The absence of polymorphisms in ADRB3, UCP1, PPARγ, and ADIPOQ genes protects morbid obese patients toward insulin resistance

Journal of Endocrinological Investigation

Volumn 35, Issue 1, 2012, Pages 2-4

  Bracale, R ^a   Labruna, G ^b,c   Finelli, C ^c   Daniele, A ^d   Sacchetti, L ^b,c   Oriani, G ^a,b   Contaldo, F ^c   Pasanisi, F ^c  

^a UNIVERSITY OF MOLISE   (Italy)

^b CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

ADIPOQ; ADRB3; Insulin resistance; PPAR ; Severe obesity; UCP1

Indexed keywords

ADIPONECTIN; BETA 3 ADRENERGIC RECEPTOR; GENOMIC DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCOUPLING PROTEIN 1;

ADULT; ARTICLE; BODY MASS; DISEASE ASSOCIATION; FEMALE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN RESISTANCE; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MORBID OBESITY; OBESITY; PREDICTIVE VALUE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84861970088     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/BF03345413     Document Type: Article

References (15)

1. Azagury DE, Lautz DB. Obesity overview: epidemiology, health and financial impact, and guidelines for qualification for surgical therapy. Gastrointest Endosc Clin N Am 2011, 21: 189-201.
2. Kopelman PG. Obesity as a medical problem. Nature 2000, 404: 635-43. (Pubitemid 30205068)
3. Bouchard C. Gene-environment interactions in the etiology of obesity: defining the fundamentals. Obesity (Silver Spring) 2008, 16 (Suppl 3): S5-10.
4. Walley AJ, Asher JE, Froguel P. The genetic contribution to non-syndromic human obesity. Nat Rev Genet 2009, 10: 431-42.
5. Martinelli R, Nardelli C, Pilone V, et al. miR-519d overexpression is associated with human obesity. Obesity (Silver Spring) 2010, 18: 2170-6.
6. Grundy SM, Cleeman Jl, Daniels SR, et al; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation 2005, 25: 2735-52.
7. Labruna G, Pasanisi F, Nardelli C, et al. High leptin/adiponectin ratio and serum triglycerides are associated with an "at-risk" phenotype in young severely obese patients. Obesity (Silver Spring) 2011, 19: 1492-6.
8. Ramachandrappa S, Farooqi IS. Genetic approaches to understanding human obesity. J Clin Invest 2011, 121: 2080-6.
9. Macias-Gonzalez M, Moreno-Santos I, García-Almeida JM, Tinahones FJ, Garcia-Fuentes E. PPARgamma2 protects against obesity by means of a mechanism that mediates insulin resistance. Eur J Clin Invest 2009, 39: 972-9.
10. Bell CG, Walley AJ, Froguel P. The genetics of human obesity. Nat Rev Genet 2005, 6: 221-34. (Pubitemid 40293032)
11. Bracale R, Pasanisi F, Labruna G, et al. Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy. Eur J Clin Nutr 2007, 61: 1213-9. (Pubitemid 47521554)
12. Labruna G, Pasanisi F, Nardelli C, et al. UCP1 -3826 AG+GG genotypes, adiponectin, and leptin/adiponectin ratio in severe obesity. J Endocrinol Invest 2009, 32: 525-9.
13. Daniele A, Cammarata R, Pasanisi F, et al. Molecular analysis of the adiponectin gene in severely obese patients from Southern Italy. Ann Nutr Metab 2008, 53: 155-61.
14. Stem SE, Williams K, Ferrannini E, DeFronzo RA, Bogardus C, Stem MP. Identification of individuals with insulin resistance using routine clinical measurements. Diabetes 2005, 54: 333-9.
15. Gabriel SB, Schaffner SF, Nguyen H, et al. The structure of haplotype blocks in the human genome. Science 2002, 296: 2225-9. (Pubitemid 34680308)