and urea in a single analysis by gas chromatography/mass spectrometry. Biol Mass Spectrom 22: 518-523, 1993.
43. Patterson BW, Horowitz JF, Wu G, Watford M, Coppack SW, and Klein S. Regional muscle and adipose tissue amino acid metabolism in lean and obese women. Am J Physiol Endocrinol Metab 282: E931-E936, 2002.
44. Patterson BW, Mittendorfer B, Elias N, Satyanarayana R, and Klein S. Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover. J Lipid Res 43: 223-233, 2002.
45. Patterson BW, Zhao G, Elias N, Hachey DL, and Klein S. Validation of a new procedure to determine plasma fatty acid concentration and isotopic enrichment. J Lipid Res 40: 2118- 2124, 1999.
46. Patterson BW, Zhao G, and Klein S. Improved accuracy and precision of gas chromatography/mass spectrometry measurements for metabolic tracers. Metabolism 47: 706-712, 1998.
47. Reichl D. Lipoproteins of human peripheral lymph. Eur Heart J 11, Suppl E: 230-236, 1990.
48. Reynisdottir S, Langin D, Carlstrom K, Holm C, Rossner S, and Arner P. Effects of weight reduction on the regulation of lipolysis in adipocytes of women with upper-body obesity. Clin Sci (Lond) 89: 421-429, 1995.
49. Riches FM, Watts GF, Hua J, Stewart GR, Naoumova RP, and Barrett PH. Reduction in visceral adipose tissue is associated with improvement in apolipoprotein B-100 metabolism in obese men. J Clin Endocrinol Metab 84: 2854-2861, 1999.
50. Ross R, Dagnone D, Jones PJ, Smith H, Paddags A, Hudson R, and Janssen I. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 133: 92-103, 2000.
51. Silverman EM, Sapala JA, and Appelman HD. Regression of hepatic steatosis in morbidly obese persons after gastric bypass. Am J Clin Pathol 104: 23-31, 1995.
52. Steele R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82: 420-430, 1959.
53. Wadden TA, Anderson DA, and Foster GD. Two-year changes in lipids and lipoproteins associated with the maintenance of a 5% to 10% reduction in initial weight: some findings and some questions. Obes Res 7: 170-178, 1999.
54. Zech LA, Grundy SM, Steinberg D, and Berman M. Kinetic model for production and metabolism of very low density hpoprotein triglycerides. Evidence for a slow production pathway and results for normolipidemic subjects. J Clin Invest 63: 1262-1273, 1979.