Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier

Endocrinology

Volumn 145, Issue 9, 2004, Pages 4384-4391

  Tohyama, Kimio ^a   Kusuhara, Hiroyuki ^a   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOBICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; AMINO ACID DERIVATIVE; ANION TRANSPORT PROTEIN; CARRIER PROTEIN; CARRIER PROTEIN OATP14; DIGOXIN; ESTRONE SULFATE; LEUCINE; PENICILLIN G; PROBENECID; TAUROCHOLIC ACID; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN; BRAIN CAPILLARY; BRAIN CORTEX; BRAIN PERFUSION; CELL LINE; CEREBELLUM; CHOROID PLEXUS; ENZYME SUBSTRATE; HORMONE TRANSPORT; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TECHNIQUE; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CEREBELLUM; CEREBRAL CORTEX; CHOROID PLEXUS; ESTRADIOL; IODINE RADIOISOTOPES; MALE; MICE; ORGANIC CATION TRANSPORT PROTEINS; THYROXINE; TRIIODOTHYRONINE;

EID: 4344581457     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0058     Document Type: Article

References (33)

1. Bernal J 2002 Action of thyroid hormone in brain. J Endocrinol Invest 25:268-288
2. Sarkar PK 2002 In quest of thyroid hormone function in mature mammalian brain. Indian J Exp Biol 40:865-873
3. Alvarez-Dolado M, Iglesias T, Rodriguez-Pena A, Bernai J, Munoz A 1994 Expression of neurotrophins and the trk family of neurotrophin receptors in normal and hypothyroid rat brain. Brain Res Mol Brain Res 27:249-257
4. Ekins R 1992 The free hormone hypothesis and measurement of free hormones. Clin Chem 38:1289-1293
5. Dratman MB, Crutchfield FL, Schoenhoff MB 1991 Transport of iodothyronines from bloodstream to brain: contributions by blood:brain and choroid plexus:cerebrospinal fluid barriers. Brain Res 554:229-236
6. Cheng LY, Outterbridge LV, Covatta ND, Martens DA, Gordon JT, Dratman MB 1994 Film autoradiography identifies unique features of [125I]3, 3′5′-(reverse) triiodothyronine transport from blood to brain. J Neurophysiol 72:380-391
7. Pardridge WM 1979 Carrier-mediated transport of thyroid hormones through the rat blood-brain barrier: primary role of albumin-bound hormone. Endocrinology 105:605-612
8. Hagen GA, Solberg Jr LA 1974 Brain and cerebrospinal fluid permeability to intravenous thyroid hormones. Endocrinology 95:1398-1410
9. Banks WA, Kastin AJ, Michals EA 1985 Transport of thyroxine across the blood-brain barrier is directed primarily from brain to blood in the mouse. Life Sci 37:2407-2414
10. Li JY, Boado RJ, Pardridge WM 2001 Blood-brain barrier genomics. J Cereb Blood Flow Metab 21:61-68
11. Sugiyama D, Kusuhara H, Taniguchi H, Ishikawa S, Nozaki Y, Aburatani H, Sugiyama Y 2003 Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. J Biol Chem 278:43489-43495
12. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ 2002 Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol 16:2283-2296
13. Abe T, Kakyo M, Sakagami H, Tokui T, Nishio T, Tanemoto M, Nomura H, Hebert SC, Matsuno S, Kondo H, Yawo H 1998 Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem 273:22395-22401
14. Reichel C, Gao B, Van Montfoort J, Cattori V, Rahner C, Hagenbuch B, Stieger B, Kamisako T, Meier PJ 1999 Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Gastroenterology 117:688-695
15. Friesema EC, Docter R, Moerings EP, Verrey F, Krenning EP, Hennemann G, Visser TJ 2001 Thyroid hormone transport by the heterodimeric human system L amino acid transporter. Endocrinology 142:4339-4348
16. Matsuo H, Tsukada S, Nakata T, Chairoungdua A, Kim DK, Cha SH, Inatomi J, Yorifuji H, Fukuda J, Endou H, Kanai Y 2000 Expression of a system L neutral amino acid transporter at the blood-brain barrier. Neuroreport 11:3507-3511
17. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ 2003 Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 278:40128-40135
18. Hearn MT, Hancock WS, Bishop CA 1978 High-pressure liquid chromatography of amino acids, peptides and proteins. V. Separation of thyroidal iodoamino acids by hydrophilic ion-paired reversed-phase high-performance liquid chromatography. J Chromatogr 157:337-344
19. Dagenais C, Rousselle C, Pollack GM, Scherrmann JM 2000 Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice. J Cereb Blood Flow Metab 20:381-386
20. Yamaoka K, Tanigawara Y, Nakagawa T, Uno T 1981 A pharmacokinetic analysis program (multi) for microcomputer. J Pharmacobiodyn 4:879-885
21. Ball HJ, McParland B, Driussi C, Hunt NH 2002 Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection. Brain Res Brain Res Protoc 9:206-213
22. Dallaire L, Tremblay L, Beliveau R 1991 Purification and characterization of metabolically active capillaries of the blood-brain barrier. Biochem J 276(Pt 3):745-752
23. Sugiyama D, Kusuhara H, Shitara Y, Abe T, Sugiyama Y 2002 Effect of 17 β-estradiol-D-17 β-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates. Drug Metab Dispos 30:220-223
24. Hulbert AJ 2000 Thyroid hormones and their effects: a new perspective. Biol Rev Camb Philos Soc 75:519-631
25. Palha JA, Episkopou V, Maeda S, Shimada K, Gottesman ME, Saraiva MJ 1994 Thyroid hormone metabolism in a transthyretin-null mouse strain. J Biol Chem 269:33135-33139
26. Abe T, Suzuki T, Unno M, Tokui T, Ito S 2002 Thyroid hormone transporters: recent advances. Trends Endocrinol Metab 13:215-220
27. Hennemann G, Docter R, Friesema EC, de Jong M, Krenning EP, Visser TJ 2001 Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev 22:451-476
28. Zheng W, Deane R, Redzic Z, Preston JE, Segal MB 2003 Transport of L-[125I]thyroxine by in situ perfused ovine choroid plexus: inhibition by lead exposure. J Toxicol Environ Health A 66:435-451
29. Chantoux F, Blondeau JP, Francon J 1995 Characterization of the thyroid hormone transport system of cerebrocortical rat neurons in primary culture. J Neurochem 65:2549-2554
30. Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T 2001 Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology 142:2005-2012
31. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S 2004 A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74:168-175
32. Guadano-Ferraz A, Obregon MJ, St. Germain DL, Bernai J 1997 The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain. Proc Natl Acad Sci USA 94:10391-10396
33. Tu HM, Legradi G, Bartha T, Salvatore D, Lechan RM, Larsen PR 1999 Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology 140:784-790