Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy

Gene

Volumn 457, Issue 1-2, 2010, Pages 35-41

  Alfieri, Andreina ^a,b   Pasanisi, Fabrizio ^c   Salzano, Salvatore ^c   Esposito, Luciana ^d   Martone, Domenico ^a   Tafuri, Domenico ^a   Daniele, Aurora ^b,e,f   Contaldo, Franco ^c   Sacchetti, Lucia ^c,f   Zagari, Adriana ^d,f   Buono, Pasqualina ^a,b,f  

^a UNIVERSITY OF NAPLES PARTHENOPE   (Italy)

^b IRCCS SDN   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d CNR   (Italy)

^e UNIVERSITY OF MOLISE   (Italy)

^f CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Confocal microscopy; Dominant negative; Functional analysis; Homology modeling; MC4R mutants; Severe obesity

Indexed keywords

MELANOCORTIN 4 RECEPTOR; ALPHA INTERMEDIN; LIGAND; MC4R PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN;

ADULT; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL MUTANT; CELLULAR DISTRIBUTION; CHILD; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; ENDOPLASMIC RETICULUM; GENE IDENTIFICATION; GENETIC ASSOCIATION; HETEROZYGOSITY; HOMEOSTASIS; HOMOZYGOSITY; HUMAN; HUMAN CELL; ITALY; LIGAND BINDING; MAJOR CLINICAL STUDY; MISSENSE MUTATION; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; WILD TYPE; CELL CULTURE; CHEMICAL STRUCTURE; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; MORBID OBESITY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION;

ALPHA-MSH; AMINO ACID SUBSTITUTION; CELLS, CULTURED; HUMANS; ITALY; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; MUTANT PROTEINS; OBESITY, MORBID; PHOSPHORYLATION; PROTEIN BINDING; RECEPTOR, MELANOCORTIN, TYPE 4; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 77951935284     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2010.03.001     Document Type: Article

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