Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: Toward in situ pharmacometabolomes

Journal of Neuroimmune Pharmacology

Volumn 5, Issue 1, 2010, Pages 31-43

  Sugiura, Yuki ^a,b,c   Setou, Mitsutoshi ^b,c  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Imaging mass spectrometry; MALDI; Pharmacometabolome

Indexed keywords

ANTINEOPLASTIC AGENT; BANOXANTRONE; DIAZEPAM; IMATINIB; OLANZAPINE; PHOSPHOLIPID; UNCLASSIFIED DRUG; VINBLASTINE;

DRUG DISTRIBUTION; DRUG METABOLISM; HUMAN; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; GANGLIOSIDES; METABOLOME; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PHOSPHOLIPIDS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE DISTRIBUTION; WORKFLOW;

EID: 77249156030     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-009-9162-6     Document Type: Review

References (60)

1. H Ageta S Asai Y Sugiura N Goto-Inoue N Zaima M Setou 2008 Layer-specific sulfatide localization in rat hippocampus middle molecular layer is revealed by nanoparticle-assisted laser desorption/ionization imaging mass spectrometry Med Mol Morphol 42 16 23 10.1007/s00795-008-0427-6
2. AF Altelaar I Klinkert K Jalink RP de Lange RA Adan RM Heeren SR Piersma 2006 Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry Anal Chem 78 734 742 10.1021/ac0513111 10.1021/ac0513111 16448046 (Pubitemid 43228580)
3. TM Annesley 2003 Ion suppression in mass spectrometry Clin Chem 49 1041 1044 10.1373/49.7.1041 10.1373/49.7.1041 12816898 (Pubitemid 36751088)
4. E Astigarraga G Barreda-Gomez L Lombardero O Fresnedo F Castano MT Giralt B Ochoa R Rodriguez-Puertas JA Fernandez 2008 Profiling and imaging of lipids on brain and liver tissue by matrix-assisted laser desorption/ionization mass spectrometry using 2-mercaptobenzothiazole as a matrix Anal Chem 80 9105 9114 10.1021/ac801662n 18959430
5. SJ Atkinson PM Loadman C Sutton LH Patterson MR Clench 2007 Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry Rapid Commun Mass Spectrom 21 1271 1276 10.1002/rcm.2952 10.1002/rcm.2952 17340571 (Pubitemid 46509403)
6. RM Caprioli TB Farmer J Gile 1997 Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS Anal Chem 69 4751 4760 10.1021/ac970888i 10.1021/ac970888i 9406525
7. S Cha ES Yeung 2007 Colloidal graphite-assisted laser desorption/ionization mass spectrometry and MSn of small molecules. 1. Imaging of cerebrosides directly from rat brain tissue Anal Chem 79 2373 2385 10.1021/ac062251h 10.1021/ac062251h 17288467 (Pubitemid 46449019)
8. P Chaurand M Stoeckli RM Caprioli 1999 Direct profiling of proteins in biological tissue sections by MALDI mass spectrometry Anal Chem 71 5263 5270 10.1021/ac990781q 10.1021/ac990781q 10596208 (Pubitemid 129563241)
9. P Chaurand JL Norris DS Cornett JA Mobley RM Caprioli 2006 New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry J Proteome Res 5 2889 2900 10.1021/pr060346u 10.1021/pr060346u 17081040 (Pubitemid 44749207)
10. Y Chen J Allegood Y Liu E Wang B Cachon-Gonzalez TM Cox AH Merrill Jr MC Sullards 2008 Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease Anal Chem 80 2780 2788 10.1021/ac702350g 10.1021/ac702350g 18314967 (Pubitemid 351556439)
11. TL Colliver CL Brummel ML Pacholski FD Swanek AG Ewing N Winograd 1997 Atomic and molecular imaging at the single-cell level with TOF-SIMS Anal Chem 69 2225 2231 10.1021/ac9701748 10.1021/ac9701748 9212701
12. DS Cornett SL Frappier RM Caprioli 2008 MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue Anal Chem 80 5648 5653 10.1021/ac800617s 10.1021/ac800617s 18564854
13. Fuchser J, Cornett S, Becker M (2008) High resolution molecular imaging of pharmaceuticals at therapeutic levels. Application note # FTMS-37. Bruker Daltonics, Billerica
14. TJ Garrett MC Prieto-Conaway V Kovtoun H Bui N Izgarian G Stafford RA Yost 2006 Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer Int J Mass Spectrom 260 11
15. F Gharahdaghi M Kirchner J Fernandez SM Mische 1996 Peptide-mass profiles of polyvinylidene difluoride-bound proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in the presence of nonionic detergents Anal Biochem 233 94 99 10.1006/abio.1996.0012 10.1006/abio.1996.0012 8789152 (Pubitemid 26036366)
16. T Hayasaka N Goto-Inoue Y Sugiura N Zaima H Nakanishi K Ohishi S Nakanishi T Naito R Taguchi M Setou 2008 Matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF)-based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina Rapid Commun Mass Spectrom 22 3415 3426 10.1002/rcm.3751 10.1002/rcm.3751 18837478
17. SN Jackson HY Wang AS Woods 2005 Direct profiling of lipid distribution in brain tissue using MALDI-TOFMS Anal Chem 77 4523 4527 10.1021/ac050276v 10.1021/ac050276v 16013869 (Pubitemid 41542275)
18. SN Jackson HY Wang AS Woods 2005 In situ structural characterization of phosphatidylcholines in brain tissue using MALDI-MS/MS J Am Soc Mass Spectrom 16 2052 2056 10.1016/j.jasms.2005.08.014 10.1016/j.jasms.2005.08.014 16253515 (Pubitemid 41642968)
19. SN Jackson M Ugarov T Egan JD Post D Langlais J Albert Schultz AS Woods 2007 MALDI-ion mobility-TOFMS imaging of lipids in rat brain tissue J Mass Spectrom 42 1093 1098 10.1002/jms.1245 10.1002/jms.1245 17621389 (Pubitemid 47255461)
20. SN Jackson HY Wang AS Woods 2007 In situ structural characterization of glycerophospholipids and sulfatides in brain tissue using MALDI-MS/MS J Am Soc Mass Spectrom 18 17 26 10.1016/j.jasms.2006.08.015 10.1016/j.jasms.2006.08.015 17005416 (Pubitemid 46038161)
21. JJ Jones S Borgmann CL Wilkins RM O'Brien 2006 Characterizing the phospholipid profiles in mammalian tissues by MALDI FTMS Anal Chem 78 3062 3071 10.1021/ac0600858 10.1021/ac0600858 16642994 (Pubitemid 43726126)
22. FB Jungalwala V Hayssen JM Pasquini RH McCluer 1979 Separation of molecular species of sphingomyelin by reversed-phase high-performance liquid chromatography J Lipid Res 20 579 587 490037
23. S Khatib-Shahidi M Andersson JL Herman TA Gillespie RM Caprioli 2006 Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry Anal Chem 78 6448 6456 10.1021/ac060788p 10.1021/ac060788p 16970320 (Pubitemid 44418954)
24. Kokaji T (2008) Applied biosystems' IMS. In: Setou M (ed) Mass microscopy; imaging mass spectrometry protocol book. Springer, Tokyo
25. M Kotani I Kawashima H Ozawa T Terashima T Tai 1993 Differential distribution of major gangliosides in rat central nervous system detected by specific monoclonal antibodies Glycobiology 3 137 146 10.1093/glycob/3.2.137 10.1093/glycob/3.2.137 8490240
26. Kowalski JM, Kowalski P, Holle A, Deininger SO, Khatib-Shahidi S, Caprioli RM (2007) MALDI tissue imaging of drugs with the ultraflex MALDI TOF/TOF. Application note # MT-87. Bruker Daltonics, Billerica
27. E Krause H Wenschuh PR Jungblut 1999 The dominance of arginine-containing peptides in MALDI-derived tryptic mass fingerprints of proteins Anal Chem 71 4160 4165 10.1021/ac990298f 10.1021/ac990298f 10517141 (Pubitemid 29466391)
28. Y Li B Shrestha A Vertes 2007 Atmospheric pressure molecular imaging by infrared MALDI mass spectrometry Anal Chem 79 523 532 10.1021/ac061577n 10.1021/ac061577n 17222016 (Pubitemid 46106116)
29. Y Li B Shrestha A Vertes 2008 Atmospheric pressure infrared MALDI imaging mass spectrometry for plant metabolomics Anal Chem 80 407 420 10.1021/ac701703f 10.1021/ac701703f 18088102
30. Q Liu Z Guo L He 2007 Mass spectrometry imaging of small molecules using desorption/ionization on silicon Anal Chem 79 3535 3541 10.1021/ac0611465 10.1021/ac0611465 17428031 (Pubitemid 46799045)
31. Q Liu Y Xiao C Pagan-Miranda YM Chiu L He 2008 Metabolite imaging using matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) J Am Soc Mass Spectrom 20 80 88 10.1016/j.jasms.2008.09.011 18926722
32. JE Mansson MT Vanier L Svennerholm 1978 Changes in the fatty acid and sphingosine composition of the major gangliosides of human brain with age J Neurochem 30 273 275 10.1111/j.1471-4159.1978.tb07064.x 10.1111/j.1471-4159. 1978.tb07064.x 621516 (Pubitemid 8266305)
33. V Mazel P Richardin D Debois D Touboul M Cotte A Brunelle P Walter O Laprevote 2007 Identification of ritual blood in African artifacts using TOF-SIMS and synchrotron radiation microspectroscopies Anal Chem 79 9253 9260 10.1021/ac070993k 10.1021/ac070993k 17990853 (Pubitemid 350276302)
34. JA McLean WB Ridenour RM Caprioli 2007 Profiling and imaging of tissues by imaging ion mobility-mass spectrometry J Mass Spectrom 42 1099 1105 10.1002/jms.1254 10.1002/jms.1254 17621390 (Pubitemid 47255462)
35. EB Monroe JC Jurchen J Lee SS Rubakhin JV Sweedler 2005 Vitamin E imaging and localization in the neuronal membrane J Am Chem Soc 127 12152 12153 10.1021/ja051223y 10.1021/ja051223y 16131155 (Pubitemid 41279202)
36. M Murakami Y Nakatani G Atsumi K Inoue I Kudo 1997 Regulatory functions of phospholipase A2 Crit Rev Immunol 17 225 283 9202883
37. TR Northen O Yanes MT Northen D Marrinucci W Uritboonthai J Apon SL Golledge A Nordstrom G Siuzdak 2007 Clathrate nanostructures for mass spectrometry Nature 449 1033 1036 10.1038/nature06195 10.1038/nature06195 17960240 (Pubitemid 350017585)
38. SG Ostrowski CT Van Bell N Winograd AG Ewing 2004 Mass spectrometric imaging of highly curved membranes during Tetrahymena mating Science 305 71 73 10.1126/science.1099791 10.1126/science.1099791 15232100 (Pubitemid 38869371)
39. P Palestini M Masserini S Sonnino A Giuliani G Tettamanti 1990 Changes in the ceramide composition of rat forebrain gangliosides with age J Neurochem 54 230 235 10.1111/j.1471-4159.1990.tb13305.x 10.1111/j.1471-4159.1990.tb13305.x 2293613 (Pubitemid 20026118)
40. P Palestini S Sonnino G Tettamanti 1991 Lack of the ganglioside molecular species containing the C20-long-chain bases in human, rat, mouse, rabbit, cat, dog, and chicken brains during prenatal life J Neurochem 56 2048 2050 10.1111/j.1471-4159.1991.tb03465.x 10.1111/j.1471-4159.1991.tb03465.x 2027012
41. D Piomelli G Astarita R Rapaka 2007 A neuroscientist's guide to lipidomics Nat Rev Neurosci 8 743 754 10.1038/nrn2233 10.1038/nrn2233 17882252 (Pubitemid 47462119)
42. B Prideaux SJ Atkinson VA Carolan J Morton MR Clench 2007 Sample preparation and data interpretation procedures for the examination of xenobiotic compounds in skin by indirect imaging MALDI-MS Int J Mass Spectrom 260 243 251 10.1016/j.ijms.2006.10.011
43. M Pulfer RC Murphy 2003 Electrospray mass spectrometry of phospholipids Mass Spectrom Rev 22 332 364 10.1002/mas.10061 10.1002/mas.10061 12949918
44. M Rujoi R Estrada MC Yappert 2004 In situ MALDI-TOF MS regional analysis of neutral phospholipids in lens tissue Anal Chem 76 1657 1663 10.1021/ac0349680 10.1021/ac0349680 15018564 (Pubitemid 38338410)
45. K Sambasivarao RH McCluer 1964 Lipid components of gangliosides J Lipid Res 15 103 108 14173314
46. HP Schwarz I Kostyk A Marmolejo C Sarappa 1967 Long-chain bases of brain and spinal cord of rabbits J Neurochem 14 91 97 10.1111/j.1471-4159.1967. tb09497.x 10.1111/j.1471-4159.1967.tb09497.x 6018082
47. S Shimma M Setou 2007 Mass microscopy to reveal distinct localization of heme B (m/z 616) in colon cancer liver metastasis J Mass Spectrom Soc Jpn 55 145 148
48. S Shimma Y Sugiura T Hayasaka N Zaima M Matsumoto M Setou 2008 Mass imaging and identification of biomolecules with MALDI-QIT-TOF-based system Anal Chem 80 878 885 10.1021/ac071301v 18166020 (Pubitemid 351206881)
49. S Sonnino V Chigorno 2000 Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures Biochim Biophys Acta 1469 63 77 10998569
50. M Stoeckli P Chaurand DE Hallahan RM Caprioli 2001 Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues Nat Med 7 493 496 10.1038/86573 10.1038/86573 11283679 (Pubitemid 32298555)
51. M Stoeckli D Staab M Staufenbiel KH Wiederhold L Signor 2002 Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry Anal Biochem 311 33 39 10.1016/S0003-2697(02)00386-X 10.1016/S0003-2697(02) 00386-X 12441150 (Pubitemid 35463486)
52. M Stoeckli D Staab A Schweitzer 2006 Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections Int J Mass Spectrom 260 195 202
53. Y Sugiura S Shimma Y Konishi MK Yamada M Setou 2008 Imaging mass spectrometry technology and application on ganglioside study; visualization of age-dependent accumulation of C20-ganglioside molecular species in the mouse hippocampus PLoS One 3 e3232 10.1371/journal.pone.0003232 10.1371/journal.pone. 0003232 18800170
54. Sugiura Y, Konishi Y, Zaima N, Kajihara S, Nakanishi H, Taguchi R, Setou M (2009) Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry. J Lipid Res (in press)
55. S Taira Y Sugiura S Moritake S Shimma Y Ichiyanagi M Setou 2008 Nanoparticle-assisted laser desorption/ionization based mass imaging with cellular resolution Anal Chem 80 4761 4766 10.1021/ac800081z 10.1021/ac800081z 18476721 (Pubitemid 351842357)
56. D Touboul A Brunelle F Halgand S De La Porte O Laprevote 2005 Lipid imaging by gold cluster time-of-flight secondary ion mass spectrometry: application to Duchenne muscular dystrophy J Lipid Res 46 1388 1395 10.1194/jlr.M500058-JLR200 10.1194/jlr.M500058-JLR200 15834124 (Pubitemid 43109802)
57. PJ Trim CM Henson JL Avery A McEwen MF Snel E Claude PS Marshall A West AP Princivalle MR Clench 2008 Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections Anal Chem 80 8628 8634 10.1021/ac8015467 18847214
58. G van Echten K Sandhoff 1993 Ganglioside metabolism. Enzymology, topology, and regulation J Biol Chem 268 5341 5344 8449895
59. HY Wang SN Jackson AS Woods 2007 Direct MALDI-MS analysis of cardiolipin from rat organs sections J Am Soc Mass Spectrom 18 567 577 10.1016/j.jasms.2006. 10.023 10.1016/j.jasms.2006.10.023 17157526 (Pubitemid 46274395)
60. H Zhang S Cha ES Yeung 2007 Colloidal graphite-assisted laser desorption/ionization MS and MS(n) of small molecules. 2. Direct profiling and MS imaging of small metabolites from fruits Anal Chem 79 6575 6584 10.1021/ac0706170 10.1021/ac0706170 17665874 (Pubitemid 47395041)