메뉴 건너뛰기




Volumn 17, Issue 9, 2011, Pages 943-949

New lipid modulating drugs: The role of microsomal transport protein inhibitors

Author keywords

Atherosclerosis; Cardiovascular prevention; Lipids; Lipoproteins; MTP inhibitors

Indexed keywords

AMINOTRANSFERASE; APOLIPOPROTEIN B; ATORVASTATIN; BAY 139953; BEZAFIBRATE; CP 346086; EZETIMIBE; FENOFIBRATE; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMPLITAPIDE; JTT 130; LOMITAPIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; SLX 4090; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 79958222144     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161211795428768     Document Type: Article
Times cited : (31)

References (76)
  • 1
    • 0036910662 scopus 로고    scopus 로고
    • Management of dyslipidemia in the high-risk patient
    • Stein EA. Management of dyslipidemia in the high-risk patient. Am Heart J 2002; 144: S43-50
    • (2002) Am Heart J , vol.144
    • Stein, E.A.1
  • 2
    • 0035897696 scopus 로고    scopus 로고
    • Evaluation, and Treatment of High Blood Cho-lesterolin Adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of HighBlood Cholesterol in Adults. Executive Summary of the Third Reportof the National Cholesterol Education Program (NCEP) ExpertPanel on Detection
    • Expert Panel on Detection, Evaluation, and Treatment of HighBlood Cholesterol in Adults. Executive Summary of the Third Reportof the National Cholesterol Education Program (NCEP) ExpertPanel on Detection, Evaluation, and Treatment of High Blood Cho-lesterolin Adults (Adult Treatment Panel III). JAMA 2001; 285:2486-97.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 3
    • 3142729178 scopus 로고    scopus 로고
    • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
    • Grundy SM, Cleeman JI, Merz CN, et al. Implications of recentclinical trials for the National Cholesterol Education Program AdultTreatment Panel III Guidelines. Circulation 2004; 110: 227-39.
    • (2004) Circulation , vol.110 , pp. 227-239
    • Grundy, S.M.1    Cleeman, J.I.2    Merz, C.N.3
  • 4
    • 78650023399 scopus 로고    scopus 로고
    • ACCF/AHA guide-linefor assessment of cardiovascular risk in asymptomatic adults: Executive summary: A report of the American College of Cardiol-ogyFoundation/American Heart Association Task Force on Practice-Guidelines
    • Greenland P, Alpert JS, Beller GA, et al. 2010 ACCF/AHA guidelinefor assessment of cardiovascular risk in asymptomatic adults: executive summary: a report of the American College of Cardiology-Foundation/American Heart Association Task Force on Practice-Guidelines. J Am Coll Cardiol 2010; 56: 2182-99.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 2182-2199
    • Greenland, P.1    Alpert, J.S.2    Beller, G.A.3
  • 5
    • 78650709475 scopus 로고    scopus 로고
    • ACCF/AHA guide-linefor assessment of cardiovascular risk in asymptomatic adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • Greenland P, Alpert JS, Beller GA, et al. 2010 ACCF/AHA guidelinefor assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.Circulation 2010; 122: e584-636.
    • (2010) Circulation , vol.122
    • Greenland, P.1    Alpert, J.S.2    Beller, G.A.3
  • 6
    • 56349154187 scopus 로고    scopus 로고
    • The Residual Risk Re-duction Initiative: A call to action to reduce residual vascular risk inpatients with dyslipidemia
    • Fruchart JC, Sacks F, Hermans MP, et al. The Residual Risk ReductionInitiative: a call to action to reduce residual vascular risk inpatients with dyslipidemia. Am J Cardiol 2008; 102 (10 Suppl):1K-34K.
    • (2008) Am J Cardiol , vol.102 , Issue.10 SUPPL
    • Fruchart, J.C.1    Sacks, F.2    Hermans, M.P.3
  • 7
    • 34748924577 scopus 로고    scopus 로고
    • European guidelines on cardiovascular disease prevention in clinical practice: Executive summary
    • Graham I, Atar D, Borch-Johnsen K, et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Atherosclerosis 2007; 194: 1-45.
    • (2007) Atherosclerosis , vol.194 , pp. 1-45
    • Graham, I.1    Atar, D.2    Borch-Johnsen, K.3
  • 8
    • 34548329882 scopus 로고    scopus 로고
    • European guidelines on cardiovascular disease prevention in clinical practice: Full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invitedexperts)
    • Graham I, Atar D, Borch-Johnsen K, et al. European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invitedexperts). Eur J Cardiovasc Prev Rehabil 2007; 14 Suppl 2:S1-113.
    • (2007) Eur J Cardiovasc Prev Rehabil , vol.14 , Issue.2 SUPPL
    • Graham, I.1    Atar, D.2    Borch-Johnsen, K.3
  • 9
    • 33644810298 scopus 로고    scopus 로고
    • JBS 2: The Joint British Societies' guidelines for prevention of cardiovascular disease in clinical practice
    • British Cardiac Society, British Hypertension Society, Diabetes UK, HEART UK, Primary Care Cardiovascular Society, TheStroke Association
    • British Cardiac Society, British Hypertension Society, Diabetes UK, HEART UK, Primary Care Cardiovascular Society, The Stroke Association. JBS 2: the Joint British Societies' guidelines for prevention of cardiovascular disease in clinical practice. Heart 2005; 91(suppl V): v1-v52.
    • (2005) Heart , vol.91 , Issue.5 SUPPL
  • 10
    • 33846637379 scopus 로고    scopus 로고
    • Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies
    • Sarwar N, Danesh J, Eiriksdottir G, et al. Triglycerides and the riskof coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation 2007;115: 450-8.
    • (2007) Circulation , vol.115 , pp. 450-458
    • Sarwar, N.1    Danesh, J.2    Eiriksdottir, G.3
  • 11
    • 0034188514 scopus 로고    scopus 로고
    • Triglyceride, small, dense low-density lipoprotein, and the atherogenic lipoprotein phenotype
    • Austin MA. Triglyceride, small, dense low-density lipoprotein, andthe atherogenic lipoprotein phenotype. Curr Atheroscler Rep 2000;2: 200-7.
    • (2000) Curr Atheroscler Rep , vol.2 , pp. 200-207
    • Austin, M.A.1
  • 12
    • 14644443612 scopus 로고    scopus 로고
    • Low-density lipopro-teinsubfractions and the long-term risk of ischemic heart disease inmen: 13-year follow-up data from the Quebec CardiovascularStudy
    • St-Pierre AC, Cantin B, Dagenais GR, et al. Low-density lipopro-teinsubfractions and the long-term risk of ischemic heart disease inmen: 13-year follow-up data from the Quebec CardiovascularStudy. Arterioscler Thromb Vasc Biol 2005; 25: 553-9.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 553-559
    • St-Pierre, A.C.1    Cantin, B.2    Dagenais, G.R.3
  • 13
    • 31144471875 scopus 로고    scopus 로고
    • Lipid triad or atherogenic lipoprotein phenotype:A role in cardiovascular prevention?
    • Rizzo M, Berneis K. Lipid triad or atherogenic lipoprotein phenotype:a role in cardiovascular prevention? J Atheroscler Thromb 2005; 12: 237-9.
    • (2005) J Atheroscler Thromb , vol.12 , pp. 237-239
    • Rizzo, M.1    Berneis, K.2
  • 15
    • 33645053280 scopus 로고    scopus 로고
    • Does low-density lipoprotein size add to atherogenic particle number in predicting the risk of fatal myocardial infarction?
    • Jungner I, Sniderman AD, Furberg C, Aastveit AH, Holme I, Walldius G. Does low-density lipoprotein size add to atherogenic particle number in predicting the risk of fatal myocardial infarction? Am J Cardiol 2006; 97: 943-6.
    • (2006) Am J Cardiol , vol.97 , pp. 943-946
    • Jungner, I.1    Sniderman, A.D.2    Furberg, C.3    Aastveit, A.H.4    Holme, I.5    Walldius, G.6
  • 16
    • 70450081001 scopus 로고    scopus 로고
    • Major lipids, apolipopro-teins,and risk of vascular disease
    • Angelantonio E, Sarwar N, Perry P, et al. Major lipids, apolipopro-teins,and risk of vascular disease. JAMA 2009; 302: 1993-2000.
    • (2009) JAMA , vol.302 , pp. 1993-2000
    • Angelantonio, E.1    Sarwar, N.2    Perry, P.3
  • 18
    • 33746095378 scopus 로고    scopus 로고
    • Small dense low-density lipoprotein and its role as an independent predictor of cardiovascular disease
    • Packard CJ. Small dense low-density lipoprotein and its role as an independent predictor of cardiovascular disease. Curr Opin Lipidol 2006; 17: 412-7.
    • (2006) Curr Opin Lipidol , vol.17 , pp. 412-417
    • Packard, C.J.1
  • 19
    • 31144439939 scopus 로고    scopus 로고
    • Low-density-lipoproteins Size and Cardiovas-cularrisk Assessment QJM
    • Rizzo M, Berneis K. Low-density-lipoproteins size and cardiovas-cularrisk assessment QJM - Int J Med 2006; 99: 1-14.
    • (2006) Int J Med , vol.99 , pp. 1-14
    • Rizzo, M.1    Berneis, K.2
  • 20
    • 33645741889 scopus 로고    scopus 로고
    • Low-density lipoproteinand high-density lipoprotein and particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    • Otvos JD, Collins D, Freedman DS, et al. Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation 2006; 113: 1556-63.
    • (2006) Circulation , vol.113 , pp. 1556-1563
    • Otvos, J.D.1    Collins, D.2    Freedman, D.S.3
  • 21
    • 0020060090 scopus 로고
    • Identification of multiple subclasses of plasma low density lipoproteins in normal humans
    • Krauss RM, Burke DJ. Identification of multiple subclasses of plasma low density lipoproteins in normal humans. J Lipid Res 1982; 23: 97-104.
    • (1982) J Lipid Res , vol.23 , pp. 97-104
    • Krauss, R.M.1    Burke, D.J.2
  • 22
    • 0036737881 scopus 로고    scopus 로고
    • Metabolic origins and clinical signify-cance of LDL heterogeneity
    • Berneis KK, Krauss RM. Metabolic origins and clinical signific-anceof LDL heterogeneity. J Lipid Res 2002; 43: 1363-79.
    • (2002) J Lipid Res , vol.43 , pp. 1363-1379
    • Berneis, K.K.1    Krauss, R.M.2
  • 23
    • 33748443205 scopus 로고    scopus 로고
    • Should we measure routinely the LDL peak particle size?
    • Rizzo M, Berneis K. Should we measure routinely the LDL peak particle size? Int J Card 2006; 107: 166-70.
    • (2006) Int J Card , vol.107 , pp. 166-170
    • Rizzo, M.1    Berneis, K.2
  • 24
    • 5444261454 scopus 로고    scopus 로고
    • Low-density lipoprotein particle number and risk for cardiovascular disease
    • Cromwell WC, Otvos JD. Low-density lipoprotein particle number and risk for cardiovascular disease. Curr Atheroscler Rep 2004; 6:381-7.
    • (2004) Curr Atheroscler Rep , vol.6 , pp. 381-387
    • Cromwell, W.C.1    Otvos, J.D.2
  • 25
    • 0027242030 scopus 로고
    • Hypercholesterolemia in-creasesendothelial superoxide anion production
    • Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia in-creasesendothelial superoxide anion production. J Clin Invest 1993; 91: 2546-51.
    • (1993) J Clin Invest , vol.91 , pp. 2546-2551
    • Ohara, Y.1    Peterson, T.E.2    Harrison, D.G.3
  • 26
    • 64349105661 scopus 로고    scopus 로고
    • Atherogenic dyslip-idemiaand oxidative stress: A new look
    • Rizzo M, Kotur-Stevuljevic J, Berneis K, et al. Atherogenic dyslip-idemiaand oxidative stress: a new look. Transl Res 2009; 153:217-23.
    • (2009) Transl Res , vol.153 , pp. 217-223
    • Rizzo, M.1    Kotur-Stevuljevic, J.2    Berneis, K.3
  • 27
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation atherosclerosis, and coronary artery disease
    • Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352: 1685-95.
    • (2005) N Engl J Med , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 28
    • 0031809817 scopus 로고    scopus 로고
    • Small dense low density lipoprotein has increased affin-ityfor LDL receptor-independent cell surface binding sites: A po-tentialmechanism for increased atherogenicity
    • Galeano NF, Al-Haideri M, Keyserman F, Rumsey SC, Deckelbaum RJ. Small dense low density lipoprotein has increased affin-ityfor LDL receptor-independent cell surface binding sites: a po-tentialmechanism for increased atherogenicity. J Lipid Res 1998;39: 1263-73.
    • (1998) J Lipid Res , vol.39 , pp. 1263-1273
    • Galeano, N.F.1    Al-Haideri, M.2    Keyserman, F.3    Rumsey, S.C.4    Deckelbaum, R.J.5
  • 29
    • 0028897701 scopus 로고
    • Greater oxidative susceptibility of the surface monolayer in small dense LDL may contribute to differences in copper-induced oxidation among LDL density subfractions
    • Tribble DL, Krauss RM, Lamberg MG, Thiel PM, van den Berg JM. Greater oxidative susceptibility of the surface monolayer in small dense LDL may contribute to differences in copper-induced oxidation among LDL density subfractions. J Lipid Res 1995; 36:662-71.
    • (1995) J Lipid Res , vol.36 , pp. 662-671
    • Tribble, D.L.1    Krauss, R.M.2    Lamberg, M.G.3    Thiel, P.M.4    van den Berg, J.M.5
  • 30
    • 0035254845 scopus 로고    scopus 로고
    • Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small, dense low-density lipo-proteins
    • Tribble DL, Rizzo M, Chait A, Lewis DM, Blanche PJ, Krauss RM. Enhanced oxidative susceptibility and reduced antioxidantcontent of metabolic precursors of small, dense low-density lipo-proteins. Am J Med 2001; 110: 103-10.
    • (2001) Am J Med , vol.110 , pp. 103-110
    • Tribble, D.L.1    Rizzo, M.2    Chait, A.3    Lewis, D.M.4    Blanche, P.J.5    Krauss, R.M.6
  • 32
    • 34547859254 scopus 로고    scopus 로고
    • Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects
    • Vekic J, Kotur-Stevuljevic J, Jelic-Ivanovic Z, et al. Association ofoxidative stress and PON1 with LDL and HDL particle size inmiddle-aged subjects. Eur J Clin Invest 2007; 37: 715-23.
    • (2007) Eur J Clin Invest , vol.37 , pp. 715-723
    • Vekic, J.1    Kotur-Stevuljevic, J.2    Jelic-Ivanovic, Z.3
  • 33
    • 60749105826 scopus 로고    scopus 로고
    • High serum uric acid and low-grade inflammation are associatedwith smaller LDL and HDL particles
    • Vekic J, Jelic-Ivanovic Z, Spasojevic-Kalimanovska V, Memon L, et al. High serum uric acid and low-grade inflammation are associatedwith smaller LDL and HDL particles. Atherosclerosis 2009;203: 236-42.
    • (2009) Atherosclerosis , vol.203 , pp. 236-242
    • Vekic, J.1    Jelic-Ivanovic, Z.2    Spasojevic-Kalimanovska, V.3    Memon, L.4
  • 34
    • 0029586644 scopus 로고
    • Influence of lipoprotein lipase and hepatic lipase on the transformation of VLDL and HDL during lipolysis of VLDL
    • Murdoch SJ, Breckenridge WC. Influence of lipoprotein lipase and hepatic lipase on the transformation of VLDL and HDL during lipolysis of VLDL. Atherosclerosis 1995; 118: 193-212.
    • (1995) Atherosclerosis , vol.118 , pp. 193-212
    • Murdoch, S.J.1    Breckenridge, W.C.2
  • 35
    • 0019137962 scopus 로고
    • Evaluation of the roles of lipoprotein lipase and hepatic lipase in lipoprotein metabolism: In vivo and in vitro studies in man
    • Nicoll A, Lewis B. Evaluation of the roles of lipoprotein lipase and hepatic lipase in lipoprotein metabolism: in vivo and in vitro studies in man. Eur J Clin Invest 1980; 10: 487-95.
    • (1980) Eur J Clin Invest , vol.10 , pp. 487-495
    • Nicoll, A.1    Lewis, B.2
  • 36
    • 0028910905 scopus 로고
    • Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low density lipoprotein subclasses
    • Campos H, Dreon DM, Krauss RM. Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low density lipoprotein subclasses. J Lipid Res 1995; 36: 462-72,
    • (1995) J Lipid Res , vol.36 , pp. 462-472
    • Campos, H.1    Dreon, D.M.2    Krauss, R.M.3
  • 38
    • 0021337236 scopus 로고
    • Plasma triglyceride determines structure-composition in low and high den-sitylipoproteins
    • Deckelbaum RJ, Granot E, Oschry Y, Rose L, Eisenberg S. Plasma triglyceride determines structure-composition in low and high den-sitylipoproteins. Arteriosclerosis 1984; 4: 225-31.,
    • (1984) Arteriosclerosis , vol.4 , pp. 225-231
    • Deckelbaum, R.J.1    Granot, E.2    Oschry, Y.3    Rose, L.4    Eisenberg, S.5
  • 39
    • 0034746490 scopus 로고    scopus 로고
    • Atherogenic role of elevated CE transfer from HDL to VLDL(1) and dense LDL in type 2 diabetes: Impact of the degree of triglyceridemia
    • Guerin M, Le Goff W, Lassel TS, Van Tol A, Steiner G, Chapman MJ. Atherogenic role of elevated CE transfer from HDL to VLDL(1) and dense LDL in type 2 diabetes: impact of the degree of triglyceridemia. Arterioscler Thromb Vasc Biol 2001; 21: 282-8.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 282-288
    • Guerin, M.1    Le, G.W.2    Lassel, T.S.3    van Tol, A.4    Steiner, G.5    Chapman, M.J.6
  • 40
    • 0013301537 scopus 로고    scopus 로고
    • Statin-fibrate com-binationtherapy for hyperlipidaemia: A review
    • Wierzbicki AS, Mikhailidis DP, Wray R, et al. Statin-fibrate com-binationtherapy for hyperlipidaemia: A review. Curr Med ResOpin 2003; 19: 155-68.
    • (2003) Curr Med ResOpin , vol.19 , pp. 155-168
    • Wierzbicki, A.S.1    Mikhailidis, D.P.2    Wray, R.3
  • 41
    • 77954921239 scopus 로고    scopus 로고
    • Fibrates: No ACCORD on their use in the treatment of dyslipidaemia
    • Wierzbicki AS. Fibrates: no ACCORD on their use in the treatment of dyslipidaemia. Curr Opin Lipidol 2010; 21: 352-8.
    • (2010) Curr Opin Lipidol , vol.21 , pp. 352-358
    • Wierzbicki, A.S.1
  • 42
    • 34249067115 scopus 로고    scopus 로고
    • The clinical significance of the size of low-density-lipoproteins and the modulation of subclasses by fibrates
    • Rizzo M, Berneis K. The clinical significance of the size of low-density-lipoproteins and the modulation of subclasses by fibrates.Curr Med Res Opin 2007; 23: 1103-11.
    • (2007) Curr Med Res Opin , vol.23 , pp. 1103-1111
    • Rizzo, M.1    Berneis, K.2
  • 43
    • 33746465844 scopus 로고    scopus 로고
    • The clinical relevance of low-density-lipoproteinssize modulation by statins
    • Rizzo M, Berneis K. The clinical relevance of low-density-lipoproteinssize modulation by statins. Cardiovasc Drugs Ther 2006; 20: 205-17.
    • (2006) Cardiovasc Drugs Ther , vol.20 , pp. 205-217
    • Rizzo, M.1    Berneis, K.2
  • 44
    • 59349087902 scopus 로고    scopus 로고
    • Quantitative and qualitative effects of rosuvastatin on LDL-cholesterol: What is the clinical significance?
    • Rizzo M, Berneis K, Spinas GA, Rini GB, Kapur NK. Quantitative and qualitative effects of rosuvastatin on LDL-cholesterol: what is the clinical significance? Int J Clin Pract 2009; 63: 478-85.
    • (2009) Int J Clin Pract , vol.63 , pp. 478-485
    • Rizzo, M.1    Berneis, K.2    Spinas, G.A.3    Rini, G.B.4    Kapur, N.K.5
  • 45
    • 21244456053 scopus 로고    scopus 로고
    • The use of ezetimibe in achieving low density lipoprotein lowering goals in clinical practice: Position statement of a United Kingdom consen-suspanel
    • Mikhailidis DP, Wierzbicki AS, Daskalopoulou SS, et al. The useof ezetimibe in achieving low density lipoprotein lowering goals inclinical practice: Position statement of a United Kingdom consen-suspanel. Curr Med Res Opin 2005; 21: 959-69.
    • (2005) Curr Med Res Opin , vol.21 , pp. 959-969
    • Mikhailidis, D.P.1    Wierzbicki, A.S.2    Daskalopoulou, S.S.3
  • 46
    • 67349093082 scopus 로고    scopus 로고
    • The effects of ezetimibe on LDL-cholesterol: Quantitative or qualitative changes?
    • Rizzo M, Rini GB, Spinas GA, Berneis K. The effects of ezetimibe on LDL-cholesterol: quantitative or qualitative changes? Atherosclerosis 2009; 204: 330-3.
    • (2009) Atherosclerosis , vol.204 , pp. 330-333
    • Rizzo, M.1    Rini, G.B.2    Spinas, G.A.3    Berneis, K.4
  • 47
    • 77954320146 scopus 로고    scopus 로고
    • Ezetimibe alone or in combination with simvastatin in-creasessmall, dense low-density lipoproteins in healthy men: A randomized trial
    • Berneis K, Rizzo M, Berthold HK, Spinas GA, Krone W, Gouni-Berthold I. Ezetimibe alone or in combination with simvastatin in-creasessmall, dense low-density lipoproteins in healthy men: a randomized trial. Eur Heart J 2010; 31: 1633-9.
    • (2010) Eur Heart J , vol.31 , pp. 1633-1639
    • Berneis, K.1    Rizzo, M.2    Berthold, H.K.3    Spinas, G.A.4    Krone, W.5    Gouni-Berthold, I.6
  • 48
    • 79951652753 scopus 로고    scopus 로고
    • The effect of simvastatin alone versus simvastatin plus ezetimibe on the concentration of small dense low-density lipoprotein cholesterol in subjects with primary hypercholesterolemia
    • Florentin M, Liberopoulos EN, Moutzouri E, Rizos CV, Tselepis AD, Elisaf MS. The effect of simvastatin alone versus simvastatinplus ezetimibe on the concentration of small dense low-densitylipoprotein cholesterol in subjects with primary hypercholesterolemia.Curr Med Res Opin 2011; 27: 685-92.
    • (2011) Curr Med Res Opin , vol.27 , pp. 685-692
    • Florentin, M.1    Liberopoulos, E.N.2    Moutzouri, E.3    Rizos, C.V.4    Tselepis, A.D.5    Elisaf, M.S.6
  • 50
    • 69149090880 scopus 로고    scopus 로고
    • Future challenges for mi-crosomaltransport protein inhibitors
    • Wierzbicki AS, Hardman T, Prince WT. Future challenges for mi-crosomaltransport protein inhibitors. Curr Vasc Pharmacol 2009;7: 277-86.
    • (2009) Curr Vasc Pharmacol , vol.7 , pp. 277-286
    • Wierzbicki, A.S.1    Hardman, T.2    Prince, W.T.3
  • 51
    • 63449098685 scopus 로고    scopus 로고
    • Mechanisms targeting apolipoprotein B100 to proteasomal degradation: Evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus
    • Rutledge AC, Qiu W, Zhang R, Kohen-Avramoglu R, Nemat-Gorgani N, Adeli K. Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus. Arterioscler Thromb Vasc Biol 2009; 29: 579-85.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 579-585
    • Rutledge, A.C.1    Qiu, W.2    Zhang, R.3    Kohen-Avramoglu, R.4    Nemat-Gorgani, N.5    Adeli, K.6
  • 52
    • 0034717836 scopus 로고    scopus 로고
    • Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein- B lipoproteinassembly
    • Gordon DA, Jamil H. Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein- B lipoproteinassembly. Biochim Biophys Acta 2000; 1486: 72-83.
    • (2000) Biochim Biophys Acta , vol.1486 , pp. 72-83
    • Gordon, D.A.1    Jamil, H.2
  • 53
    • 0027209301 scopus 로고
    • Abetalipoproteinemia. New insights into lipoprotein assembly and vitamin E metabolism from a rare geneticdisease
    • Rader DJ, Brewer HB. Abetalipoproteinemia. New insights into lipoprotein assembly and vitamin E metabolism from a rare geneticdisease. JAMA 1993; 270: 865-9.
    • (1993) JAMA , vol.270 , pp. 865-869
    • Rader, D.J.1    Brewer, H.B.2
  • 54
    • 0028022939 scopus 로고
    • Human micro-somaltriglyceride transfer protein large subunit gene structure
    • Sharp D, Ricci B, Kienzle B, Lin MC, Wetterau JR. Human micro-somaltriglyceride transfer protein large subunit gene structure. Biochemistry 1994; 33: 9057-61.
    • (1994) Biochemistry , vol.33 , pp. 9057-9061
    • Sharp, D.1    Ricci, B.2    Kienzle, B.3    Lin, M.C.4    Wetterau, J.R.5
  • 55
    • 0027428820 scopus 로고
    • Cloning and gene de-fectsin microsomal triglyceride transfer protein associated withabetalipoproteinaemia
    • Sharp D, Blinderman L, Combs KA, et al. Cloning and gene de-fectsin microsomal triglyceride transfer protein associated withabetalipoproteinaemia. Nature 1993; 365: 65-9.
    • (1993) Nature , vol.365 , pp. 65-69
    • Sharp, D.1    Blinderman, L.2    Combs, K.A.3
  • 56
    • 0032561425 scopus 로고    scopus 로고
    • An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits
    • Wetterau JR, Gregg RE, Harrity TW, et al. An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. Science 1998; 282: 751-4.
    • (1998) Science , vol.282 , pp. 751-754
    • Wetterau, J.R.1    Gregg, R.E.2    Harrity, T.W.3
  • 57
    • 18144363262 scopus 로고    scopus 로고
    • Current biology of MTP: Implications for selective inhibition
    • Shoulders CC, Shelness GS. Current biology of MTP: implications for selective inhibition. Curr Top Med Chem 2005; 5: 283-300.
    • (2005) Curr Top Med Chem , vol.5 , pp. 283-300
    • Shoulders, C.C.1    Shelness, G.S.2
  • 58
    • 33846151732 scopus 로고    scopus 로고
    • Inhibition of microso-maltriglyceride transfer protein in familial hypercholesterolemia
    • Cuchel M, Bloedon LT, Szapary PO, et al. Inhibition of microso-maltriglyceride transfer protein in familial hypercholesterolemia. N Engl J Med 2007; 356: 148-56.
    • (2007) N Engl J Med , vol.356 , pp. 148-156
    • Cuchel, M.1    Bloedon, L.T.2    Szapary, P.O.3
  • 59
    • 0035866584 scopus 로고    scopus 로고
    • A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors
    • Robl JA, Sulsky R, Sun CQ, et al. A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors. Journal of Medicinal Chemistry 2001; 44: 851-6.
    • (2001) Journal of Medicinal Chemistry , vol.44 , pp. 851-856
    • Robl, J.A.1    Sulsky, R.2    Sun, C.Q.3
  • 60
    • 0037195602 scopus 로고    scopus 로고
    • Atorvastatin increases hepatic fatty acid beta-oxidation in sucrose-fed rats: Comparison with an MTP inhibitor
    • Funatsu T, Kakuta H, Takasu T, Miyata K. Atorvastatin increaseshepatic fatty acid beta-oxidation in sucrose-fed rats: comparison with an MTP inhibitor. Eur J Pharmacol 2002; 455: 161-7.
    • (2002) Eur J Pharmacol , vol.455 , pp. 161-167
    • Funatsu, T.1    Kakuta, H.2    Takasu, T.3    Miyata, K.4
  • 61
    • 0242290829 scopus 로고    scopus 로고
    • CP-346086: An MTP inhibitor that lowers plasma cholesterol and triglycerides in ex-perimentalanimals and in humans
    • Chandler CE, Wilder DE, Pettini JL, et al. CP-346086: an MTPinhibitor that lowers plasma cholesterol and triglycerides in ex-perimentalanimals and in humans. J Lipid Res 2003; 44: 1887-901
    • (2003) J Lipid Res , vol.44 , pp. 1887-1901
    • Chandler, C.E.1    Wilder, D.E.2    Pettini, J.L.3
  • 62
    • 79952777250 scopus 로고    scopus 로고
    • SLx-4090, an Enterocyte Specific Micorsomal Triglyceride Transport Protein (MTP) Inhibit-orLowers LDL Cholesterol and Triglycerides While Raising HDL Cholesterol in Apo E-/- Mice Fed a High Fat Diet
    • Ellis J, Bartolozzi A, Ferkany J, et al. SLx-4090, an Enterocyte Specific Micorsomal Triglyceride Transport Protein (MTP) Inhibi-torLowers LDL Cholesterol and Triglycerides While Raising HDL Cholesterol in Apo E-/- Mice Fed a High Fat Diet. ArteriosclerThromb Vasc Biol 2007; 27: e64.
    • (2007) ArteriosclerThromb Vasc Biol , vol.6427
    • Ellis, J.1    Bartolozzi, A.2    Ferkany, J.3
  • 63
    • 19444384186 scopus 로고    scopus 로고
    • Implitapide, a microsomal triglyceride transfer proteininhibitor, reduces progression of atherosclerosis in apolipoprotein Eknockout mice fed a Western-type diet: Involvement of the inhibition of postprandial triglyceride elevation
    • Ueshima K, Kihisa-Umeno H, Nagayoshi A, Takakura S, Matsuo M, Mutoh S. Implitapide, a microsomal triglyceride transfer proteininhibitor, reduces progression of atherosclerosis in apolipoprotein Eknockout mice fed a Western-type diet: involvement of the inhibitionof postprandial triglyceride elevation. Biol Pharm Bull 2005;28: 247-52.
    • (2005) Biol Pharm Bull , vol.28 , pp. 247-252
    • Ueshima, K.1    Kihisa-Umeno, H.2    Nagayoshi, A.3    Takakura, S.4    Matsuo, M.5    Mutoh, S.6
  • 64
    • 26844580001 scopus 로고    scopus 로고
    • JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guineapigs
    • Aggarwal D, West KL, Zern TL, Shrestha S, Vergara-Jimenez M,Fernandez ML. JTT-130, a microsomal triglyceride transfer protein(MTP) inhibitor lowers plasma triglycerides and LDL cholesterolconcentrations without increasing hepatic triglycerides in guineapigs. BMC Cardiovasc Disord 2005; 5: 30.
    • (2005) BMC Cardiovasc Disord , vol.5 , pp. 30
    • Aggarwal, D.1    West, K.L.2    Zern, T.L.3    Shrestha, S.4    Vergara-Jimenez, M.5    Fernandez, M.L.6
  • 65
    • 79958208604 scopus 로고    scopus 로고
    • SLx-4090: First human experience and proof of concept for an enterocyte-specific microsomal triglyceride transfer protein inhibitor
    • Prince WT, Warwick Tong E, Andersen G, et al. SLx-4090: Firsthuman experience and proof of concept for an enterocyte-specificmicrosomal triglyceride transfer protein inhibitor. Circulation.2006; 114: 2427.
    • (2427) Circulation , vol.2006 , pp. 114
    • Prince, W.T.1    Warwick, T.E.2    Andersen, G.3
  • 66
    • 70349643568 scopus 로고    scopus 로고
    • SLX-4090-repeat dose treatment with a novel enterocyte specific MTP inhibitor re-ducespost-prandial triglyceride response and lowers LDL-C inhealthy volunteers
    • Prince WJ, Tong W, Frekany J, Andersen G. SLX-4090- repeatdose treatment with a novel enterocyte specific MTP inhibitor re-ducespost-prandial triglyceride response and lowers LDL-C inhealthy volunteers. J Clin Lipidol 2007; 1: 471.
    • (2007) J Clin Lipidol , vol.1 , pp. 471
    • Prince, W.J.1    Tong, W.2    Frekany, J.3    Andersen, G.4
  • 68
    • 48349088178 scopus 로고    scopus 로고
    • In-hibitionof microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia
    • Samaha FF, McKenney J, Bloedon LT, Sasiela WJ, Rader DJ. In-hibitionof microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia. Nat ClinPract Cardiovasc Med 2008; 5: 497-505.
    • (2008) Nat ClinPract Cardiovasc Med , vol.5 , pp. 497-505
    • Samaha, F.F.1    McKenney, J.2    Bloedon, L.T.3    Sasiela, W.J.4    Rader, D.J.5
  • 69
    • 79958202924 scopus 로고    scopus 로고
    • Aegerion Pharmaceuticals, Inc. Presents Final Results of Phase IIClinical Trials for AEGR-733 at Drugs Affecting Lipid Metabolism(DALM)
    • Aegerion Pharmaceuticals, Inc. Presents Final Results of Phase IIClinical Trials for AEGR-733 at Drugs Affecting Lipid Metabolism(DALM) 2007 Conference. Aegerion Pharmaceuticals Inc Press Release 2007.
    • (2007) Conference. Aegerion Pharmaceuticals Inc PressRelease , pp. 2007
  • 70
    • 77749240456 scopus 로고    scopus 로고
    • Lomitapide, a microsomal triglyceride transfer protein inhibitor for the treatment of hypercholesterolemia
    • Rizzo M. Lomitapide, a microsomal triglyceride transfer protein inhibitor for the treatment of hypercholesterolemia. IDrugs 2010;13: 103-11.
    • (2010) IDrugs , vol.13 , pp. 103-111
    • Rizzo, M.1
  • 71
    • 79952784515 scopus 로고    scopus 로고
    • Abstract 1077: A phase III study of microsomal triglyceride transfer protein inhibitor lomi-tapide(AEGR-733) in patients with homozygous familial hyper-cholesterolemia:Interim results at 6 months
    • Cuchel M, Meagher E, Marais AD, et al. Abstract 1077: A phaseIII study of microsomal triglyceride transfer protein inhibitor lomitapide(AEGR-733) in patients with homozygous familial hypercholesterolemia:interim results at 6 months. Circulation 2009; 120:S441.
    • (2009) Circulation , vol.120
    • Cuchel, M.1    Meagher, E.2    Marais, A.D.3
  • 72
    • 77952674608 scopus 로고    scopus 로고
    • Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight lossdiet
    • Chan DC, Watts GF, Gan SK, Ooi EM, Barrett PH. Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight lossdiet. Diabetes Care 2010; 33: 1134-9.
    • (2010) Diabetes Care , vol.33 , pp. 1134-1139
    • Chan, D.C.1    Watts, G.F.2    Gan, S.K.3    Ooi, E.M.4    Barrett, P.H.5
  • 73
    • 0035894648 scopus 로고    scopus 로고
    • High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): Aprospective study
    • Walldius G, Jungner I, Holme I, Aastveit AH, Kolar W, Steiner E.High apolipoprotein B, low apolipoprotein A-I, and improvementin the prediction of fatal myocardial infarction (AMORIS study): aprospective study. Lancet 2001; 358: 2026-33.
    • (2001) Lancet , vol.358 , pp. 2026-2033
    • Walldius, G.1    Jungner, I.2    Holme, I.3    Aastveit, A.H.4    Kolar, W.5    Steiner, E.6
  • 74
    • 33645982907 scopus 로고    scopus 로고
    • Errors that result from using the TC/HDL C ratio rather than the apoB/apoA-I ratio to identify the lipoprotein-related risk of vascu-lardisease
    • Sniderman AD, Jungner I, Holme I, Aastveit A, Walldius G. Errorsthat result from using the TC/HDL C ratio rather than theapoB/apoA-I ratio to identify the lipoprotein-related risk of vascu-lardisease. J Intern Med 2006; 259: 455-61.
    • (2006) J Intern Med , vol.259 , pp. 455-461
    • Sniderman, A.D.1    Jungner, I.2    Holme, I.3    Aastveit, A.4    Walldius, G.5
  • 75
    • 33645096052 scopus 로고    scopus 로고
    • Apo B versus choles-terolin estimating cardiovascular risk and in guiding therapy: Re-portof the thirty-person/ten-country panel
    • Barter PJ, Ballantyne CM, Carmena, et al. Apo B versus choles-terolin estimating cardiovascular risk and in guiding therapy: re-portof the thirty-person/ten-country panel. J Intern Med 2006; 259:247-58.
    • (2006) J Intern Med , vol.259 , pp. 247-258
    • Barter, P.J.1    Ballantyne, C.M.C.2
  • 76
    • 44949118531 scopus 로고    scopus 로고
    • Relationships be-tweenlipoprotein components and risk of myocardial infarction: Age, gender and short versus longer follow-up periods in the Apol-ipoproteinMOrtality RISk study (AMORIS)
    • Holme I, Aastveit AH, Jungner I, Walldius G. Relationships be-tweenlipoprotein components and risk of myocardial infarction:age, gender and short versus longer follow-up periods in the Apol-ipoproteinMOrtality RISk study (AMORIS). Intern Med 2008;264: 30-8.
    • (2008) Intern Med , vol.264 , pp. 30-38
    • Holme, I.1    Aastveit, A.H.2    Jungner, I.3    Walldius, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.