Model analysis of the concentration-dependent permeability of p-gp substrates

Pharmaceutical Research

Volumn 27, Issue 3, 2010, Pages 442-446

  Tachibana, Tatsuhiko ^a   Kitamura, Satoshi ^b   Kato, Motohiro ^a   Mitsui, Tetsuya ^a   Shirasaka, Yoshiyuki ^c   Yamashita, Shinji ^d   Sugiyama, Yuichi ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

^d SETSUNAN UNIVERSITY   (Japan)

Author keywords

Absorption; Caco 2; Km; MDCK; P glycoprotein.

Indexed keywords

GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; QUINIDINE; VERAPAMIL; VINBLASTINE;

ARTICLE; CELL STRAIN; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; DRUG PENETRATION; ENZYME SUBSTRATE; KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STANDARDIZATION;

ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; GENE EXPRESSION; HUMANS; MODELS, BIOLOGICAL; P-GLYCOPROTEIN; QUINIDINE; VERAPAMIL; VINBLASTINE;

EID: 77949269469     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-0026-9     Document Type: Article

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