메뉴 건너뛰기




Volumn 10, Issue , 2014, Pages 63-100

Blood-brain barrier (BBB) pharmacoproteomics: A new research field opened up by quantitative targeted absolute proteomics (QTAP)

Author keywords

[No Author keywords available]

Indexed keywords

IODOTHYRONINE; THYROXINE; ABC TRANSPORTER A1; ABC TRANSPORTER A2; ABC TRANSPORTER A8; ALBUMIN; BREAST CANCER RESISTANCE PROTEIN; CD147 ANTIGEN; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; GLUCOSE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 1; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER B; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A2; TAURINE TRANSPORTER; TRYPSIN;

EID: 84905011656     PISSN: 22107371     EISSN: 2210738X     Source Type: Book Series    
DOI: 10.1007/978-1-4614-9105-7_3     Document Type: Article
Times cited : (5)

References (80)
  • 1
    • 0035668339 scopus 로고    scopus 로고
    • Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein
    • Adachi Y, Suzuki H, Sugiyama Y (2001) Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res 18:1660-1668
    • (2001) Pharm Res , vol.18 , pp. 1660-1668
    • Adachi, Y.1    Suzuki, H.2    Sugiyama, Y.3
  • 2
    • 0037435030 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics
    • Aebersold R, Mann M (2003) Mass spectrometry-based proteomics. Nature 422:198-207
    • (2003) Nature , vol.422 , pp. 198-207
    • Aebersold, R.1    Mann, M.2
  • 3
    • 78650664718 scopus 로고    scopus 로고
    • The discovery and validation of colorectal cancer biomarkers
    • Ang CS, Phung J, Nice EC (2011) The discovery and validation of colorectal cancer biomarkers. Biomed Chromatogr 25:82-99
    • (2011) Biomed Chromatogr , vol.25 , pp. 82-99
    • Ang, C.S.1    Phung, J.2    Nice, E.C.3
  • 7
    • 0037372571 scopus 로고    scopus 로고
    • P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists
    • Chen C, Hanson E, Watson JW, Lee JS (2003) P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos 31:312-318
    • (2003) Drug Metab Dispos , vol.31 , pp. 312-318
    • Chen, C.1    Hanson, E.2    Watson, J.W.3    Lee, J.S.4
  • 8
    • 33746414366 scopus 로고    scopus 로고
    • Proteomic analysis of rat hippocampal plasma membrane: Characterization of potential neuronal-specific plasma membrane proteins
    • Chen P, Li X, Sun Y, Liu Z, Cao R, He Q, Wang M, Xiong J, Xie J, Wang X, Liang S (2006) Proteomic analysis of rat hippocampal plasma membrane: characterization of potential neuronal-specific plasma membrane proteins. J Neurochem 98:1126-1140
    • (2006) J Neurochem , vol.98 , pp. 1126-1140
    • Chen, P.1    Li, X.2    Sun, Y.3    Liu, Z.4    Cao, R.5    He, Q.6    Wang, M.7    Xiong, J.8    Xie, J.9    Wang, X.10    Liang, S.11
  • 9
    • 66149118232 scopus 로고    scopus 로고
    • Absolute quantification of phosphorylation on the kinase activation loop of cellular focal adhesion kinase by stable isotope dilution liquid chromatography/ mass spectrometry
    • Ciccimaro E, Hanks SK, Yu KH, Blair IA (2009) Absolute quantification of phosphorylation on the kinase activation loop of cellular focal adhesion kinase by stable isotope dilution liquid chromatography/ mass spectrometry. Anal Chem 81:3304-3313
    • (2009) Anal Chem , vol.81 , pp. 3304-3313
    • Ciccimaro, E.1    Hanks, S.K.2    Yu, K.H.3    Blair, I.A.4
  • 10
    • 79953684931 scopus 로고    scopus 로고
    • Doctor’s thesis, Division of Clinical Chemistry, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands and Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, Amsterdam, The Netherlands
    • de Vries NA (2009) Preclinical models to study the impact of the blood-brain barrier in brain tumor chemotherapy. Doctor’s thesis, Division of Clinical Chemistry, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands and Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, Amsterdam, The Netherlands
    • (2009) Preclinical Models to Study the Impact of the Blood-Brain Barrier in Brain Tumor Chemotherapy
    • De Vries, N.A.1
  • 11
    • 77954185457 scopus 로고    scopus 로고
    • Assay development for the determination of phosphorylation stoichiometry using multiple reaction monitoring methods with and without phosphatase treatment: Application to breast cancer signaling pathways
    • Domanski D, Murphy LC, Borchers CH (2010) Assay development for the determination of phosphorylation stoichiometry using multiple reaction monitoring methods with and without phosphatase treatment: application to breast cancer signaling pathways. Anal Chem 82:5610-5620
    • (2010) Anal Chem , vol.82 , pp. 5610-5620
    • Domanski, D.1    Murphy, L.C.2    Borchers, C.H.3
  • 12
    • 33645813378 scopus 로고    scopus 로고
    • Mass spectrometry and protein analysis
    • Domon B, Aebersold R (2006) Mass spectrometry and protein analysis. Science 312:212-217
    • (2006) Science , vol.312 , pp. 212-217
    • Domon, B.1    Aebersold, R.2
  • 14
    • 0031584092 scopus 로고    scopus 로고
    • Nutrient regulation of the intestinal Na+/glucose co-transporter (SGLT1) gene expression
    • Dyer J, Barker PJ, Shirazi-Beechey SP (1997) Nutrient regulation of the intestinal Na+/glucose co-transporter (SGLT1) gene expression. Biochem Biophys Res Commun 230:624-629
    • (1997) Biochem Biophys Res Commun , vol.230 , pp. 624-629
    • Dyer, J.1    Barker, P.J.2    Shirazi-Beechey, S.P.3
  • 15
    • 0038004636 scopus 로고    scopus 로고
    • Clinical biomarkers in drug discovery and development
    • Frank R, Hargreaves R (2003) Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov 2:566-580
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 566-580
    • Frank, R.1    Hargreaves, R.2
  • 16
    • 34548071206 scopus 로고    scopus 로고
    • In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids
    • Friden M, Gupta A, Antonsson M, Bredberg U, Hammarlund-Udenaes M (2007) In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids. Drug Metab Dispos 35:1711-1719
    • (2007) Drug Metab Dispos , vol.35 , pp. 1711-1719
    • Friden, M.1    Gupta, A.2    Antonsson, M.3    Bredberg, U.4    Hammarlund-Udenaes, M.5
  • 17
    • 70350054854 scopus 로고    scopus 로고
    • Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids
    • Friden M, Winiwarter S, Jerndal G, Bengtsson O, Wan H, Bredberg U, Hammarlund-Udenaes M, Antonsson M (2009) Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. J Med Chem 52:6233-6243
    • (2009) J Med Chem , vol.52 , pp. 6233-6243
    • Friden, M.1    Winiwarter, S.2    Jerndal, G.3    Bengtsson, O.4    Wan, H.5    Bredberg, U.6    Hammarlund-Udenaes, M.7    Antonsson, M.8
  • 18
    • 79951865101 scopus 로고    scopus 로고
    • Measurement of unbound drug exposure in brain: Modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods
    • Friden M, Bergstrom F, Wan H, Rehngren M, Ahlin G, Hammarlund-Udenaes M, Bredberg U (2011) Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug Metab Dispos 39:353-362
    • (2011) Drug Metab Dispos , vol.39 , pp. 353-362
    • Friden, M.1    Bergstrom, F.2    Wan, H.3    Rehngren, M.4    Ahlin, G.5    Hammarlund-Udenaes, M.6    Bredberg, U.7
  • 19
    • 0036718272 scopus 로고    scopus 로고
    • Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
    • Fukumoto H, Cheung BS, Hyman BT, Irizarry MC (2002) Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol 59:1381-1389
    • (2002) Arch Neurol , vol.59 , pp. 1381-1389
    • Fukumoto, H.1    Cheung, B.S.2    Hyman, B.T.3    Irizarry, M.C.4
  • 21
    • 34250013578 scopus 로고    scopus 로고
    • The importance of thyroid hormone transporters for brain development and function
    • Heuer H (2007) The importance of thyroid hormone transporters for brain development and function. Best Pract Res Clin Endocrinol Metab 21:265-276
    • (2007) Best Pract Res Clin Endocrinol Metab , vol.21 , pp. 265-276
    • Heuer, H.1
  • 23
    • 0032818545 scopus 로고    scopus 로고
    • Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: In vivo evidence using the brain efflux index method
    • Hosoya K, Sugawara M, Asaba H, Terasaki T (1999) Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem 73:1206-1211
    • (1999) J Neurochem , vol.73 , pp. 1206-1211
    • Hosoya, K.1    Sugawara, M.2    Asaba, H.3    Terasaki, T.4
  • 24
    • 79953718797 scopus 로고    scopus 로고
    • Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys
    • Ito K, Uchida Y, Ohtsuki S, Aizawa S, Kawakami H, Katsukura Y, Kamiie J, Terasaki T (2011) Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys. J Pharm Sci 100:3939-3950
    • (2011) J Pharm Sci , vol.100 , pp. 3939-3950
    • Ito, K.1    Uchida, Y.2    Ohtsuki, S.3    Aizawa, S.4    Kawakami, H.5    Katsukura, Y.6    Kamiie, J.7    Terasaki, T.8
  • 26
    • 43049114146 scopus 로고    scopus 로고
    • Quantitative atlas of membrane transporter proteins: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria
    • Kamiie J, Ohtsuki S, Iwase R, Ohmine K, Katsukura Y, Yanai K, Sekine Y, Uchida Y, Ito S, Terasaki T (2008) Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm Res 25:1469-1483
    • (2008) Pharm Res , vol.25 , pp. 1469-1483
    • Kamiie, J.1    Ohtsuki, S.2    Iwase, R.3    Ohmine, K.4    Katsukura, Y.5    Yanai, K.6    Sekine, Y.7    Uchida, Y.8    Ito, S.9    Terasaki, T.10
  • 28
    • 78650054715 scopus 로고    scopus 로고
    • Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with In silico target peptide selection
    • Kawakami H, Ohtsuki S, Kamiie J, Suzuki T, Abe T, Terasaki T (2011) Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with In silico target peptide selection. J Pharm Sci 100:341-352
    • (2011) J Pharm Sci , vol.100 , pp. 341-352
    • Kawakami, H.1    Ohtsuki, S.2    Kamiie, J.3    Suzuki, T.4    Abe, T.5    Terasaki, T.6
  • 29
    • 0442313667 scopus 로고    scopus 로고
    • The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice
    • Kemper EM, Cleypool C, Boogerd W, Beijnen JH, Van Tellingen O (2004) The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice. Cancer Chemother Pharmacol 53:173-178
    • (2004) Cancer Chemother Pharmacol , vol.53 , pp. 173-178
    • Kemper, E.M.1    Cleypool, C.2    Boogerd, W.3    Beijnen, J.H.4    Van Tellingen, O.5
  • 30
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR (1998) The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 101:289-294
    • (1998) J Clin Invest , vol.101 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandel, C.3    Leake, B.4    Wood, A.J.5    Roden, D.M.6    Wilkinson, G.R.7
  • 31
    • 33847416604 scopus 로고    scopus 로고
    • A synthetic protein approach toward accurate mass spectrometric quantification of component stoichiometry of multiprotein complexes
    • Kito K, Ota K, Fujita T, Ito T (2007) A synthetic protein approach toward accurate mass spectrometric quantification of component stoichiometry of multiprotein complexes. J Proteome Res 6:792-800
    • (2007) J Proteome Res , vol.6 , pp. 792-800
    • Kito, K.1    Ota, K.2    Fujita, T.3    Ito, T.4
  • 32
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J (2004) Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3:711-715
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 33
    • 66449128354 scopus 로고    scopus 로고
    • In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney
    • Kusuhara H, Sugiyama Y (2009) In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney. Drug Metab Pharmacokinet 24:37-52
    • (2009) Drug Metab Pharmacokinet , vol.24 , pp. 37-52
    • Kusuhara, H.1    Sugiyama, Y.2
  • 35
    • 66149182998 scopus 로고    scopus 로고
    • Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver
    • Langenfeld E, Zanger UM, Jung K, Meyer HE, Marcus K (2009) Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver. Proteomics 9: 2313-2323
    • (2009) Proteomics , vol.9 , pp. 2313-2323
    • Langenfeld, E.1    Zanger, U.M.2    Jung, K.3    Meyer, H.E.4    Marcus, K.5
  • 36
  • 37
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • Loscher W, Potschka H (2005) Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 6:591-602
    • (2005) Nat Rev Neurosci , vol.6 , pp. 591-602
    • Loscher, W.1    Potschka, H.2
  • 38
    • 46949098349 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein at the blood-brain barrier: Opportunities to improve central nervous system pharmacotherapy
    • Miller DS, Bauer B, Hartz AM (2008) Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy. Pharmacol Rev 60: 196-209
    • (2008) Pharmacol Rev , vol.60 , pp. 196-209
    • Miller, D.S.1    Bauer, B.2    Hartz, A.M.3
  • 42
    • 84872742054 scopus 로고    scopus 로고
    • Identification of transporters associated with etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics
    • Obuchi W, Ohtsuki S, Uchida Y, Ohmine K, Yamori T, Terasaki T (2013) Identification of transporters associated with etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics. Mol Pharmacol 83:490-500. doi:10.1124/mol.112.081083
    • (2013) Mol Pharmacol , vol.83 , pp. 490-500
    • Obuchi, W.1    Ohtsuki, S.2    Uchida, Y.3    Ohmine, K.4    Yamori, T.5    Terasaki, T.6
  • 43
    • 84862608491 scopus 로고    scopus 로고
    • Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: Targeted proteomic and metabolomic analyses in PK9 cells
    • Ohmine K, Kawaguchi K, Ohtsuki S, Motoi F, Egawa S, Unno M, Terasaki T (2012) Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells. Pharm Res 29:2006-2016
    • (2012) Pharm Res , vol.29 , pp. 2006-2016
    • Ohmine, K.1    Kawaguchi, K.2    Ohtsuki, S.3    Motoi, F.4    Egawa, S.5    Unno, M.6    Terasaki, T.7
  • 44
    • 34547632714 scopus 로고    scopus 로고
    • Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development
    • Ohtsuki S, Terasaki T (2007) Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm Res 24:1745-1758
    • (2007) Pharm Res , vol.24 , pp. 1745-1758
    • Ohtsuki, S.1    Terasaki, T.2
  • 45
    • 79960116572 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: Methodology, advantages, strategy, and prospects
    • Ohtsuki S, Uchida Y, Kubo Y, Terasaki T (2011) Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects. J Pharm Sci 100:3547-3559
    • (2011) J Pharm Sci , vol.100 , pp. 3547-3559
    • Ohtsuki, S.1    Uchida, Y.2    Kubo, Y.3    Terasaki, T.4
  • 46
    • 84455194082 scopus 로고    scopus 로고
    • Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities
    • Ohtsuki S, Schaefer O, Kawakami H, Inoue T, Liehner S, Saito A, Ishiguro N, Kishimoto W, Ludwig-Schwellinger E, Ebner T, Terasaki T (2012) Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab Dispos 40:83-92
    • (2012) Drug Metab Dispos , vol.40 , pp. 83-92
    • Ohtsuki, S.1    Schaefer, O.2    Kawakami, H.3    Inoue, T.4    Liehner, S.5    Saito, A.6    Ishiguro, N.7    Kishimoto, W.8    Ludwig-Schwellinger, E.9    Ebner, T.10    Terasaki, T.11
  • 47
    • 84872159164 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model
    • Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T (2013) Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model. Mol Pharm 10:289-296. doi:10.1021/mp3004308
    • (2013) Mol Pharm , vol.10 , pp. 289-296
    • Ohtsuki, S.1    Ikeda, C.2    Uchida, Y.3    Sakamoto, Y.4    Miller, F.5    Glacial, F.6    Decleves, X.7    Scherrmann, J.M.8    Couraud, P.O.9    Kubo, Y.10    Tachikawa, M.11    Terasaki, T.12
  • 48
    • 0039967156 scopus 로고    scopus 로고
    • Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal
    • O’kane RL, Martinez-Lopez I, Dejoseph MR, Vina JR, Hawkins RA (1999) Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal. J Biol Chem 274:31891-31895
    • (1999) J Biol Chem , vol.274 , pp. 31891-31895
    • O’Kane, R.L.1    Martinez-Lopez, I.2    Dejoseph, M.R.3    Vina, J.R.4    Hawkins, R.A.5
  • 50
    • 59649111761 scopus 로고    scopus 로고
    • Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxyl ate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4)
    • Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y (2009) Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxyl ate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). Drug Metab Dispos 37:315-321
    • (2009) Drug Metab Dispos , vol.37 , pp. 315-321
    • Ose, A.1    Ito, M.2    Kusuhara, H.3    Yamatsugu, K.4    Kanai, M.5    Shibasaki, M.6    Hosokawa, M.7    Schuetz, J.D.8    Sugiyama, Y.9
  • 51
    • 0036007257 scopus 로고    scopus 로고
    • Why is the global CNS pharmaceutical market so under-penetrated?
    • Pardridge WM (2002) Why is the global CNS pharmaceutical market so under-penetrated? Drug Discov Today 7:5-7
    • (2002) Drug Discov Today , vol.7 , pp. 5-7
    • Pardridge, W.M.1
  • 52
    • 0037370373 scopus 로고    scopus 로고
    • Proteomics: The first decade and beyond
    • Patterson SD, Aebersold RH (2003) Proteomics: the first decade and beyond. Nat Genet 33 Suppl:311-323
    • (2003) Nat Genet , vol.33 , pp. 311-323
    • Patterson, S.D.1    Aebersold, R.H.2
  • 55
    • 78651367221 scopus 로고    scopus 로고
    • ATP-binding cassette transporters in primary central nervous system lymphoma: Decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells
    • Sakata S, Fujiwara M, Ohtsuka K, Kamma H, Nagane M, Sakamoto A, Fujioka Y (2011) ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells. Oncol Rep 25:333-339
    • (2011) Oncol Rep , vol.25 , pp. 333-339
    • Sakata, S.1    Fujiwara, M.2    Ohtsuka, K.3    Kamma, H.4    Nagane, M.5    Sakamoto, A.6    Fujioka, Y.7
  • 56
    • 78349308405 scopus 로고    scopus 로고
    • MALDI imaging mass spectrometry-painting molecular pictures
    • Schwamborn K, Caprioli RM (2010) MALDI imaging mass spectrometry-painting molecular pictures. Mol Oncol 4:529-538
    • (2010) Mol Oncol , vol.4 , pp. 529-538
    • Schwamborn, K.1    Caprioli, R.M.2
  • 58
    • 38349174530 scopus 로고    scopus 로고
    • Effect of P-glycoprotein expression levels on the concentration-dependent permeability of drugs to the cell membrane
    • Shirasaka Y, Sakane T, Yamashita S (2008) Effect of P-glycoprotein expression levels on the concentration-dependent permeability of drugs to the cell membrane. J Pharm Sci 97:553-565
    • (2008) J Pharm Sci , vol.97 , pp. 553-565
    • Shirasaka, Y.1    Sakane, T.2    Yamashita, S.3
  • 59
    • 77249156030 scopus 로고    scopus 로고
    • Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: Toward in situ pharmacometabolomes
    • Sugiura Y, Setou M (2010) Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: toward in situ pharmacometabolomes. J Neuroimmune Pharmacol 5:31-43
    • (2010) J Neuroimmune Pharmacol , vol.5 , pp. 31-43
    • Sugiura, Y.1    Setou, M.2
  • 61
    • 61449118888 scopus 로고    scopus 로고
    • Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport
    • Syvanen S, Lindhe O, Palner M, Kornum BR, Rahman O, Langstrom B, Knudsen GM, Hammarlund-Udenaes M (2009) Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport. Drug Metab Dispos 37:635-643
    • (2009) Drug Metab Dispos , vol.37 , pp. 635-643
    • Syvanen, S.1    Lindhe, O.2    Palner, M.3    Kornum, B.R.4    Rahman, O.5    Langstrom, B.6    Knudsen, G.M.7    Hammarlund-Udenaes, M.8
  • 63
    • 25644458407 scopus 로고    scopus 로고
    • Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain
    • Tachikawa M, Watanabe M, Hori S, Fukaya M, Ohtsuki S, Asashima T, Terasaki T (2005) Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. J Neurochem 95:294-304
    • (2005) J Neurochem , vol.95 , pp. 294-304
    • Tachikawa, M.1    Watanabe, M.2    Hori, S.3    Fukaya, M.4    Ohtsuki, S.5    Asashima, T.6    Terasaki, T.7
  • 66
    • 0344393085 scopus 로고    scopus 로고
    • The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier
    • Tetsuka K, Takanaga H, Ohtsuki S, Hosoya K, Terasaki T (2003) The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier. J Neurochem 87:891-901
    • (2003) J Neurochem , vol.87 , pp. 891-901
    • Tetsuka, K.1    Takanaga, H.2    Ohtsuki, S.3    Hosoya, K.4    Terasaki, T.5
  • 67
    • 4344581457 scopus 로고    scopus 로고
    • Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier
    • Tohyama K, Kusuhara H, Sugiyama Y (2004) Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology 145:4384-4391
    • (2004) Endocrinology , vol.145 , pp. 4384-4391
    • Tohyama, K.1    Kusuhara, H.2    Sugiyama, Y.3
  • 71
    • 35948934719 scopus 로고    scopus 로고
    • Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter
    • Uchida Y, Kamiie J, Ohtsuki S, Terasaki T (2007) Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter. Pharm Res 24:2281-2296
    • (2007) Pharm Res , vol.24 , pp. 2281-2296
    • Uchida, Y.1    Kamiie, J.2    Ohtsuki, S.3    Terasaki, T.4
  • 72
    • 80054792485 scopus 로고    scopus 로고
    • Blood-brain barrier (BBB) pharmacoproteomics: Reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice
    • Uchida Y, Ohtsuki S, Kamiie J, Terasaki T (2011a) Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice. J Pharmacol Exp Ther 339:579-588
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 579-588
    • Uchida, Y.1    Ohtsuki, S.2    Kamiie, J.3    Terasaki, T.4
  • 73
    • 79953686193 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
    • Uchida Y, Ohtsuki S, Katsukura Y, Ikeda C, Suzuki T, Kamiie J, Terasaki T (2011b) Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J Neurochem 117:333-345
    • (2011) J Neurochem , vol.117 , pp. 333-345
    • Uchida, Y.1    Ohtsuki, S.2    Katsukura, Y.3    Ikeda, C.4    Suzuki, T.5    Kamiie, J.6    Terasaki, T.7
  • 74
    • 70350223814 scopus 로고    scopus 로고
    • Blood-brain barrier transporters and response to CNS-active drugs
    • Urquhart BL, Kim RB (2009) Blood-brain barrier transporters and response to CNS-active drugs. Eur J Clin Pharmacol 65:1063-1070
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 1063-1070
    • Urquhart, B.L.1    Kim, R.B.2
  • 76
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359:492-507
    • (2008) N Engl J Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 77
    • 84904976896 scopus 로고    scopus 로고
    • Cost and time period for drug discovery and development
    • Yagi T, Ohkubo M (2010) Cost and time period for drug discovery and development. JPMA Newslett 136:33-35
    • (2010) JPMA Newslett , vol.136 , pp. 33-35
    • Yagi, T.1    Ohkubo, M.2
  • 79
    • 84860706745 scopus 로고    scopus 로고
    • The transport of antiepileptic drugs by P-glycoprotein
    • Zhang C, Kwan P, Zuo Z, Baum L (2012) The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev 64:930-942
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 930-942
    • Zhang, C.1    Kwan, P.2    Zuo, Z.3    Baum, L.4
  • 80
    • 0027525354 scopus 로고
    • Excitotoxic neuronal damage and neuropsychiatric disorders
    • Zorumski CF, Olney JW (1993) Excitotoxic neuronal damage and neuropsychiatric disorders. Pharmacol Ther 59:145-162
    • (1993) Pharmacol Ther , vol.59 , pp. 145-162
    • Zorumski, C.F.1    Olney, J.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.